{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:58:52Z","timestamp":1758632332189,"version":"3.41.2"},"reference-count":43,"publisher":"IMR Press","issue":"1","license":[{"start":{"date-parts":[[2019,3,30]],"date-time":"2019-03-30T00:00:00Z","timestamp":1553904000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Hypertension remains a major public health problem and one of the most relevant causes of cardiovascular mortality and morbidity worldwide. Roughly 10% of hypertensive individuals are considered as \u201cresistant\u201d as they are not able to achieve and maintain optimal blood pressure values despite the concurrent use of 3 antihypertensive agents of different classes at optimal doses. As resistant hypertension conveys a higher risk of adverse outcomes, the search for effective treatments to properly manage this condition has progressively surged as a true health priority. The renal nerve plexus plays a central role in regulating arterial blood pressure and renal sympathetic overactivity is a major component in the development and progression of hypertension. On these premises, minimally-invasive catheter based devices for renal nerve ablation have been developed and tested as an alternative treatment for resistant hypertension, but clinical study results have been ambiguous. This review provides a historical perspective on the scientific evidence forming the foundation of renal never ablation from accrued clinical evidence to possible future applications, reaching a tentative conclusion that more research and clinical experience is needed to fully reveal limits and potential indications of this procedure.<\/jats:p>","DOI":"10.31083\/j.rcm.2019.01.51","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T03:24:58Z","timestamp":1560223498000},"source":"Crossref","is-referenced-by-count":3,"title":["Renal nerve ablation for resistant hypertension: facts, fictions and future directions"],"prefix":"10.31083","volume":"20","author":[{"given":"Davide","family":"Bolignano","sequence":"first","affiliation":[{"name":"CNR Institute of Clinical Physiology, c\/o EUROLINE, Via Vallone Petrara 55-57, 89124 Reggio Calabria, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Coppolino","sequence":"first","affiliation":[{"name":"Renal Unit, Department of Health Sciences, \"Magna Graecia\" University, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2019,3,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Azizi, M., Sapoval, M., Gosse, P., Monge, M., Bobrie, G., Delsart, P., Midulla, M., Mounier-Vehier, C., Courand, P. 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