{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T12:54:12Z","timestamp":1776862452990,"version":"3.51.2"},"reference-count":52,"publisher":"IMR Press","issue":"3","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Myocardial ischemia-reperfusion (I\/R) injury is leading cause of death worldwide. miR-34a-5p was up-regulated in myocardial ischemia-reperfusion injury rats. We aim to explore how miR-34a-5p inhibition protected myocardium against I\/R injury in both cell and animal models. In vivo rat and in vitro cell model were firstly constructed. Quantitative real-time polymerase chain reaction was employed to investigate expression of miR-34a-5p and its target genes. Functional assays were conducted to detect the impact of miR-34a-5p on myocardial I\/R injury. Enzyme-linked immunosorbent assay was performed to validate the expression levels of marker proteins of ischemia-reperfusion I\/R-induced myocardial injury. MTT was performed to assess the cell viability and flow cytometry was utilized to detect cell apoptosis and reactive oxygen species accumulation. The interaction between miR-34a-5p and Notch Receptor 1 were also examined through luciferase reporter assay. miR-34a-5p was up-regulated post-reperfusion at rat myocardium. miR-34a-5p inhibitor attenuated myocardial ischemia-reperfusion injury, as shown by decreasing apoptosis rate, reducing infarct size and reactive oxygen species accumulation. In in vitro cell model, miR-34a-5p inhibitor also promoted cell proliferation, inhibited cell apoptosis and reactive oxygen species accumulation through targeting Notch Receptor 1 signaling. Our results revealed that miR-34a-5p knocking down attenuated myocardial I\/R injury by promoting Notch Receptor 1 signaling-mediated inhibition of reactive oxygen species accumulation and cell apoptosis. Hence, miR-34a-5p might be a potential target for treatment of myocardial ischemia-reperfusion injury.<\/jats:p>","DOI":"10.31083\/j.rcm.2019.03.545","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T11:04:42Z","timestamp":1569841482000},"source":"Crossref","is-referenced-by-count":26,"title":["Inhibition of miR-34a-5p protected myocardial ischemia reperfusion injury-induced apoptosis and reactive oxygen species accumulation through regulation of Notch Receptor 1 signaling"],"prefix":"10.31083","volume":"20","author":[{"given":"Zheng","family":"Wang","sequence":"first","affiliation":[{"name":"Research division of the Linfen People\u2019s Hospital, Linfen, Shanxi, 041000, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhan","family":"Wang","sequence":"first","affiliation":[{"name":"Research division in National health commission of the people\u2019s Government of Linfen city, Linfen, Shanxi, 041000, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiezhong","family":"Wang","sequence":"first","affiliation":[{"name":"Research division of the Linfen People\u2019s Hospital, Linfen, Shanxi, 041000, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayang","family":"Yuan","sequence":"first","affiliation":[{"name":"Research division of the Linfen People\u2019s Hospital, Linfen, Shanxi, 041000, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuechen","family":"Wang","sequence":"first","affiliation":[{"name":"Research division in National health commission of the people\u2019s Government of Linfen city, Linfen, Shanxi, 041000, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiguo","family":"Zhang","sequence":"first","affiliation":[{"name":"Research division in National health commission of the people\u2019s Government of Linfen city, Linfen, Shanxi, 041000, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"ref1","unstructured":"Abak, A., Amini, S., Sakhinia, E. and Abhari, A. (2018) Microrna-221: biogenesis, function and signatures in human cancers. European Review for Medical and Pharmacological sciences 22, 3094-3117. f0602d0f4e6eb34d3b8ae12f386e2487http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F29863255"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Britto, R. M., Silva-Neto, J. A. D., Mesquita, T. R. R., Vasconcelos, C. M. L., de Almeida, G. K. M., Jesus, I. C. G., Santos, P. H. D., Souza, D. S., Miguel-Dos-Santos, R., de Sa, L. A., Dos Santos, F. S. M., Pereira-Filho, R. N., Albuquerque-Junior, R. L. C., Quintans-Junior, L. J., Guatimosim, S. and Lauton-Santos, S. (2018) Myrtenol protects against myocardial ischemia-reperfusion injury through antioxidant and anti-apoptotic dependent mechanisms. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 111, 557-566. a28132a7aa1f7ed350a08d80b263bdfbhttp%3A%2F%2Feuropepmc.org%2Fabstract%2FMED%2F29208507","DOI":"10.1016\/j.fct.2017.12.003"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Budihardjo, I., Oliver, H., Lutter, M., Luo, X. and Wang, X. (1999) Biochemical pathways of caspase activation during apoptosis. Annual Review of Cell and Developmental Biology 15, 269-290. 690a360633dcf5402db9e3481f87444ahttp%3A%2F%2Fwww.annualreviews.org%2Fdoi%2Fpdf%2F10.1146%2Fannurev.cellbio.15.1.269","DOI":"10.1146\/annurev.cellbio.15.1.269"},{"key":"ref4","unstructured":"Cai, W., Yang, X., Han, S., Guo, H., Zheng, Z., Wang, H., Guan, H., Jia, Y., Gao, J., Yang, T., Zhu, X. and Hu, D. (2016) Notch1 pathway protects against burn-induced myocardial injury by repressing reactive oxygen species production through Jak2\/Stat3 signaling. Oxidative Medicine and Cellular Longevity 2016, 5638943. 059f84d04a3b0191cf93d33697cd0c97http%3A%2F%2Feuropepmc.org%2Farticles%2FPMC4736405%2F"},{"key":"ref5","unstructured":"Calin, G., A. and Croce,C. M. (2006) Microrna signatures in human cancers. Nature reviews Cancer 6, 857-866. 57a724fb850e34bfa588ae60472184b5https%3A%2F%2Fwww.nature.com%2Fnrc%2Fjournal%2Fv6%2Fn11%2Fabs%2Fnrc1997.html"},{"key":"ref6","unstructured":"Chiba, S. (2006) Notch Signaling in Stem Cell Systems. Stem Cells 24, 2437-2447. 714833eb8c35dfee63dfdb6cef0984aahttp%3A%2F%2Feuropepmc.org%2Fabstract%2FMED%2F16888285"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Das, A., Salloum, F. N., Durrant, D., Ockaili, R. and Kukreja, R. C. (2012) Rapamycin protects against myocardial ischemia-reperfusion injury through Jak2-Stat3 signaling pathway. Journal of Molecular and Cellular cardiology 53, 858-869. 95758abb873058b3b09ea3f0ee14731fhttp%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F22999860","DOI":"10.1016\/j.yjmcc.2012.09.007"},{"key":"ref8","unstructured":"del Monte, G., Casanova, J. C., Guadix, J. A., MacGrogan, D., Burch, J. B., Perez-Pomares, J. M. and de la Pompa, J. L. (2011) Differential notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis. Circulation Research 108, 824-836. b08bd2ceaa5266dcc4c39166aa4dc15ehttp%3A%2F%2Feuropepmc.org%2Fabstract%2FMED%2F21311046"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Duan, W., Yang, Y., Yan, J., Yu, S., Liu, J., Zhou, J., Zhang, J., Jin, Z. and Yi, D. (2012) The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the Jak2\/Stat3 signaling pathway. Basic Research in Cardiology 107, 263. b0bcd4ba2bb087cf01358daaf44f112chttp%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F22466958","DOI":"10.1007\/s00395-012-0263-7"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Faiao-Flores, F., Coelho, P. R., Toledo Arruda-Neto, J. D., Maria-Engler, S. S., Tiago, M., Capelozzi, V. L., Giorgi, R. R. and Maria, D. A. (2013) Apoptosis through Bcl-2\/Bax and cleaved caspase up-regulation in melanoma treated by boron neutron capture therapy. PloS One 8, e59639. ae0638c3fd2adbcefafa882da6ed7c93http%3A%2F%2Feuropepmc.org%2Farticles%2FPMC3603877%2F","DOI":"10.1371\/journal.pone.0059639"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Fan, Z. X. and Yang, J. (2015) The role of micrornas in regulating myocardial ischemia reperfusion injury. Saudi medical journal 36, 787-793.","DOI":"10.15537\/smj.2015.7.11089"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Fu, B. C., Lang, J. L., Zhang, D. Y., Sun, L., Chen, W., Liu, W., Liu, K. Y., Ma, C. Y., Jiang, S. L., Li, R. K. and Tian, H. (2017) Suppression of mir-34a expression in the myocardium protects against ischemia-reperfusion injury through sirt1 protective pathway. Stem Cells and Development 26, 1270-1282. 7ae8998bd7f24639ccb50d56f57f0c23http%3A%2F%2Feuropepmc.org%2Fabstract%2FMED%2F28599575","DOI":"10.1089\/scd.2017.0062"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Garzon, R., Pichiorri, F., Palumbo, T., Iuliano, R., Cimmino, A., Aqeilan, R., Volinia, S., Bhatt, D., Alder, H., Marcucci, G., Calin, G. A., Liu, C. G., Bloomfield, C. D., Andreeff, M. and Croce, C. M. (2006) Microrna fingerprints during human megakaryocytopoiesis. Proceedings of the National Academy of Sciences of the United States of America 103, 5078-5083. a5f9513d0763d4c3053325b222847a9ahttp%3A%2F%2Fwww.jstor.org%2Fstable%2F30048748","DOI":"10.1073\/pnas.0600587103"},{"key":"ref14","unstructured":"Granger, D. N. and Kvietys, P. R. (2015) Reperfusion injury and reactive oxygen species: the evolution of a concept. Redox biology 6, 524-551. ad48602947e6c42206f08ccc0a2e1e0bhttp%3A%2F%2Feuropepmc.org%2Farticles%2FPMC4625011%2F"},{"key":"ref15","unstructured":"Gude, N. A., Emmanuel, G., Wu, W., Cottage, C. T., Fischer, K., Quijada, P., Muraski, J. A., Alvarez, R., Rubio, M., Schaefer, E. and Sussman, M. A. (2008) Activation of notch-mediated protective signaling in the myocardium. Circulation Research 102, 1025-1035. b1e090dbf9a9f5477a84ca22c50938b5http%3A%2F%2Fpubmedcentralcanada.ca%2Fpmcc%2Farticles%2FPMC3760732%2F"},{"key":"ref16","unstructured":"Hashmi, S. and Al-Salam, S. (2015) Acute myocardial infarction and myocardial ischemia-reperfusion injury: a comparison. International journal of clinical and experimental pathology 8, 8786-8796. 6c6c545d5083afcbee9eca90c4d4a116http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F26464621"},{"key":"ref17","unstructured":"High, F. A. and Epstein, J. A. (2008) The multifaceted role of notch in cardiac development and disease. Nature Reviews Genetics 9, 49-61. 3a9e162eeeaf688e74f25d718a8de4a1http%3A%2F%2Feurheartj.oxfordjournals.org%2Fexternal-ref%3Faccess_num%3D18071321%26amp%3Blink_type%3DMED"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Kalogeris, T., Bao, Y. and Korthuis, R. J. (2014) Mitochondrial reactive oxygen species: a double edged sword in ischemia\/reperfusion vs preconditioning. Redox Biology 2, 702-714.","DOI":"10.1016\/j.redox.2014.05.006"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Kaur, H., Parikh, V., Sharma, A. and Singh, M. (1997) Effect of amiloride a Na + \/H + exchange inhibitor on cardioprotective effect of ischaemic preconditioning: possible involvement of resident cardiac mast cells . Pharmacological Research 36, 95-102. 0f130c63f497f3c49bd232df784d872bhttp%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F9344636","DOI":"10.1006\/phrs.1997.0174"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Kenny, D., Polson, J. W., Martin, R. P., Paton, J. F. and Wolf, A. R. (2011) Hypertension and coarctation of the aorta: an inevitable consequence of developmental pathophysiology. Hypertension research : official journal of the Japanese Society of Hypertension 34, 543-547. 2197b00752c9b2c848448eaa450e4056http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F21412243","DOI":"10.1038\/hr.2011.22"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Krijnen, P. A., Nijmeijer, R., Meijer, C. J., Visser, C. A., Hack, C. E. and Niessen, H. W. (2002) Apoptosis in myocardial ischaemia and infarction. Journal of clinical pathology 55, 801-811. dc0eaf7251769d7a1a8d54dbcda65d66http%3A%2F%2Feuropepmc.org%2Fabstract%2Fmed%2F12401816","DOI":"10.1136\/jcp.55.11.801"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Kwekkeboom, R. F., Sluijter, J. P., van Middelaar, B. J., Metz, C. H., Brans, M. A., Kamp, O., Paulus, W. J. and Musters, R. J. (2016) Increased local delivery of antagomir therapeutics to the rodent myocardium using ultrasound and microbubbles. Journal of Controlled Release : Official Journal of the Controlled Release Society 222, 18-31. d644f0fd2d7ca8494ed9b456065dee66http%3A%2F%2Feuropepmc.org%2Fabstract%2FMED%2F26616760","DOI":"10.1016\/j.jconrel.2015.11.020"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Lazou, A., Iliodromitis, E. K., Cieslak, D., Voskarides, K., Mousikos, S., Bofilis, E. and Kremastinos, D. T. (2006) Ischemic but not mechanical preconditioning attenuates ischemia\/reperfusion induced myocardial apoptosis in anaesthetized rabbits: the role of Bcl-2 family proteins and Erk1\/2. Apoptosis : an international journal on programmed cell death 11, 2195-2204. f37d38f83375a6dd8a9cc840fe2c0eabhttp%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs10495-006-0292-5","DOI":"10.1007\/s10495-006-0292-5"},{"key":"ref24","unstructured":"Li, Y., Hiroi, Y. and Liao, J. K. (2010) Notch signaling as an important mediator of cardiac repair and regeneration after myocardial infarction. Trends in Cardiovascular Medicine 20, 228-231. 3e57dcf5c93e533a5985a0ab9aaea46bhttp%3A%2F%2Feuropepmc.org%2Farticles%2FPMC3307142%2F"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Liu, B., Zhang, Y. H., Jiang, Y., Li, L. L., Chen, Q., He, G. Q., Tan, X. D. and Li, C. Q. (2015) Gadd45b is a novel mediator of neuronal apoptosis in ischemic stroke. International Journal of Biological Sciences 11, 353-360. 333843880822f411e08e46b5e59e376fhttp%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F25678854","DOI":"10.7150\/ijbs.9813"},{"key":"ref26","unstructured":"Liu, Y. F., Chu, Y. Y., Zhang, X. Z., Zhang, M., Xie, F. G., Zhou, M., Wen, H. H. and Shu, A. H. (2017) Tgfbeta1 protects myocardium from apoptosis and oxidative damage after ischemia reperfusion. European Review for Medical and Pharmacological Sciences 21, 1551-1558. ab710053122c3351d4de7bc4c7ac1053http%3A%2F%2Feuropepmc.org%2Fabstract%2FMED%2F28429351"},{"key":"ref27","unstructured":"Mackman, N. (2008) Triggers, targets and treatments for thrombosis. Nature 451, 914-918. 07c7f7a1a94e63d5a3e20376b5741d5bhttp%3A%2F%2Feuropepmc.org%2Farticles%2FPMC2848509%2F"},{"key":"ref28","unstructured":"Marenzi, G., Cosentino, N., Boeddinghaus, J., Trinei, M., Giorgio, M., Milazzo, V., Moltrasio, M., Cardinale, D., Sandri, M. T., Veglia, F., Bonomi, A., Kaech, M., Twerenbold, R., Nestelberger, T., Reichlin, T., Wildi, K., Shrestha, S., Kohzuharov, N., Sabti, Z., Cipolla, C. M., Mueller, C. and Bartorelli, A. L. (2016) Diagnostic and prognostic utility of circulating cytochrome c in acute myocardial infarction. Circulation Research 119, 1339-1346. 823d316992cc1d007a0250c750b2b3a7http%3A%2F%2Feuropepmc.org%2Farticles%2FPMC5627527%2F"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Mayer, B. and Oberbauer, R. (2003) Mitochondrial regulation of apoptosis. News in Physiological Sciences 18, 89-94.","DOI":"10.1152\/nips.01433.2002"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Miele, L. (2006) Notch signaling. Clinical Cancer Research : An Official journal of the American Association for Cancer Research 12, 1074-1079.","DOI":"10.1158\/1078-0432.CCR-05-2570"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Mumm, J. S. and Kopan, R. (2000) Notch signaling: from the outside in. Developmental Biology 228, 151-165. 7c2c429876e72d5179e03862e6a22625http%3A%2F%2Feuropepmc.org%2Fabstract%2FMED%2F11112321","DOI":"10.1006\/dbio.2000.9960"},{"key":"ref32","unstructured":"Namura, S., Zhu, J., Fink, K., Endres, M., Srinivasan, A., Tomaselli, K. J., Yuan, J. and Moskowitz, M. A. (1998) Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 18, 3659-3668. 623196f1210843859bddb6a5e47e902chttp%3A%2F%2Fbrain.oxfordjournals.org%2Flookup%2Fijlink%3FlinkType%3DABST%26amp%3BjournalCode%3Djneuro%26amp%3Bresid%3D18%2F10%2F3659%26amp%3Batom%3D%252Fbrain%252F132%252F8%252F2239.atom"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Nemir, M. and Pedrazzini, T. (2008) Functional role of notch signaling in the developing and postnatal heart. Journal of Molecular and Cellular Cardiology 45, 495-504. ae75170b50ebf719a0c045fed1485522http%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fpii%2FS0022282808003179","DOI":"10.1016\/j.yjmcc.2008.02.273"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Noh, H. S., Shin, I. W., Ha, J. H., Hah, Y. S., Baek, S. M. and Kim, D. R. (2010) Propofol protects the autophagic cell death induced by the ischemia\/reperfusion injury in rats. Molecules and Cells 30, 455-460. e95fd998e826a88a427bc0e4c2826e65http%3A%2F%2Feuropepmc.org%2Fabstract%2FMED%2F20821058","DOI":"10.1007\/s10059-010-0130-z"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Pei, H., Song, X., Peng, C., Tan, Y., Li, Y., Li, X., Ma, S., Wang, Q., Huang, R., Yang, D., Li, D., Gao, E. and Yang, Y. (2015) Tnf-alpha inhibitor protects against myocardial ischemia\/reperfusion injury via notch1-mediated suppression of oxidative\/nitrative stress. Free Radical Biology &Medicine 82, 114-121.","DOI":"10.1016\/j.freeradbiomed.2015.02.002"},{"key":"ref36","unstructured":"Pei, H., Yu, Q., Xue, Q., Guo, Y., Sun, L., Hong, Z., Han, H., Gao, E., Qu, Y. and Tao, L. (2013) Notch1 cardioprotection in myocardial ischemia\/reperfusion involves reduction of oxidative\/nitrative stress. Basic Research in Cardiology 108, 373. 0acaa8746fb3fb9913399834007ae81dhttp%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs00395-013-0373-x"},{"key":"ref37","unstructured":"Poljsak, B. (2011) Strategies for reducing or preventing the generation of oxidative stress. Oxidative Medicine and Cellular Longevity 2011, 194586. fc7187b03e39b76af5d17258103e6244http%3A%2F%2Feuropepmc.org%2Farticles%2FPMC3236599%2F"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Rybnikova, E., Sitnik, N., Gluschenko, T., Tjulkova, E. and Samoilov, M. O. (2006) The preconditioning modified neuronal expression of apoptosis-related proteins of Bcl-2 superfamily following severe hypobaric hypoxia in rats. Brain Research 1089, 195-202. 66988da329ffc7d6c7e2e25409cb14b5http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F16638610","DOI":"10.1016\/j.brainres.2006.03.053"},{"key":"ref39","unstructured":"Shao, H., Yang, L., Wang, L., Tang, B., Wang, J. and Li, Q. (2018) Microrna-34a protects myocardial cells against ischemia-reperfusion injury through inhibiting autophagy via regulating tnfalpha expression. Biochemistry and Cell Biology = Biochimie et Biologie Cellulaire 96, 349-354. c776f91e0388e2e0d7ad9473b2241aa1http%3A%2F%2Fwww.nrcresearchpress.com%2Fdoi%2Fabs%2F10.1139%2Fbcb-2016-0158"},{"key":"ref40","unstructured":"Sharma, A. and Singh, M. (2000) Possible mechanism of cardioprotective effect of angiotensin preconditioning in isolated rat heart. European Journal of Pharmacology 406, 85-92. cc6f758ab80d50c24182aa81136a1bb6http%3A%2F%2Fcardiovascres.oxfordjournals.org%2Flookup%2Fexternal-ref%3Faccess_num%3D11011038%26amp%3Blink_type%3DMED%26amp%3Batom%3D%252Fcardiovascres%252F73%252F1%252F153.atom"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Tariq, M. U., Tariq, A. M., Tan, C. D., Rodriguez, E. R. and Menon, V. (2016) Left ventricular thrombosis can still complicate acute myocardial infarction. Cleveland Clinic Journal of Medicine 83, 819-826. 541e6f07a5f10c2cfd81e11a9e4fe947http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F27824538","DOI":"10.3949\/ccjm.83a.14078"},{"key":"ref42","unstructured":"Tavazoie, S. F., Alarcon, C., Oskarsson, T., Padua, D., Wang, Q., Bos, P. D., Gerald, W. L. and Massague, J. (2008) Endogenous human micrornas that suppress breast cancer metastasis. Nature 451, 147-152. 409f707ed6aad58ae2dd609d42c25908http%3A%2F%2Fpubmedcentralcanada.ca%2Fpmcc%2Farticles%2FPMC2782491%2F"},{"key":"ref43","unstructured":"Valikhnovs'kyi, R. L. (2009) Modern view on basic principles of the standard treatment and diagnostics in reconstructive surgery of the acquired nose defects. Klinichna Khirurhiia 120-123. cb6e9fba300176d4a9651da3593ff36ehttp%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F20458959"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Vilahur, G., Juan-Babot, O., Pena, E., Onate, B., Casani, L. and Badimon, L. (2011) Molecular and cellular mechanisms involved in cardiac remodeling after acute myocardial infarction. Journal of Molecular and Cellular Cardiology 50, 522-533. bc772f846cde2f75d7995130de851874http%3A%2F%2Feuropepmc.org%2Fabstract%2Fmed%2F21219908","DOI":"10.1016\/j.yjmcc.2010.12.021"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Wang, G., Yao, J., Li, Z., Zu, G., Feng, D., Shan, W., Li, Y., Hu, Y., Zhao, Y. and Tian, X. (2016) Mir-34a-5p inhibition alleviates intestinal ischemia\/reperfusion-induced reactive oxygen species accumulation and apoptosis via activation of sirt1 signaling. Antioxidants &Redox Signaling 24, 961-973. ad9d9d1604656675831d88dbc8c2124dhttp%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F26935288","DOI":"10.1089\/ars.2015.6492"},{"key":"ref46","unstructured":"Wong, C. H., Bozinovski, S., Hertzog, P. J., Hickey, M. J. and Crack, P. J. (2008) Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion. Journal of Neurochemistry 107, 241-252. 7559a877e2c3aef963f2f27c939ad54ahttp%3A%2F%2Fonlinelibrary.wiley.com%2Fdoi%2F10.1111%2Fj.1471-4159.2008.05605.x%2Ffull"},{"key":"ref47","unstructured":"Xia, Y. W. and Wang, S. B. (2018) Microvesicles containing microrna-21 induce myocardial fibrosis via akt pathway. European Review for Medical and Pharmacological sciences 22, 4634-4641."},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Xue, L., Li, M., Chen, T., Sun, H., Zhu, J., Li, X., Wu, F., Wang, B., Li, J. and Chen, Y. (2014) Peinduced apoptosis in smmc7721 cells: involvement of Erk and stat signalling pathways. International journal of Molecular Medicine 34, 119-129. 5b6a325d17ba87168109f1cefc2f33a8http%3A%2F%2Feuropepmc.org%2Farticles%2FPMC4072400","DOI":"10.3892\/ijmm.2014.1777"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Yu, B. and Song, B. (2014) Notch 1 signalling inhibits cardiomyocyte apoptosis in ischaemic postconditioning. Heart, Lung &Circulation 23, 152-158. fdeceb436c7c2943cad6f4d7d907ff06http%3A%2F%2Feuropepmc.org%2Fabstract%2Fmed%2F23948289","DOI":"10.1016\/j.hlc.2013.07.004"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Yu, H. C., Bai, L., Yue, S. Q., Wang, D. S., Wang, L., Han, H. and Dou, K. F. (2013) Notch signal protects non-parenchymal cells from ischemia\/reperfusion injury in vitro by repressing ros. Annals of Hepatology 12, 815-821. b73fd44cc634c0dd888e4cabb9e9f41ahttp%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F24018501","DOI":"10.1016\/S1665-2681(19)31325-0"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Yu, H. C., Qin, H. Y., He, F., Wang, L., Fu, W., Liu, D., Guo, F. C., Liang, L., Dou, K. F. and Han, H. (2011) Canonical notch pathway protects hepatocytes from ischemia\/reperfusion injury in mice by repressing reactive oxygen species production through Jak2\/Stat3 signaling. Hepatology 54, 979-988. 55d116b225a5bccbc48cddd47f125923http%3A%2F%2Fonlinelibrary.wiley.com%2Fdoi%2F10.1002%2Fhep.24469%2Ffull","DOI":"10.1002\/hep.24469"},{"key":"ref52","unstructured":"Zeng, X. C., Li, L., Wen, H. and Bi, Q. (2016) Microrna-128 inhibition attenuates myocardial ischemia\/reperfusion injury-induced cardiomyocyte apoptosis by the targeted activation of peroxisome proliferator-activated receptor gamma. Molecular Medicine Reports 14, 129-136. 640e3e73636d77962e901a11f3772022http%3A%2F%2Fpubmedcentralcanada.ca%2Fpmcc%2Farticles%2FPMC4918621%2F"}],"container-title":["Reviews in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/20\/3\/10.31083\/j.rcm.2019.03.545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T16:59:54Z","timestamp":1732726794000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/20\/3\/10.31083\/j.rcm.2019.03.545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,30]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019]]}},"alternative-id":["2153-8174-20-3-187"],"URL":"https:\/\/doi.org\/10.31083\/j.rcm.2019.03.545","relation":{},"ISSN":["1530-6550","2153-8174"],"issn-type":[{"value":"1530-6550","type":"print"},{"value":"2153-8174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,30]]},"article-number":"187"}}