{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:22:35Z","timestamp":1762431755387,"version":"3.41.2"},"reference-count":22,"publisher":"IMR Press","issue":"4","license":[{"start":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T00:00:00Z","timestamp":1577664000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>The objective of this study was to explore the effects of myocardial bridge compression on blood flow, normal stress, circumferential stress and shear stress in mural coronary artery. An original mural coronary artery simulative device has been greatly improved and its measured hemodynamic parameters have been expanded from a single stress (normal stress) to multiple stresses to more fully and accurately simulate the true hemodynamic environment under normal stress, circumferential stress and shear stress. This device was used to more fully explore the relationship between hemodynamics and mural coronary atherosclerosis under the combined effects of multiple stresses. Results obtained from the mural coronary artery simulator showed stress abnormality to be mainly located in the proximal mural coronary artery where myocardial bridge compression was intensified and average and fluctuation values (maximum minus minimum) of proximal stress were significantly increased by 27.8% and 139%, respectively. It is concluded that myocardial bridge compression causes abnormalities in the proximal hemodynamics of the mural coronary artery. This is of great significance for understanding the hemodynamic mechanism of coronary atherosclerosis and has potential clinical value for the pathological effect and treatment of myocardial bridge.<\/jats:p>","DOI":"10.31083\/j.rcm.2019.04.554","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T01:36:22Z","timestamp":1578879382000},"source":"Crossref","is-referenced-by-count":4,"title":["Simulated coronary arterial hemodynamics of myocardial bridging"],"prefix":"10.31083","volume":"20","author":[{"given":"Hao","family":"Ding","sequence":"first","affiliation":[{"name":"Shanghai University of Medicine & Health Sciences, Shanghai 201318, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujia","family":"Liu","sequence":"first","affiliation":[{"name":"School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhilin","family":"Liu","sequence":"first","affiliation":[{"name":"Shanghai General Hospital, Shanghai 200080, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxun","family":"Shi","sequence":"first","affiliation":[{"name":"School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhichao","family":"Nie","sequence":"first","affiliation":[{"name":"School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhehua","family":"Chen","sequence":"first","affiliation":[{"name":"Shanghai University of Medicine & Health Sciences, Shanghai 201318, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjun","family":"Zeng","sequence":"first","affiliation":[{"name":"Biomechanics & Medical Information Institute, Beijing University of Technology, No. 100 PingLeYuan, Beijing, 100022, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2019,12,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Cunningham, K. S. and Gotlieb, A. I. (2005) The role of shear stress in the pathogenesis of atherosclerosis. Laboratory Investigation 85, 9-23.","DOI":"10.1038\/labinvest.370021515568038https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15568038"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"De Marco, T., Chatterjee, K., Rouleau, J. L. and Parmley, W. W. (1988) Abnormal coronary hemodynamics and myocardial energetics in patients with chronic heart failure caused by ischemic heart disease and dilated cardiomyopathy. American Heart Journal 115, 809-815.","DOI":"10.1016\/0002-8703(88)90883-63354409https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3354409"},{"key":"ref3","unstructured":"Dong, M. and Qian, J. Y. (2006) Research status of coronary artery myocardial bridge. Chinese Journal of Cardiology 34, 474-476. 16776972https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16776972"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Doriot, P. A. (2003) Some unusual considerations about vessel walls and wall stresses. Journal of Theoretical Biology 221, 133-141.","DOI":"10.1006\/jtbi.2003.318212634050https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12634050"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Ge, J., Jeremias, A., Rupp, A., Abels, M., Baumgart, D., Liu, F., Haude, M., G\u00f6rge, G., von, Birgelen. C., Sack, S. and Erbel, R. (1999) New signs characteristic of myocardial bridging demonstrated by intracoronary ultrasound and Doppler. European Heart Journal 20, 1707-1716.","DOI":"10.1053\/euhj.1999.166110562478https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10562478"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Hashimoto, A. and Takekoshi, N. (1984) Murakmi E. clinical significance of myocardial squeezing of the coronary artery. Japanese Heart Journal 25, 913-922.","DOI":"10.1536\/ihj.25.9136530751https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/6530751"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"He, F. and Li, X. Y. (2007) Numerical study on the residual strain and stress of normal arterial wall. Chinese Journal of Biomedical Engineering 26, 567-572.","DOI":"10.1114\/1.19110468230https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10468230"},{"key":"ref8","unstructured":"Hu, X. Q., Qin, K. R., Wu, H. and Jiang, Z. L. (2006) Simulation of arterial pulsatile fluid shear stress and circumferential stress using a silicone tube flow chamber system. Journal of Medical Biomechanics 21, 94-99."},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Huo, Y. and Kassab, G. S. (2007) A hybrid one-dimensional\/Womersley model of pulsatile blood flow in the entire coronary arterial tree. AJP Heart and Circulatory Physiology 292, H2623-H2633.","DOI":"10.1152\/ajpheart.00987.200617208998https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17208998"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Klues, H. G., Schwarz, E. R., vom Dahl, J., Reffelmann, T., Reul, H., Potthast, K., Schmitz, C., Minartz, J., Krebs, W. and Hanrath, P. (1997) Disturbed intracoronary hemodynamics in myocardial bridging: early normalization by intracoronary stent placement. Circulation, 96, 2005-2013.","DOI":"10.1161\/01.cir.96.9.29059386156https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9386156"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Krizanac-Bengez, L., Mayberg, M. R. and Janigro, D. (2004) The cerebral vasculature as a therapeutic target for neurological disorders and the role of shear stress in vascular homeostatis and pathophysiology. Neurological Research 26, 846-853.","DOI":"10.1179\/016164104X378915727268https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15727268"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Lee, B. K., Kwon, H. M., Hong, B. K., Park, B. E., Suh, S. H., Cho, M. T., Lee, C. S., Kim, M. C., Kim, C. J., Yoo., S. S. and Kim, H. S. (2001) Hemodynamic Effects on Atherosclerosis-Prone Coronary Artery: Wall Shear Stress \/ Rate Distribution and Impedance Phase Angle in Coronary and Aortic Circulation. Yonsei Medical Journal 42, 375-383.","DOI":"10.3349\/ymj.2001.42.4.37511519078https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11519078"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Liu, L. S., Hua, Q. and Pang, B. L. (2007) Relationship between coronary atherosclerosis and aortic pulse pressure in patients with primary hypertension. Journal of Clinical Rehabilitative Tissue Engineering Research 11, 1567-1569.","DOI":"10.1007\/s12325-018-0773-2301286423ea5e6fa-219f-41a9-ae4c-e264fb7d2479https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30128642"},{"key":"ref14","unstructured":"Liu, Y., Tang, R. K. and Li, J. B. (2011) Morphologic features of myocardial bridge and its relationship with coronary atherosclerosis. Chinese Journal of Clinical Anatomy 29, 524-526. 9a12d54c-4b15-4458-a969-57dba33e4262http:\/\/www.chjcana.com\/CN\/abstract\/abstract8780.shtml"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Liu, Z. R., He, F., Xu, G. and Chen, Y. (2001) Determination of artery wall shear stress. Science in China Series A: Mathematics 31, 651-660.","DOI":"10.3171\/2019.9.JNS19146631881533https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31881533"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"M\u00f6hlenkamp, S., Hort, W., Ge, J. and Erbel, R. (2002) Update on myocardial bridging. Circulation 106, 2616-2622.","DOI":"10.1161\/01.cir.0000038420.14867.7a12427660https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12427660"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Naruse, K. and Sokabe, M. (1993) Involvement of stretch-activated ion channels in Ca2+ mobilization to mechanical stretch in endothelial cells . American Journal of Physiology 264, 797-805.","DOI":"10.1152\/ajpcell.1993.264.4.C10378386448https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8386448"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Pagliaro, B. R., Cannata, F., Stefanini, G. G. and Bolognese, L. (2019) Myocardial ischemia and coronary disease in heart failure. Heart Failure Reviews.","DOI":"10.1007\/s10741-019-09910-131900788https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31900788"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Pola\u2032cek, P. and Kralove, H. (1961) Relation of myocardial bridges and loops on the coronary arteries to coronary occlusions. American Heart Journal 61, 44-52.","DOI":"10.1016\/0002-8703(61)90515-413736661https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/13736661"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Schwarz, E. R., Klues, H. G., vom Dahl, J., Klein, I., Krebs, W. and Hanrath, P. (1997) Functional characteristics of myocardial bridging. A combined angiographic and intracoronary Doppler flow study. European Heart Journal 18, 434-442.","DOI":"10.1093\/oxfordjournals.eurheartj.a0152639076380https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9076380"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Sipahi, I., Tuzcu, E. M., Schoenhagen, P., Wolski, K. E., Nicholls, S. J., Balog, C., Crowe, T. D. and Nissen, S. E. (2006) Effects of normal, pre-hypertensive, and hypertensive blood pressure levels on progression of coronary atherosclerosis, Journal of the American College of Cardiology 48, 833-838.","DOI":"10.1016\/j.jacc.2006.05.04516904557https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16904557"},{"key":"ref22","unstructured":"Valenta, J., Svoboda, J., Valerianova, D. and Vitek, K. (1999) Residual strain in human atherosclerotic coronary arteries and age related geometrical changes. Bio-medical Materials and Engineering 9, 311-317. 10822486https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10822486"}],"container-title":["Reviews in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/20\/4\/10.31083\/j.rcm.2019.04.554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T16:54:00Z","timestamp":1732726440000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/20\/4\/10.31083\/j.rcm.2019.04.554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,30]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019]]}},"alternative-id":["2153-8174-20-4-273"],"URL":"https:\/\/doi.org\/10.31083\/j.rcm.2019.04.554","relation":{},"ISSN":["1530-6550","2153-8174"],"issn-type":[{"type":"print","value":"1530-6550"},{"type":"electronic","value":"2153-8174"}],"subject":[],"published":{"date-parts":[[2019,12,30]]},"article-number":"273"}}