{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T06:21:57Z","timestamp":1775888517522,"version":"3.50.1"},"reference-count":15,"publisher":"IMR Press","issue":"1","license":[{"start":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T00:00:00Z","timestamp":1585526400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Patients with heart failure (HF) are prone to combine with renal insufficiency. Recently, LCZ696 has been used in the treatment of HF, but whether LCZ696 is better than angiotensin converting enzyme inhibitors\/angiotensin receptor antagonists (ACEI\/ARB) in renal protection for HF patients has not been investigated. Therefore, we conducted a meta-analysis focusing on LCZ696 and its role in preservation of renal function in HF patients. Embase, PubMed, the Cochrane Library and ClinicalTrials.gov databases were electronically searched for available randomized controlled trials (RCTs). HF patients taking LCZ696 or ACEI\/ARB were assessed for renal adverse events. The last search date was Sep 20, 2019. A total of 14959 patients from 6 trials were included in this meta-analysis. As compared to ACEI\/ARB, LCZ696 significantly reduced the risk of renal function deterioration (odds ratio 0.77, 95% confidence interval 0.61-0.97, P = 0.02). In summary, LCZ696 may have superior renal protection in HF patients compared with ACEI\/ARB.<\/jats:p>","DOI":"10.31083\/j.rcm.2020.01.2","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T01:16:51Z","timestamp":1586308611000},"source":"Crossref","is-referenced-by-count":12,"title":["LCZ696 and preservation of renal function in heart failure: A meta-analysis of 6 randomized trials"],"prefix":"10.31083","volume":"21","author":[{"given":"Xiaogen","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Key Lab of Cardiovascular Disease of Zhejiang Province, Hangzhou, Zhejiang 310009, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunna","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Cardiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Key Lab of Cardiovascular Disease of Zhejiang Province, Hangzhou, Zhejiang 310009, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Cardiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Key Lab of Cardiovascular Disease of Zhejiang Province, Hangzhou, Zhejiang 310009, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meixiang","family":"Xiang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Key Lab of Cardiovascular Disease of Zhejiang Province, Hangzhou, Zhejiang 310009, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2020,3,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Berliner, D. and Bauersachs, J. (2019) New Drugs: Big Changes in Conservative Heart Failure Therapy? European Journal of Cardio-Thoracic Surgery 55, i3-i10.","DOI":"10.1093\/ejcts\/ezy421"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Damman, K., Gori, M., Claggett, B., Jhund, P. S., Senni, M., Lefkowitz, M. P., Prescott, M. F., Shi, V. C., Rouleau, J. L. and Swedberg, K. (2018) Renal Effects and Associated Outcomes During Angiotensin-Neprilysin Inhibition in Heart Failure. JACC: Heart Failure 6, 489-498.","DOI":"10.1016\/j.jchf.2018.02.004"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Della Penna, S., Ros\u00f3n, M., Toblli, J. and Fern\u00e1ndez, B. (2015) Role of Angiotensin Ii and Oxidative Stress in Renal Inflammation by Hypernatremia: Benefits of Atrial Natriuretic Peptide, Losartan, and Tempol. Free Radical Research 49, 383-396.","DOI":"10.3109\/10715762.2015.1006216"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Desai, A. S., Solomon, S. D., Shah, A. M., Claggett, B. L., Fang, J. C., Izzo, J., McCague, K., Abbas, C. A., Rocha, R. and Mitchell, G. F. (2019) Effect of Sacubitril-Valsartan Vs Enalapril on Aortic Stiffness in Patients with Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial. Jama 322, 1077-1084.","DOI":"10.1001\/jama.2019.12843"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Judge, P., Haynes, R., Landray, M. J. and Baigent, C. (2015) Neprilysin Inhibition in Chronic Kidney Disease. Nephrology Dialysis Transplantation 30, 738-743.","DOI":"10.1093\/ndt\/gfu269"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Kang, D.-H., Park, S.-J., Shin, S.-H., Hong, G.-R., Lee, S., Kim, M.-S., Yun, S.-C., Song, J.-M., Park, S.-W. and Kim, J.-J. (2019) Angiotensin Receptor Neprilysin Inhibitor for Functional Mitral Regurgitation: Prime Study. Circulation 139, 1354-1365.","DOI":"10.1161\/CIRCULATIONAHA.118.037077"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Kiemer, A. K., Vollmar, A. M., Bilzer, M., Gerwig, T. and Gerbes, A. L. (2000) Atrial Natriuretic Peptide Reduces Expression of Tnf-\u0391 Mrna During Reperfusion of the Rat Liver Upon Decreased Activation of Nf-\u039ab and Ap-1. Journal of Hepatology 33, 236-246.","DOI":"10.1016\/S0168-8278(00)80364-5"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"L\u00f6fman, I., Szummer, K., Evans, M., Carrero, J.-J., Lund, L. H. and Jernberg, T. (2019) Incidence of, Associations with and Prognostic Impact of Worsening Renal Function in Heart Failure with Different Ejection Fraction Categories. The American Journal of Cardiology 124, 1575-1583.","DOI":"10.1016\/j.amjcard.2019.07.065"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"McMurray, J. J., Packer, M., Desai, A. S., Gong, J., Lefkowitz, M. P., Rizkala, A. R., Rouleau, J. L., Shi, V. C., Solomon, S. D. and Swedberg, K. (2014) Angiotensin-Neprilysin Inhibition Versus Enalapril in Heart Failure. The New England Journal of Medicine 371, 993-1004.","DOI":"10.1056\/NEJMoa1409077"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Ros\u00f3n, M. I., Toblli, J. E., Della Penna, S. L., Gorzalczany, S., Pandolfo, M., Cavallero, S. and Fern\u00e1ndez, B. E. (2006) Renal Protective Role of Atrial Natriuretic Peptide in Acute Sodium Overload-Induced Inflammatory Response. American Journal of Nephrology 26, 590-601.","DOI":"10.1159\/000098148"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Senni, M., McMurray, J. J., Wachter, R., McIntyre, H. F., Reyes, A., Majercak, I., Andreka, P., Shehova\u2010Yankova, N., Anand, I. and Yilmaz, M. B. (2016) Initiating Sacubitril\/Valsartan (Lcz696) in Heart Failure: Results of Titration, a Double\u2010Blind, Randomized Comparison of Two Uptitration Regimens. European Journal of Heart Failure 18, 1193-1202.","DOI":"10.1002\/ejhf.548"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Solomon, S. D., McMurray, J. J., Anand, I. S., Ge, J., Lam, C. S., Maggioni, A. P., Martinez, F., Packer, M., Pfeffer, M. A. and Pieske, B. (2019) Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction. New England Journal of Medicine 381, 1609-1620.","DOI":"10.1056\/NEJMoa1908655"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Solomon, S. D., Zile, M., Pieske, B., Voors, A., Shah, A., Kraigher-Krainer, E., Shi, V., Bransford, T., Takeuchi, M. and Gong, J. (2012) The Angiotensin Receptor Neprilysin Inhibitor Lcz696 in Heart Failure with Preserved Ejection Fraction: A Phase 2 Double-Blind Randomised Controlled Trial. The Lancet 380, 1387-1395.","DOI":"10.1016\/S0140-6736(12)61227-6"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Velazquez, E. J., Morrow, D. A., DeVore, A. D., Duffy, C. I., Ambrosy, A. P., McCague, K., Rocha, R. and Braunwald, E. (2019) Angiotensin-Neprilysin Inhibition in Acute Decompensated Heart Failure. New England Journal of Medicine 380, 539-548.","DOI":"10.1056\/NEJMoa1812851"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Wachter, R., Senni, M., Belohlavek, J., Straburzynska\u2010Migaj, E., Witte, K. K., Kobalava, Z., Fonseca, C., Goncalvesova, E., Cavusoglu, Y. and Fernandez, A. (2019) Initiation of Sacubitril\/Valsartan in Haemodynamically Stabilised Heart Failure Patients in Hospital or Early after Discharge: Primary Results of the Randomised Transition Study. European Journal of Heart Failure 21, 998-1007.","DOI":"10.1002\/ejhf.1498"}],"container-title":["Reviews in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/21\/1\/10.31083\/j.rcm.2020.01.2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T17:00:46Z","timestamp":1732726846000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/21\/1\/10.31083\/j.rcm.2020.01.2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,30]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020]]}},"alternative-id":["2153-8174-21-1-113"],"URL":"https:\/\/doi.org\/10.31083\/j.rcm.2020.01.2","relation":{},"ISSN":["1530-6550","2153-8174"],"issn-type":[{"value":"1530-6550","type":"print"},{"value":"2153-8174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,30]]},"article-number":"113"}}