{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:12:37Z","timestamp":1771632757003,"version":"3.50.1"},"reference-count":13,"publisher":"IMR Press","issue":"2","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Myxedema coma occurs mostly in patients with long-standing untreated or undertreated hypothyroidism. Bradycardia is a well-known cardiac manifestation for myxedema coma; however, not all bradycardia with hypothyroidism are sinus bradycardia. Sick sinus syndrome is a group of arrhythmias caused by the malfunction of the natural pacemaker of the heart. Tachy-Brady syndrome is considered to be a type of sick sinus syndrome, where the heart alternates between tachycardia and bradycardia, and it is usually treated with pacemaker implantation along with rate slowing medical therapy. Here we report a case of an 83-year-old female who presented with myxedema coma and atrial fibrillation with tachycardia and intermittent slow ventricular response. We attempt to review the relationship between these two diseases and conclude that appropriate diagnosis of myxedema coma, may be beneficial in reducing the need for pacemaker implantation.<\/jats:p>","DOI":"10.31083\/j.rcm.2020.02.26","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T07:12:31Z","timestamp":1593587551000},"source":"Crossref","is-referenced-by-count":5,"title":["Reversible bradycardia secondary to myxedema coma: case-report"],"prefix":"10.31083","volume":"21","author":[{"given":"Omar","family":"Kousa","sequence":"first","affiliation":[{"name":"Creighton University School of Medicine, Department of Internal Medicine 7500 Mercy Road, Omaha, NE 68124, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Mansour","sequence":"first","affiliation":[{"name":"Sheikh Shakhbout Medical City, Department of Internal Medicine, Abu-Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Awad","sequence":"first","affiliation":[{"name":"Creighton University School of Medicine, Department of Internal Medicine 7500 Mercy Road, Omaha, NE 68124, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr","family":"Essa","sequence":"first","affiliation":[{"name":"Creighton University School of Medicine, Department of Internal Medicine 7500 Mercy Road, Omaha, NE 68124, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdallah","family":"Qasim","sequence":"first","affiliation":[{"name":"Creighton University School of Medicine, Department of Internal Medicine 7500 Mercy Road, Omaha, NE 68124, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arindam","family":"Sharma","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Creighton University School of Medicine, Omaha, NE 68124, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Holmberg","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Creighton University School of Medicine, Omaha, NE 68124, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2020,6,30]]},"reference":[{"key":"ref1","unstructured":"Dhakal, P., Pant, M., Acharya, P. S., Dahal, S. and Bhatt, V. R. (2015) Myxedema coma with reversible cardiopulmonary failure: a rare entity in 21 century. Maedica 10, 268-271. 28261365https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28261365"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Harada, K., Murakami, S., Tokumasu, K., Togawa, Y. and Otsuka, F. (2019) Myxedema coma accompanied by sick sinus syndrome and hypoventilation: A case report. Journal of General and Family Medicine 20, 206-208. 31516809https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31516809","DOI":"10.1002\/jgf2.267"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Lee, R. W., Huang, S. K., Mechling, E. and Bazgan, I. (1986) Runaway atrioventricular sequential pacemaker after radiation therapy. The American Journal of Medicine 81, 883-886. 3776991https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3776991","DOI":"10.1016\/0002-9343(86)90361-X"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Mangrum, J. M. and DiMarco, J. P. (2000) The evaluation and management of bradycardia. The New England Journal of Medicine 342, 703-709.","DOI":"10.1056\/NEJM20000309342100610706901https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10706901"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Mond, H. G. and Proclemer, A. (2011) The 11th world survey of cardiac pacing and implantable cardioverter-defibrillators: calendar year 2009--a World Society of Arrhythmia's project. Pacing and Clinical Electrophysiology: PACE 34, 1013-1027. 21707667https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21707667","DOI":"10.1111\/j.1540-8159.2011.03150.x"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Ozcan, K. S., Osmonov, D., Erdinler, I., Altay, S., Yildirim, E., Turkkan, C., Hasdemir, H., Cakmak, N., Alper, A. T., Satilmis, S. and Gurkan, K. (2012) Atrioventricular block in patients with thyroid dysfunction: prognosis after treatment with hormone supplementation or antithyroid medication. Journal of Cardiology 60, 327-332.","DOI":"10.1016\/j.jjcc.2012.05.012abc8d7f2-ac0d-45a1-8aad-5cd9b32e9a66http:\/\/dx.doi.org\/10.1016\/j.jjcc.2012.05.012"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Raatikainen, M. J. P., Arnar, D. O., Zeppenfeld, K., Merino, J. L., Levya, F., Hindriks, G. and Kuck, K.-H. (2015) Statistics on the use of cardiac electronic devices and electrophysiological procedures in the European Society of Cardiology countries: 2014 report from the European Heart Rhythm Association. 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(2019) Successful treatment of myxedema coma with a combination of levothyroxine and liothyronine. Endocrine Journal 66, 469-474. 30853666https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30853666","DOI":"10.1507\/endocrj.EJ18-0469"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Waseem, H., Hashmi, A. T., Anser, M., Wali, N., Rodriguez, D. and Greenberg, Y. (2018) A Pacemaker that was Avoided. Cureus 10, e2555 29974011https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29974011","DOI":"10.7759\/cureus.2555"}],"container-title":["Reviews in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/21\/2\/10.31083\/j.rcm.2020.02.26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T16:57:59Z","timestamp":1732726679000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/21\/2\/10.31083\/j.rcm.2020.02.26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,30]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020]]}},"alternative-id":["2153-8174-21-2-297"],"URL":"https:\/\/doi.org\/10.31083\/j.rcm.2020.02.26","relation":{},"ISSN":["1530-6550","2153-8174"],"issn-type":[{"value":"1530-6550","type":"print"},{"value":"2153-8174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,30]]},"article-number":"297"}}