{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:22:26Z","timestamp":1793467346789,"version":"4.5.0"},"reference-count":102,"publisher":"IMR Press","issue":"1","license":[{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Sudden cardiac death (SCD) is an unexpected sudden death due to a heart condition, that occurs within one hour of symptoms onset. SCD is a leading cause of death in western countries, and is responsible for the majority of deaths from cardiovascular disease. Moreover, SCD accounts for mortality in approximately half of all coronary heart disease patients. Nevertheless, the recent advancements made in screening, prevention, treatment, and management of the underlying causes has decreased this number. In this article, we sought to review established and new modes of screening patients at risk for SCD, treatment and prevention of SCD, and the role of new technologies in the field. Further, we delineate the current epidemiologic trends and pathogenesis. In particular, we describe the advancement in molecular autopsy and genetic testing, the role of target temperature management, extracorporeal membrane oxygenation (ECMO), cardiopulmonary resuscitation (CPR), and transvenous and subcutaneous implantable cardioverter devices (ICDs).<\/jats:p>","DOI":"10.31083\/j.rcm.2021.01.207","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T20:44:00Z","timestamp":1617309840000},"source":"Crossref","is-referenced-by-count":157,"title":["Sudden cardiac death: epidemiology, pathogenesis and management"],"prefix":"10.31083","volume":"22","author":[{"given":"Akshay","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, University of Pittsburgh, PA 15213, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dor Mordehay","family":"Avishay","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Milan, 21022 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin Richard","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Milan, 21022 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juber Dastagir","family":"Shaikh","sequence":"first","affiliation":[{"name":"Department of Neurology, Mahatma Gandhi Mission Hospital, 400703 New Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roopvir","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Government Medical College, 143001 Amritsar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Aljadah","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Medical College of Wisconsin, Milwaukee, WI 53201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim","family":"Kichloo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Central Michigan University, Mt Pleasant, MI 48859, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimisha","family":"Shiwalkar","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, University of Texas Health Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Keshavamurthy","sequence":"first","affiliation":[{"name":"Division of Cardiothoracic Surgery, University of Kentucky, Lexington, KY 40506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2021,3,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, et al. 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