{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:37:29Z","timestamp":1770701849477,"version":"3.49.0"},"reference-count":45,"publisher":"IMR Press","issue":"1","license":[{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Transcatheter mitral valve repair with MitraClip has emerged as a possible therapeutic option for patients with severe mitral regurgitation (MR) with high risk for surgical valve repair. MitraClip intervention has demonstrated to improve haemodynamics and clinical outcomes in selected patients in observational and randomized studies. Preoperative pulmonary hypertension (PH) is known to affect prognosis in patients undergoing surgical mitral valve intervention. The aim of the present review is to discuss the available literature focused on the haemodynamic and clinical effects of MitraClip in patients with severe MR and PH.<\/jats:p>","DOI":"10.31083\/j.rcm.2021.01.214","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:44:00Z","timestamp":1617324240000},"source":"Crossref","is-referenced-by-count":7,"title":["Transcatheter mitral valve repair with MitraClip in patients with pulmonary hypertension: hemodynamic and prognostic perspectives"],"prefix":"10.31083","volume":"22","author":[{"given":"Alessandro","family":"Mandurino-Mirizzi","sequence":"first","affiliation":[{"name":"Division of Cardiology, Fondazione IRCCS Policlinico San Matteo and University of Pavia, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Tua","sequence":"first","affiliation":[{"name":"Division of Cardiology, Fondazione IRCCS Policlinico San Matteo and University of Pavia, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Arzuffi","sequence":"first","affiliation":[{"name":"Division of Cardiology, Fondazione IRCCS Policlinico San Matteo and University of Pavia, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Demarchi","sequence":"first","affiliation":[{"name":"Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Somaschini","sequence":"first","affiliation":[{"name":"Division of Cardiology and Cardiac Intensive Care Unit, San Paolo Hospital, 17100 Savona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Tournas","sequence":"first","affiliation":[{"name":"Cardiocentro Ticino, 6900 Lugano, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Crimi","sequence":"first","affiliation":[{"name":"Interventional Cardiology Unit, Cardio-Thoraco Vascular Department (DICATOV), IRCCS Ospedale Policlinico San Martino, Genova, Italy; IRCCS Italian Cardiovascular Network & Department of Internal Medicine, University of Genova, 16122 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Androulakis","sequence":"first","affiliation":[{"name":"National Kapodistrian University of Athens, Medical School, 106 71 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandros","family":"Briasoulis","sequence":"first","affiliation":[{"name":"University of Iowa, Section of Advanced Heart Failure and Transplantation, Iowa City, IA 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Cornara","sequence":"first","affiliation":[{"name":"Division of Cardiology and Cardiac Intensive Care Unit, San Paolo Hospital, 17100 Savona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2021,3,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Iung B, Baron G, Butchart EG, Delahaye F, Gohlke-B\u00e4rwolf C, Levang OW, et al. A prospective survey of patients with valvular heart disease in Europe: the Euro Heart Survey on Valvular Heart Disease. European Heart Journal. 2003; 24: 1231-1243.","DOI":"10.1016\/S0195-668X(03)00201-X"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano M. Burden of valvular heart diseases: a population-based study. Lancet. 2006; 368: 1005-1011.","DOI":"10.1016\/S0140-6736(06)69208-8"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Monteagudo Ruiz JM, Galderisi M, Buonauro A, Badano L, Aruta P, Swaans MJ, et al. Overview of mitral regurgitation in Europe: results from the European Registry of mitral regurgitation (EuMiClip). European Heart Journal - Cardiovascular Imaging. 2018; 19: 503-507.","DOI":"10.1093\/ehjci\/jey011"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Levine RA, Schwammenthal E. Ischemic mitral regurgitation on the threshold of a solution: from paradoxes to unifying concepts. Circulation. 2005; 112: 745-758.","DOI":"10.1161\/CIRCULATIONAHA.104.486720"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Hoeper MM, Humbert M, Souza R, Idrees M, Kawut SM, Sliwa-Hahnle K, et al. A global view of pulmonary hypertension. The Lancet Respiratory Medicine. 2016; 4: 306-322.","DOI":"10.1016\/S2213-2600(15)00543-3"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Simonneau G, Montani D, Celermajer DS, Denton CP, Gatzoulis MA, Krowka M, et al. Haemodynamic definitions and updated clinical classification of pulmonary hypertension. European Respiratory Journal. 2019; 53: 1801913.","DOI":"10.1183\/13993003.01913-2018"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Naeije R, Gerges M, Vachiery JL, Caravita S, Gerges C, Lang IM. Hemodynamic phenotyping of pulmonary hypertension in left heart failure. 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International Journal of Cardiology. 2017; 228: 191-197.","DOI":"10.1016\/j.ijcard.2016.11.241"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Garatti A, Castelvecchio S, Bandera F, Medda M, Menicanti L. MitraClip procedure as a bridge therapy in a patient with heart failure listed for heart transplantation. The Annals of Thoracic Surgery. 2015; 99: 1796-1799.","DOI":"10.1016\/j.athoracsur.2014.07.079"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Godino C, Munaf\u00f2 A, Scotti A, Est\u00e9vez-Loureiro R, Portol\u00e9s Hern\u00e1ndez A, Arzamendi D, et al. MitraClip in secondary mitral regurgitation as a bridge to heart transplantation: 1-year outcomes from the International MitraBridge Registry. The Journal of Heart and Lung Transplantation. 2020; 39: 1353-1362.","DOI":"10.1016\/j.healun.2020.09.005"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Patzelt J, Zhang W, Sauter R, Mezger M, Nording H, Ulrich M, et al. Elevated mitral valve pressure gradient is predictive of long-term outcome after percutaneous edge-to-edge mitral valve repair in patients with degenerative mitral regurgitation (MR), but not in functional MR. Journal of the American Heart Association. 2019; 8: e011366.","DOI":"10.1161\/JAHA.118.011366"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Utsunomiya H, Itabashi Y, Kobayashi S, Rader F, Hussaini A, Makar M, et al. Effect of percutaneous edge-to-edge repair on mitral valve area and its association with pulmonary hypertension and outcomes. The American Journal of Cardiology. 2017; 120: 662-669.","DOI":"10.1016\/j.amjcard.2017.05.036"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Neuss M, Schau T, Isotani A, Pilz M, Sch\u00f6pp M, Butter C. Elevated mitral valve pressure gradient after MitraClip implantation deteriorates long-term outcome in patients with severe mitral regurgitation and severe heart failure. JACC: Cardiovascular Interventions. 2017; 10: 931-939.","DOI":"10.1016\/j.jcin.2016.12.280"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Schueler R, \u00d6zt\u00fcrk C, Wedekind JA, Werner N, St\u00f6ckigt F, Mellert F, et al. Persistence of iatrogenic atrial septal defect after interventional mitral valve repair with the MitraClip system. JACC: Cardiovascular Interventions. 2015; 8: 450-459.","DOI":"10.1016\/j.jcin.2014.10.024"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Eden M, Leeb L, Frey N, Rosenberg M. Haemodynamics of an iatrogenic atrial septal defect after MitraClip implantation. European Journal of Clinical Investigation. 2020; 50: e13295.","DOI":"10.1111\/eci.13295"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Obadia JF, Messika-Zeitoun D, Leurent G, Iung B, Bonnet G, Piriou N, et al. Percutaneous repair or medical treatment for secondary mitral regurgitation. New England Journal of Medicine. 2018; 379: 2297-2306.","DOI":"10.1056\/NEJMoa1805374"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Matsumoto T, Nakamura M, Yeow WL, Hussaini A, Ram V, Makar M, et al. Impact of pulmonary hypertension on outcomes in patients with functional mitral regurgitation undergoing percutaneous edge-to-edge repair. The American Journal of Cardiology. 2014; 114: 1735-1739.","DOI":"10.1016\/j.amjcard.2014.08.044"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Tigges E, Blankenberg S, von Bardeleben RS, Z\u00fcrn C, Bekeredjian R, Ouarrak T, et al. Implication of pulmonary hypertension in patients undergoing MitraClip therapy: results from the German transcatheter mitral valve interventions (TRAMI) registry. European Journal of Heart Failure. 2018; 20: 585-594.","DOI":"10.1002\/ejhf.864"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Al-Bawardy R, Vemulapalli S, Thourani VH, Mack M, Dai D, Stebbins A, et al. 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