{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:09:50Z","timestamp":1772762990138,"version":"3.50.1"},"reference-count":48,"publisher":"IMR Press","issue":"3","license":[{"start":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:00:00Z","timestamp":1632441600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>We evaluated the age-specific mortality of unselected adult outpatients infected with SARS-CoV-2 treated early in a dedicated COVID-19 day hospital and we assessed whether the use of hydroxychloroquine (HCQ) + azithromycin (AZ) was associated with improved survival in this cohort. A retrospective monocentric cohort study was conducted in the day hospital of our center from March to December 2020 in adults with PCR-proven infection who were treated as outpatients with a standardized protocol. The primary endpoint was 6-week mortality, and secondary endpoints were transfer to the intensive care unit and hospitalization rate. Among 10,429 patients (median age, 45 [IQR 32\u201357] years; 5597 [53.7%] women), 16 died (0.15%). The infection fatality rate was 0.06% among the 8315 patients treated with HCQ+AZ. No deaths occurred among the 8414 patients younger than 60 years. Older age and male sex were associated with a higher risk of death, ICU transfer, and hospitalization. Treatment with HCQ+AZ (0.17 [0.06\u20130.48]) was associated with a lower risk of death, independently of age, sex and epidemic period. Meta-analysis evidenced consistency with 4 previous outpatient studies (32,124 patients\u2014Odds ratio 0.31 [0.20\u20130.47], I2 = 0%). Early ambulatory treatment of COVID-19 with HCQ+AZ as a standard of care is associated with very low mortality, and HCQ+AZ improve COVID-19 survival compared to other regimens.<\/jats:p>","DOI":"10.31083\/j.rcm2203116","type":"journal-article","created":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T02:35:45Z","timestamp":1632623745000},"source":"Crossref","is-referenced-by-count":25,"title":["Early combination therapy with hydroxychloroquine and azithromycin reduces mortality in 10,429 COVID-19 outpatients"],"prefix":"10.31083","volume":"22","author":[{"given":"Matthieu","family":"MILLION","sequence":"first","affiliation":[{"name":"IHU-M\u00e9diterran\u00e9e Infection, Aix Marseille Univ, Assistance Publique H\u00f4pitaux de Marseille (AP-HM), Institut de recherche pour le d\u00e9veloppement (IRD), Unit\u00e9 Microbes Evolution Phylog\u00e9nie et Infections (MEPHI),13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Christophe","family":"LAGIER","sequence":"first","affiliation":[{"name":"IHU-M\u00e9diterran\u00e9e Infection, Aix Marseille Univ, Assistance Publique H\u00f4pitaux de Marseille (AP-HM), Institut de recherche pour le d\u00e9veloppement (IRD), Unit\u00e9 Microbes Evolution Phylog\u00e9nie et Infections (MEPHI),13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herv\u00e9","family":"TISSOT-DUPONT","sequence":"first","affiliation":[{"name":"IHU-M\u00e9diterran\u00e9e Infection, Aix Marseille Univ, Assistance Publique H\u00f4pitaux de Marseille (AP-HM), Institut de recherche pour le d\u00e9veloppement (IRD), Unit\u00e9 Microbes Evolution Phylog\u00e9nie et Infections (MEPHI),13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"RAVAUX","sequence":"first","affiliation":[{"name":"IHU-M\u00e9diterran\u00e9e Infection, Aix 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COVID-19 Coronavirus pandemic. 2021. Available at: https:\/\/www.worldometers.info\/coronavirus\/ (Accessed: 4 August 2021)."},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"McCullough PA, Alexander PE, Armstrong R, Arvinte C, Bain AF, Bartlett RP, et al. Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19). Reviews in Cardiovascular Medicine. 2020; 21: 517\u2013530.","DOI":"10.31083\/j.rcm.2020.04.264"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"McCullough PA, Kelly RJ, Ruocco G, Lerma E, Tumlin J, Wheelan KR, et al. Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection. The American Journal of Medicine. 2021; 134: 16\u201322.","DOI":"10.1016\/j.amjmed.2020.07.003"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Procter BC, Ross C, Pickard V, Smith E, Hanson C, McCullough PA. Clinical outcomes after early ambulatory multidrug therapy for high-risk SARS-CoV-2 (COVID-19) infection. Reviews in Cardiovascular Medicine. 2020; 21: 611\u2013614.","DOI":"10.31083\/j.rcm.2020.04.260"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Mokhtari M, Mohraz M, Gouya MM, Namdari Tabar H, Tabrizi J, Tayeri K, et al. Clinical outcomes of patients with mild COVID-19 following treatment with hydroxychloroquine in an outpatient setting. International Immunopharmacology. 2021; 96: 107636.","DOI":"10.1016\/j.intimp.2021.107636"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Sulaiman T, Mohana A, Alawdah L, Mahmoud N, Hassanein M, Wani T, et al. The Effect of Early Hydroxychloroquine-based Therapy in COVID-19 Patients in Ambulatory Care Settings: A Nationwide Prospective Cohort Study. medRxiv. 2020.","DOI":"10.1101\/2020.09.09.20184143"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Su Y, Ling Y, Ma Y, Tao L, Miao Q, Shi Q, et al. Efficacy of early hydroxychloroquine treatment in preventing COVID-19 pneumonia aggravation, the experience from Shanghai, China. Bioscience Trends. 2021; 14: 408\u2013414.","DOI":"10.5582\/bst.2020.03340"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Gangopadhyay KK, Sinha B, Ghosal S. \u201cCompliance of the Indian National Task Force guidelines for COVID-19 recommendation by Indian doctors - a survey\u201d. Diabetes & Metabolic Syndrome. 2020; 14: 1413\u20131418.","DOI":"10.1016\/j.dsx.2020.07.040"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Izoulet M. National consumption of antimalarial drugs and COVID-19 deaths dynamics: An econometric study. Journal of Clinical Toxicology. 2020; 10: 456.","DOI":"10.1101\/2020.04.18.20063875"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Liu J, Cao R, Xu M, Wang X, Zhang H, Hu H, et al. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discovery. 2020; 6: 16.","DOI":"10.1038\/s41421-020-0156-0"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research. 2020; 30: 269\u2013271.","DOI":"10.1038\/s41422-020-0282-0"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Gautret P, Lagier J, Parola P, Hoang VT, Meddeb L, Mailhe M, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. International Journal of Antimicrobial Agents. 2020; 56: 105949.","DOI":"10.1016\/j.ijantimicag.2020.105949"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Andreani J, Le Bideau M, Duflot I, Jardot P, Rolland C, Boxberger M, et al. In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect. Microbial Pathogenesis. 2020; 145: 104228.","DOI":"10.1016\/j.micpath.2020.104228"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Gautret P, Million M, Jarrot P, Camoin-Jau L, Colson P, Fenollar F, et al. Natural history of COVID-19 and therapeutic options. Expert Review of Clinical Immunology. 2020; 16: 1159\u20131184.","DOI":"10.1080\/1744666X.2021.1847640"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Lagier J, Million M, Gautret P, Colson P, Cortaredona S, Giraud-Gatineau A, et al. Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine\/azithromycin and other regimens in Marseille, France: a retrospective analysis. Travel Medicine and Infectious Disease. 2020; 36: 101791.","DOI":"10.1016\/j.tmaid.2020.101791"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Jaafar R, Aherfi S, Wurtz N, Grimaldier C, Van Hoang T, Colson P, et al. Correlation between 3790 Quantitative Polymerase Chain Reaction-Positives Samples and Positive Cell Cultures, Including 1941 Severe Acute Respiratory Syndrome Coronavirus 2 Isolates. Clinical Infectious Diseases. 2021; 72: e921.","DOI":"10.1093\/cid\/ciaa1491"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Amrane S, Tissot-Dupont H, Doudier B, Eldin C, Hocquart M, Mailhe M, et al. Rapid viral diagnosis and ambulatory management of suspected COVID-19 cases presenting at the infectious diseases referral hospital in Marseille, France, - January 31st to March 1st, 2020: a respiratory virus snapshot. Travel Medicine and Infectious Disease. 2020; 36: 101632.","DOI":"10.1016\/j.tmaid.2020.101632"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Fournier P, Zandotti C, Ninove L, Prudent E, Colson P, Gazin C, et al. Contribution of VitaPCR SARS-CoV-2 to the emergency diagnosis of COVID-19. Journal of Clinical Virology. 2020; 133: 104682.","DOI":"10.1016\/j.jcv.2020.104682"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Tang N, Bai H, Chen X, Gong J, Li D, Sun Z. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. Journal of Thrombosis and Haemostasis. 2020; 18: 1094\u20131099.","DOI":"10.1111\/jth.14817"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Ayerbe L, Risco C, Ayis S. The association between treatment with heparin and survival in patients with Covid-19. Journal of Thrombosis and Thrombolysis. 2020; 50: 298\u2013301.","DOI":"10.1007\/s11239-020-02162-z"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Carlucci PM, Ahuja T, Petrilli C, Rajagopalan H, Jones S, Rahimian J. Zinc sulfate in combination with a zinc ionophore may improve outcomes in hospitalized COVID-19 patients. Journal of Medical Microbiology. 2020; 69: 1228\u20131234.","DOI":"10.1099\/jmm.0.001250"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Colson P, Levasseur A, Gautret P, Fenollar F, Thuan Hoang V, Delerce J, et al. Introduction into the Marseille geographical area of a mild SARS-CoV-2 variant originating from sub-Saharan Africa: an investigational study. Travel Medicine and Infectious Disease. 2021; 40: 101980.","DOI":"10.1016\/j.tmaid.2021.101980"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Fournier P, Colson P, Levasseur A, Devaux CA, Gautret P, Bedotto M, et al. Emergence and outcomes of the SARS-CoV-2 \u2018Marseille-4\u2019 variant. International Journal of Infectious Diseases. 2021; 106: 228\u2013236.","DOI":"10.1016\/j.ijid.2021.03.068"},{"key":"ref24","unstructured":"Institut National de la Statistique et des Etudes Economiques (INSEE). French national register of deceased persons. Year. Available at: https:\/\/www.data.gouv.fr\/fr\/datasets\/fichier-des-personnes-decedees\/#_(Accessed: 1 March 2021)."},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Ip A, Ahn J, Zhou Y, Goy AH, Hansen E, Pecora AL, et al. Hydroxychloroquine in the treatment of outpatients with mildly symptomatic COVID-19: a multi-center observational study. BMC Infectious Diseases. 2021; 21: 72.","DOI":"10.1186\/s12879-021-05773-w"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Lima-Morales R, M\u00e9ndez-Hern\u00e1ndez P, Flores YN, Osorno-Romero P, Sancho-Hern\u00e1ndez CR, Cuecuecha-Rugerio E, et al. Effectiveness of a multidrug therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico. International Journal of Infectious Diseases. 2021; 105: 598\u2013605.","DOI":"10.1016\/j.ijid.2021.02.014"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Reis G, Moreira Silva EADS, Medeiros Silva DC, Thabane L, Singh G, Park JJH, et al. Effect of Early Treatment with Hydroxychloroquine or Lopinavir and Ritonavir on Risk of Hospitalization among Patients with COVID-19. JAMA Network Open. 2021; 4: e216468.","DOI":"10.1001\/jamanetworkopen.2021.6468"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Szente Fonseca SN, de Queiroz Sousa A, Wolkoff AG, Moreira MS, Pinto BC, Valente Takeda CF, et al. Risk of hospitalization for Covid-19 outpatients treated with various drug regimens in Brazil: Comparative analysis. Travel Medicine and Infectious Disease. 2020; 38: 101906.","DOI":"10.1016\/j.tmaid.2020.101906"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Seftel D, Boulware DR. Prospective Cohort of Fluvoxamine for Early Treatment of Coronavirus Disease 19. Open Forum Infectious Diseases. 2021; 8: ofab050.","DOI":"10.1093\/ofid\/ofab050"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Altman DG, Bland JM. How to obtain the P value from a confidence interval. British Medical Journal. 2011; 343: d2304.","DOI":"10.1136\/bmj.d2304"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Gudbjartsson DF, Norddahl GL, Melsted P, Gunnarsdottir K, Holm H, Eythorsson E, et al. Humoral Immune Response to SARS-CoV-2 in Iceland. New England Journal of Medicine. 2020; 383: 1724\u20131734.","DOI":"10.1056\/NEJMoa2026116"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Erikstrup C, Hother CE, Pedersen OBV, M\u00f8lbak K, Skov RL, Holm DK, et al. Estimation of SARS-CoV-2 Infection Fatality Rate by Real-time Antibody Screening of Blood Donors. Clinical Infectious Diseases. 2021; 72: 249\u2013253.","DOI":"10.1093\/cid\/ciaa849"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"White NJ. Cardiotoxicity of antimalarial drugs. The Lancet Infectious Diseases. 2007; 7: 549\u2013558.","DOI":"10.1016\/S1473-3099(07)70187-1"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Mehra MR, Desai SS, Ruschitzka F, Patel AN. RETRACTED: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis. The Lancet. 2020; S0140-6736(20)31180-6.","DOI":"10.1016\/S0140-6736(20)31180-6"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Maille B, Wilkin M, Million M, Ress\u00e9guier N, Franceschi F, Koutbi-Franceschi L, et al. Smartwatch Electrocardiogram and Artificial Intelligence for Assessing Cardiac-Rhythm Safety of Drug Therapy in the COVID-19 Pandemic. The QT-logs study. International Journal of Cardiology. 2021; 331: 333\u2013339.","DOI":"10.1016\/j.ijcard.2021.01.002"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Jim\u00e9nez-J\u00e1imez J, Mac\u00edas-Ruiz R, Berm\u00fadez-Jim\u00e9nez F, Rubini-Costa R, Ram\u00edrez-Taboada J, Flores PIG, et al. Absence of relevant QT interval prolongation in not critically ill COVID-19 patients. Scientific Reports. 2020; 10: 21417.","DOI":"10.1038\/s41598-020-78360-9"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Anglemyer A, Horvath HT, Bero L. Healthcare outcomes assessed with observational study designs compared with those assessed in randomized trials. The Cochrane Database of Systematic Reviews. 2014; 2014: MR000034.","DOI":"10.1002\/14651858.MR000034.pub2"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Concato J, Shah N, Horwitz RI. Randomized, Controlled Trials, Observational Studies, and the Hierarchy of Research Designs. New England Journal of Medicine. 2000; 342: 1887\u20131892.","DOI":"10.1056\/NEJM200006223422507"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Lenze EJ, Mattar C, Zorumski CF, Stevens A, Schweiger J, Nicol GE, et al. Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients with Symptomatic COVID-19: A Randomized Clinical Trial. Journal of the American Medical Association. 2020; 324: 2292\u20132300.","DOI":"10.1001\/jama.2020.22760"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, et al. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020; 583: 459\u2013468.","DOI":"10.1038\/s41586-020-2286-9"},{"key":"ref41","unstructured":"Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, et al. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science. 2020; 370: eabe9403."},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Ladapo JA, McKinnon JE, McCullogh PA, Risch HA. Randomized Controlled Trials of Early Ambulatory Hydroxychloroquine in the Prevention of COVID-19 Infection, Hospitalization, and Death: Meta-Analysis. medRxiv. 2020.","DOI":"10.1101\/2020.09.30.20204693"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Cangiano B, Fatti LM, Danesi L, Gazzano G, Croci M, Vitale G, et al. Mortality in an Italian nursing home during COVID-19 pandemic: correlation with gender, age, ADL, vitamin D supplementation, and limitations of the diagnostic tests. Aging. 2020; 12: 24522\u201324534.","DOI":"10.18632\/aging.202307"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Heras E, Garibaldi P, Boix M, Valero O, Castillo J, Curbelo Y, et al. COVID-19 mortality risk factors in older people in a long-term care center. European Geriatric Medicine. 2021; 12: 601\u2013607.","DOI":"10.1007\/s41999-020-00432-w"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Ly TDA, Zanini D, Laforge V, Arlotto S, Gentile S, Mendizabal H, et al. Pattern of SARS-CoV-2 infection among dependant elderly residents living in long-term care facilities in Marseille, France, March\u2013June 2020. International Journal of Antimicrobial Agents. 2020; 56: 106219.","DOI":"10.1016\/j.ijantimicag.2020.106219"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Rajter JC, Sherman MS, Fatteh N, Vogel F, Sacks J, Rajter J. Use of Ivermectin is Associated with Lower Mortality in Hospitalized Patients with Coronavirus Disease 2019. Chest. 2021; 159: 85\u201392.","DOI":"10.1016\/j.chest.2020.10.009"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Long L, Wu L, Chen L, Zhou D, Wu H, Lu D, et al. Effect of early oxygen therapy and antiviral treatment on disease progression in patients with COVID-19: A retrospective study of medical charts in China. PLoS Neglected Tropical Diseases. 2021; 15: e0009051.","DOI":"10.1371\/journal.pntd.0009051"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Godlee F. Covid-19: The lost lessons of Tamiflu. British Medical Journal. 2020; 371: m4701.","DOI":"10.1136\/bmj.m4701"}],"container-title":["Reviews in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/22\/3\/10.31083\/j.rcm2203116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T17:43:08Z","timestamp":1732729388000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/22\/3\/10.31083\/j.rcm2203116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,24]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021]]}},"alternative-id":["1632453113256-204528530"],"URL":"https:\/\/doi.org\/10.31083\/j.rcm2203116","relation":{},"ISSN":["1530-6550","2153-8174"],"issn-type":[{"value":"1530-6550","type":"print"},{"value":"2153-8174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,24]]},"article-number":"1063"}}