{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T02:26:43Z","timestamp":1778552803112,"version":"3.51.4"},"reference-count":39,"publisher":"IMR Press","issue":"4","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Left ventricular outflow tract (LVOT) obstruction and systolic anterior motion (SAM) of the mitral valve (MV) occurs in 70% of hypertrophic cardiomyopathy (HCM) patients. In individuals undergoing septal myectomy, concomitant MV surgery is considered for SAM with residual LVOT obstruction or mitral regurgitation (MR); however, the optimal approach remains debated. A literature search was performed in Pubmed, EMBASE, Ovid, and the Cochrane library of published articles through June 2021 reporting on combined septal myectomy and edge-to-edge MV repair for obstructive HCM. Continuous variables were weighted and compared using a student\u2019s t-test, and categorical variables using a chi-square test with Yates correction. Six studies with 158 total patients were included. The mean follow-up was 2.8 \u00b1 2.7 years. Compared with pre-operative values, there were significant reductions in the LV ejection fraction (69 \u00b1 10 vs 59 \u00b1 8%), peak LVOT gradient (82 \u00b1 34 vs 16 \u00b1 13 mmHg), prevalence of moderate or greater MR (84 vs 5 %), and presence of SAM (96% vs 0) (p &lt; 0.001 for all). There was no change in LV internal diastolic diameter (4.2 \u00b1 1.3 vs 4.4 \u00b1 1.5 cm, p = 0.32). There were 2 (1%) operative mortalities. At follow-up, the survival rate was 97%, there were 3 (2%) re-operative MV replacements, 4 (3%) patients remained in New York Heart Association functional class III\/IV, and 8 (6%) required permanent pacemaker implantation. In conclusion, combined septal myectomy and edge-to-edge MV repair is a safe and effective treatment strategy in carefully selected patients requiring surgical HCM management.<\/jats:p>","DOI":"10.31083\/j.rcm2204151","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T02:04:36Z","timestamp":1640225076000},"source":"Crossref","is-referenced-by-count":9,"title":["A systematic review and pooled analysis of septal myectomy and edge-to-edge mitral valve repair in obstructive hypertrophic cardiomyopathy"],"prefix":"10.31083","volume":"22","author":[{"given":"Christos G.","family":"Mihos","sequence":"first","affiliation":[{"name":"Echocardiography Laboratory, Columbia University Division of Cardiology, Mount Sinai Heart Institute, Miami Beach, FL 33140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban","family":"Escolar","sequence":"first","affiliation":[{"name":"Coronary Care Unit, Columbia University Division of Cardiology, Mount Sinai Heart Institute, Miami Beach, FL 33140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafle","family":"Fernandez","sequence":"first","affiliation":[{"name":"Echocardiography Laboratory, Columbia University Division of Cardiology, Mount Sinai Heart Institute, Miami Beach, FL 33140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Nappi","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Centre Cardiologique du Nord de Saint-Denis, 93200 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Maron BJ, Gardin JM, Flack JM, Gidding SS, Kurosaki TT, Bild DE. 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