{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:28:52Z","timestamp":1792276132110,"version":"4.4.0"},"reference-count":118,"publisher":"IMR Press","issue":"1","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Acute myocardial infarction (AMI) is a major cause of morbidity and mortality worldwide. Timely reperfusion with primary percutaneous coronary intervention (PPCI) remains the gold standard in patients presenting with ST-segment elevation myocardial infarction (STEMI), limiting infarct size, preserving left ventricular ejection fraction (LVEF), and improving clinical outcomes. Despite this, a significant proportion of STEMI patients develop post-infarct heart failure. We review the current understanding and up-to-date evidence base for therapeutic intervention of ischaemia-reperfusion injury (IRI), a combination of myocardial ischaemia secondary to acute coronary occlusion and reperfusion injury leading to further myocardial injury and cell death. Multiple treatment modalities have been shown to be cardioprotective and reduce IRI in experimental animal models. Recent phase II\/III randomised controlled trials (RCT) have assessed multiple cardioprotective strategies ranging from ischaemic conditioning, therapeutic hypothermia and hyperoxaemia to pharmacological therapies. While several therapies have been shown to reduce infarct size in animal models or proof-of-concept studies, many larger scale trial results have proven inconsistent and disappointing. Hard clinical outcomes remain elusive. We discuss potential reasons for the difficulties in translation to clinical practice.<\/jats:p>","DOI":"10.31083\/j.rcm2301023","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T09:29:35Z","timestamp":1642757375000},"source":"Crossref","is-referenced-by-count":29,"title":["Treatment of myocardial ischaemia-reperfusion injury in patients with ST-segment elevation myocardial infarction: promise, disappointment, and hope"],"prefix":"10.31083","volume":"23","author":[{"given":"Jingzhou","family":"He","sequence":"first","affiliation":[{"name":"Diabetes and Vascular Medicine Research Centre, Institute of Biomedical and Clinical Science and University of Exeter, College of Medicine and Health, Royal Devon & Exeter Hospital, EX2 5AX Exeter, UK"},{"name":"Department of Cardiology, Royal Devon & Exeter Hospital, EX2 5AX Exeter, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick G","family":"Bellenger","sequence":"first","affiliation":[{"name":"Diabetes and Vascular Medicine Research Centre, Institute of Biomedical and Clinical Science and University of Exeter, College of Medicine and Health, Royal Devon & Exeter Hospital, EX2 5AX Exeter, UK"},{"name":"Department of Cardiology, Royal Devon & Exeter Hospital, EX2 5AX Exeter, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Ludman","sequence":"first","affiliation":[{"name":"Diabetes and Vascular Medicine Research Centre, Institute of Biomedical and Clinical Science and University of Exeter, College of Medicine and Health, Royal Devon & Exeter Hospital, EX2 5AX Exeter, UK"},{"name":"Department of Cardiology, Royal Devon & Exeter Hospital, EX2 5AX Exeter, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela C","family":"Shore","sequence":"first","affiliation":[{"name":"Diabetes and Vascular Medicine Research Centre, Institute of Biomedical and Clinical Science and University of Exeter, College of Medicine and Health, Royal Devon & Exeter Hospital, EX2 5AX Exeter, UK"},{"name":"NIHR Exeter Clinical Research Facility, Royal Devon & Exeter NHS Foundation Trust and University of Exeter, College of Medicine and Health, RILD building, Royal Devon & Exeter Hospital, EX2 5DW Exeter, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W David","family":"Strain","sequence":"first","affiliation":[{"name":"Diabetes and Vascular Medicine Research Centre, Institute of Biomedical and Clinical Science and University of Exeter, College of Medicine and Health, Royal Devon & Exeter Hospital, EX2 5AX Exeter, UK"},{"name":"NIHR Exeter Clinical Research Facility, Royal Devon & Exeter NHS Foundation Trust and University of Exeter, College of Medicine and Health, RILD building, Royal Devon & Exeter Hospital, EX2 5DW Exeter, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Townsend N, Wilson L, Bhatnagar P, Wickramasinghe K, Rayner M, Nichols M. Cardiovascular disease in Europe: epidemiological update 2016. European Heart Journal. 2016; 37: 3232\u20133245.","DOI":"10.1093\/eurheartj\/ehw334"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Lambert L, Brown K, Segal E, Brophy J, Rodes-Cabau J, Bogaty P. Association between timeliness of reperfusion therapy and clinical outcomes in ST-elevation myocardial infarction. The Journal of the American Medical Association. 2010; 303: 2148\u20132155.","DOI":"10.1001\/jama.2010.712"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Berger PB, Ellis SG, Holmes DR, Granger CB, Criger DA, Betriu A, et al. Relationship between delay in performing direct coronary angioplasty and early clinical outcome in patients with acute myocardial infarction: results from the global use of strategies to open occluded arteries in Acute Coronary Syndromes (GUSTO-IIb) trial. Circulation. 1999; 100: 14\u201320.","DOI":"10.1161\/01.CIR.100.1.14"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). European Heart Journal. 2018; 39: 119\u2013177.","DOI":"10.1093\/eurheartj\/ehx393"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Gibson CM, Sch\u00f6mig A. Coronary and myocardial angiography: angiographic assessment of both epicardial and myocardial perfusion. Circulation. 2004; 109: 3096\u20133105.","DOI":"10.1161\/01.CIR.0000134278.50359.CB"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Burns RJ, Gibbons RJ, Yi Q, Roberts RS, Miller TD, Schaer GL, et al. The relationships of left ventricular ejection fraction, end-systolic volume index and infarct size to six-month mortality after hospital discharge following myocardial infarction treated by thrombolysis. Journal of the American College of Cardiology. 2002; 39: 30\u201336.","DOI":"10.1016\/S0735-1097(01)01711-9"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Wu E, Ortiz JT, Tejedor P, Lee DC, Bucciarelli-Ducci C, Kansal P, et al. Infarct size by contrast enhanced cardiac magnetic resonance is a stronger predictor of outcomes than left ventricular ejection fraction or end-systolic volume index: prospective cohort study. Heart. 2008; 94: 730\u2013736.","DOI":"10.1136\/hrt.2007.122622"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Majidi M, Kosinski AS, Al-Khatib SM, Lemmert ME, Smolders L, van Weert A, et al. Reperfusion ventricular arrhythmia \u2018bursts\u2019 predict larger infarct size despite TIMI 3 flow restoration with primary angioplasty for anterior ST-elevation myocardial infarction. European Heart Journal. 2009; 30: 757\u2013764.","DOI":"10.1093\/eurheartj\/ehp005"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Saia F, Grigioni F, Marzocchi A, Branzi A. Management of acute left ventricular dysfunction after primary percutaneous coronary intervention for ST elevation acute myocardial infarction. American Heart Journal. 2010; 160: S16\u2013S21.","DOI":"10.1016\/j.ahj.2010.10.011"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Stone GW, Selker HP, Thiele H, Patel MR, Udelson JE, Ohman EM, et al. Relationship between Infarct Size and Outcomes Following Primary PCI. Journal of the American College of Cardiology. 2016; 67: 1674\u20131683.","DOI":"10.1016\/j.jacc.2016.01.069"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. The New England Journal of Medicine. 2007; 357: 1121\u20131135.","DOI":"10.1056\/NEJMra071667"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Piper HM, Garc\u00eda-Dorado D, Ovize M. A fresh look at reperfusion injury. Cardiovascular Research. 1998; 38: 291\u2013300.","DOI":"10.1016\/S0008-6363(98)00033-9"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Rochitte CE, Azevedo CF. The myocardial area at risk. Heart. 2012; 98: 348\u2013350.","DOI":"10.1136\/heartjnl-2011-301332"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Reimer KA, Lowe JE, Rasmussen MM, Jennings RB. The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs. Circulation. 1977; 56: 786\u2013794.","DOI":"10.1161\/01.CIR.56.5.786"},{"key":"ref15","unstructured":"Reimer KA, Jennings RB. The \u2018wavefront phenomenon\u2019 of myocardial ischemic cell death. II. Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flow. Laboratory Investigation. 1979; 40: 633\u2013644."},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Lee JT, Ideker RE, Reimer KA. Myocardial infarct size and location in relation to the coronary vascular bed at risk in man. Circulation. 1981; 64: 526\u2013534.","DOI":"10.1161\/01.CIR.64.3.526"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Kim RJ, Fieno DS, Parrish TB, Harris K, Chen EL, Simonetti O, et al. Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation. 1999; 100: 1992\u20132002.","DOI":"10.1161\/01.CIR.100.19.1992"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Arai AE, Leung S, Kellman P. Controversies in cardiovascular MR imaging: reasons why imaging myocardial T2 has clinical and pathophysiologic value in acute myocardial infarction. Radiology. 2012; 265: 23\u201332.","DOI":"10.1148\/radiol.12112491"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Abdel-Aty H, Simonetti O, Friedrich MG. T2-weighted cardiovascular magnetic resonance imaging. Journal of Magnetic Resonance Imaging. 2007; 26: 452\u2013459.","DOI":"10.1002\/jmri.21028"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Wince WB, Kim RJ. Molecular imaging: T2-weighted CMR of the area at risk\u2013a risky business? Nature Reviews Cardiology. 2010; 7: 547\u2013549.","DOI":"10.1038\/nrcardio.2010.124"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"L\u00f8nborg J, Vejlstrup N, Mathiasen AB, Thomsen C, Jensen JS, Engstr\u00f8m T. Myocardial area at risk and salvage measured by T2-weighted cardiovascular magnetic resonance: reproducibility and comparison of two T2-weighted protocols. Journal of Cardiovascular Magnetic Resonance. 2011; 13: 50.","DOI":"10.1186\/1532-429X-13-50"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Nordlund D, Klug G, Heiberg E, Koul S, Larsen TH, Hoffmann P, et al. Multi-vendor, multicentre comparison of contrast-enhanced SSFP and T2-STIR CMR for determining myocardium at risk in ST-elevation myocardial infarction. European Heart Journal Cardiovascular Imaging. 2016; 17: 744\u2013753.","DOI":"10.1093\/ehjci\/jew027"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"G\u00f6ransson C, Ahtarovski KA, Kyhl K, L\u00f8nborg J, Nepper-Christensen L, Bertelsen L, et al. Assessment of the myocardial area at risk: comparing T2-weighted cardiovascular magnetic resonance imaging with contrast-enhanced cine (CE-SSFP) imaging\u2014a DANAMI3 substudy. European Heart Journal Cardiovascular Imaging. 2019; 20: 361\u2013366.","DOI":"10.1093\/ehjci\/jey106"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Ib\u00e1\u00f1ez B, Heusch G, Ovize M, Van de Werf F. Evolving therapies for myocardial ischemia\/reperfusion injury. Journal of the American College of Cardiology. 2015; 65: 1454\u20131471.","DOI":"10.1016\/j.jacc.2015.02.032"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Sch\u00f6mig A, Mehilli J, Antoniucci D, Ndrepepa G, Markwardt C, Di Pede F, et al. Mechanical reperfusion in patients with acute myocardial infarction presenting more than 12 hours from symptom onset: a randomized controlled trial. The Journal of the American Medical Association. 2005; 293: 2865\u20132872.","DOI":"10.1001\/jama.293.23.2865"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Fibrinolytic Therapy Trialists\u2019 (FTT) Collaborative Group. Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. The Lancet. 1994; 343: 311\u2013322.","DOI":"10.1016\/S0140-6736(94)91161-4"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Alkhalil M, Choudhury RP. Reperfusion Treatment in Late Presentation Acute Myocardial Infarction: Timing Is Not Everything. Circulation: Cardiovascular Interventions. 2018; 11: e007287.","DOI":"10.1161\/CIRCINTERVENTIONS.118.007287"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Boersma E. Does time matter? A pooled analysis of randomized clinical trials comparing primary percutaneous coronary intervention and in-hospital fibrinolysis in acute myocardial infarction patients. European Heart Journal. 2006; 27: 779\u2013788.","DOI":"10.1093\/eurheartj\/ehi810"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Ndrepepa G. Mechanical Reperfusion and Long-term Mortality in Patients with Acute Myocardial Infarction Presenting 12 to 48 Hours from Onset of Symptoms. The Journal of the American Medical Association. 2009; 301: 487.","DOI":"10.1001\/jama.2009.32"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Hochman JS, Lamas GA, Buller CE, Dzavik V, Reynolds HR, Abramsky SJ, et al. Coronary intervention for persistent occlusion after myocardial infarction. The New England Journal of Medicine. 2006; 355: 2395\u20132407.","DOI":"10.1056\/NEJMoa066139"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"PITT B. Interarterial coronary anastomoses. Occurrence in normal hearts and in certain pathologic conditions. Circulation. 1959; 20: 816\u2013822.","DOI":"10.1161\/01.CIR.20.5.816"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Seiler C. The human coronary collateral circulation. European Journal of Clinical Investigation. 2010; 40: 465\u2013476.","DOI":"10.1111\/j.1365-2362.2010.02282.x"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Habib GB, Heibig J, Forman SA, Brown BG, Roberts R, Terrin ML, et al. Influence of coronary collateral vessels on myocardial infarct size in humans. Results of phase I thrombolysis in myocardial infarction (TIMI) trial. The TIMI Investigators. Circulation. 1991; 83: 739\u2013746.","DOI":"10.1161\/01.CIR.83.3.739"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Billinger M, Kloos P, Eberli FR, Windecker S, Meier B, Seiler C. Physiologically assessed coronary collateral flow and adverse cardiac ischemic events: a follow-up study in 403 patients with coronary artery disease. Journal of the American College of Cardiology. 2002; 40: 1545\u20131550.","DOI":"10.1016\/S0735-1097(02)02378-1"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Meier P, Gloekler S, Zbinden R, Beckh S, de Marchi SF, Zbinden S, et al. Beneficial effect of recruitable collaterals: a 10-year follow-up study in patients with stable coronary artery disease undergoing quantitative collateral measurements. Circulation. 2007; 116: 975\u2013983.","DOI":"10.1161\/CIRCULATIONAHA.107.703959"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Bolli R. Myocardial \u2018stunning\u2019 in man. Circulation. 1992; 86: 1671\u20131691.","DOI":"10.1161\/01.CIR.86.6.1671"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Ito H, Maruyama A, Iwakura K, Takiuchi S, Masuyama T, Hori M, et al. Clinical implications of the \u2018no reflow\u2019 phenomenon. a predictor of complications and left ventricular remodeling in reperfused anterior wall myocardial infarction. Circulation. 1996; 93: 223\u2013228.","DOI":"10.1161\/01.CIR.93.2.223"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Taylor AJ, Al-Saadi N, Abdel-Aty H, Schulz-Menger J, Messroghli DR, Friedrich MG. Detection of acutely impaired microvascular reperfusion after infarct angioplasty with magnetic resonance imaging. Circulation. 2004; 109: 2080\u20132085.","DOI":"10.1161\/01.CIR.0000127812.62277.50"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Harrison RW, Aggarwal A, Ou F, Klein LW, Rumsfeld JS, Roe MT, et al. Incidence and outcomes of no-reflow phenomenon during percutaneous coronary intervention among patients with acute myocardial infarction. The American Journal of Cardiology. 2013; 111: 178\u2013184.","DOI":"10.1016\/j.amjcard.2012.09.015"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Schwartz BG, Kloner RA. Coronary no reflow. Journal of Molecular and Cellular Cardiology. 2012; 52: 873\u2013882.","DOI":"10.1016\/j.yjmcc.2011.06.009"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Resnic FS, Wainstein M, Lee MKY, Behrendt D, Wainstein RV, Ohno-Machado L, et al. No-reflow is an independent predictor of death and myocardial infarction after percutaneous coronary intervention. American Heart Journal. 2003; 145: 42\u201346.","DOI":"10.1067\/mhj.2003.36"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Ndrepepa G, Tiroch K, Fusaro M, Keta D, Seyfarth M, Byrne RA, et al. 5-year prognostic value of no-reflow phenomenon after percutaneous coronary intervention in patients with acute myocardial infarction. Journal of the American College of Cardiology. 2010; 55: 2383\u20132389.","DOI":"10.1016\/j.jacc.2009.12.054"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Niccoli G, Scalone G, Lerman A, Crea F. Coronary microvascular obstruction in acute myocardial infarction. European Heart Journal. 2016; 37: 1024\u20131033.","DOI":"10.1093\/eurheartj\/ehv484"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Fr\u00f6bert O, Lagerqvist B, Olivecrona GK, Omerovic E, Gudnason T, Maeng M, et al. Thrombus Aspiration during ST-Segment Elevation Myocardial Infarction. New England Journal of Medicine. 2013; 369: 1587\u20131597.","DOI":"10.1056\/NEJMoa1308789"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Jolly SS, James S, D\u017eav\u00edk V, Cairns JA, Mahmoud KD, Zijlstra F, et al. Thrombus Aspiration in ST-Segment-Elevation Myocardial Infarction: an Individual Patient Meta-Analysis: Thrombectomy Trialists Collaboration. Circulation. 2017; 135: 143\u2013152.","DOI":"10.1161\/CIRCULATIONAHA.116.025371"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Tranum-Jensen J, Janse MJ, Fiolet WT, Krieger WJ, D\u2019Alnoncourt CN, Durrer D. Tissue osmolality, cell swelling, and reperfusion in acute regional myocardial ischemia in the isolated porcine heart. Circulation Research. 1981; 49: 364\u2013381.","DOI":"10.1161\/01.RES.49.2.364"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Durante A, Camici PG. Novel insights into an \u201cold\u201d phenomenon: the no reflow. International Journal of Cardiology. 2015; 187: 273\u2013280.","DOI":"10.1016\/j.ijcard.2015.03.359"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Jelinek M, Santamaria J. Metamorphosis: the natural history of coronary heart disease. Sudden death is common. Unexpected death is not. International Journal of Cardiology. 2007; 118: 10\u201313.","DOI":"10.1016\/j.ijcard.2006.05.031"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Garcia-Dorado D, Ruiz-Meana M, Piper HM. Lethal reperfusion injury in acute myocardial infarction: facts and unresolved issues. Cardiovascular Research. 2009; 83: 165\u2013168.","DOI":"10.1093\/cvr\/cvp185"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Kin H, Zhao Z, Sun H, Wang N, Corvera JS, Halkos ME, et al. Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion. Cardiovascular Research. 2004; 62: 74\u201385.","DOI":"10.1016\/j.cardiores.2004.01.006"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Inserte J, Barba I, Hernando V, Garcia-Dorado D. Delayed recovery of intracellular acidosis during reperfusion prevents calpain activation and determines protection in postconditioned myocardium. Cardiovascular Research. 2009; 81: 116\u2013122.","DOI":"10.1093\/cvr\/cvn260"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Wu M, Yiang G, Liao W, Tsai AP, Cheng Y, Cheng P, et al. Current Mechanistic Concepts in Ischemia and Reperfusion Injury. Cellular Physiology and Biochemistry. 2018; 46: 1650\u20131667.","DOI":"10.1159\/000489241"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Zweier JL, Flaherty JT, Weisfeldt ML. Direct measurement of free radical generation following reperfusion of ischemic myocardium. Proceedings of the National Academy of Sciences of the United States of America. 1987; 84: 1404\u20131407.","DOI":"10.1073\/pnas.84.5.1404"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Hearse DJ, Humphrey SM, Chain EB. Abrupt reoxygenation of the anoxic potassium-arrested perfused rat heart: a study of myocardial enzyme release. Journal of Molecular and Cellular Cardiology. 1973; 5: 395\u2013407.","DOI":"10.1016\/0022-2828(73)90030-8"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Ma S, Wang Y, Chen Y, Cao F. The role of the autophagy in myocardial ischemia\/reperfusion injury. Biochimica Et Biophysica Acta. 2015; 1852: 271\u2013276.","DOI":"10.1016\/j.bbadis.2014.05.010"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Kalogeris T, Bao Y, Korthuis RJ. Mitochondrial reactive oxygen species: a double edged sword in ischemia\/reperfusion vs preconditioning. Redox Biology. 2014; 2: 702\u2013714.","DOI":"10.1016\/j.redox.2014.05.006"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Hausenloy DJ, Yellon DM. Myocardial ischemia-reperfusion injury: a neglected therapeutic target. The Journal of Clinical Investigation. 2013; 123: 92\u2013100.","DOI":"10.1172\/JCI62874"},{"key":"ref58","doi-asserted-by":"crossref","unstructured":"Lemasters JJ, Bond JM, Chacon E, Harper IS, Kaplan SH, Ohata H, et al. The pH paradox in ischemia-reperfusion injury to cardiac myocytes. Experientia Supplementum. 1996; 76: 99\u2013114.","DOI":"10.1007\/978-3-0348-8988-9_7"},{"key":"ref59","doi-asserted-by":"crossref","unstructured":"Hausenloy DJ, Yellon DM. The mitochondrial permeability transition pore: its fundamental role in mediating cell death during ischaemia and reperfusion. Journal of Molecular and Cellular Cardiology. 2003; 35: 339\u2013341.","DOI":"10.1016\/S0022-2828(03)00043-9"},{"key":"ref60","doi-asserted-by":"crossref","unstructured":"Heusch G, Boengler K, Schulz R. Inhibition of mitochondrial permeability transition pore opening: the Holy Grail of cardioprotection. Basic Research in Cardiology. 2010; 105: 151\u2013154.","DOI":"10.1007\/s00395-009-0080-9"},{"key":"ref61","doi-asserted-by":"crossref","unstructured":"Griffiths EJ, Halestrap AP. Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion. Biochemical Journal. 1995; 307: 93\u201398.","DOI":"10.1042\/bj3070093"},{"key":"ref62","doi-asserted-by":"crossref","unstructured":"Boulanger CM, Loyer X, Rautou P, Amabile N. Extracellular vesicles in coronary artery disease. Nature Reviews Cardiology. 2017; 14: 259\u2013272.","DOI":"10.1038\/nrcardio.2017.7"},{"key":"ref63","doi-asserted-by":"crossref","unstructured":"Davidson SM, Yellon DM. Exosomes and cardioprotection - A critical analysis. Molecular Aspects of Medicine. 2018; 60: 104\u2013114.","DOI":"10.1016\/j.mam.2017.11.004"},{"key":"ref64","doi-asserted-by":"crossref","unstructured":"Lawson C, Vicencio JM, Yellon DM, Davidson SM. Microvesicles and exosomes: new players in metabolic and cardiovascular disease. The Journal of Endocrinology. 2016; 228: R57\u2013R71.","DOI":"10.1530\/JOE-15-0201"},{"key":"ref65","doi-asserted-by":"crossref","unstructured":"Barani B, Rajasingh S, Rajasingh J. Exosomes: Outlook for Future Cell-Free Cardiovascular Disease Therapy. Exosomes in Cardiovascular Diseases. 2017; 123: 285\u2013307.","DOI":"10.1007\/978-981-10-4397-0_19"},{"key":"ref66","doi-asserted-by":"crossref","unstructured":"Barile L, Lionetti V, Cervio E, Matteucci M, Gherghiceanu M, Popescu LM, et al. Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction. Cardiovascular Research. 2014; 103: 530\u2013541.","DOI":"10.1093\/cvr\/cvu167"},{"key":"ref67","doi-asserted-by":"crossref","unstructured":"de Couto G, Gallet R, Cambier L, Jaghatspanyan E, Makkar N, Dawkins JF, et al. Exosomal MicroRNA Transfer into Macrophages Mediates Cellular Postconditioning. Circulation. 2017; 136: 200\u2013214.","DOI":"10.1161\/CIRCULATIONAHA.116.024590"},{"key":"ref68","doi-asserted-by":"crossref","unstructured":"Zhang Q, Shang M, Zhang M, Wang Y, Chen Y, Wu Y, et al. Microvesicles derived from hypoxia\/reoxygenation-treated human umbilical vein endothelial cells promote apoptosis and oxidative stress in H9c2 cardiomyocytes. BMC Cell Biology. 2016; 17: 25.","DOI":"10.1186\/s12860-016-0100-1"},{"key":"ref69","doi-asserted-by":"crossref","unstructured":"D\u2019Ascenzo F, Femmin\u00f2 S, Ravera F, Angelini F, Caccioppo A, Franchin L, et al. Extracellular vesicles from patients with Acute Coronary Syndrome impact on ischemia-reperfusion injury. Pharmacological Research. 2021; 170: 105715.","DOI":"10.1016\/j.phrs.2021.105715"},{"key":"ref70","doi-asserted-by":"crossref","unstructured":"Hausenloy DJ, Garcia-Dorado D, B\u00f8tker HE, Davidson SM, Downey J, Engel FB, et al. Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart. Cardiovascular Research. 2017; 113: 564\u2013585.","DOI":"10.1093\/cvr\/cvx049"},{"key":"ref71","doi-asserted-by":"crossref","unstructured":"Davidson SM, Ferdinandy P, Andreadou I, B\u00f8tker HE, Heusch G, Ib\u00e1\u00f1ez B, et al. Multitarget Strategies to Reduce Myocardial Ischemia\/Reperfusion Injury: JACC Review Topic of the Week. Journal of the American College of Cardiology. 2019; 73: 89\u201399.","DOI":"10.1016\/j.jacc.2018.09.086"},{"key":"ref72","doi-asserted-by":"crossref","unstructured":"Thibault H, Piot C, Staat P, Bontemps L, Sportouch C, Rioufol G, et al. Long-Term Benefit of Postconditioning. Circulation. 2008; 117: 1037\u20131044.","DOI":"10.1161\/CIRCULATIONAHA.107.729780"},{"key":"ref73","doi-asserted-by":"crossref","unstructured":"Staat P, Rioufol G, Piot C, Cottin Y, Cung TT, L\u2019Huillier I, et al. Postconditioning the human heart. Circulation. 2005; 112: 2143\u20132148.","DOI":"10.1161\/CIRCULATIONAHA.105.558122"},{"key":"ref74","doi-asserted-by":"crossref","unstructured":"Engstr\u00f8m T, Kelb\u00e6k H, Helqvist S, H\u00f8fsten DE, Kl\u00f8vgaard L, Clemmensen P, et al. Effect of Ischemic Postconditioning during Primary Percutaneous Coronary Intervention for Patients with ST-Segment Elevation Myocardial Infarction: a Randomized Clinical Trial. JAMA Cardiology. 2017; 2: 490\u2013497.","DOI":"10.1001\/jamacardio.2017.0022"},{"key":"ref75","doi-asserted-by":"crossref","unstructured":"Przyklenk K, Bauer B, Ovize M, Kloner RA, Whittaker P. Regional ischemic \u2018preconditioning\u2019 protects remote virgin myocardium from subsequent sustained coronary occlusion. Circulation. 1993; 87: 893\u2013899.","DOI":"10.1161\/01.CIR.87.3.893"},{"key":"ref76","doi-asserted-by":"crossref","unstructured":"White SK, Frohlich GM, Sado DM, Maestrini V, Fontana M, Treibel TA, et al. Remote Ischemic Conditioning Reduces Myocardial Infarct Size and Edema in Patients with ST-Segment Elevation Myocardial Infarction. JACC: Cardiovascular Interventions. 2015; 8: 178\u2013188.","DOI":"10.1016\/j.jcin.2014.05.015"},{"key":"ref77","doi-asserted-by":"crossref","unstructured":"Crimi G, Pica S, Raineri C, Bramucci E, De Ferrari GM, Klersy C, et al. Remote ischemic post-conditioning of the lower limb during primary percutaneous coronary intervention safely reduces enzymatic infarct size in anterior myocardial infarction: a randomized controlled trial. JACC: Cardiovascular Interventions. 2013; 6: 1055\u20131063.","DOI":"10.1016\/j.jcin.2013.05.011"},{"key":"ref78","doi-asserted-by":"crossref","unstructured":"B\u00f8tker HE, Kharbanda R, Schmidt MR, B\u00f8ttcher M, Kaltoft AK, Terkelsen CJ, et al. Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial. The Lancet. 2010; 375: 727\u2013734.","DOI":"10.1016\/S0140-6736(09)62001-8"},{"key":"ref79","doi-asserted-by":"crossref","unstructured":"Hausenloy DJ, Kharbanda RK, M\u00f8ller UK, Ramlall M, Aar\u00f8e J, Butler R, et al. Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2\/ERIC-PPCI): a single-blind randomised controlled trial. The Lancet. 2019; 394: 1415\u20131424.","DOI":"10.1093\/cvr\/cvz242"},{"key":"ref80","doi-asserted-by":"crossref","unstructured":"Hausenloy DJ, Ntsekhe M, Yellon DM. A future for remote ischaemic conditioning in high-risk patients. Basic Research in Cardiology. 2020; 115: 35.","DOI":"10.1007\/s00395-020-0794-2"},{"key":"ref81","doi-asserted-by":"crossref","unstructured":"Sonne DP, Engstr\u00f8m T, Treiman M. Protective effects of GLP-1 analogues exendin-4 and GLP-1(9-36) amide against ischemia-reperfusion injury in rat heart. Regulatory Peptides. 2008; 146: 243\u2013249.","DOI":"10.1016\/j.regpep.2007.10.001"},{"key":"ref82","doi-asserted-by":"crossref","unstructured":"L\u00f8nborg J, Vejlstrup N, Kelb\u00e6k H, B\u00f8tker HE, Kim WY, Mathiasen AB, et al. Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction. European Heart Journal. 2012; 33: 1491\u20131499.","DOI":"10.1093\/eurheartj\/ehr309"},{"key":"ref83","doi-asserted-by":"crossref","unstructured":"Zhang Y, Qian P, Zhou H, Shen R, Hu B, Shen Y, et al. Pharmacological Signatures of the Exenatide Nanoparticles Complex against Myocardial Ischemia Reperfusion Injury. Kidney and Blood Pressure Research. 2018; 43: 1273\u20131284.","DOI":"10.1159\/000492409"},{"key":"ref84","doi-asserted-by":"crossref","unstructured":"Siddiqi N, Neil C, Bruce M, MacLennan G, Cotton S, Papadopoulou S, et al. Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI). European Heart Journal. 2014; 35: 1255\u20131262.","DOI":"10.1093\/eurheartj\/ehu096"},{"key":"ref85","doi-asserted-by":"crossref","unstructured":"Jones DA, Pellaton C, Velmurugan S, Rathod KS, Andiapen M, Antoniou S, et al. Randomized Phase 2 Trial of Intracoronary Nitrite during Acute Myocardial Infarction. Circulation Research. 2015; 116: 437\u2013447.","DOI":"10.1161\/CIRCRESAHA.116.305082"},{"key":"ref86","doi-asserted-by":"crossref","unstructured":"Piot C, Croisille P, Staat P, Thibault H, Rioufol G, Mewton N, et al. Effect of cyclosporine on reperfusion injury in acute myocardial infarction. The New England Journal of Medicine. 2008; 359: 473\u2013481.","DOI":"10.1056\/NEJMoa071142"},{"key":"ref87","doi-asserted-by":"crossref","unstructured":"Mewton N, Croisille P, Gahide G, Rioufol G, Bonnefoy E, Sanchez I, et al. Effect of cyclosporine on left ventricular remodeling after reperfused myocardial infarction. Journal of the American College of Cardiology. 2010; 55: 1200\u20131205.","DOI":"10.1016\/j.jacc.2009.10.052"},{"key":"ref88","doi-asserted-by":"crossref","unstructured":"Cung T, Morel O, Cayla G, Rioufol G, Garcia-Dorado D, Angoulvant D, et al. Cyclosporine before PCI in Patients with Acute Myocardial Infarction. The New England Journal of Medicine. 2015; 373: 1021\u20131031.","DOI":"10.1056\/NEJMoa1505489"},{"key":"ref89","doi-asserted-by":"crossref","unstructured":"Dai W, Shi J, Gupta RC, Sabbah HN, Hale SL, Kloner RA. Bendavia, a mitochondria-targeting peptide, improves postinfarction cardiac function, prevents adverse left ventricular remodeling, and restores mitochondria-related gene expression in rats. Journal of Cardiovascular Pharmacology. 2014; 64: 543\u2013553.","DOI":"10.1097\/FJC.0000000000000155"},{"key":"ref90","doi-asserted-by":"crossref","unstructured":"Shi J, Dai W, Hale SL, Brown DA, Wang M, Han X, et al. Bendavia restores mitochondrial energy metabolism gene expression and suppresses cardiac fibrosis in the border zone of the infarcted heart. Life Sciences. 2015; 141: 170\u2013178.","DOI":"10.1016\/j.lfs.2015.09.022"},{"key":"ref91","doi-asserted-by":"crossref","unstructured":"Gibson CM, Giugliano RP, Kloner RA, Bode C, Tendera M, J\u00e1nosi A, et al. EMBRACE STEMI study: a Phase 2a trial to evaluate the safety, tolerability, and efficacy of intravenous MTP-131 on reperfusion injury in patients undergoing primary percutaneous coronary intervention. European Heart Journal. 2016; 37: 1296\u20131303.","DOI":"10.1093\/eurheartj\/ehv597"},{"key":"ref92","doi-asserted-by":"crossref","unstructured":"Bulluck H, Sirker A, Loke YK, Garcia-Dorado D, Hausenloy DJ. Clinical benefit of adenosine as an adjunct to reperfusion in ST-elevation myocardial infarction patients: an updated meta-analysis of randomized controlled trials. International Journal of Cardiology. 2016; 202: 228\u2013237.","DOI":"10.1016\/j.ijcard.2015.09.005"},{"key":"ref93","doi-asserted-by":"crossref","unstructured":"Ibanez B, Prat-Gonza\u0301lez S, Speidl WS, Vilahur G, Pinero A, Cimmino G, et al. Early Metoprolol Administration before Coronary Reperfusion Results in Increased Myocardial Salvage: analysis of ischemic myocardium at risk using cardiac magnetic resonance. Circulation. 2007; 115: 2909\u20132916.","DOI":"10.1161\/CIRCULATIONAHA.106.679639"},{"key":"ref94","doi-asserted-by":"crossref","unstructured":"Ibanez B, Macaya C, S\u00e1nchez-Brunete V, Pizarro G, Fern\u00e1ndez-Friera L, Mateos A, et al. Effect of early metoprolol on infarct size in ST-segment-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention: the Effect of Metoprolol in Cardioprotection during an Acute Myocardial Infarction (METOCARD-CNIC) trial. Circulation. 2013; 128: 1495\u20131503.","DOI":"10.1161\/CIRCULATIONAHA.113.003653"},{"key":"ref95","doi-asserted-by":"crossref","unstructured":"Roolvink V, Ib\u00e1\u00f1ez B, Ottervanger JP, Pizarro G, van Royen N, Mateos A, et al. Early Intravenous Beta-Blockers in Patients With ST-Segment Elevation Myocardial Infarction Before Primary Percutaneous Coronary Intervention. Journal of the American College of Cardiology. 2016; 67: 2705\u20132715.","DOI":"10.1016\/j.jacc.2016.03.522"},{"key":"ref96","doi-asserted-by":"crossref","unstructured":"Hausenloy DJ, Barrabes JA, B\u00f8tker HE, Davidson SM, Di Lisa F, Downey J, et al. Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery. Basic Research in Cardiology. 2016; 111: 70.","DOI":"10.1007\/s00395-016-0588-8"},{"key":"ref97","doi-asserted-by":"crossref","unstructured":"Lobo-Gonzalez M, Gal\u00e1n-Arriola C, Rossello X, Gonz\u00e1lez\u2010Del\u2010Hoyo M, Vilchez JP, Higuero-Verdejo MI, et al. Metoprolol blunts the time-dependent progression of infarct size. Basic Research in Cardiology. 2020; 115: 55.","DOI":"10.1007\/s00395-020-0812-4"},{"key":"ref98","doi-asserted-by":"crossref","unstructured":"Kleinbongard P. Cardioprotection by early metoprolol- attenuation of ischemic vs. reperfusion injury? Basic Research in Cardiology. 2020; 115: 54.","DOI":"10.1007\/s00395-020-0814-2"},{"key":"ref99","doi-asserted-by":"crossref","unstructured":"B\u00f8tker HE, Hausenloy D, Andreadou I, Antonucci S, Boengler K, Davidson SM, et al. Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection. Basic Research in Cardiology. 2018; 113: 39.","DOI":"10.1007\/s00395-018-0696-8"},{"key":"ref100","doi-asserted-by":"crossref","unstructured":"Kim H, Kim H, Lee K, Kim J, Kim HS, Kim J, et al. \u0391-Lipoic acid attenuates vascular calcification via reversal of mitochondrial function and restoration of Gas6\/Axl\/Akt survival pathway. Journal of Cellular and Molecular Medicine. 2012; 16: 273\u2013286.","DOI":"10.1111\/j.1582-4934.2011.01294.x"},{"key":"ref101","doi-asserted-by":"crossref","unstructured":"Sen U, Vacek TP, Hughes WM, Kumar M, Moshal KS, Tyagi N, et al. Cardioprotective role of sodium thiosulfate on chronic heart failure by modulating endogenous H2S generation. Pharmacology. 2008; 82: 201\u2013213.","DOI":"10.1159\/000156486"},{"key":"ref102","doi-asserted-by":"crossref","unstructured":"Araya CE, Fennell RS, Neiberger RE, Dharnidharka VR. Sodium thiosulfate treatment for calcific uremic arteriolopathy in children and young adults. Clinical Journal of the American Society of Nephrology. 2006; 1: 1161\u20131166.","DOI":"10.2215\/CJN.01520506"},{"key":"ref103","doi-asserted-by":"crossref","unstructured":"Marutani E, Yamada M, Ida T, Tokuda K, Ikeda K, Kai S, et al. Thiosulfate Mediates Cytoprotective Effects of Hydrogen Sulfide against Neuronal Ischemia. Journal of the American Heart Association. 2015; 4: e002125","DOI":"10.1161\/JAHA.115.002125"},{"key":"ref104","doi-asserted-by":"crossref","unstructured":"Ravindran S, Jahir Hussain S, Boovarahan SR, Kurian GA. Sodium thiosulfate post-conditioning protects rat hearts against ischemia reperfusion injury via reduction of apoptosis and oxidative stress. Chemico-Biological Interactions. 2017; 274: 24\u201334.","DOI":"10.1016\/j.cbi.2017.07.002"},{"key":"ref105","doi-asserted-by":"crossref","unstructured":"Ravindran S, Kurian GA. Effect of Sodium Thiosulfate Postconditioning on Ischemia-Reperfusion Injury Induced Mitochondrial Dysfunction in Rat Heart. Journal of Cardiovascular Translational Research. 2018; 11: 246\u2013258.","DOI":"10.1007\/s12265-018-9808-y"},{"key":"ref106","doi-asserted-by":"crossref","unstructured":"O\u2019Neill WW, Martin JL, Dixon SR, Bartorelli AL, Trabattoni D, Oemrawsingh PV, et al. Acute Myocardial Infarction with Hyperoxemic Therapy (AMIHOT): a prospective, randomized trial of intracoronary hyperoxemic reperfusion after percutaneous coronary intervention. Journal of the American College of Cardiology. 2007; 50: 397\u2013405.","DOI":"10.1016\/j.jacc.2007.01.099"},{"key":"ref107","doi-asserted-by":"crossref","unstructured":"Stone GW, Martin JL, de Boer M, Margheri M, Bramucci E, Blankenship JC, et al. Effect of supersaturated oxygen delivery on infarct size after percutaneous coronary intervention in acute myocardial infarction. Circulation: Cardiovascular Interventions. 2009; 2: 366\u2013375.","DOI":"10.1161\/CIRCINTERVENTIONS.108.840066"},{"key":"ref108","doi-asserted-by":"crossref","unstructured":"David SW, Khan ZA, Patel NC, Metzger DC, Wood FO, Wasserman HS, et al. Evaluation of intracoronary hyperoxemic oxygen therapy in acute anterior myocardial infarction: the IC\u2010HOT study. Catheterization and Cardiovascular Interventions. 2019; 93: 882\u2013890.","DOI":"10.1002\/ccd.27905"},{"key":"ref109","doi-asserted-by":"crossref","unstructured":"Chen S, David SW, Khan ZA, Metzger DC, Wasserman HS, Lotfi AS, et al. One\u2010year outcomes of supersaturated oxygen therapy in acute anterior myocardial infarction: the IC\u2010HOT study. Catheterization and Cardiovascular Interventions. 2021; 97: 1120\u20131126.","DOI":"10.1002\/ccd.29090"},{"key":"ref110","doi-asserted-by":"crossref","unstructured":"Herring MJ, Hale SL, Dai W, Oskui PM, Kloner RA. Hypothermia in the setting of experimental acute myocardial infarction: a comprehensive review. Therapeutic Hypothermia and Temperature Management. 2014; 4: 159\u2013167.","DOI":"10.1089\/ther.2014.0016"},{"key":"ref111","doi-asserted-by":"crossref","unstructured":"Villablanca PA, Rao G, Briceno DF, Lombardo M, Ramakrishna H, Bortnick A, et al. Therapeutic hypothermia in ST elevation myocardial infarction: a systematic review and meta-analysis of randomised control trials. Heart. 2016; 102: 712\u2013719.","DOI":"10.1136\/heartjnl-2015-308559"},{"key":"ref112","doi-asserted-by":"crossref","unstructured":"Testori C, Beitzke D, Mangold A, Sterz F, Loewe C, Weiser C, et al. Out-of-hospital initiation of hypothermia in ST-segment elevation myocardial infarction: a randomised trial. Heart. 2019; 105: 531\u2013537.","DOI":"10.1136\/heartjnl-2018-313705"},{"key":"ref113","doi-asserted-by":"crossref","unstructured":"Noc M, Laanmets P, Neskovic AN, Petrovi\u0107 M, Stanetic B, Aradi D, et al. A multicentre, prospective, randomised controlled trial to assess the safety and effectiveness of cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction: the COOL AMI EU Pivotal Trial. EuroIntervention. 2021; 17: 466\u2013473.","DOI":"10.4244\/EIJ-D-21-00348"},{"key":"ref114","doi-asserted-by":"crossref","unstructured":"Ferdinandy P, Hausenloy DJ, Heusch G, Baxter GF, Schulz R. Interaction of risk factors, comorbidities, and comedications with ischemia\/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote conditioning. Pharmacological Reviews. 2014; 66: 1142\u20131174.","DOI":"10.1124\/pr.113.008300"},{"key":"ref115","doi-asserted-by":"crossref","unstructured":"Schulz R, Andreadou I, Hausenloy DJ, Ferdinandy P. Risk factors, co\u2010morbidities, and co\u2010medications in cardioprotection: Importance for translation. British Journal of Pharmacology. 2020; 177: 5249\u20135251.","DOI":"10.1111\/bph.15294"},{"key":"ref116","doi-asserted-by":"crossref","unstructured":"Roubille F, Mewton N, Elbaz M, Roth O, Prunier F, Cung TT, et al. No post-conditioning in the human heart with thrombolysis in myocardial infarction flow 2-3 on admission. European Heart Journal. 2014; 35: 1675\u20131682.","DOI":"10.1093\/eurheartj\/ehu054"},{"key":"ref117","doi-asserted-by":"crossref","unstructured":"Schwartz Longacre L, Kloner RA, Arai AE, Baines CP, Bolli R, Braunwald E, et al. New Horizons in Cardioprotection. Circulation: recommendations from the 2010 National Heart, Lung, and Blood Institute Workshop. 2011; 124: 1172\u20131179.","DOI":"10.1161\/CIRCULATIONAHA.111.032698"},{"key":"ref118","doi-asserted-by":"crossref","unstructured":"Hausenloy DJ, Botker HE, Engstrom T, Erlinge D, Heusch G, Ibanez B, et al. Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations. European Heart Journal. 2017; 38: 935\u2013941.","DOI":"10.1093\/eurheartj\/ehw145"}],"container-title":["Reviews in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/23\/1\/10.31083\/j.rcm2301023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T17:27:34Z","timestamp":1732728454000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/23\/1\/10.31083\/j.rcm2301023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,17]]},"references-count":118,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"alternative-id":["S1530-6550(22)00310-6"],"URL":"https:\/\/doi.org\/10.31083\/j.rcm2301023","relation":{},"ISSN":["1530-6550","2153-8174"],"issn-type":[{"value":"1530-6550","type":"print"},{"value":"2153-8174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,17]]},"article-number":"23"}}