{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:58:11Z","timestamp":1780394291250,"version":"3.54.1"},"reference-count":47,"publisher":"IMR Press","issue":"8","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Objective: To assess the clinical effectiveness of Yangxinshi (YXS) tablets on exercise capacity and symptoms of anxiety and depression in patients with coronary heart disease (CHD). Methods and Results: A randomized, double-blind, placebo-controlled, multicenter clinical trial was performed to assess the effects of YXS tablets on exercise capacity and quality of life in patients with CHD. A total of 82 patients were included in this trial. Compared with the placebo group, the YXS group showed significant improvement in peak VO2 (0.22 L\/min vs 0.01 L\/min; difference 0.1, 95% confidence interval (CI) 0.04\u20130.16, p = 0.000), peak Mets (0.58 vs 0.09; difference 0.3, 95% CI 0.12\u20130.47, p = 0.005), anaerobic threshold (AT) VO2 (0.23 L\/min vs 0.04 L\/min; difference 0.12, 95% CI 0.07\u20130.18, p = 0.000), AT Mets (0.62 vs 0.16; difference 0.35, 95% CI 0.2\u20130.5, p = 0.001), and 6 minutes walking test (6MWT) (50.05 m vs 11.91 m; difference 29.92, 95% CI 18.78\u201341.07, p = 0.000). There were no differences in Hamilton anxiety rating scale (HAM-A score (1.97 vs 2.07; difference 2.03, 95% CI 0.99\u20133.06, p = 0.926) and Hamilton depression rating scale (HAM-D) score (1.06 vs 1.7; difference1.42, 95% CI 0.24\u20132.6, p = 0.592). Conclusions: In patients with CHD, YXS tablets, compared with placebo, could improve exercise capacity, without beneficial effects on anxiety and depression symptoms.<\/jats:p>","DOI":"10.31083\/j.rcm2308266","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T09:27:58Z","timestamp":1658482078000},"source":"Crossref","is-referenced-by-count":5,"title":["Yangxinshi Tablet Improves Exercise Capacity for Patients with Coronary Heart Disease: Results from a Randomized, Double-Blind, Placebo-Controlled, and Multicenter Trial"],"prefix":"10.31083","volume":"23","author":[{"given":"Sisi","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, 430030 Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Research Center for Translational Medicine, Tongji Hospital Affiliated with Shanghai Tongji University, 200065 Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiliang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The Jinqiu Hospital of Liaoning Province, 110067 Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine and Cardiac Rehabilitation Center, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, 130000 Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayi","family":"Hu","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, 430030 Wuhan, Hubei, China"},{"name":"Heart Center, Peking University People's Hospital, 1000044 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012; 380: 2095\u20132128.","DOI":"10.1016\/S0140-6736(12)61728-0"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Wang X, Song D, Tao T, He T, Wu X, Li X, et al. Qi-Regulating and Blood Circulation-Promoting Therapy Improves Health Status of Stable Angina Pectoris Patients with Depressive Symptoms. Evidence-Based Complementary and Alternative Medicine. 2021; 2021: 1\u201312.","DOI":"10.1155\/2021\/7319417"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Richards SH, Anderson L, Jenkinson CE, Whalley B, Rees K, Davies P, et al. Psychological interventions for coronary heart disease. Cochrane Library: Cochrane Reviews. 2017; 4: CD002902.","DOI":"10.1002\/14651858.CD002902.pub4"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Alam M, Huang HD, Shahzad SA, Kar B, Virani SS, Rogers PA, et al. Percutaneous Coronary Intervention vs. Coronary Artery Bypass Graft Surgery for Unprotected Left Main Coronary Artery Disease in the Drug-Eluting Stents Era. Circulation Journal. 2013; 77: 372\u2013382.","DOI":"10.1253\/circj.CJ-12-0747"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Sipahi I, Akay MH, Dagdelen S, Blitz A, Alhan C. Coronary Artery Bypass Grafting vs Percutaneous Coronary Intervention and Long-term Mortality and Morbidity in Multivessel Disease. JAMA Internal Medicine. 2014; 174: 223.","DOI":"10.1001\/jamainternmed.2013.12844"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Rosendorff C, Lackland DT, Allison M, Aronow WS, Black HR, Blumenthal RS, et al. Treatment of hypertension in patients with coronary artery disease: a scientific statement from the American Heart Association, American College of Cardiology, and American Society of Hypertension. Hypertension. 2015; 65: 1372\u20134407.","DOI":"10.1161\/HYP.0000000000000018"},{"key":"ref7","unstructured":"Authors\/Task Force Members, Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts): Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). European Journal of Preventive Cardiology. 2016; 23: NP1\u2013NP96."},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Balady GJ, Williams MA, Ades PA, Bittner V, Comoss P, Foody JM, et al. Core Components of Cardiac Rehabilitation\/Secondary Prevention Programs: 2007 Update. Circulation. 2007; 115: 2675\u20132682.","DOI":"10.1161\/CIRCULATIONAHA.106.180945"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Taylor RS, Brown A, Ebrahim S, Jolliffe J, Noorani H, Rees K, et al. Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials. The American Journal of Medicine. 2004; 116: 682\u2013692.","DOI":"10.1016\/j.amjmed.2004.01.009"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Vanhees L, Rauch B, Piepoli M, van Buuren F, Takken T, B\u00f6rjesson M, et al. Importance of characteristics and modalities of physical activity and exercise in the management of cardiovascular health in individuals with cardiovascular disease (Part III). European Journal of Preventive Cardiology. 2012; 19: 1333\u20131356.","DOI":"10.1177\/2047487312437063"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Mezzani A, Hamm LF, Jones AM, McBride PE, Moholdt T, Stone JA, et al. Aerobic exercise intensity assessment and prescription in cardiac rehabilitation: a joint position statement of the European Association for Cardiovascular Prevention and Rehabilitation, the American Association of Cardiovascular and Pulmonary Rehabilitation and the Canadian Association of Cardiac Rehabilitation. European Journal of Preventive Cardiology. 2013; 20: 442\u2013467.","DOI":"10.1177\/2047487312460484"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Winnige P, Vysoky R, Dosbaba F, Batalik L. Cardiac rehabilitation and its essential role in the secondary prevention of cardiovascular diseases. World Journal of Clinical Cases. 2021; 9: 1761\u20131784","DOI":"10.12998\/wjcc.v9.i8.1761"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Shepherd CW, While AE. Cardiac rehabilitation and quality of life: a systematic review. International Journal of Nursing Studies. 2012; 49: 755\u2013771.","DOI":"10.1016\/j.ijnurstu.2011.11.019"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"van Engen-Verheul M, de Vries H, Kemps H, Kraaijenhagen R, de Keizer N, Peek N. Cardiac rehabilitation uptake and its determinants in the Netherlands. European Journal of Preventive Cardiology. 2013; 20: 349\u2013356.","DOI":"10.1177\/2047487312439497"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Turk-Adawi KI, Oldridge NB, Tarima SS, Stason WB, Shepard DS. Cardiac Rehabilitation Enrollment among Referred Patients. Journal of Cardiopulmonary Rehabilitation and Prevention. 2014; 34: 114\u2013122.","DOI":"10.1097\/HCR.0000000000000017"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Wang J, Chu F, Li J, Yao K, Zhong J, Zhou K, et al. Study on syndrome element characteristics and its correlation with coronary angiography in 324 patients with coronary heart disease. Chinese Journal of Integrative Medicine. 2008; 14: 274\u2013280.","DOI":"10.1007\/s11655-008-0274-2"},{"key":"ref17","unstructured":"Zhang C, Mi ZY, Tian WJ. Clinical Observation on Therapeutic Effect of Clopidogrel Bisulfate Tablets Combined with Atorvastatin Calcium Capsules and Yangxinshi Tablets on 78 Cases of Angina Pectoris after PCI. World Chinese Medicine. 2014; 3: 1299\u20131301. (In Chinese)"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Zhang S, Liang C, Yang Y, Zhao Z, Li J, Meng X. Effects of Yangxinshi tablet on exercise tolerance in patients with coronary heart disease. Medicine. 2020; 99: e21485.","DOI":"10.1097\/MD.0000000000021485"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"American College of Sports Medicine Position Stand. The recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness, and flexibility in healthy adults. Medicine & Science in Sports & Exercise. 1998; 30: 975\u2013991.","DOI":"10.1249\/00005768-199806000-00032"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Fletcher GF, Balady GJ, Amsterdam EA, Chaitman B, Eckel R, Fleg J, et al. Exercise Standards for Testing and Training. Circulation. 2001; 104: 1694\u20131740.","DOI":"10.1161\/hc3901.095960"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Fletcher GF, Ades PA, Kligfield P, Arena R, Balady GJ, Bittner VA, et al. Exercise Standards for Testing and Training. Circulation. 2013; 128: 873\u2013934.","DOI":"10.1161\/CIR.0b013e31829b5b44"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. American Journal of Respiratory and Critical Care Medicine. 2002; 166: 111\u2013117.","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Beaver WL, Wasserman K, Whipp BJ. A new method for detecting anaerobic threshold by gas exchange. Journal of Applied Physiology. 1986; 60: 2020\u20132027.","DOI":"10.1152\/jappl.1986.60.6.2020"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Morris CK, Myers J, Froelicher VF, Kawaguchi T, Ueshima K, Hideg A. Nomogram based on metabolic equivalents and age for assessing aerobic exercise capacity in men. Journal of the American College of Cardiology. 1993; 22: 175\u2013182.","DOI":"10.1016\/0735-1097(93)90832-L"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Gulati M, Black HR, Shaw LJ, Arnsdorf MF, Merz CNB, Lauer MS, et al. The Prognostic Value of a Nomogram for Exercise Capacity in Women. New England Journal of Medicine. 2005; 353: 468\u2013475.","DOI":"10.1056\/NEJMoa044154"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Drazner MH, et al. 2013 ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines. Journal of the American College of Cardiology. 2013; 62: e147\u2013e239.","DOI":"10.1161\/CIR.0b013e31829e8776"},{"key":"ref27","unstructured":"Huan N, Wang CL, Wang PL, Yu YH. Advantage evaluation of cardiopulmonary exercise test in clinical rehabilitation of cardiovascular disease. Chinese Heart Journal. 2021; 33: 95\u2013100. (In Chinese)"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Zigmond AS, Snaith RP. The Hospital Anxiety and Depression Scale. Acta Psychiatrica Scandinavica. 1983; 67: 361\u2013370.","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Ventura-Clapier R, Garnier A, Veksler V. Energy metabolism in heart failure. The Journal of Physiology. 2004; 555: 1\u201313.","DOI":"10.1113\/jphysiol.2003.055095"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Brown DA, Perry JB, Allen ME, Sabbah HN, Stauffer BL, Shaikh SR, et al. Mitochondrial function as a therapeutic target in heart failure. Nature Reviews Cardiology. 2017; 14: 238\u2013250.","DOI":"10.1038\/nrcardio.2016.203"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Rosca MG, Hoppel CL. Mitochondrial dysfunction in heart failure. Heart Failure Reviews. 2013; 18: 607\u2013622.","DOI":"10.1007\/s10741-012-9340-0"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Wu R, Jiang B, Li H, Dang W, Bao W, Li H, et al. A network pharmacology approach to discover action mechanisms of Yangxinshi Tablet for improving energy metabolism in chronic ischemic heart failure. Journal of Ethnopharmacology. 2020; 246: 112227.","DOI":"10.1016\/j.jep.2019.112227"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Zhu J, Yi X, Zhang J, Chen S, Wu Y. Chemical profiling and antioxidant evaluation of Yangxinshi Tablet by HPLC\u2013ESI-Q-TOF-MS\/MS combined with DPPH assay. Journal of Chromatography B. 2017; 1060: 262\u2013271.","DOI":"10.1016\/j.jchromb.2017.06.022"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Han J, Li Q, Ma Z, Fan J. Effects and mechanisms of compound Chinese medicine and major ingredients on microcirculatory dysfunction and organ injury induced by ischemia\/reperfusion. Pharmacology & Therapeutics. 2017; 177: 146\u2013173.","DOI":"10.1016\/j.pharmthera.2017.03.005"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Leong PK, Wong HS, Chen J, Ko KM. Yang\/Qi Invigoration: an Herbal Therapy for Chronic Fatigue Syndrome with Yang Deficiency? Evidence-Based Complementary and Alternative Medicine. 2015; 2015: 1\u20138.","DOI":"10.1155\/2015\/945901"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Ko K-M, Leon TYY, Mak DHF, Chiu P-Y, Du Y, Poon MKT. A characteristic pharmacological action of \u2018Yang-invigorating\u2019 Chinese tonifying herbs: Enhancement of myocardial ATP-generation capacity. Phytomedicine. 2006; 13: 636\u2013642.","DOI":"10.1016\/j.phymed.2006.02.007"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"MENG Y, LI W, SHI Y, ZHOU B, MA R, LI W. Danshensu protects against ischemia\/reperfusion injury and inhibits the apoptosis of H9c2 cells by reducing the calcium overload through the p-JNK-NF-\u03baB-TRPC6 pathway. International Journal of Molecular Medicine. 2016; 37: 258\u2013266.","DOI":"10.3892\/ijmm.2015.2419"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"He K, Yan L, Pan C, Liu Y, Cui Y, Hu B, et al. ROCK-dependent ATP5D modulation contributes to the protection of notoginsenoside NR1 against ischemia-reperfusion-induced myocardial injury. American Journal of Physiology-Heart and Circulatory Physiology. 2014; 307: H1764\u2013H1776.","DOI":"10.1152\/ajpheart.00259.2014"},{"key":"ref39","unstructured":"Chen GL, Xu S, Wu ZJ, Wu Y. Protective Effect of Salvianolic Acid B on Intestinal Ischemia-reperfusion Injury in Rats. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2020; 42: 30\u201336. (In Chinese)"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Luiken JJ, Ouwens DM, Habets DD, van der Zon GC, Coumans WA, Schwenk RW, et al. Permissive action of protein kinase C-zeta in insulin-induced CD36- and GLUT4 translocation in cardiac myocytes. Journal of Endocrinology. 2009; 201: 199\u2013209.","DOI":"10.1677\/JOE-09-0046"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Wei B, You M, Ling J, Wei L, Wang K, Li W, et al. Regulation of antioxidant system, lipids and fatty acid \u03b2-oxidation contributes to the cardioprotective effect of sodium tanshinone IIA sulphonate in isoproterenol-induced myocardial infarction in rats. Atherosclerosis. 2013; 230: 148\u2013156.","DOI":"10.1016\/j.atherosclerosis.2013.07.005"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Zheng X, Wang S, Zou X, Jing Y, Yang R, Li S, et al. Ginsenoside Rb1 improves cardiac function and remodeling in heart failure. Experimental Animals. 2017; 66: 217\u2013228.","DOI":"10.1538\/expanim.16-0121"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Zhang Q, Xiao X, Feng K, Wang T, Li W, Yuan T, et al. Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism. Evidence-Based Complementary and Alternative Medicine. 2011; 2011: 1\u201310.","DOI":"10.1155\/2011\/924851"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Rasekaba T, Lee AL, Naughton MT, Williams TJ, Holland AE. The six-minute walk test: a useful metric for the cardiopulmonary patient. Internal Medicine Journal. 2009; 39: 495\u2013501.","DOI":"10.1111\/j.1445-5994.2008.01880.x"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Mikkelsen N, Cadarso-Su\u00e1rez C, Lado-Baleato O, D\u00edaz-Louzao C, Gil CP, Reeh J, et al. Improvement in VO2peak predicts readmissions for cardiovascular disease and mortality in patients undergoing cardiac rehabilitation. European Journal of Preventive Cardiology. 2020; 27: 811\u2013819.","DOI":"10.1177\/2047487319887835"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Abu-Haniyeh A, Shah NP, Wu Y, Cho L, Ahmed HM. Predictors of cardiorespiratory fitness improvement in phase II cardiac rehabilitation. Clinical Cardiology. 2018; 41: 1563\u20131569.","DOI":"10.1002\/clc.23101"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Stefanakis M, Batalik L, Antoniou V, Pepera G. Safety of home-based cardiac rehabilitation: A systematic review. Heart Lung. 2022; 55: 117\u2013126.","DOI":"10.1016\/j.hrtlng.2022.04.016"}],"container-title":["Reviews in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/23\/8\/10.31083\/j.rcm2308266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T18:00:00Z","timestamp":1732730400000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/23\/8\/10.31083\/j.rcm2308266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,21]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022]]}},"alternative-id":["S1530-6550(22)00618-4"],"URL":"https:\/\/doi.org\/10.31083\/j.rcm2308266","relation":{},"ISSN":["1530-6550","2153-8174"],"issn-type":[{"value":"1530-6550","type":"print"},{"value":"2153-8174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,21]]},"article-number":"266"}}