{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:59:18Z","timestamp":1787025558031,"version":"build-2736575974"},"reference-count":48,"publisher":"IMR Press","issue":"8","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Background: This study examined the clinical characteristics, genetic basis, healthcare utilisation and costs of catecholaminergic ventricular tachycardia (CPVT) patients from a Chinese city. Methods: This was a territory-wide retrospective cohort study of consecutive CPVT patients at public hospitals or clinics in Hong Kong. Healthcare resource utilisation for accident and emergency (A&amp;E), inpatient and outpatient attendances were analysed over 19 years (2001\u20132019) followed by calculations of annualised costs (in USD). Results: Sixteen patients with a median presentation age (interquartile range (IQR) of 11 (9\u201314) years old) were included. Fifteen patients (93.8%) were initially symptomatic. Ten patients had both premature ventricular complexes (PVCs) and ventricular tachycardia\/fibrillation (VT\/VF). One patient had PVCs without VT\/VF. Genetic tests were performed on 14 patients (87.5%). Eight (57.1%) tested positive for the ryanodine receptor 2 (RyR2) gene. Seven variants have been described elsewhere (c.14848G&gt;A, c.12475C&gt;A, c.7420A&gt;G, c.11836G&gt;A, c.14159T&gt;C, c.10046C&gt;T and c.7202G&gt;A). c.14861C&gt;G is a novel RyR2 variant not been reported outside this cohort. Patients were treated with beta-blockers (n = 16), amiodarone (n = 3) and verapamil (n = 2). Sympathectomy (n = 8) and implantable-cardioverter defibrillator implantation (n = 3) were performed. Over a median follow-up of 13.3 years (IQR: 8.4\u201318.1) years, six patients exhibited incident VT\/VF. At the patient level, the median (IQR) annualised costs for A&amp;E, inpatient and outpatient attendances were $66 (40\u201395), $10521 (5240\u201366887) and $791 (546\u20131105), respectively. Conclusions: All patients presented before the age of 19. The yield of genetic testing was 57%. The most expensive attendance type was inpatient stays, followed by outpatients and A&amp;E attendances.<\/jats:p>","DOI":"10.31083\/j.rcm2308276","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T02:12:37Z","timestamp":1659665557000},"source":"Crossref","is-referenced-by-count":6,"title":["Clinical Characteristics, Genetic Basis and Healthcare Resource Utilisation and Costs in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia: A Retrospective Cohort Study"],"prefix":"10.31083","volume":"23","author":[{"given":"Cheuk To","family":"Chung","sequence":"first","affiliation":[{"name":"Cardiac Electrophysiology Unit, Cardiovascular Analytics Group, Laboratory of Cardiovascular Physiology, 999077 Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharen","family":"Lee","sequence":"first","affiliation":[{"name":"Cardiac Electrophysiology Unit, Cardiovascular Analytics Group, Laboratory of Cardiovascular Physiology, 999077 Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandong","family":"Zhou","sequence":"first","affiliation":[{"name":"School of Data Science, City University of Hong Kong, 999077 Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar Hou In","family":"Chou","sequence":"first","affiliation":[{"name":"Cardiac Electrophysiology Unit, Cardiovascular Analytics Group, Laboratory of Cardiovascular Physiology, 999077 Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teddy Tai Loy","family":"Lee","sequence":"first","affiliation":[{"name":"Cardiac Electrophysiology Unit, Cardiovascular Analytics Group, Laboratory of Cardiovascular Physiology, 999077 Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith Sai Kit","family":"Leung","sequence":"first","affiliation":[{"name":"Cardiac Electrophysiology Unit, Cardiovascular Analytics Group, Laboratory of Cardiovascular Physiology, 999077 Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamalan","family":"Jeevaratnam","sequence":"first","affiliation":[{"name":"Faculty of Health and Medical Sciences, University of Surrey, GU2 7XH Guildford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing Tak","family":"Wong","sequence":"first","affiliation":[{"name":"State Key Laboratory of Agrobiotechnology (CUHK), School of Life Sciences, Chinese University of Hong Kong, 999077 Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Liu","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, 300211 Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Tse","sequence":"first","affiliation":[{"name":"Cardiac Electrophysiology Unit, Cardiovascular Analytics Group, Laboratory of Cardiovascular Physiology, 999077 Hong Kong, China"},{"name":"Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, 300211 Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Rucinski C, Winbo A, Marcondes L, Earle N, Stiles M, Stiles R, et al. 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Conduction slowing contributes to spontaneous ventricular arrhythmias in intrinsically active murine RyR2-P2328S hearts. Journal of Cardiovascular Electrophysiology. 2013; 24: 210\u2013218.","DOI":"10.1111\/jce.12015"}],"container-title":["Reviews in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/23\/8\/10.31083\/j.rcm2308276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T12:52:23Z","timestamp":1732711943000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/23\/8\/10.31083\/j.rcm2308276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,5]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022]]}},"alternative-id":["S1530-6550(22)00588-9"],"URL":"https:\/\/doi.org\/10.31083\/j.rcm2308276","relation":{},"ISSN":["1530-6550","2153-8174"],"issn-type":[{"value":"1530-6550","type":"print"},{"value":"2153-8174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,5]]},"article-number":"276"}}