{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T13:42:39Z","timestamp":1783518159299,"version":"3.55.0"},"reference-count":15,"publisher":"IMR Press","issue":"3","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Background: This study sought to evaluate the incidence of acute kidney injury (AKI) defined by the Kidney Disease: Improving Global Outcomes (KDIGO) group in patients supported by veno-arterial extracorporeal membrane oxygenation (VA ECMO) after post-cardiotomy cardiogenic shock (PCS), and to identify the risk factors for AKI \u22653. Methods: Patients with and without AKI \u22653 were divided into two groups. Potential risk factors for developing AKI \u22653 were evaluated by univariate logistic regression analysis. Patient risk factors (p &lt; 0.1) in the univariate analysis were entered into the multivariable logistic regression model. The tolerance and variance inflation factors (VIF) were calculated to evaluate the collinearity of the potential variables. Results: 136 patients with a mean age of 53.6 \u00b1 13.9 years (66.9% male) were enrolled in the study. 80 patients (58.8%) developed AKI \u22653. Patients with AKI \u22653 required significantly longer mechanical ventilation (200.9 [128.0, 534.8] hours vs. 78.9 [13.0, 233.0] hours, p &lt; 0.001). The ICU stay and hospital stay of patients with AKI \u22653 were much longer than patients with AKI &lt;3 (384 [182, 648] hours vs. 216 [48, 456] hours, p = 0.001; 25.0 [15.3, 46.6] days vs. 13.4 [7.4, 38.4] days, p = 0.022, respectively). There was no difference in preoperative risk factors between the two groups. Age, cross-clamp time, cardiopulmonary bypass (CPB) time, the timing of ECMO implantation, mean artery pressure (MAP), lactate concentration before ECMO, and preoperative ejection fraction (EF) were entered into the multivariable analysis. The timing of ECMO implantation was an independent risk factor for AKI \u22653 (p = 0.036). Intraoperatively implantation of ECMO may decrease the incidence of AKI \u22653 (odds ratio (OR) = 0.298, 95% confidence interval (CI) = 0.096\u20130.925). The tolerance and variance inflation factors showed that there was no collinearity among these variables. Conclusions: The incidence of AKI \u22653 in patients supported by VA ECMO after PCS was 58.8% in our center. Patients with AKI \u22653 required significantly longer mechanical ventilation and hospital stay. Intraoperative implantation VA ECMO was associated with a decreased incidence of AKI \u22653.<\/jats:p>","DOI":"10.31083\/j.rcm2403091","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T08:01:52Z","timestamp":1679299312000},"source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of Acute Kidney Injury in Postcardiotomy Cardiogenic Shock Patients Supported by Extracorporeal Membrane Oxygenation"],"prefix":"10.31083","volume":"24","author":[{"given":"Jiachen","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Cardiopulmonary Bypass, Fuwai Hospital, National Center for Cardiovascular Disease, State Key Laboratory of Cardiovascular Medicine, Chinese Academy of Medical Science & Peking Union Medical College, 100037 Beijing, China"},{"name":"Department of Pain Medicine, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, 102218 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Cardiopulmonary Bypass, Fuwai Hospital, National Center for Cardiovascular Disease, State Key Laboratory of Cardiovascular Medicine, Chinese Academy of Medical Science & Peking Union Medical College, 100037 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiopulmonary Bypass, Fuwai Hospital, National Center for Cardiovascular Disease, State Key Laboratory of Cardiovascular Medicine, Chinese Academy of Medical Science & Peking Union Medical College, 100037 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Teng","sequence":"first","affiliation":[{"name":"Department of Cardiopulmonary Bypass, Fuwai Hospital, National Center for Cardiovascular Disease, State Key Laboratory of Cardiovascular Medicine, Chinese Academy of Medical Science & Peking Union Medical College, 100037 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sizhe","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Cardiopulmonary Bypass, Fuwai Hospital, National Center for Cardiovascular Disease, State Key Laboratory of Cardiovascular Medicine, Chinese Academy of Medical Science & Peking Union Medical College, 100037 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujie","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Cardiopulmonary Bypass, Fuwai Hospital, National Center for Cardiovascular Disease, State Key Laboratory of Cardiovascular Medicine, Chinese Academy of Medical Science & Peking Union Medical College, 100037 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiopulmonary Bypass, Fuwai Hospital, National Center for Cardiovascular Disease, State Key Laboratory of Cardiovascular Medicine, Chinese Academy of Medical Science & Peking Union Medical College, 100037 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyi","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Cardiopulmonary Bypass, Fuwai Hospital, National Center for Cardiovascular Disease, State Key Laboratory of Cardiovascular Medicine, Chinese Academy of Medical Science & Peking Union Medical College, 100037 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyang","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Cardiopulmonary Bypass, Fuwai Hospital, National Center for Cardiovascular Disease, State Key Laboratory of Cardiovascular Medicine, Chinese Academy of Medical Science & Peking Union Medical College, 100037 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Patel B, Diaz-Gomez JL, Ghanta RK, Bracey AW, Chatterjee S. Management of Extracorporeal Membrane Oxygenation for Postcardiotomy Cardiogenic Shock. Anesthesiology. 2021; 135: 497\u2013507.","DOI":"10.1097\/ALN.0000000000003876"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Kowalewski M, Zieli\u0144ski K, Brodie D, MacLaren G, Whitman G, Raffa GM, et al. Venoarterial Extracorporeal Membrane Oxygenation for Postcardiotomy Shock-Analysis of the Extracorporeal Life Support Organization Registry. Critical Care Medicine. 2021; 49: 1107\u20131117.","DOI":"10.1097\/CCM.0000000000004922"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Cheng R, Hachamovitch R, Kittleson M, Patel J, Arabia F, Moriguchi J, et al. Complications of extracorporeal membrane oxygenation for treatment of cardiogenic shock and cardiac arrest: a meta-analysis of 1,866 adult patients. The Annals of Thoracic Surgery. 2014; 97: 610\u2013616.","DOI":"10.1016\/j.athoracsur.2013.09.008"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Melehy A, Ning Y, Kurlansky P, Kaku Y, Fried J, Hastie J, et al. Bleeding and Thrombotic Events During Extracorporeal Membrane Oxygenation for Postcardiotomy Shock. The Annals of Thoracic Surgery. 2022; 113: 131\u2013137.","DOI":"10.1016\/j.athoracsur.2021.02.008"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Rastan AJ, Dege A, Mohr M, Doll N, Falk V, Walther T, et al. Early and late outcomes of 517 consecutive adult patients treated with extracorporeal membrane oxygenation for refractory postcardiotomy cardiogenic shock. The Journal of Thoracic and Cardiovascular Surgery. 2010; 139: 302\u2013311, 311.e1.","DOI":"10.1016\/j.jtcvs.2009.10.043"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Ding X, Xie H, Yang F, Wang L, Hou X. Risk factors of acute renal injury and in-hospital mortality in adult patients with postcardiotomy cardiogenic shock requiring veno-arterial extracorporeal membrane oxygenation: utility of MELD-XI score. Perfusion. 2022; 37: 505\u2013514.","DOI":"10.1177\/02676591211006619"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Lep\u00e8re V, Duceau B, Lebreton G, Bombled C, Dujardin O, Boccara L, et al. Risk Factors for Developing Severe Acute Kidney Injury in Adult Patients With Refractory Postcardiotomy Cardiogenic Shock Receiving Venoarterial Extracorporeal Membrane Oxygenation. Critical Care Medicine. 2020; 48: e715\u2013e721.","DOI":"10.1097\/CCM.0000000000004433"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Fux T, Holm M, Corbascio M, Lund LH, van der Linden J. Venoarterial extracorporeal membrane oxygenation for postcardiotomy shock: Risk factors for mortality. The Journal of Thoracic and Cardiovascular Surgery. 2018; 156: 1894\u20131902.e3.","DOI":"10.1016\/j.jtcvs.2018.05.061"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Mou Z, Guan T, Chen L. Risk Factors of Acute Kidney Injury in ECMO Patients: A Systematic Review and Meta-Analysis. Journal of Intensive Care Medicine. 2022; 37: 267\u2013277.","DOI":"10.1177\/08850666211003485"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Kilburn DJ, Shekar K, Fraser JF. The Complex Relationship of Extracorporeal Membrane Oxygenation and Acute Kidney Injury: Causation or Association? BioMed Research International. 2016; 2016: 1094296.","DOI":"10.1155\/2016\/1094296"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Chen F, Wang L, Shao J, Wang H, Hou X, Jia M. Survival following venoarterial extracorporeal membrane oxygenation in postcardiotomy cardiogenic shock adults. Perfusion. 2020; 35: 747\u2013755.","DOI":"10.1177\/0267659120931306"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Rustenbach CJ, Djordjevic I, David L, Ivanov B, Gerfer S, Gaisendrees C, et al. Risk factors associated with in-hospital mortality for patients with ECLS due to postcardiotomy cardiogenic shock after isolated coronary surgery. Artificial Organs. 2022; 46: 1158\u20131164.","DOI":"10.1111\/aor.14166"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Lee SW, Yu M, Lee H, Ahn SY, Kim S, Chin HJ, et al. Risk Factors for Acute Kidney Injury and In-Hospital Mortality in Patients Receiving Extracorporeal Membrane Oxygenation. PLoS ONE. 2015; 10: e0140674.","DOI":"10.1371\/journal.pone.0140674"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Pilarczyk K, Huenges K, Bewig B, Balke L, Cremer J, Haneya A, et al. Acute Kidney Injury in Patients with Severe ARDS Requiring Extracorporeal Membrane Oxygenation: Incidence, Prognostic Impact and Risk Factors. Journal of Clinical Medicine. 2022; 11: 1079.","DOI":"10.3390\/jcm11041079"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Ronco C, Bellomo R, Kellum JA. Acute kidney injury. Lancet (London, England). 2019; 394: 1949\u20131964.","DOI":"10.1016\/S0140-6736(19)32563-2"}],"container-title":["Reviews in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/24\/3\/10.31083\/j.rcm2403091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T18:27:37Z","timestamp":1732732057000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/24\/3\/10.31083\/j.rcm2403091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,16]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"alternative-id":["S1530-6550(22)00815-8"],"URL":"https:\/\/doi.org\/10.31083\/j.rcm2403091","relation":{},"ISSN":["1530-6550","2153-8174"],"issn-type":[{"value":"1530-6550","type":"print"},{"value":"2153-8174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,16]]},"article-number":"91"}}