{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:03:25Z","timestamp":1784232205303,"version":"3.55.0"},"reference-count":11,"publisher":"IMR Press","issue":"6","license":[{"start":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T00:00:00Z","timestamp":1687651200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sharpe - Strumia Research Foundation","award":["SSRF2022-10"],"award-info":[{"award-number":["SSRF2022-10"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Background: To investigate the impact of Cryo Nerve Block with cryoICE\u2122 device utilization, on post-operative pain in patients undergoing isolated coronary artery bypass grafting (CABG) through left thoracotomy. Methods: All consecutive patients undergoing isolated CABG through left thoracotomy between July 2021 and July 2022 from a single surgeon were included in the study. Patients using the cryoICE\u2122 device for nerve block were compared for baseline demographics and pre-operative characteristics with those that did not use the cryoICE\u2122 device. A propensity-adjusted analysis was used to compare the two groups. The primary outcome was degree of incisional pain and numbness. Results: A total of 103 patients underwent isolated CABG through left thoracotomy. After matching, the cryoICE\u2122 device was used for nerve block in 60 patients while the control group included 43 patients. Mean follow-up was 5.7 months. The cryoICE\u2122 device group had a mean value of incisional pain at hospital discharge was 1.5 (scale 0\u201310) while at follow-up was 0.69 (scale 0\u201310). Mean values of skin numbness at hospital discharge were 1 (scale 0\u201310) and 0.57 (scale 0\u201310) at follow-up. After univariate analysis comparison of cryoICE\u2122 device group (60 patients) versus non-cryoICE\u2122 device group (43 patients), the total in-hospital morphine use was 49% lower in the cryoICE\u2122 versus the non-cryoICE\u2122 cohort (73.8 + 79.37 mg vs 144.1 + 118.99 mg). Conclusions: Good clinical outcomes were observed in patients undergoing isolated left thoracotomy CABG with cryoICE\u2122 utilization, including a very low incidence of post-operative pain, numbness, and hypersensitivity for all comers.<\/jats:p>","DOI":"10.31083\/j.rcm2406182","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:44:56Z","timestamp":1687913096000},"source":"Crossref","is-referenced-by-count":5,"title":["Clinical Outcomes of Cryo Nerve Ablation Technique for Pain Management: An Exploratory Study in Patients Undergoing Left Thoracotomy Coronary Artery Bypass Grafting"],"prefix":"10.31083","volume":"24","author":[{"given":"Aleksander","family":"Dokollari","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 3450, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Sicouri","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 3450, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozgun","family":"Erten","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 3450, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basel","family":"Ramlawi","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 3450, USA"},{"name":"Department of Cardiac Surgery, Lankenau Heart Institute, Lankenau Medical Center, Main Line Health, Wynnewood, PA 3450, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Cameli","sequence":"first","affiliation":[{"name":"Department of Cardiology, Le Scotte Hospital, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia Elena","family":"Mandoli","sequence":"first","affiliation":[{"name":"Department of Cardiology, Le Scotte Hospital, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Bacchi","sequence":"first","affiliation":[{"name":"F.U. of Cardiac Surgery, Department of Experimental and Clinical Medicine - University of Florence, 50134 Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cabrucci","sequence":"first","affiliation":[{"name":"F.U. of Cardiac Surgery, Department of Experimental and Clinical Medicine - University of Florence, 50134 Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis P.","family":"Sutter","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Lankenau Heart Institute, Lankenau Medical Center, Main Line Health, Wynnewood, PA 3450, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Kjelstrom","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Population Health, Lankenau Institute for Medical Research, Wynnewood, PA 3450, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Montone","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Population Health, Lankenau Institute for Medical Research, Wynnewood, PA 3450, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"Sicouri","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Lankenau Heart Institute, Lankenau Medical Center, Main Line Health, Wynnewood, PA 3450, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Hosseinian","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Lankenau Heart Institute, Lankenau Medical Center, Main Line Health, Wynnewood, PA 3450, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Bonacchi","sequence":"first","affiliation":[{"name":"F.U. of Cardiac Surgery, Department of Experimental and Clinical Medicine - University of Florence, 50134 Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Torregrossa","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 3450, USA"},{"name":"Department of Cardiac Surgery, Lankenau Heart Institute, Lankenau Medical Center, Main Line Health, Wynnewood, PA 3450, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2023,6,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Brown CR, Chen Z, Khurshan F, Groeneveld PW, Desai ND. 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