{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:12:22Z","timestamp":1791043942605,"version":"4.1.0"},"reference-count":91,"publisher":"IMR Press","issue":"4","license":[{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Investissement d\u2019avenir","award":["IHU LIRYC ANR-10-IAHU-04"],"award-info":[{"award-number":["IHU LIRYC ANR-10-IAHU-04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>The Ligament of Marshall (LOM) is a remnant of the embryonic sinus venosus and the left cardinal vein, containing a combination of fat, fibrous tissue, blood vessels, muscle bundles, nerve fibers, and ganglia. Various muscular connections exist between the LOM and the left atrium (LA) and the coronary sinus (CS). The LOM is richly innervated by autonomic nerves, with ganglion cells distributed around it. The unique characteristics of the LOM are responsible for generating focal electrical activities and enable it to serve as a substrate for micro- and macro-reentrant circuits. This, in turn, leads to the initiation and perpetuation of atrial fibrillation (AF) and atrial tachycardia (AT). Endocardial ablation in this region does not consistently succeed due to anatomical constraints within the left lateral LA, including the presence of a thicker and longer mitral isthmus (MI), anatomical variations between the MI and epicardial structures such as the CS and vein of Marshall (VOM) and circumflex artery, and the presence of fibrofatty tissue insulating the LOM. Furthermore, epicardial ablation is challenging for inexperienced institutions because of its invasive nature. Ethanol infusion into the VOM (EI-VOM) represents an effective and safe approach that can be employed in conjunction with radiofrequency ablation to eliminate this arrhythmogenic structure.<\/jats:p>","DOI":"10.31083\/j.rcm2504112","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T09:03:37Z","timestamp":1712135017000},"source":"Crossref","is-referenced-by-count":13,"title":["Mechanisms of Vein of Marshall-Related Tachyarrhythmias and the Impact of Ethanol Infusion"],"prefix":"10.31083","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8473-7514","authenticated-orcid":true,"given":"Masateru","family":"Takigawa","sequence":"first","affiliation":[{"name":"Department of Cardiac Pacing and Electrophysiology, Bordeaux University Hospital (CHU), 33000 Bordeaux, France"},{"name":"IHU Liryc, Electrophysiology and Heart Modelling Institute, Univ. Bordeaux, 33000 Bordeaux, France"},{"name":"Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan"},{"name":"Department of Advanced Arrhythmia Research, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Martin","sequence":"first","affiliation":[{"name":"Department of Cardiac Pacing and Electrophysiology, Bordeaux University Hospital (CHU), 33000 Bordeaux, France"},{"name":"Department of Cardiology, Royal Papworth Hospital, Papworth Road, CB2 0AY Cambridge, UK"},{"name":"Department of Medicine, Cambridge University, CB2 1TN Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Ja\u00efs","sequence":"first","affiliation":[{"name":"Department of Cardiac Pacing and Electrophysiology, Bordeaux University Hospital (CHU), 33000 Bordeaux, France"},{"name":"IHU Liryc, Electrophysiology and Heart Modelling Institute, Univ. Bordeaux, 33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2024,3,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Marshall J. On the development of the great anterior veins in man and mammalia; including an account of certain remnants of f\u0153tal structure found in the adult, a comparative view of these great veins the different mammalia, and an analysis of their occasional peculia. Philosophical Transactions of the Royal Society of London. 1850; 140: 133\u2013170.","DOI":"10.1098\/rstl.1850.0007"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Scherlag BJ, Yeh BK, Robinson MJ. Inferior interatrial pathway in the dog. Circulation Research. 1972; 31: 18\u201335.","DOI":"10.1161\/01.RES.31.1.18"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Kim DT, Lai AC, Hwang C, Fan LT, Karagueuzian HS, Chen PS, et al. The ligament of Marshall: a structural analysis in human hearts with implications for atrial arrhythmias. Journal of the American College of Cardiology. 2000; 36: 1324\u20131327.","DOI":"10.1016\/S0735-1097(00)00819-6"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Hwang C, Wu TJ, Doshi RN, Peter CT, Chen PS. Vein of marshall cannulation for the analysis of electrical activity in patients with focal atrial fibrillation. Circulation. 2000; 101: 1503\u20131505.","DOI":"10.1161\/01.CIR.101.13.1503"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Katritsis D, Ioannidis JP, Anagnostopoulos CE, Sarris GE, Giazitzoglou E, Korovesis S, et al. Identification and catheter ablation of extracardiac and intracardiac components of ligament of Marshall tissue for treatment of paroxysmal atrial fibrillation. Journal of Cardiovascular Electrophysiology. 2001; 12: 750\u2013758.","DOI":"10.1046\/j.1540-8167.2001.00750.x"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Kurotobi T, Ito H, Inoue K, Iwakura K, Kawano S, Okamura A, et al. Marshall vein as arrhythmogenic source in patients with atrial fibrillation: correlation between its anatomy and electrophysiological findings. Journal of Cardiovascular Electrophysiology. 2006; 17: 1062\u20131067.","DOI":"10.1111\/j.1540-8167.2006.00542.x"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Hwang C, Fishbein MC, Chen PS. How and when to ablate the ligament of Marshall. Heart Rhythm. 2006; 3: 1505\u20131507.","DOI":"10.1016\/j.hrthm.2006.09.014"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Tan AY, Chou CC, Zhou S, Nihei M, Hwang C, Peter CT, et al. Electrical connections between left superior pulmonary vein, left atrium, and ligament of Marshall: implications for mechanisms of atrial fibrillation. 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Heart Rhythm. 2019; 16: 1341\u20131347.","DOI":"10.1016\/j.hrthm.2019.05.019"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Hayashi T, Fukamizu S, Mitsuhashi T, Kitamura T, Aoyama Y, Hojo R, et al. Peri-Mitral Atrial Tachycardia Using the Marshall Bundle Epicardial Connections. JACC. Clinical Electrophysiology. 2016; 2: 27\u201335.","DOI":"10.1016\/j.jacep.2015.08.011"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Takigawa M, Derval N, Martin CA, Vlachos K, Denis A, Nakatani Y, et al. Mechanism of Recurrence of Atrial Tachycardia: Comparison Between First Versus Redo Procedures in a High-Resolution Mapping System. Circulation. Arrhythmia and Electrophysiology. 2020; 13: e007273.","DOI":"10.1161\/CIRCEP.119.007273"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Makino M, Inoue S, Matsuyama TA, Ogawa G, Sakai T, Kobayashi YI, et al. Diverse myocardial extension and autonomic innervation on ligament of Marshall in humans. 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Radiographics: a Review Publication of the Radiological Society of North America, Inc. 2012; 32: E1\u2013E32.","DOI":"10.1148\/rg.321115014"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Liu H, Lim KT, Murray C, Weerasooriya R. Electrogram-guided isolation of the left superior vena cava for treatment of atrial fibrillation. Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 2007; 9: 775\u2013780.","DOI":"10.1093\/europace\/eum118"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Hsu LF, Ja\u00efs P, Keane D, Wharton JM, Deisenhofer I, Hocini M, et al. Atrial fibrillation originating from persistent left superior vena cava. 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Journal of Cardiovascular Electrophysiology. 2006; 17: 839\u2013846.","DOI":"10.1111\/j.1540-8167.2006.00516.x"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Fujisawa T, Kimura T, Nakajima K, Nishiyama T, Katsumata Y, Aizawa Y, et al. Importance of the vein of Marshall involvement in mitral isthmus ablation. Pacing and Clinical Electrophysiology: PACE. 2019; 42: 617\u2013624.","DOI":"10.1111\/pace.13640"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Barkagan M, Shapira-Daniels A, Leshem E, Shen C, Anter E. Pseudoblock of the Posterior Mitral Line With Epicardial Bridging Connections Is a Frequent Cause of Complex Perimitral Tachycardias. Circulation. Arrhythmia and Electrophysiology. 2019; 12: e006933.","DOI":"10.1161\/CIRCEP.118.006933"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Martinez BK, Baker WL, Konopka A, Giannelli D, Coleman CI, Kluger J, et al. Systematic review and meta-analysis of catheter ablation of ventricular tachycardia in ischemic heart disease. Heart Rhythm. 2020; 17: e206\u2013e219.","DOI":"10.1016\/j.hrthm.2019.04.024"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Takigawa M, Denis A, Vlachos K, Martin CA, Jais P, Derval N. Two consecutive ATs demonstrating a centrifugal pattern; What is the mechanism? Journal of Cardiovascular Electrophysiology. 2019; 30: 978\u2013980.","DOI":"10.1111\/jce.13883"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Takigawa M, Goya M, Yamaguchi J, Shirai Y, Martin CA, Sasano T. Perimitral flutter with a long epicardial bypass tract successfully treated by selective ethanol infusion to a branch of the vein of Marshall. Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 2020; 22: 1787.","DOI":"10.1093\/europace\/euaa119"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Takigawa M, Takagi T, Martin CA, Derval N, Denis A, Vlachos K, et al. Differentiating atrial tachycardias with centrifugal activation: Lessons from high-resolution mapping. Heart Rhythm. 2021; 18: 1122\u20131131.","DOI":"10.1016\/j.hrthm.2021.03.038"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Nakatani Y, Nakashima T, Duchateau J, Vlachos K, Krisai P, Takagi T, et al. Characteristics of macroreentrant atrial tachycardias using an anatomical bypass: Pseudo-focal atrial tachycardia case series. Journal of Cardiovascular Electrophysiology. 2021; 32: 2451\u20132461.","DOI":"10.1111\/jce.15186"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Sosa E, Scanavacca M, d\u2019Avila A, Pilleggi F. A new technique to perform epicardial mapping in the electrophysiology laboratory. Journal of Cardiovascular Electrophysiology. 1996; 7: 531\u2013536.","DOI":"10.1111\/j.1540-8167.1996.tb00559.x"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Berruezo A, Bisbal F, Fern\u00e1ndez-Armenta J, Calvo N, Cabrera J\u00c1, Sanchez-Quintana D, et al. Transthoracic epicardial ablation of mitral isthmus for treatment of recurrent perimitral flutter. Heart Rhythm. 2014; 11: 26\u201333.","DOI":"10.1016\/j.hrthm.2013.10.030"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Matsuo S, Wright M, Knecht S, Nault I, Lellouche N, Lim KT, et al. Peri-mitral atrial flutter in patients with atrial fibrillation ablation. Heart Rhythm. 2010; 7: 2\u20138.","DOI":"10.1016\/j.hrthm.2009.09.067"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Ja\u00efs P, Hocini M, Hsu LF, Sanders P, Scavee C, Weerasooriya R, et al. Technique and results of linear ablation at the mitral isthmus. Circulation. 2004; 110: 2996\u20133002.","DOI":"10.1161\/01.CIR.0000146917.75041.58"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Knecht S, Hocini M, Wright M, Lellouche N, O\u2019Neill MD, Matsuo S, et al. Left atrial linear lesions are required for successful treatment of persistent atrial fibrillation. European Heart Journal. 2008; 29: 2359\u20132366.","DOI":"10.1093\/eurheartj\/ehn302"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Takatsuki S, Extramiana F, Hayashi M, Haggui A, Messali A, Milliez P, et al. High take-off left inferior pulmonary vein as an obstacle in creating a conduction block at the lateral mitral isthmus. Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 2009; 11: 910\u2013916.","DOI":"10.1093\/europace\/eup151"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Fassini G, Riva S, Chiodelli R, Trevisi N, Berti M, Carbucicchio C, et al. Left mitral isthmus ablation associated with PV Isolation: long-term results of a prospective randomized study. Journal of Cardiovascular Electrophysiology. 2005; 16: 1150\u20131156.","DOI":"10.1111\/j.1540-8167.2005.50192.x"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Pak HN, Oh YS, Lim HE, Kim YH, Hwang C. Comparison of voltage map-guided left atrial anterior wall ablation versus left lateral mitral isthmus ablation in patients with persistent atrial fibrillation. Heart Rhythm. 2011; 8: 199\u2013206.","DOI":"10.1016\/j.hrthm.2010.10.015"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Latcu DG, Squara F, Massaad Y, Bun SS, Saoudi N, Marchlinski FE. Electroanatomic characteristics of the mitral isthmus associated with successful mitral isthmus ablation. Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 2016; 18: 274\u2013280.","DOI":"10.1093\/europace\/euv097"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Yokokawa M, Sundaram B, Garg A, Stojanovska J, Oral H, Morady F, et al. Impact of mitral isthmus anatomy on the likelihood of achieving linear block in patients undergoing catheter ablation of persistent atrial fibrillation. Heart Rhythm. 2011; 8: 1404\u20131410.","DOI":"10.1016\/j.hrthm.2011.04.030"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Holda MK, Koziej M, Holda J, Tyrak K, Piatek K, Krawczyk-Oz\u00f3g A, et al. Spatial relationship of blood vessels within the mitral isthmus line. Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 2018; 20: 706\u2013711.","DOI":"10.1093\/europace\/euw423"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Ho SY. Normal and Abnormal Atrial Anatomy Relevant to Atrial Flutters: Areas of Physiological and Acquired Conduction Blocks and Delays Predisposing to Re-entry. Cardiac Electrophysiology Clinics. 2022; 14: 375\u2013384.","DOI":"10.1016\/j.ccep.2022.03.001"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Becker AE. Left atrial isthmus: anatomic aspects relevant for linear catheter ablation procedures in humans. Journal of Cardiovascular Electrophysiology. 2004; 15: 809\u2013812.","DOI":"10.1046\/j.1540-8167.2004.03651.x"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Piorkowski C, Kronborg M, Hourdain J, Piorkowski J, Kirstein B, Neudeck S, et al. Endo-\/Epicardial Catheter Ablation of Atrial Fibrillation: Feasibility, Outcome, and Insights Into Arrhythmia Mechanisms. Circulation. Arrhythmia and Electrophysiology. 2018; 11: e005748.","DOI":"10.1161\/CIRCEP.117.005748"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Sakamoto Y, Lockwood D, Yamaguchi R, Yoshimoto D, Suzuki T, Ho SY, et al. Systematic Evaluation of High-Resolution Activation Mapping to Identify Residual Endocardial and Epicardial Conduction Across the Mitral Isthmus. JACC. Clinical Electrophysiology. 2021; 7: 292\u2013304.","DOI":"10.1016\/j.jacep.2020.09.025"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Cho Y, Lee W, Park EA, Oh IY, Choi EK, Seo JW, et al. The anatomical characteristics of three different endocardial lines in the left atrium: evaluation by computed tomography prior to mitral isthmus block attempt. Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 2012; 14: 1104\u20131111.","DOI":"10.1093\/europace\/eus051"},{"key":"ref58","doi-asserted-by":"crossref","unstructured":"Dang S, Wang RX, Jons C, Jacobsen PK, Pehrson S, Chen X. Comparison of the Anterior Septal Line and Mitral Isthmus Line for Perimitral Atrial Flutter Ablation Using Robotic Magnetic Navigation. Journal of Interventional Cardiology. 2022; 2022: 1793590.","DOI":"10.1155\/2022\/1793590"},{"key":"ref59","doi-asserted-by":"crossref","unstructured":"Tzeis S, Luik A, Jilek C, Schmitt C, Estner HL, Wu J, et al. The modified anterior line: an alternative linear lesion in perimitral flutter. Journal of Cardiovascular Electrophysiology. 2010; 21: 665\u2013670.","DOI":"10.1111\/j.1540-8167.2009.01681.x"},{"key":"ref60","doi-asserted-by":"crossref","unstructured":"Ammar S, Luik A, Hessling G, Bruhm A, Reents T, Semmler V, et al. Ablation of perimitral flutter: acute and long-term success of the modified anterior line. 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Heart Rhythm. 2022; 19: 1255\u20131262.","DOI":"10.1016\/j.hrthm.2022.03.1228"},{"key":"ref72","doi-asserted-by":"crossref","unstructured":"Laredo M, Ferchaud V, Thomas O, Moubarak G, Cauchemez B, Zhao A. Durability of Left Atrial Lesions After Ethanol Infusion in the Vein of Marshall. JACC. Clinical Electrophysiology. 2022; 8: 41\u201348.","DOI":"10.1016\/j.jacep.2021.06.019"},{"key":"ref73","doi-asserted-by":"crossref","unstructured":"He Z, Yang L, Bai M, Yao Y, Zhang Z. Feasibility, efficacy, and safety of ethanol infusion into the vein of Marshall for atrial fibrillation: A meta-analysis. Pacing and Clinical Electrophysiology: PACE. 2021; 44: 1151\u20131162.","DOI":"10.1111\/pace.14263"},{"key":"ref74","doi-asserted-by":"crossref","unstructured":"Valderr\u00e1bano M, Liu X, Sasaridis C, Sidhu J, Little S, Khoury DS. Ethanol infusion in the vein of Marshall: Adjunctive effects during ablation of atrial fibrillation. 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Effectiveness of ethanol infusion into the vein of Marshall combined with a fixed anatomical ablation strategy (the \u201cupgraded 2C3L\u201d approach) for catheter ablation of persistent atrial fibrillation. Journal of Cardiovascular Electrophysiology. 2021; 32: 1849\u20131856.","DOI":"10.1111\/jce.15108"},{"key":"ref78","doi-asserted-by":"crossref","unstructured":"Liu XX, Liu Q, Lai YW, Guo Q, Bai R, Long DY, et al. Prospective randomized comparison between upgraded \u20182C3L\u2019 vs. PVI approach for catheter ablation of persistent atrial fibrillation: PROMPT-AF trial design. American Heart Journal. 2023; 260: 34\u201343.","DOI":"10.1016\/j.ahj.2023.01.019"},{"key":"ref79","doi-asserted-by":"crossref","unstructured":"Lador A, Valderrabano M. B-Po05-066 Vein of Marshall Alcohol in Repeat Ablation of Persistent Atrial Fibrillation (Mars-Af). Heart Rhythm. 2021; 18: S398.","DOI":"10.1016\/j.hrthm.2021.06.986"},{"key":"ref80","doi-asserted-by":"crossref","unstructured":"Valderr\u00e1bano M. Vein of Marshall ethanol infusion in the treatment of atrial fibrillation: From concept to clinical practice. Heart Rhythm. 2021; 18: 1074\u20131082.","DOI":"10.1016\/j.hrthm.2021.03.032"},{"key":"ref81","doi-asserted-by":"crossref","unstructured":"Kitamura T, Vlachos K, Denis A, Andre C, Martin R, Pambrun T, et al. Ethanol infusion for Marshall bundle epicardial connections in Marshall bundle-related atrial tachycardias following atrial fibrillation ablation: The accessibility and success rate of ethanol infusion by using a femoral approach. Journal of Cardiovascular Electrophysiology. 2019; 30: 1443\u20131451.","DOI":"10.1111\/jce.14019"},{"key":"ref82","doi-asserted-by":"crossref","unstructured":"Ishimura M, Yamamoto M, Himi T, Kobayashi Y. Durability of mitral isthmus ablation with and without ethanol infusion in the vein of Marshall. Journal of Cardiovascular Electrophysiology. 2021; 32: 2116\u20132126.","DOI":"10.1111\/jce.15107"},{"key":"ref83","doi-asserted-by":"crossref","unstructured":"Kamakura T, Derval N, Duchateau J, Denis A, Nakashima T, Takagi T, et al. Vein of Marshall Ethanol Infusion: Feasibility, Pitfalls, and Complications in Over 700 Patients. Circulation. Arrhythmia and Electrophysiology. 2021; 14: e010001.","DOI":"10.1161\/CIRCEP.121.010001"},{"key":"ref84","doi-asserted-by":"crossref","unstructured":"Valderr\u00e1bano M, Chen HR, Sidhu J, Rao L, Ling Y, Khoury DS. Retrograde ethanol infusion in the vein of Marshall: regional left atrial ablation, vagal denervation and feasibility in humans. Circulation. Arrhythmia and Electrophysiology. 2009; 2: 50\u201356.","DOI":"10.1161\/CIRCEP.108.818427"},{"key":"ref85","doi-asserted-by":"crossref","unstructured":"Kitamura T, Vlachos K, Denis A, Andre C, Martin R, Pambrun T, et al. Ethanol infusion for Marshall bundle epicardial connections in Marshall bundle-related atrial tachycardias following atrial fibrillation ablation: The accessibility and success rate of ethanol infusion by using a femoral approach. Journal of Cardiovascular Electrophysiology. 2019; 30: 1443\u20131451.","DOI":"10.1111\/jce.14019"},{"key":"ref86","doi-asserted-by":"crossref","unstructured":"Kamakura T, Andr\u00e9 C, Duchateau J, Nakashima T, Nakatani Y, Takagi T, et al. Distribution of atrial low voltage induced by vein of Marshall ethanol infusion. Journal of Cardiovascular Electrophysiology. 2022; 33: 1687\u20131693.","DOI":"10.1111\/jce.15573"},{"key":"ref87","doi-asserted-by":"crossref","unstructured":"Takigawa M, Ikenouchi T, Goya M, Shigeta T, Miyazaki S, Sasano T. Arrhythmogenic epicardial LA-PV connection at the peri-oesophageal posterior LA is safely and effectively blocked by ethanol infusion to the vein of Marshall. Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 2023; 25: euac195.","DOI":"10.1093\/europace\/euac195"},{"key":"ref88","doi-asserted-by":"crossref","unstructured":"Takagi T, Derval N, Pambrun T, Nakatani Y, Andr\u00e9 C, Ramirez FD, et al. Optimized Computed Tomography Acquisition Protocol for Ethanol Infusion Into the Vein of Marshall. JACC. Clinical Electrophysiology. 2022; 8: 168\u2013178.","DOI":"10.1016\/j.jacep.2021.09.020"},{"key":"ref89","doi-asserted-by":"crossref","unstructured":"Kronzon I, Tunick PA, Jortner R, Drenger B, Katz ES, Bernstein N, et al. Echocardiographic evaluation of the coronary sinus. Journal of the American Society of Echocardiography: Official Publication of the American Society of Echocardiography. 1995; 8: 518\u2013526.","DOI":"10.1016\/S0894-7317(05)80340-2"},{"key":"ref90","doi-asserted-by":"crossref","unstructured":"Leyton-Mange JS, Tandon K, Sze EY, Carpenter CM, Sesselberg HW. The Maine vein of Marshall ethanol experience: learning curve and safety. Journal of Interventional Cardiac Electrophysiology: an International Journal of Arrhythmias and Pacing. 2023; 66: 661\u2013671.","DOI":"10.1007\/s10840-022-01378-8"},{"key":"ref91","doi-asserted-by":"crossref","unstructured":"Cappato R, Calkins H, Chen SA, Davies W, Iesaka Y, Kalman J, et al. Delayed cardiac tamponade after radiofrequency catheter ablation of atrial fibrillation: a worldwide report. Journal of the American College of Cardiology. 2011; 58: 2696\u20132697.","DOI":"10.1016\/j.jacc.2011.09.028"}],"container-title":["Reviews in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/25\/4\/10.31083\/j.rcm2504112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T19:26:21Z","timestamp":1732735581000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/25\/4\/10.31083\/j.rcm2504112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,25]]},"references-count":91,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024]]}},"alternative-id":["S1530-6550(23)01267-X"],"URL":"https:\/\/doi.org\/10.31083\/j.rcm2504112","relation":{},"ISSN":["1530-6550","2153-8174"],"issn-type":[{"value":"1530-6550","type":"print"},{"value":"2153-8174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,25]]},"article-number":"112"}}