{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:48:03Z","timestamp":1783838883342,"version":"3.55.0"},"reference-count":42,"publisher":"IMR Press","issue":"4","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2022YFC3602400"],"award-info":[{"award-number":["2022YFC3602400"]}]},{"name":"National Key Research and Development Program of China","award":["2022YFC3602404"],"award-info":[{"award-number":["2022YFC3602404"]}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["82270474"],"award-info":[{"award-number":["82270474"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Henan Provincial Medical Science and Technology Tackling Program Joint Co-construction Project","award":["LHGJ20220102"],"award-info":[{"award-number":["LHGJ20220102"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Background: Drug-coated balloons (DCBs) have become increasingly vital to percutaneous coronary intervention, offering many advantages. However, a significant challenge is that many patients are intolerant to the myocardial ischemia caused by DCB dilation. Remote ischemic preconditioning (RIPC) is known to enhance heart\u2019s tolerance to ischemia and hypoxia. This study investigated whether preoperative RIPC could extend the tolerated DCB inflation time and improve the long-term prognosis of patients with coronary artery disease (CAD). Methods: A total of 653 patients with CAD were recruited and randomized into a RIPC group (n = 323) and a control (n = 330) group. The RIPC group underwent RIPC on the left upper limb twice daily, starting three days before the DCB implantation. The patients were followed up for one year after the operation, and 197 patients returned for coronary angiography (CAG) examination where the quantitative flow ratio (QFR) of the target vessels was measured. The primary endpoint of the study was the incidence of target lesion failure (TLF), which included target lesion revascularization (TLR), target vessel myocardial infarction, and cardiac death. The secondary endpoint was the rate of QFR loss in the target vessels. Results: The findings revealed a significantly lower incidence of TLR in the RIPC group compared to the control group. Additionally, at the one-year follow-up, the rate of QFR loss in target vessels was lower in the RIPC group than in the control group. Conclusions: The preoperative application of RIPC effectively extended the duration patients could tolerate DCB inflation. Furthermore, this approach positively impacted the long-term prognosis of CAD patients undergoing DCB treatment. Clinical Trial Registration Information: NCT04766749.<\/jats:p>","DOI":"10.31083\/j.rcm2504116","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T09:03:37Z","timestamp":1712135017000},"source":"Crossref","is-referenced-by-count":2,"title":["Remote Ischemic Preconditioning Before Drug-Coated Balloon Implantation can Improve the Long-Term Prognosis of Patients with CAD"],"prefix":"10.31083","volume":"25","author":[{"given":"Zhenzhou","family":"Zhao","sequence":"first","affiliation":[{"name":"Heart Center of Henan Provincial People\u2019s Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University, Henan Provincial People\u2019s Hospital, 450003 Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haosen","family":"Yu","sequence":"first","affiliation":[{"name":"Heart Center of Henan Provincial People\u2019s Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University, Henan Provincial People\u2019s Hospital, 450003 Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Nie","sequence":"first","affiliation":[{"name":"Heart Center of Henan Provincial People\u2019s Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University, Henan Provincial People\u2019s Hospital, 450003 Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejie","family":"Li","sequence":"first","affiliation":[{"name":"Heart Center of Henan Provincial People\u2019s Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University, Henan Provincial People\u2019s Hospital, 450003 Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muwei","family":"Li","sequence":"first","affiliation":[{"name":"Heart Center of Henan Provincial People\u2019s Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University, Henan Provincial People\u2019s Hospital, 450003 Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Axel DI, Kunert W, G\u00f6ggelmann C, Oberhoff M, Herdeg C, K\u00fcttner A, et al. Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using local drug delivery. Circulation. 1997; 96: 636\u2013645.","DOI":"10.1161\/01.CIR.96.2.636"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Unverdorben M, Vallbracht C, Cremers B, Heuer H, Hengstenberg C, Maikowski C, et al. Paclitaxel-coated balloon catheter versus paclitaxel-coated stent for the treatment of coronary in-stent restenosis: the three-year results of the PEPCAD II ISR study. EuroIntervention: Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology. 2015; 11: 926\u2013934.","DOI":"10.4244\/EIJY14M08_12"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Byrne RA, Neumann FJ, Mehilli J, Pinieck S, Wolff B, Tiroch K, et al. Paclitaxel-eluting balloons, paclitaxel-eluting stents, and balloon angioplasty in patients with restenosis after implantation of a drug-eluting stent (ISAR-DESIRE 3): a randomised, open-label trial. The Lancet (London, England). 2013; 381: 461\u2013467.","DOI":"10.1016\/S0140-6736(12)61964-3"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Neumann FJ, Sousa-Uva M, Ahlsson A, Alfonso F, Banning AP, Benedetto U, et al. 2018 ESC\/EACTS Guidelines on myocardial revascularization. European Heart Journal. 2019; 40: 87\u2013165.","DOI":"10.1093\/eurheartj\/ehy855"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Tang Y, Qiao S, Su X, Chen Y, Jin Z, Chen H, et al. Drug-Coated Balloon Versus Drug-Eluting Stent for Small-Vessel Disease: The RESTORE SVD China Randomized Trial. JACC. Cardiovascular Interventions. 2018; 11: 2381\u20132392.","DOI":"10.1016\/j.jcin.2018.09.009"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Jeger RV, Farah A, Ohlow MA, Mangner N, M\u00f6bius-Winkler S, Leibundgut G, et al. Drug-coated balloons for small coronary artery disease (BASKET-SMALL 2): an open-label randomised non-inferiority trial. The Lancet (London, England). 2018; 392: 849\u2013856.","DOI":"10.2139\/ssrn.3210892"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Jeger RV, Farah A, Ohlow MA, Mangner N, M\u00f6bius-Winkler S, Weilenmann D, et al. Long-term efficacy and safety of drug-coated balloons versus drug-eluting stents for small coronary artery disease (BASKET-SMALL 2): 3-year follow-up of a randomised, non-inferiority trial. The Lancet (London, England). 2020; 396: 1504\u20131510.","DOI":"10.1016\/S0140-6736(20)32173-5"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Przyklenk K, Bauer B, Ovize M, Kloner RA, Whittaker P. Regional ischemic \u2018preconditioning\u2019 protects remote virgin myocardium from subsequent sustained coronary occlusion. Circulation. 1993; 87: 893\u2013899.","DOI":"10.1161\/01.CIR.87.3.893"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Kharbanda RK, Mortensen UM, White PA, Kristiansen SB, Schmidt MR, Hoschtitzky JA, et al. Transient limb ischemia induces remote ischemic preconditioning in vivo. Circulation. 2002; 106: 2881\u20132883.","DOI":"10.1161\/01.CIR.0000043806.51912.9B"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"B\u00f8tker HE, Kharbanda R, Schmidt MR, B\u00f8ttcher M, Kaltoft AK, Terkelsen CJ, et al. Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial. The Lancet (London, England). 2010; 375: 727\u2013734.","DOI":"10.1016\/S0140-6736(09)62001-8"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Munk K, Andersen NH, Schmidt MR, Nielsen SS, Terkelsen CJ, Sloth E, et al. Remote Ischemic Conditioning in Patients With Myocardial Infarction Treated With Primary Angioplasty: Impact on Left Ventricular Function Assessed by Comprehensive Echocardiography and Gated Single-Photon Emission CT. Circulation. Cardiovascular Imaging. 2010; 3: 656\u2013662.","DOI":"10.1161\/CIRCIMAGING.110.957340"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Gaspar A, Louren\u00e7o AP, Pereira M\u00c1, Azevedo P, Roncon-Albuquerque R, Jr, Marques J, et al. Randomized controlled trial of remote ischaemic conditioning in ST-elevation myocardial infarction as adjuvant to primary angioplasty (RIC-STEMI). Basic Research in Cardiology. 2018; 113: 14.","DOI":"10.1007\/s00395-018-0672-3"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Cai ZP, Parajuli N, Zheng X, Becker L. Remote ischemic preconditioning confers late protection against myocardial ischemia-reperfusion injury in mice by upregulating interleukin-10. Basic Research in Cardiology. 2012; 107: 277.","DOI":"10.1007\/s00395-012-0277-1"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Breivik L, Helgeland E, Aarnes EK, Mrdalj J, Jonassen AK. Remote postconditioning by humoral factors in effluent from ischemic preconditioned rat hearts is mediated via PI3K\/Akt-dependent cell-survival signaling at reperfusion. Basic Research in Cardiology. 2011; 106: 135\u2013145.","DOI":"10.1007\/s00395-010-0133-0"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Lau JK, Roy P, Javadzadegan A, Moshfegh A, Fearon WF, Ng M, et al. Remote Ischemic Preconditioning Acutely Improves Coronary Microcirculatory Function. Journal of the American Heart Association. 2018; 7: e009058.","DOI":"10.1161\/JAHA.118.009058"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Traverse JH, Swingen CM, Henry TD, Fox J, Wang YL, Chavez IJ, et al. NHLBI-Sponsored Randomized Trial of Postconditioning During Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction. Circulation Research. 2019; 124: 769\u2013778.","DOI":"10.1161\/CIRCRESAHA.118.314060"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Tu S, Westra J, Yang J, von Birgelen C, Ferrara A, Pellicano M, et al. Diagnostic Accuracy of Fast Computational Approaches to Derive Fractional Flow Reserve From Diagnostic Coronary Angiography: The International Multicenter FAVOR Pilot Study. JACC. Cardiovascular Interventions. 2016; 9: 2024\u20132035.","DOI":"10.1016\/j.jcin.2016.07.013"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Tu S, Barbato E, K\u00f6szegi Z, Yang J, Sun Z, Holm NR, et al. Fractional flow reserve calculation from 3-dimensional quantitative coronary angiography and TIMI frame count: a fast computer model to quantify the functional significance of moderately obstructed coronary arteries. JACC. Cardiovascular Interventions. 2014; 7: 768\u2013777.","DOI":"10.1016\/j.jcin.2014.03.004"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Xu B, Tu S, Qiao S, Qu X, Chen Y, Yang J, et al. Diagnostic Accuracy of Angiography-Based Quantitative Flow Ratio Measurements for Online Assessment of Coronary Stenosis. Journal of the American College of Cardiology. 2017; 70: 3077\u20133087.","DOI":"10.1016\/j.jacc.2017.10.035"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Collet C, Onuma Y, Sonck J, Asano T, Vandeloo B, Kornowski R, et al. Diagnostic performance of angiography-derived fractional flow reserve: a systematic review and Bayesian meta-analysis. European Heart Journal. 2018; 39: 3314\u20133321.","DOI":"10.1093\/eurheartj\/ehy445"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Jeger RV, Eccleshall S, Wan Ahmad WA, Ge J, Poerner TC, Shin ES, et al. Drug-Coated Balloons for Coronary Artery Disease: Third Report of the International DCB Consensus Group. JACC. Cardiovascular Interventions. 2020; 13: 1391\u20131402.","DOI":"10.1016\/j.jcin.2020.02.043"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Anderson JA, Lamichhane S, Remund T, Kelly P, Mani G. Preparation, characterization, in vitro drug release, and cellular interactions of tailored paclitaxel releasing polyethylene oxide films for drug-coated balloons. Acta Biomaterialia. 2016; 29: 333\u2013351.","DOI":"10.1016\/j.actbio.2015.09.036"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Cao Z, Li J, Fang Z, Feierkaiti Y, Zheng X, Jiang X. The factors influencing the efficiency of drug-coated balloons. Frontiers in Cardiovascular Medicine. 2022; 9: 947776.","DOI":"10.3389\/fcvm.2022.947776"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Heusch G. The Coronary Circulation as a Target of Cardioprotection. Circulation Research. 2016; 118: 1643\u20131658.","DOI":"10.1161\/CIRCRESAHA.116.308640"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Ahmed RM, Mohamed EHA, Ashraf M, Maithili S, Nabil F, Rami R, et al. Effect of remote ischemic preconditioning on serum troponin T level following elective percutaneous coronary intervention. Catheterization and Cardiovascular Interventions: Official Journal of the Society for Cardiac Angiography & Interventions. 2013; 82: E647\u2013E653.","DOI":"10.1002\/ccd.24825"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Luo SJ, Zhou YJ, Shi DM, Ge HL, Wang JL, Liu RF. Remote ischemic preconditioning reduces myocardial injury in patients undergoing coronary stent implantation. The Canadian Journal of Cardiology. 2013; 29: 1084\u20131089.","DOI":"10.1016\/j.cjca.2012.11.022"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Zhao Z, Shi Q, Guo Q, Peng L, Li X, Rao L, et al. Remote ischemic preconditioning can extend the tolerance to extended drug-coated balloon inflation time by reducing myocardial damage during percutaneous coronary intervention. International Journal of Cardiology. 2022; 353: 3\u20138.","DOI":"10.1016\/j.ijcard.2022.01.049"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Morris AA, Patel RS, Binongo JNG, Poole J, Al Mheid I, Ahmed Y, et al. Racial differences in arterial stiffness and microcirculatory function between Black and White Americans. Journal of the American Heart Association. 2013; 2: e002154.","DOI":"10.1161\/JAHA.112.002154"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Andreadou I, Farmakis D, Prokovas E, Sigala F, Zoga A, Spyridaki K, et al. Short-term statin administration in hypercholesterolaemic rabbits resistant to postconditioning: effects on infarct size, endothelial nitric oxide synthase, and nitro-oxidative stress. Cardiovascular Research. 2012; 94: 501\u2013509.","DOI":"10.1093\/cvr\/cvs121"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Miki T, Itoh T, Sunaga D, Miura T. Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning. Cardiovascular Diabetology. 2012; 11: 67.","DOI":"10.1186\/1475-2840-11-67"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Heusch G. Reduction of infarct size by ischaemic post-conditioning in humans: fact or fiction? European Heart Journal. 2012; 33: 13\u201315.","DOI":"10.1093\/eurheartj\/ehr341"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Kleinbongard P, B\u00f8tker HE, Ovize M, Hausenloy DJ, Heusch G. Co-morbidities and co-medications as confounders of cardioprotection-Does it matter in the clinical setting? British Journal of Pharmacology. 2020; 177: 5252\u20135269.","DOI":"10.1111\/bph.14839"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Hausenloy DJ, Kharbanda RK, M\u00f8ller UK, Ramlall M, Aar\u00f8e J, Butler R, et al. Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2\/ERIC-PPCI): a single-blind randomised controlled trial. The Lancet (London, England). 2019; 394: 1415\u20131424.","DOI":"10.1093\/cvr\/cvz242"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Buccheri D, Piraino D, Andolina G, Cortese B. Understanding and managing in-stent restenosis: a review of clinical data, from pathogenesis to treatment. Journal of Thoracic Disease. 2016; 8: E1150\u2013E1162.","DOI":"10.21037\/jtd.2016.10.93"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Mitra AK, Agrawal DK. In stent restenosis: bane of the stent era. Journal of Clinical Pathology. 2006; 59: 232\u2013239.","DOI":"10.1136\/jcp.2005.025742"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Grewe PH, Deneke T, Machraoui A, Barmeyer J, M\u00fcller KM. Acute and chronic tissue response to coronary stent implantation: pathologic findings in human specimen. Journal of the American College of Cardiology. 2000; 35: 157\u2013163.","DOI":"10.1016\/S0735-1097(99)00486-6"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Kibos A, Campeanu A, Tintoiu I. Pathophysiology of coronary artery in-stent restenosis. Acute Cardiac Care. 2007; 9: 111\u2013119.","DOI":"10.1080\/17482940701263285"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Ikeda U, Shimada K. Elevated circulating levels of monocyte chemoattractant protein-1 in patients with restenosis after coronary angioplasty. Arteriosclerosis, Thrombosis, and Vascular Biology. 2001; 21: 1090\u20131091.","DOI":"10.1161\/01.ATV.21.6.1090"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Shi N, Chen SY. Mechanisms simultaneously regulate smooth muscle proliferation and differentiation. Journal of Biomedical Research. 2014; 28: 40\u201346.","DOI":"10.7555\/JBR.28.20130130"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Adzika GK, Mprah R, Rizvi R, Adekunle AO, Ndzie Noah ML, Wowui PI, et al. Occlusion preconditioned mice are resilient to hypobaric hypoxia-induced myocarditis and arrhythmias due to enhanced immunomodulation, metabolic homeostasis, and antioxidants defense. Frontiers in Immunology. 2023; 14: 1124649.","DOI":"10.3389\/fimmu.2023.1124649"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Orlandi M, Masi S, Bhowruth D, Leira Y, Georgiopoulos G, Yellon D, et al. Remote Ischemic Preconditioning Protects Against Endothelial Dysfunction in a Human Model of Systemic Inflammation: A Randomized Clinical Trial. Arteriosclerosis, Thrombosis, and Vascular Biology. 2021; 41: e417\u2013e426.","DOI":"10.1161\/ATVBAHA.121.316388"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Speck U, H\u00e4ckel A, Schellenberger E, Kamann S, L\u00f6chel M, Clever YP, et al. Drug Distribution and Basic Pharmacology of Paclitaxel\/Resveratrol-Coated Balloon Catheters. 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