{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:29:22Z","timestamp":1780990162265,"version":"3.54.1"},"reference-count":28,"publisher":"IMR Press","issue":"6","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Science and Technology Planning Project of Zhuhai","award":["ZH22036201210063PWC"],"award-info":[{"award-number":["ZH22036201210063PWC"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Background: Pheochromocytoma-induced takotsubo syndrome (Pheo-TTS) significantly increases the risk of adverse events for inpatient. The early identification of risk factors at admission is crucial for effective risk stratification and minimizing complications in Pheo-TTS patients. Methods: We conducted a systematic review combined with hierarchical cluster and feature importance analysis of demographic, clinical and laboratory data upon admission, alongside in-hospital complication data for Pheo-TTS patients. We analyzed cases published in PubMed and Embase from 2 May 2006 to 27 April 2023. Results: Among 172 Pheo-TTS patients, cluster analysis identified two distinct groups: a chest pain dominant (CPD) group (n = 86) and a non-chest pain dominant (non-CPD) group (n = 86). The non-CPD group was characterized by a younger age (44.0 \u00b1 15.2 vs. 52.4 \u00b1 14.4, p &lt; 0.001), a higher prevalence of neurological\/psychiatric disorders (53.5% vs. 32.6%), and increased presentation of dyspnea (87.2% vs. 17.4%), pulmonary rales (59.3% vs. 8.1%), and tachycardia (77.9% vs. 30.2%). Additionally, they exhibited more atypical takotsubo syndrome (TTS) imaging phenotypes (55.8% vs. 36.5%, all p &lt; 0.05). The non-CPD group experienced more than a 2-fold increase for in-hospital adverse events compared to the CPD group (70.9% vs. 30.2%, p &lt; 0.001). After adjusting for confounding factors, the absence of chest pain (odds ratio [OR] = 0.407, 95% confidence interval [CI] 0.169\u20130.979, p = 0.045), the presence of abdominal symptoms (OR = 3.939, 95% CI 1.770\u20138.766, p = 0.001), pulmonary rales (OR = 4.348, 95% CI 1.857\u201310.179, p = 0.001), and atypical TTS imaging phenotype (OR = 3.397, 95% CI 1.534\u20137.525, p = 0.003) remained as independent predictors of in-hospital complications. Conclusions: Clinical manifestations and imaging features at admission help to predict in-hospital complications for Pheo-TTS patients.<\/jats:p>","DOI":"10.31083\/j.rcm2506216","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T09:24:31Z","timestamp":1718357071000},"source":"Crossref","is-referenced-by-count":5,"title":["In-Hospital Adverse Events of Pheochromocytoma-Induced Takotsubo Syndrome: A Literature Review and Cluster Analysis of 172 Cases"],"prefix":"10.31083","volume":"25","author":[{"given":"Mei","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, 519000 Zhuhai, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianglin","family":"Guan","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, 519000 Zhuhai, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianmin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, 519000 Zhuhai, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxi","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, 519000 Zhuhai, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cunxue","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Radiology, The Fifth Affiliated Hospital of Sun Yat-sen University, 519000 Zhuhai, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, 519000 Zhuhai, Guangdong, China"},{"name":"Center for Interventional Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, 519000 Zhuhai, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, 519000 Zhuhai, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, 519000 Zhuhai, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsi","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, 519000 Zhuhai, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, 519000 Zhuhai, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Cardiology, Heart and Vascular Center, Washington University in St Louis, Barnes-Jewish Hospital, St Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, 519000 Zhuhai, Guangdong, China"},{"name":"Center for Interventional Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, 519000 Zhuhai, Guangdong, China"},{"name":"Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, 519000 Zhuhai, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Lenders JWM, Eisenhofer G, Mannelli M, Pacak K. 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