{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:37:11Z","timestamp":1789983431659,"version":"4.0.1"},"reference-count":51,"publisher":"IMR Press","issue":"7","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Gansu Province Major Science and Technology Project","award":["22ZD6FA033"],"award-info":[{"award-number":["22ZD6FA033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Background: Cardiac autonomic neuropathy (CAN) is a severe complication of type 1 diabetes mellitus (T1DM). This meta-analysis aimed to synthesize relevant literature on the prevalence of CAN and its risk factors in individuals with T1DM. Methods: We screened relevant literature from databases based on predefined search criteria until June 28, 2022. Data extraction and quality assessment were conducted independently by two reviewers. A meta-analysis was conducted to determine the prevalence of CAN and its risk factors in individuals with T1DM using a random-effects model. A subgroup analysis was conducted to assess variations in CAN prevalence based on diabetes duration, diagnostic criteria, study quality, study design, and geographic region of the participants. Results: A total of 21 studies provided information on the prevalence of CAN, while 18 studies explored the potential risk factors for CAN. The overall estimated prevalence of CAN in individuals with T1DM was 25.8% (95% confidence interval (95% CI): 0.208\u20130.307), with no significant differences observed among the five regions. Additionally, smoking, lipid abnormalities, hypertension, duration of diabetes, increased body mass index, elevated glycated haemoglobin concentrations, and presence of chronic complications of diabetes, such as diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy, were associated with a higher prevalence of CAN in individuals with diabetes. Conclusions: CAN is prevalent in individuals with T1DM worldwide. Efforts should be made to improve early screening and intervention for CAN, as well as to implement strategies aimed at improving or controlling early risk factors associated with CAN.<\/jats:p>","DOI":"10.31083\/j.rcm2507244","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T09:29:14Z","timestamp":1720171754000},"source":"Crossref","is-referenced-by-count":3,"title":["Prevalence and Risk Factors of Cardiovascular Autonomic Neuropathy in Individuals with Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis"],"prefix":"10.31083","volume":"25","author":[{"given":"Xin","family":"Huang","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, Ningxia Medical University, 750000 Yinchuan, Ningxia, China"},{"name":"Department of Endocrinology, Gansu Provincial Hospital, 730000 Lanzhou, Gansu, China"},{"name":"Gansu Province Metabolic Disease Clinical Research Center, 730000 Lanzhou, Gansu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Bao","sequence":"first","affiliation":[{"name":"Gansu Province Metabolic Disease Clinical Research Center, 730000 Lanzhou, Gansu, China"},{"name":"Institute of Clinical Research and Evidence Based Medicine, Gansu Provincial Hospital, 730000 Lanzhou, Gansu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, Ningxia Medical University, 750000 Yinchuan, Ningxia, China"},{"name":"Department of Endocrinology, Gansu Provincial Hospital, 730000 Lanzhou, Gansu, China"},{"name":"Gansu Province Metabolic Disease Clinical Research Center, 730000 Lanzhou, Gansu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Gansu Provincial Hospital, 730000 Lanzhou, Gansu, China"},{"name":"Gansu Province Metabolic Disease Clinical Research Center, 730000 Lanzhou, Gansu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Syed FZ. Type 1 Diabetes Mellitus. Annals of Internal Medicine. 2022; 175: ITC33\u2013ITC48.","DOI":"10.7326\/AITC202203150"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Gregory GA, Robinson TIG, Linklater SE, Wang F, Colagiuri S, de Beaufort C, et al. Global incidence, prevalence, and mortality of type 1 diabetes in 2021 with projection to 2040: a modelling study. The Lancet. Diabetes & Endocrinology. 2022; 10: 741\u2013760.","DOI":"10.1016\/S2213-8587(22)00218-2"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Duque A, Mediano MFF, De Lorenzo A, Rodrigues LF, Jr. Cardiovascular autonomic neuropathy in diabetes: Pathophysiology, clinical assessment and implications. World Journal of Diabetes. 2021; 12: 855\u2013867.","DOI":"10.4239\/wjd.v12.i6.855"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Balc\u0131o\u011flu AS, M\u00fcderriso\u011flu H. Diabetes and cardiac autonomic neuropathy: Clinical manifestations, cardiovascular consequences, diagnosis and treatment. World Journal of Diabetes. 2015; 6: 80\u201391.","DOI":"10.4239\/wjd.v6.i1.80"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Agashe S, Petak S. Cardiac Autonomic Neuropathy in Diabetes Mellitus. Methodist DeBakey Cardiovascular Journal. 2018; 14: 251\u2013256.","DOI":"10.14797\/mdcj-14-4-251"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Franceschi R, Mozzillo E, Di Candia F, Rosanio FM, Leonardi L, Liguori A, et al. A systematic review of the prevalence, risk factors and screening tools for autonomic and diabetic peripheral neuropathy in children, adolescents and young adults with type 1 diabetes. Acta Diabetologica. 2022; 59: 293\u2013308.","DOI":"10.1007\/s00592-022-01850-x"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. Journal of Clinical Epidemiology. 2021; 134: 178\u2013189.","DOI":"10.1016\/j.jclinepi.2021.03.001"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Neal BS, Lack SD, Lankhorst NE, Raye A, Morrissey D, van Middelkoop M. Risk factors for patellofemoral pain: a systematic review and meta-analysis. British Journal of Sports Medicine. 2019; 53: 270\u2013281.","DOI":"10.1136\/bjsports-2017-098890"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Song P, Zhang Y, Yu J, Zha M, Zhu Y, Rahimi K, et al. Global Prevalence of Hypertension in Children: A Systematic Review and Meta-analysis. JAMA Pediatrics. 2019; 173: 1154\u20131163.","DOI":"10.1001\/jamapediatrics.2019.3310"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"von Elm E, Altman DG, Egger M, Pocock SJ, G\u00f8tzsche PC, Vandenbroucke JP, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: guidelines for reporting observational studies. International Journal of Surgery (London, England). 2014; 12: 1495\u20131499.","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Ewing DJ, Martyn CN, Young RJ, Clarke BF. The value of cardiovascular autonomic function tests: 10 years experience in diabetes. Diabetes Care. 1985; 8: 491\u2013498.","DOI":"10.2337\/diacare.8.5.491"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Cho YH, Craig ME, Jopling T, Chan A, Donaghue KC. Higher body mass index predicts cardiac autonomic dysfunction: A longitudinal study in adolescent type 1 diabetes. Pediatric Diabetes. 2018; 19: 794\u2013800.","DOI":"10.1111\/pedi.12642"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Razanskaite-Virbickiene D, Danyte E, Mockeviciene G, Dobrovolskiene R, Verkauskiene R, Zalinkevicius R. Can coefficient of variation of time-domain analysis be valuable for detecting cardiovascular autonomic neuropathy in young patients with type 1 diabetes: a case control study. BMC Cardiovascular Disorders. 2017; 17: 34.","DOI":"10.1186\/s12872-016-0467-0"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Jaiswal M, Divers J, Urbina EM, Dabelea D, Bell RA, Pettitt DJ, et al. Cardiovascular autonomic neuropathy in adolescents and young adults with type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Cohort Study. Pediatric Diabetes. 2018; 19: 680\u2013689.","DOI":"10.1111\/pedi.12633"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Abd El Dayem SM, Battah AA, Soliman RA. Natural progression of cardiac autonomic neuropathy in patients with type 1 diabetes: a four-year follow-up study. Anadolu Kardiyoloji Dergisi: AKD = the Anatolian Journal of Cardiology. 2011; 11: 224\u2013231.","DOI":"10.5152\/akd.2011.061"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Orlov S, Cherney DZI, Pop-Busui R, Lovblom LE, Ficociello LH, Smiles AM, et al. Cardiac autonomic neuropathy and early progressive renal decline in patients with nonmacroalbuminuric type 1 diabetes. Clinical Journal of the American Society of Nephrology: CJASN. 2015; 10: 1136\u20131144.","DOI":"10.2215\/CJN.11441114"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Varley BJ, Gow ML, Cho YH, Benitez-Aguirre P, Cusumano J, Pryke A, et al. Higher frequency of cardiovascular autonomic neuropathy in youth with type 2 compared to type 1 diabetes: Role of cardiometabolic risk factors. Pediatric Diabetes. 2022; 23: 1073\u20131079.","DOI":"10.1111\/pedi.13393"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Metwalley KA, Hamed SA, Farghaly HS. Cardiac autonomic function in children with type 1 diabetes. European Journal of Pediatrics. 2018; 177: 805\u2013813.","DOI":"10.1007\/s00431-018-3122-1"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Gomes MB, Calliari LE, Conte D, Correa CL, Drummond KRG, Mallmann F, et al. Diabetes-related chronic complications in Brazilian adolescents with type 1 diabetes. A multicenter cross-sectional study. Diabetes Research and Clinical Practice. 2021; 177: 108895.","DOI":"10.1016\/j.diabres.2021.108895"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Matta M, Pavy-Le Traon A, Perez-Lloret S, Laporte C, Berdugo I, Nasr N, et al. Predictors of Cardiovascular Autonomic Neuropathy Onset and Progression in a Cohort of Type 1 Diabetic Patients. Journal of Diabetes Research. 2018; 2018: 5601351.","DOI":"10.1155\/2018\/5601351"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Stella P, Ellis D, Maser RE, Orchard TJ. Cardiovascular autonomic neuropathy (expiration and inspiration ratio) in type 1 diabetes. Incidence and predictors. Journal of Diabetes and its Complications. 2000; 14: 1\u20136.","DOI":"10.1016\/S1056-8727(00)00054-4"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Hansen CS, Suvitaival T, Theilade S, Mattila I, Lajer M, Tro\u0161t K, et al. Cardiovascular Autonomic Neuropathy in Type 1 Diabetes Is Associated With Disturbances in TCA, Lipid, and Glucose Metabolism. Frontiers in Endocrinology. 2022; 13: 831793.","DOI":"10.3389\/fendo.2022.831793"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Admoni SN, Santos-Bezerra DP, Perez RV, Patente TA, Monteiro MB, Cavaleiro AM, et al. Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes. Diabetes & Vascular Disease Research. 2019; 16: 297\u2013299.","DOI":"10.1177\/1479164118820641"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Pawli\u0144ski \u0141, Gasto\u0142 J, Fiema M, Matejko B, Kie\u0107-Wilk B. Is treatment of type 1 diabetes mellitus (insulin therapy, metabolic control) optimal for preventing cardiovascular autonomic neuropathy? Endokrynologia Polska. 2019; 70: 323\u2013329.","DOI":"10.5603\/EP.a2019.0011"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Pan Q, Li Q, Deng W, Zhao D, Qi L, Huang W, et al. Prevalence and Diagnosis of Diabetic Cardiovascular Autonomic Neuropathy in Beijing, China: A Retrospective Multicenter Clinical Study. Frontiers in Neuroscience. 2019; 13: 1144.","DOI":"10.3389\/fnins.2019.01144"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Mogensen UM, Jensen T, K\u00f8ber L, Kelb\u00e6k H, Mathiesen AS, Dixen U, et al. Cardiovascular autonomic neuropathy and subclinical cardiovascular disease in normoalbuminuric type 1 diabetic patients. Diabetes. 2012; 61: 1822\u20131830.","DOI":"10.2337\/db11-1235"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Pavy-Le Traon A, Fontaine S, Tap G, Guidolin B, Senard JM, Hanaire H. Cardiovascular autonomic neuropathy and other complications in type 1 diabetes. Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society. 2010; 20: 153\u2013160.","DOI":"10.1007\/s10286-010-0062-x"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Witte DR, Tesfaye S, Chaturvedi N, Eaton SEM, Kempler P, Fuller JH, et al. Risk factors for cardiac autonomic neuropathy in type 1 diabetes mellitus. Diabetologia. 2005; 48: 164\u2013171.","DOI":"10.1007\/s00125-004-1617-y"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Braffett BH, Gubitosi-Klug RA, Albers JW, Feldman EL, Martin CL, White NH, et al. Risk Factors for Diabetic Peripheral Neuropathy and Cardiovascular Autonomic Neuropathy in the Diabetes Control and Complications Trial\/Epidemiology of Diabetes Interventions and Complications (DCCT\/EDIC) Study. Diabetes. 2020; 69: 1000\u20131010.","DOI":"10.2337\/db19-1046"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Serdarova M, Dimova R, Chakarova N, Grozeva G, Todorova A, Tankova T. Relationship between cardiac autonomic neuropathy and cardio-metabolic risk profile in adults with type 1 diabetes. Diabetes Research and Clinical Practice. 2021; 174: 108721.","DOI":"10.1016\/j.diabres.2021.108721"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Riguetto CM, Takano CR, Admoni SN, Parisi MCR, Giannella MLC, Pavin EJ, et al. Identification and performance of multiple clinical and laboratorial risk factors for diagnosis of cardiac autonomic neuropathy in type 1 diabetes patients. Journal of Diabetes and Metabolic Disorders. 2019; 18: 565\u2013573.","DOI":"10.1007\/s40200-019-00467-2"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Kim HY, Jung HW, Lee YA, Shin CH, Yang SW. Cardiac autonomic neuropathy in nonobese young adults with type 1 diabetes. Annals of Pediatric Endocrinology & Metabolism. 2019; 24: 180\u2013186.","DOI":"10.6065\/apem.2019.24.3.180"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Jun JE, Lee SE, Lee YB, Ahn JY, Kim G, Hur KY, et al. Continuous glucose monitoring defined glucose variability is associated with cardiovascular autonomic neuropathy in type 1 diabetes. Diabetes\/metabolism Research and Reviews. 2019; 35: e3092.","DOI":"10.1002\/dmrr.3092"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Tannus LRM, Drummond KRG, Clemente ELDS, da Matta MDFB, Gomes MB, Brazilian Type 1 Diabetes Study Group (BrazDiab1SG). Predictors of cardiovascular autonomic neuropathy in patients with type 1 diabetes. Frontiers in Endocrinology. 2014; 5: 191.","DOI":"10.3389\/fendo.2014.00191"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Voulgari C, Psallas M, Kokkinos A, Argiana V, Katsilambros N, Tentolouris N. The association between cardiac autonomic neuropathy with metabolic and other factors in subjects with type 1 and type 2 diabetes. Journal of Diabetes and its Complications. 2011; 25: 159\u2013167.","DOI":"10.1016\/j.jdiacomp.2010.06.001"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Maddaloni E, Moretti C, Del Toro R, Sterpetti S, Ievolella MV, Arnesano G, et al. Risk of cardiac autonomic neuropathy in latent autoimmune diabetes in adults is similar to type 1 diabetes and lower compared to type 2 diabetes: A cross-sectional study. Diabetic Medicine: a Journal of the British Diabetic Association. 2021; 38: e14455.","DOI":"10.1111\/dme.14455"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Christensen MMB, Hommel EE, J\u00f8rgensen ME, von Scholten BJ, Fleischer J, Hansen CS. Prevalence of Diabetic Neuropathy in Young Adults with Type 1 Diabetes and the Association with Insulin Pump Therapy. Diabetes Technology & Therapeutics. 2018. (online ahead of print)","DOI":"10.1089\/dia.2018.0249"},{"key":"ref38","unstructured":"Khoharo HK, Ansari S, Ali Shaikh I, Qureshi F. Cardiac autonomic neuropathy (CAN) in type-1 diabetes mellitus patients and its association with the duration of disease and glycemic control. Journal of the College of Physicians and Surgeons\u2013Pakistan: JCPSP. 2009; 19: 232\u2013235."},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Svensson J, Lyngaae-J\u00f8rgensen A, Carstensen B, Simonsen LB, Mortensen HB, Danish Childhood Diabetes Registry. Long-term trends in the incidence of type 1 diabetes in Denmark: the seasonal variation changes over time. Pediatric Diabetes. 2009; 10: 248\u2013254.","DOI":"10.1111\/j.1399-5448.2008.00483.x"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Tiwari R, Kumar R, Malik S, Raj T, Kumar P. Analysis of Heart Rate Variability and Implication of Different Factors on Heart Rate Variability. Current Cardiology Reviews. 2021; 17: e160721189770.","DOI":"10.2174\/1573403X16999201231203854"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Shah MS, Brownlee M. Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes. Circulation Research. 2016; 118: 1808\u20131829.","DOI":"10.1161\/CIRCRESAHA.116.306923"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Spallone V. Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: What Is Defined, What Is New, and What Is Unmet. Diabetes & Metabolism Journal. 2019; 43: 3\u201330.","DOI":"10.4093\/dmj.2018.0259"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Chowdhury M, Nevitt S, Eleftheriadou A, Kanagala P, Esa H, Cuthbertson DJ, et al. Cardiac autonomic neuropathy and risk of cardiovascular disease and mortality in type 1 and type 2 diabetes: a meta-analysis. BMJ Open Diabetes Research & Care. 2021; 9: e002480.","DOI":"10.1136\/bmjdrc-2021-002480"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Spallone V, Ziegler D, Freeman R, Bernardi L, Frontoni S, Pop-Busui R, et al. Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management. Diabetes\/metabolism Research and Reviews. 2011; 27: 639\u2013653.","DOI":"10.1002\/dmrr.1239"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Tahrani AA, Dubb K, Raymond NT, Begum S, Altaf QA, Sadiqi H, et al. Cardiac autonomic neuropathy predicts renal function decline in patients with type 2 diabetes: a cohort study. Diabetologia. 2014; 57: 1249\u20131256.","DOI":"10.1007\/s00125-014-3211-2"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Ayad F, Belhadj M, Pari\u00e9s J, Attali JR, Valensi P. Association between cardiac autonomic neuropathy and hypertension and its potential influence on diabetic complications. Diabetic Medicine: a Journal of the British Diabetic Association. 2010; 27: 804\u2013811.","DOI":"10.1111\/j.1464-5491.2010.03027.x"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Williams SM, Eleftheriadou A, Alam U, Cuthbertson DJ, Wilding JPH. Cardiac Autonomic Neuropathy in Obesity, the Metabolic Syndrome and Prediabetes: A Narrative Review. Diabetes Therapy: Research, Treatment and Education of Diabetes and Related Disorders. 2019; 10: 1995\u20132021.","DOI":"10.1007\/s13300-019-00693-0"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Astrup AS, Tarnow L, Rossing P, Hansen BV, Hilsted J, Parving HH. Cardiac autonomic neuropathy predicts cardiovascular morbidity and mortality in type 1 diabetic patients with diabetic nephropathy. Diabetes Care. 2006; 29: 334\u2013339.","DOI":"10.2337\/diacare.29.02.06.dc05-1242"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Kempler P, Tesfaye S, Chaturvedi N, Stevens LK, Webb DJ, Eaton S, et al. Autonomic neuropathy is associated with increased cardiovascular risk factors: the EURODIAB IDDM Complications Study. Diabetic Medicine: a Journal of the British Diabetic Association. 2002; 19: 900\u2013909.","DOI":"10.1046\/j.1464-5491.2002.00821.x"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Dal Canto E, Ceriello A, Ryd\u00e9n L, Ferrini M, Hansen TB, Schnell O, et al. Diabetes as a cardiovascular risk factor: An overview of global trends of macro and micro vascular complications. European Journal of Preventive Cardiology. 2019; 26: 25\u201332.","DOI":"10.1177\/2047487319878371"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Tesfaye S, Boulton AJM, Dyck PJ, Freeman R, Horowitz M, Kempler P, et al. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care. 2010; 33: 2285\u20132293.","DOI":"10.2337\/dc10-1303"}],"container-title":["Reviews in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/25\/7\/10.31083\/j.rcm2507244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T19:31:03Z","timestamp":1732735863000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/25\/7\/10.31083\/j.rcm2507244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,3]]},"references-count":51,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024]]}},"alternative-id":["S1530-6550(24)01341-3"],"URL":"https:\/\/doi.org\/10.31083\/j.rcm2507244","relation":{},"ISSN":["1530-6550","2153-8174"],"issn-type":[{"value":"1530-6550","type":"print"},{"value":"2153-8174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,3]]},"article-number":"244"}}