{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:17:30Z","timestamp":1772806650694,"version":"3.50.1"},"reference-count":35,"publisher":"IMR Press","issue":"4","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81974270"],"award-info":[{"award-number":["81974270"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["82472014"],"award-info":[{"award-number":["82472014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Science and Technology Commission","doi-asserted-by":"crossref","award":["22Y11904100"],"award-info":[{"award-number":["22Y11904100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>Objective: The aim of this study was to investigate the correlation between dopamine transporter (DAT) positron emission tomography (PET)\/computed tomography (CT) and the clinical characteristics and rating scales of Parkinson\u2019s disease (PD) patients. Additionally, we sought to assess the scientific validity and feasibility of integrating 3D-dopaminergic binding parameters into the clinical scoring system for PD. Methods: A total of 75 patients with PD who underwent 11C-methyl-N-2\u03b2-methyl ester-3\u03b2-(4-fluorophenyl) tropane (11C-CFT) PET\/CT from April, 2019 to June, 2021 were retrospectively analyzed. Clinical characteristics, including age, sex, and disease duration, as well as the modified Hoehn-Yahr (H-Y) scale, Unified Parkinson\u2019s Disease Rating Scale (UPDRS) parts II and III (II-III), and Mini-Mental State Examination (MMSE) scores of PD patients during the corresponding time periods were collected. DAT binding parameters and their derived parameters based on plane and 3D images in the neostriatum were analyzed for consistency with plane and 3D parameters, and the correlation between DAT parameters and the clinical features of patients were assessed using SPSS software. Results: The DAT binding parameters derived from 3D images demonstrated good consistency with the plane parameters (p &lt; 0.05). The asymmetry index (ai) of DAT binding parameters based on 3D and plane images showed good consistency in the anterior putamen (p &lt; 0.05). The plane parameters of the anterior and posterior putamen were statistically correlated with the UPDRS II-III score and H-Y score of PD patients (p &lt; 0.05), whereas those of the caudate nucleus were correlated with UPDRS II and MMSE scores. The 3D parameters in the neostriatum showed good statistical correlation with disease duration, UPDRS II-III score, H-Y score, and H-Y stage of PD patients (p &lt; 0.05), and the ai was significantly correlated with MMSE score (p &lt; 0.05). The 3D parameters in the putamen and posterior putamen exhibited significant statistical correlation with the UPDRS II-III score, H-Y score, and H-Y stage in PD patients (p &lt; 0.05). The ai in the putamen showed statistical correlation with UPDRS III and MMSE scores, and the ai in the posterior putamen showed statistical correlation with UPDRS II score (p &lt; 0.05). Conclusions: Quantitative parameters based on plane and 3D images of 11C-CFT PET\/CT showed good consistency. Moreover, 3D parameters in the neostriatum had a stronger correlation with activities of daily living, UPDRS motor scores, disease severity and duration, and cognition compared with plane parameters in PD patients.<\/jats:p>","DOI":"10.31083\/jin24440","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T05:53:52Z","timestamp":1745992432000},"source":"Crossref","is-referenced-by-count":2,"title":["Correlation Analysis Between 3D and Plane DAT Binding Parameters of 11C-CFT PET\/CT and the Clinical Characteristics of Patients with Parkinson\u2019s Disease"],"prefix":"10.31083","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0863-5733","authenticated-orcid":true,"given":"Xiaodong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092 Shanghai, China"},{"name":"Department of Radiology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, 250000 Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092 Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Gan","sequence":"first","affiliation":[{"name":"Department of Neurology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092 Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092 Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Wu","sequence":"first","affiliation":[{"name":"PET Center, Hua Shan Hospital, Fudan University, 200040 Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092 Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufei","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092 Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092 Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuantao","family":"Zuo","sequence":"first","affiliation":[{"name":"PET Center, Hua Shan Hospital, Fudan University, 200040 Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenguo","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092 Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092 Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4818-6655","authenticated-orcid":true,"given":"Yafu","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092 Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Klingelhoefer L, Reichmann H. Pathogenesis of Parkinson disease\u2013the gut-brain axis and environmental factors. Nature Reviews. Neurology. 2015; 11: 625\u2013636.","DOI":"10.1038\/nrneurol.2015.197."},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Ashok AH, Mizuno Y, Volkow ND, Howes OD. Association of Stimulant Use With Dopaminergic Alterations in Users of Cocaine, Amphetamine, or Methamphetamine: A Systematic Review and Meta-analysis. JAMA Psychiatry. 2017; 74: 511\u2013519.","DOI":"10.1001\/jamapsychiatry.2017.0135."},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Tang H, Huang J, Nie K, Gan R, Wang L, Zhao J, et al. Cognitive profile of Parkinson\u2019s disease patients: a comparative study between early-onset and late-onset Parkinson\u2019s disease. The International Journal of Neuroscience. 2016; 126: 227\u2013234.","DOI":"10.3109\/00207454.2015.1010646."},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Liu FT, Ge JJ, Wu JJ, Wu P, Ma Y, Zuo CT, et al. Clinical, Dopaminergic, and Metabolic Correlations in Parkinson Disease: A Dual-Tracer PET Study. Clinical Nuclear Medicine. 2018; 43: 562\u2013571.","DOI":"10.1097\/RLU.0000000000002148."},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Hansen AK, Damholdt MF, Fedorova TD, Knudsen K, Parbo P, Ismail R, et al. In Vivo cortical tau in Parkinson\u2019s disease using 18F-AV-1451 positron emission tomography. Movement Disorders: Official Journal of the Movement Disorder Society. 2017; 32: 922\u2013927.","DOI":"10.1002\/mds.26961."},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Kang Y, Henchcliffe C, Verma A, Vallabhajosula S, He B, Kothari PJ, et al. 18F-FPEB PET\/CT Shows mGluR5 Upregulation in Parkinson\u2019s Disease. Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging. 2019; 29: 97\u2013103.","DOI":"10.1111\/jon.12563."},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Stoessl AJ, Martin WW, McKeown MJ, Sossi V. Advances in imaging in Parkinson\u2019s disease. The Lancet. Neurology. 2011; 10: 987\u20131001.","DOI":"10.1016\/S1474-4422(11)70214-9."},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Brooks DJ. Molecular imaging of dopamine transporters. Ageing Research Reviews. 2016; 30: 114\u2013121.","DOI":"10.1016\/j.arr.2015.12.009."},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Stoessl AJ. Neuroimaging in Parkinson\u2019s disease: from pathology to diagnosis. Parkinsonism & Related Disorders. 2012; 18 Suppl 1: S55\u2013S59.","DOI":"10.1016\/S1353-8020(11)70019-0."},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Cummings JL, Henchcliffe C, Schaier S, Simuni T, Waxman A, Kemp P. The role of dopaminergic imaging in patients with symptoms of dopaminergic system neurodegeneration. Brain: a Journal of Neurology. 2011; 134: 3146\u20133166.","DOI":"10.1093\/brain\/awr177."},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Fazio P, Svenningsson P, Forsberg A, J\u00f6nsson EG, Amini N, Nakao R, et al. Quantitative Analysis of \u00b9\u2078F-(E)-N-(3-Iodoprop-2-Enyl)-2\u03b2-Carbofluoroethoxy-3\u03b2-(4\u2019-Methyl-Phenyl) Nortropane Binding to the Dopamine Transporter in Parkinson Disease. Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine. 2015; 56: 714\u2013720.","DOI":"10.2967\/jnumed.114.152421."},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Burger IA, Casanova R, Steiger S, Husmann L, Stolzmann P, Huellner MW, et al. 18F-FDG PET\/CT of Non-Small Cell Lung Carcinoma Under Neoadjuvant Chemotherapy: Background-Based Adaptive-Volume Metrics Outperform TLG and MTV in Predicting Histopathologic Response. Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine. 2016; 57: 849\u2013854.","DOI":"10.2967\/jnumed.115.167684."},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Kostakoglu L, Mattiello F, Martelli M, Sehn LH, Belada D, Ghiggi C, et al. Total metabolic tumor volume as a survival predictor for patients with diffuse large B-cell lymphoma in the GOYA study. Haematologica. 2022; 107: 1633\u20131642.","DOI":"10.3324\/haematol.2021.278663."},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Dall\u2019Olio FG, Marabelle A, Caramella C, Garcia C, Aldea M, Chaput N, et al. Tumour burden and efficacy of immune-checkpoint inhibitors. Nature Reviews. Clinical Oncology. 2022; 19: 75\u201390.","DOI":"10.1038\/s41571-021-00564-3."},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Gibb WR, Lees AJ. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson\u2019s disease. Journal of Neurology, Neurosurgery, and Psychiatry. 1988; 51: 745\u2013752.","DOI":"10.1136\/jnnp.51.6.745."},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Fahn S, Oakes D, Shoulson I, Kieburtz K, Rudolph A, Lang A, et al. Levodopa and the progression of Parkinson\u2019s disease. The New England Journal of Medicine. 2004; 351: 2498\u20132508.","DOI":"10.1056\/NEJMoa033447."},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Wen MC, Chan LL, Tan LCS, Tan EK. Depression, anxiety, and apathy in Parkinson\u2019s disease: insights from neuroimaging studies. European Journal of Neurology. 2016; 23: 1001\u20131019.","DOI":"10.1111\/ene.13002."},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Huang Z, Jiang C, Li L, Xu Q, Ge J, Li M, et al. Correlations between dopaminergic dysfunction and abnormal metabolic network activity in REM sleep behavior disorder. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 2020; 40: 552\u2013562.","DOI":"10.1177\/0271678X19828916."},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Ma Y, Tang C, Spetsieris PG, Dhawan V, Eidelberg D. Abnormal metabolic network activity in Parkinson\u2019s disease: test-retest reproducibility. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 2007; 27: 597\u2013605.","DOI":"10.1038\/sj.jcbfm.9600358."},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Ma Y, Tang C, Chaly T, Greene P, Breeze R, Fahn S, et al. Dopamine cell implantation in Parkinson\u2019s disease: long-term clinical and (18)F-FDOPA PET outcomes. Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine. 2010; 51: 7\u201315.","DOI":"10.2967\/jnumed.109.066811."},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Jiang L, Wang X, Li P, Feng Z, Shi X, Shao H. Efficacy of 11C-2\u03b2-carbomethoxy-3\u03b2-(4-fluorophenyl) tropane positron emission tomography combined with 18F-fluorodeoxyglucose positron emission tomography in the diagnosis of early Parkinson disease: A protocol for systematic review and meta analysis. Medicine. 2020; 99: e23395.","DOI":"10.1097\/MD.0000000000023395."},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Bloem BR, Okun MS, Klein C. Parkinson\u2019s disease. Lancet (London, England). 2021; 397: 2284\u20132303.","DOI":"10.1016\/S0140-6736(21)00218-X."},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Xu J, Xu Q, Liu S, Li L, Li L, Yen TC, et al. Computer-Aided Classification Framework of Parkinsonian Disorders Using 11C-CFT PET Imaging. Frontiers in Aging Neuroscience. 2022; 13: 792951.","DOI":"10.3389\/fnagi.2021.792951."},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Sun X, Liu F, Liu Q, Gai Y, Ruan W, Wimalarathne DN, et al. Quantitative Research of 11C-CFT and 18F-FDG PET in Parkinson\u2019s Disease: A Pilot Study With NeuroQ Software. Frontiers in Neuroscience. 2019; 13: 299.","DOI":"10.3389\/fnins.2019.00299."},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Jackson H, Anzures-Cabrera J, Taylor KI, Pagano G, PASADENA Investigators, Prasinezumab Study Group. Hoehn and Yahr Stage and Striatal Dat-SPECT Uptake Are Predictors of Parkinson\u2019s Disease Motor Progression. Frontiers in Neuroscience. 2021; 15: 765765.","DOI":"10.3389\/fnins.2021.765765."},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Lorio S, Sambataro F, Bertolino A, Draganski B, Dukart J. The Combination of DAT-SPECT, Structural and Diffusion MRI Predicts Clinical Progression in Parkinson\u2019s Disease. Frontiers in Aging Neuroscience. 2019; 11: 57.","DOI":"10.3389\/fnagi.2019.00057."},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Rosano C, Metti AL, Rosso AL, Studenski S, Bohnen NI. Influence of Striatal Dopamine, Cerebral Small Vessel Disease, and Other Risk Factors on Age-Related Parkinsonian Motor Signs. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2020; 75: 696\u2013701.","DOI":"10.1093\/gerona\/glz161."},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Booij J, Tissingh G, Winogrodzka A, Boer GJ, Stoof JC, Wolters EC, et al. Practical benefit of [123I]FP-CIT SPET in the demonstration of the dopaminergic deficit in Parkinson\u2019s disease. European Journal of Nuclear Medicine. 1997; 24: 68\u201371.","DOI":"10.1007\/BF01728311."},{"key":"ref29","unstructured":"Tissingh G, Booij J, Bergmans P, Winogrodzka A, Janssen AG, van Royen EA, et al. Iodine-123-N-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iod ophenyl)tropane SPECT in healthy controls and early-stage, drug-naive Parkinson\u2019s disease. Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine. 1998; 39: 1143\u20131148."},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Benamer HT, Patterson J, Wyper DJ, Hadley DM, Macphee GJ, Grosset DG. Correlation of Parkinson\u2019s disease severity and duration with 123I-FP-CIT SPECT striatal uptake. Movement Disorders: Official Journal of the Movement Disorder Society. 2000; 15: 692\u2013698. <692::aid-mds1014>3.0.co;2-v.","DOI":"10.1002\/1531-8257(200007)15:4"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Wen W, Piao Y, Xu D, Li X. Prognostic Value of MTV and TLG of 18F-FDG PET in Patients with Stage I and II Non-Small-Cell Lung Cancer: a Meta-Analysis. Contrast Media & Molecular Imaging. 2021; 2021: 7528971.","DOI":"10.1155\/2021\/7528971."},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Kaymak ZA, Karahan N, Erdo\u011fan M, Erdemo\u011flu E, Zihni \u0130, \u015eeng\u00fcl SS. Correlation of 18F-FDG\/PET SUVm\u2062a\u2062x, SUVm\u2062e\u2062a\u2062n, MTV, and TLG with HIF-1\u03b1 in Patients with Colorectal Cancer. Molecular Imaging and Radionuclide Therapy. 2021; 30: 93\u2013100.","DOI":"10.4274\/mirt.galenos.2021.04934."},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Troiano AR, Schulzer M, de la Fuente-Fernandez R, Mak E, McKenzie J, Sossi V, et al. Dopamine transporter PET in normal aging: dopamine transporter decline and its possible role in preservation of motor function. Synapse (New York, N.Y.). 2010; 64: 146\u2013151.","DOI":"10.1002\/syn.20708."},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Ishibashi K, Oda K, Ishiwata K, Ishii K. Comparison of dopamine transporter decline in a patient with Parkinson\u2019s disease and normal aging effect. Journal of the Neurological Sciences. 2014; 339: 207\u2013209.","DOI":"10.1016\/j.jns.2014.01.015."},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"Kangli F, Hongguang Z, Yinghua L, Xiaoxiao D, Yuyin D, Lulu G, et al. Characteristics and influencing factors of 11C-CFT PET imaging in patients with early and late onset Parkinson\u2019s disease. 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