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Integr. Neurosci."],"abstract":"<jats:p>Aims: Parkinson\u2019s disease (PD) is characterized by dopaminergic neuron degeneration and disruption to mitochondria-associated endoplasmic reticulum membranes (MAMs). This study explores whether electroacupuncture (EA) can alleviate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced PD symptoms and investigates the underlying mechanisms using RNA sequencing (RNA-seq). Methods: A PD mouse model was established using MPTP, followed by EA treatment at governing vessel 20 (GV20) and gallbladder meridian 34 (GB34) acupoints, with sham EA treatments as a control. Behavioral assays, immunohistochemistry, and Western blotting assessed neuroprotective effects. MAM integrity was assessed using Western blot, immunofluorescence staining, and transmission electron microscopy. RNA-seq and protein-protein interaction (PPI) analysis identified differentially expressed genes which were validated by real-time fluorescence quantitative polymerase chain reaction (qRT-PCR). Results: EA treatment improved motor performance, increased substantia nigra (SN) and striatum tyrosine hydroxylase expression, reduced SN alpha-synuclein, and improved SN dopamine neuron MAM structure. Transcriptomic analysis identified 32 MAM-associated genes, of which fibronectin-1 (Fn1) was identified as a key regulator. EA was found to upregulate Fn1 expression, suggesting its involvement in MAM stabilization and neuroprotection. Conclusion: EA at GV20 and GB34 alleviated motor and neural impairments in a PD mouse model potentially through modulation of Fn1 and its role in MAM-associated pathways.<\/jats:p>","DOI":"10.31083\/jin40105","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T04:40:06Z","timestamp":1760157606000},"source":"Crossref","is-referenced-by-count":3,"title":["Electroacupuncture Regulates Mitochondria-Endoplasmic Reticulum interactions via Fn1 in a Parkinson\u2019s Disease Model: Transcriptomic Evidence"],"prefix":"10.31083","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7634-6744","authenticated-orcid":true,"given":"Peilin","family":"Lyu","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine, Southern Medical University, 510000 Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9100-3919","authenticated-orcid":true,"given":"Feng","family":"Wen","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine, Southern Medical University, 510000 Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8773-8822","authenticated-orcid":true,"given":"Zhiyi","family":"Fu","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine, Southern Medical University, 510000 Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3821-1040","authenticated-orcid":true,"given":"Junying","family":"Li","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine, Southern Medical University, 510000 Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9254-6531","authenticated-orcid":true,"given":"Qiyan","family":"Li","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine, Southern Medical University, 510000 Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8388-6449","authenticated-orcid":true,"given":"Xiaowen","family":"Cai","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine, Southern Medical University, 510000 Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0792-5359","authenticated-orcid":true,"given":"Shengtao","family":"Huang","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine, Southern Medical University, 510000 Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9402-5527","authenticated-orcid":true,"given":"Xiaoke","family":"Qiu","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine, Southern Medical University, 510000 Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0500-2112","authenticated-orcid":true,"given":"Zhinan","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine, Southern Medical University, 510000 Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2652-8586","authenticated-orcid":true,"given":"Yong","family":"Huang","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine, Southern Medical University, 510000 Guangzhou, Guangdong, China"},{"name":"Nanfang Hospital, Southern Medical University, 510000 Guangzhou, Guangdong, China"},{"name":"Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases, 510000 Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2734-2126","authenticated-orcid":true,"given":"Jiping","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine, Southern Medical University, 510000 Guangzhou, Guangdong, China"},{"name":"Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases, 510000 Guangzhou, Guangdong, China"},{"name":"Zhujiang Hospital, Southern Medical University, 510000 Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Cheng Y, Tong Q, Yuan Y, Song X, Jiang W, Wang Y, et al. \u03b1-Synuclein induces prodromal symptoms of Parkinson\u2019s disease via activating TLR2\/MyD88\/NF-\u03baB pathway in Schwann cells of vagus nerve in a rat model. Journal of Neuroinflammation. 2023; 20: 36.","DOI":"10.1186\/s12974-023-02720-1"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Kalia LV, Lang AE. Parkinson\u2019s disease. Lancet (London, England). 2015; 386: 896\u2013912.","DOI":"10.1016\/S0140-6736(14)61393-3"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Tysnes OB, Storstein A. Epidemiology of Parkinson\u2019s disease. Journal of Neural Transmission (Vienna, Austria: 1996). 2017; 124: 901\u2013905.","DOI":"10.1007\/s00702-017-1686-y"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Dong-Chen X, Yong C, Yang X, Chen-Yu S, Li-Hua P. Signaling pathways in Parkinson\u2019s disease: molecular mechanisms and therapeutic interventions. Signal Transduction and Targeted Therapy. 2023; 8: 73.","DOI":"10.1038\/s41392-023-01353-3"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Angelopoulou E, Stanitsa E, Karpodini CC, Bougea A, Kontaxopoulou D, Fragkiadaki S, et al. 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Journal of Neuroscience Methods. 2010; 189: 180\u2013185.","DOI":"10.1016\/j.jneumeth.2010.03.026"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"Huang D, Wang Z, Tong J, Wang M, Wang J, Xu J, et al. Long-term Changes in the Nigrostriatal Pathway in the MPTP Mouse Model of Parkinson\u2019s Disease. Neuroscience. 2018; 369: 303\u2013313.","DOI":"10.1016\/j.neuroscience.2017.11.041"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"Nemutlu Samur D, Ak\u00e7ay G, Y\u0131ld\u0131r\u0131m S, \u00d6zkan A, \u00c7eker T, Derin N, et al. Vortioxetine ameliorates motor and cognitive impairments in the rotenone-induced Parkinson\u2019s disease via targeting TLR-2 mediated neuroinflammation. Neuropharmacology. 2022; 208: 108977.","DOI":"10.1016\/j.neuropharm.2022.108977"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"Yan B, Li Y, Min S, Zhang P, Xu B, Wang Z, et al. Effects of the Bone\/Bone Marrow Microenvironments on Prostate Cancer Cells and CD59 Expression. BioMed Research International. 2020; 2020: 2753414.","DOI":"10.1155\/2020\/2753414"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"Jonas RK, Roh E, Montojo CA, Pacheco LA, Rosser T, Silva AJ, et al. Risky Decision Making in Neurofibromatosis Type 1: An Exploratory Study. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. 2017; 2: 170\u2013179.","DOI":"10.1016\/j.bpsc.2016.12.003"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"Sumi-Akamaru H, Beck G, Shinzawa K, Kato S, Riku Y, Yoshida M, et al. High expression of \u03b1-synuclein in damaged mitochondria with PLA2G6 dysfunction. Acta Neuropathologica Communications. 2016; 4: 27.","DOI":"10.1186\/s40478-016-0298-3"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"Zhang QQ, Chen Q, Cao P, Shi CX, Zhang LY, Wang LW, et al. AGK2 pre-treatment protects against thioacetamide-induced acute liver failure via regulating the MFN2-PERK axis and ferroptosis signaling pathway. Hepatobiliary & Pancreatic Diseases International: HBPD INT. 2024; 23: 43\u201351.","DOI":"10.1016\/j.hbpd.2023.03.003"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"Paillusson S, Stoica R, Gomez-Suaga P, Lau DHW, Mueller S, Miller T, et al. There\u2019s Something Wrong with my MAM; the ER-Mitochondria Axis and Neurodegenerative Diseases. Trends in Neurosciences. 2016; 39: 146\u2013157.","DOI":"10.1016\/j.tins.2016.01.008"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"Liu Y, Zhu X. Endoplasmic reticulum-mitochondria tethering in neurodegenerative diseases. Translational Neurodegeneration. 2017; 6: 21.","DOI":"10.1186\/s40035-017-0092-6"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"Nizamutdinov D, Qi X, Berman MH, Dougal G, Dayawansa S, Wu E, et al. 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CTGF, FN1, IL-6, THBS1, and WISP1 genes and PI3K-Akt signaling pathway as prognostic and therapeutic targets in gastric cancer identified by gene network modeling. Discover Oncology. 2024; 15: 344.","DOI":"10.1007\/s12672-024-01225-4"},{"key":"ref61","doi-asserted-by":"publisher","unstructured":"Li X, Yang JY, Hu WZ, Ruan Y, Chen HY, Zhang Q, et al. Mitochondria-associated membranes contribution to exercise-mediated alleviation of hepatic insulin resistance: Contrasting high-intensity interval training with moderate-intensity continuous training in a high-fat diet mouse model. Journal of Diabetes. 2024; 16: e13540.","DOI":"10.1111\/1753-0407.13540"},{"key":"ref62","doi-asserted-by":"publisher","unstructured":"Li M, Zhang Y, Yu G, Gu L, Zhu H, Feng S, et al. Mitochondria-associated endoplasmic reticulum membranes tethering protein VAPB-PTPIP51 protects against ischemic stroke through inhibiting the activation of autophagy. 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