{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:14:04Z","timestamp":1783462444596,"version":"3.55.0"},"reference-count":44,"publisher":"IMR Press","issue":"2","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shenzhen Science and Technology Program","award":["JCYJ20241202130703005"],"award-info":[{"award-number":["JCYJ20241202130703005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>Background: The stage-specific dynamics of functional brain networks in early Parkinson\u2019s disease cognitive impairment (PD-CI) remain unclear. This study investigated caudate-centric hierarchical functional network reconfiguration across early PD-CI stages using simultaneous [18F]fluoropropyl-(+)-dihydrotetrabenazine positron emission tomography (18F-FP-DTBZ PET) and resting-state functional magnetic resonance imaging (rs-fMRI). Methods: Forty-six Parkinson\u2019s disease (PD) patients underwent simultaneous 18F-FP-DTBZ PET\/MR with rs-fMRI sequences. Patients were categorized as normal cognition (PD-NC, n = 15), subjective cognitive decline (PD-SCD, n = 16), and mild cognitive impairment (PD-MCI, n = 15). PET-identified striatal regions with significant dopaminergic deficits were used as seeds for stepwise functional connectivity (SFC) analysis. Associations with cognitive factors and network coupling in early PD-CI were evaluated. Results: 18F-FP-DTBZ PET revealed that the caudate nucleus was a critical dopaminergic hub in early PD-CI. Caudate seed-based SFC analysis revealed a triphasic reconfiguration: stable integration in PD-NC, compensatory hyperconnectivity in PD-SCD, and global inefficiency with rigidity in PD-MCI. Key circuits showed reduced connectivity in PD-MCI including caudate linkages with the globus pallidus, thalamus, right superior frontal gyrus, left inferior temporal gyrus, right superior orbitofrontal cortex, supplementary motor area, and right hippocampus. Clinical analysis showed that both global cognitive efficiency and memory control were associated with specific short- and long-range caudate connectivity. Conclusions: The caudate nucleus is central to the interplay between dopaminergic metabolic deficits and functional network reconfiguration during early PD-CI progression, shifting from compensatory hyperconnectivity to network rigidity. These findings provide a mechanistic framework for targeted neuromodulation strategies in early PD-CI.<\/jats:p>","DOI":"10.31083\/jin46634","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T13:15:17Z","timestamp":1772284517000},"source":"Crossref","is-referenced-by-count":1,"title":["Caudate-Centric Triphasic Network Reconfiguration Characterizes the Early Progression of Cognitive Impairment in Parkinson\u2019s Disease: A Simultaneous PET\/fMRI Study"],"prefix":"10.31083","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9939-6978","authenticated-orcid":true,"given":"Wenli","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology, Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), 518020 Shenzhen, Guangdong, China"},{"name":"Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People\u2019s Hospital, 518020 Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8901-0496","authenticated-orcid":true,"given":"Guoyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), 518020 Shenzhen, Guangdong, China"},{"name":"Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People\u2019s Hospital, 518020 Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5877-4506","authenticated-orcid":true,"given":"Fengju","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), 518020 Shenzhen, Guangdong, China"},{"name":"Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People\u2019s Hospital, 518020 Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0077-5503","authenticated-orcid":true,"given":"Hong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), 518020 Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9804-0899","authenticated-orcid":true,"given":"Long","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), 518020 Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4335-4015","authenticated-orcid":true,"given":"Lei","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), 518020 Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2832-0190","authenticated-orcid":true,"given":"Yutong","family":"Guo","sequence":"additional","affiliation":[{"name":"Shenzhen United Imaging Healthcare Co. 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Patterns of striatal dopamine depletion in early Parkinson disease: Prognostic relevance. Neurology. 2020; 95: e280\u2013e290.","DOI":"10.1212\/WNL.0000000000009878"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Siepel FJ, Br\u00f8nnick KS, Booij J, Ravina BM, Lebedev AV, Pereira JB, et al. Cognitive executive impairment and dopaminergic deficits in de novo Parkinson\u2019s disease. Movement Disorders. 2014; 29: 1802\u20131808.","DOI":"10.1002\/mds.26051"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Ekman U, Eriksson J, Forsgren L, Mo SJ, Riklund K, Nyberg L. Functional brain activity and presynaptic dopamine uptake in patients with Parkinson\u2019s disease and mild cognitive impairment: a cross-sectional study. The Lancet Neurology. 2012; 11: 679\u2013687.","DOI":"10.1016\/S1474-4422(12)70138-2"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Monchi O, Petrides M, Mejia-Constain B, Strafella AP. 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Neurobiology of Aging. 2020; 88: 51\u201360.","DOI":"10.1016\/j.neurobiolaging.2019.12.005"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Fiorenzato E, Strafella AP, Kim J, Schifano R, Weis L, Antonini A, et al. Dynamic functional connectivity changes associated with dementia in Parkinson\u2019s disease. Brain. 2019; 142: 2860\u20132872.","DOI":"10.1093\/brain\/awz192"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Lee B, Cai W, Young CB, Yuan R, Ryman S, Kim J, et al. Latent brain state dynamics and cognitive flexibility in older adults. Progress in Neurobiology. 2022; 208: 102180.","DOI":"10.1016\/j.pneurobio.2021.102180"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Mak E, Su L, Williams GB, Firbank MJ, Lawson RA, Yarnall AJ, et al. Baseline and longitudinal grey matter changes in newly diagnosed Parkinson\u2019s disease: ICICLE-PD study. Brain. 2015; 138: 2974\u20132986.","DOI":"10.1093\/brain\/awv211"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Melzer TR, Watts R, MacAskill MR, Pitcher TL, Livingston L, Keenan RJ, et al. Grey matter atrophy in cognitively impaired Parkinson\u2019s disease. Journal of Neurology, Neurosurgery, and Psychiatry. 2012; 83: 188\u2013194.","DOI":"10.1136\/jnnp-2011-300828"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of Neuroscience. 1986; 9: 357\u2013381.","DOI":"10.1146\/annurev.ne.09.030186.002041"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Uchida Y, Kan H, Sakurai K, Arai N, Kato D, Kawashima S, et al. Voxel-based quantitative susceptibility mapping in Parkinson\u2019s disease with mild cognitive impairment. Movement Disorders. 2019; 34: 1164\u20131173.","DOI":"10.1002\/mds.27717"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"Low A, Foo H, Yong TT, Tan LCS, Kandiah N. Hippocampal subfield atrophy of CA1 and subicular structures predict progression to dementia in idiopathic Parkinson\u2019s disease. Journal of Neurology, Neurosurgery, and Psychiatry. 2019; 90: 681\u2013687.","DOI":"10.1136\/jnnp-2018-319592"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"Marklund P, Larsson A, Elgh E, Linder J, Riklund KA, Forsgren L, et al. Temporal dynamics of basal ganglia under-recruitment in Parkinson\u2019s disease: transient caudate abnormalities during updating of working memory. Brain. 2009; 132: 336\u2013346.","DOI":"10.1093\/brain\/awn309"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"Knudsen EB, Wallis JD. Taking stock of value in the orbitofrontal cortex. Nature Reviews Neuroscience. 2022; 23: 428\u2013438.","DOI":"10.1038\/s41583-022-00589-2"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"Schultz W, Tremblay L, Hollerman JR. Reward processing in primate orbitofrontal cortex and basal ganglia. Cerebral Cortex. 2000; 10: 272\u2013284.","DOI":"10.1093\/cercor\/10.3.272"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"Burke JF, Long NM, Zaghloul KA, Sharan AD, Sperling MR, Kahana MJ. Human intracranial high-frequency activity maps episodic memory formation in space and time. NeuroImage. 2014; 85 Pt 2: 834\u2013843.","DOI":"10.1016\/j.neuroimage.2013.06.067"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"Kim Y, Lee D, Cho KH, Lee JJ, Ham JH, Ye BS, et al. Cognitive and Neuroanatomical Correlates in Early Versus Late Onset Parkinson\u2019s Disease Dementia. Journal of Alzheimer\u2019s Disease. 2017; 55: 485\u2013495.","DOI":"10.3233\/jad-160597"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"Ju P, Zhao D, Ma L, Chen J. Biomarker development perspective: Exploring comorbid chronic pain in depression through deep transcranial magnetic stimulation. Journal of Translational Internal Medicine. 2024; 12: 123\u2013128.","DOI":"10.2478\/jtim-2023-0145"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"Ni Z, Chen R. Transcranial magnetic stimulation to understand pathophysiology and as potential treatment for neurodegenerative diseases. 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