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Animal models, especially rodent-based, are a valuable tool to study brain disorders, including HD. Given the existence of multiple valid and predictive models of HD and other brain disorders, we are now entering a phase of mechanistic discovery, as research shifts towards phenotype-based screening and multi-omic validation. In addition to rodent models, zebrafish (Danio rerio) are rapidly becoming a promising model organism for translational HD research. With considerable genetic homology to humans, embryonic transparency for real-time pathology tracking, physiological similarity to mammals, and high-throughput drug screening potential, zebrafish have become a valuable alternative model organism in translational HD research. Here, we discuss zebrafish HD models, their advantages and limitations, and future directions of translational research in this field.<\/jats:p>","DOI":"10.31083\/jin49403","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:16:31Z","timestamp":1790698591000},"source":"Crossref","is-referenced-by-count":0,"title":["Zebrafish as an Alternative Animal Model of Huntington\u2019s Disease: Challenges and Future Directions"],"prefix":"10.31083","volume":"25","author":[{"given":"Jiahao","family":"Cui","sequence":"first","affiliation":[{"name":"Suzhou Key Laboratory of Neurobiology and Cell Signaling, School of Science, Xi\u2019an Jiaotong-Liverpool University, 215123 Suzhou, Jiangsu, China"},{"name":"Department of Biological Sciences, School of Science, Xi\u2019an Jiaotong-Liverpool University, 215123 Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhili","family":"Yu","sequence":"additional","affiliation":[{"name":"Suzhou Key Laboratory of Neurobiology and Cell Signaling, School of Science, Xi\u2019an Jiaotong-Liverpool University, 215123 Suzhou, Jiangsu, China"},{"name":"Department of Biological Sciences, School of Science, Xi\u2019an Jiaotong-Liverpool University, 215123 Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhike","family":"Fu","sequence":"additional","affiliation":[{"name":"Suzhou Key Laboratory of Neurobiology and Cell Signaling, School of Science, Xi\u2019an Jiaotong-Liverpool University, 215123 Suzhou, Jiangsu, China"},{"name":"Department of Biological Sciences, School of Science, Xi\u2019an Jiaotong-Liverpool University, 215123 Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Pushkina","sequence":"additional","affiliation":[{"name":"Suzhou Key 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murilo S.","family":"de Abreu","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences, Federal University of Health Sciences of Porto Alegre, 90050-170 Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longen","family":"Yang","sequence":"additional","affiliation":[{"name":"Suzhou Key Laboratory of Neurobiology and Cell Signaling, School of Science, Xi\u2019an Jiaotong-Liverpool University, 215123 Suzhou, Jiangsu, China"},{"name":"Department of Biological Sciences, School of Science, Xi\u2019an Jiaotong-Liverpool University, 215123 Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina N.","family":"Perfilova","sequence":"additional","affiliation":[{"name":"Volgograd State Medical University, 400131 Volgograd, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam 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