{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:01:09Z","timestamp":1785412869437,"version":"3.56.0"},"reference-count":20,"publisher":"IMR Press","issue":"7","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Open Fund Program of the Key Laboratory of Anesthesiology and Resuscitation, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China","award":["2024MZFS003"],"award-info":[{"award-number":["2024MZFS003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>Background:Reactive gliosis serves as a characteristic feature of the pathophysiology of Alzheimer\u2019s disease (AD). Nevertheless, the influence of anesthetics on the morphological dynamics of astrocytes remains ambiguous.Methods:Employing ex vivo hippocampal slices, in this study, we explored the impacts of sevoflurane and Amyloid-\u03b2 peptide 1-42 (A\u03b21-42) oligomers on astrocytic morphology. The primary outcomes encompassed the fluorescence intensity of glial fibrillary acidic protein (GFAP), the levels of a 38-kDa GFAP breakdown product (a marker of astroglial injury), and quantitative morphometric analyses (cell volume, surface area, branch complexity, and Sholl intersections).Results:Co-exposure to sevoflurane and A\u03b21-42 led to an elevation of the 38-kDa GFAP breakdown product and a significant reduction in the mean fluorescence intensity of GFAP. Moreover, it resulted in a decrease in astrocytic volume, surface area, branch complexity, and Sholl intersections. These synergistic alterations were not observed when either treatment was administered alone.Conclusions:These findings imply that sevoflurane aggravates A\u03b21-42-induced astrocytic dysfunction, which has implications for perioperative management in patients with AD or those at risk of developing AD.<\/jats:p>","DOI":"10.31083\/jin50442","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:01:26Z","timestamp":1785409286000},"source":"Crossref","is-referenced-by-count":0,"title":["Sevoflurane and A\u03b21-42 Oligomers Synergistically Induce Morphological Changes of Astrocytes in the Hippocampus of Male Mice"],"prefix":"10.31083","volume":"25","author":[{"given":"Qinfang","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, Hubei, China"},{"name":"Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, 430022 Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpit Kumar","family":"Pradhan","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, Hubei, China"},{"name":"Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, 430022 Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Rammes","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, School of Medicine and Health, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany"},{"name":"Graduate School of Systemic Neuroscience, Ludwig Maximilian University of Munich, 82152 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5867-1550","authenticated-orcid":true,"given":"Xingxing","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, 201203 Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Rajmohan R, Reddy PH. 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