{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:02:46Z","timestamp":1785412966756,"version":"3.56.0"},"reference-count":68,"publisher":"IMR Press","issue":"7","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Shanghai","award":["24ZR1463100"],"award-info":[{"award-number":["24ZR1463100"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>Background:Glucagon-like peptide-1 receptor (GLP1R) is a G-protein-coupled receptor recognized for its essential role in metabolic homeostasis and insulin secretion. Emerging evidence suggests that central GLP-1 signaling also modulates sensory information processing and cognitive functions. The thalamic reticular nucleus (TRN) serves as a critical inhibitory hub that filters and prioritizes sensory transmission between the thalamus and the cerebral cortex. We have identified a distinct population of GLP1R-expressing neurons distributed within the TRN; however, their long-range structural connectivity remains largely uncharacterized.Methods:In this study we used Glp1r-Cre mice combined with viral-genetic tracing strategies to map the whole-brain inputs and outputs of GLP1R-linked neurons. To identify direct monosynaptic inputs, a Cre-dependent retrograde rabies virus system was employed. To delineate the efferent axonal projections, a Cre-dependent synaptophysin-based tracing strategy was employed.Results:GLP1R neurons exhibited a distinct rostrocaudal distribution, with most located in the middle region of the TRN. The starter neurons, identified by the colocalization of adeno-associated virus (AAV)-double-floxed inverted orientation (DIO)-enhanced green fluorescent protein (EGFP)-tumor virus A receptor (TVA), AAV-DIO-rabies virus glycoprotein from the CVS-N2c strain (N2cG), and rabies virus (RV)-envelope protein A (EnvA)-glycoprotein-deleted (\u0394G)-mCherry, were primarily located in the TRN. Retrograde-labeled neurons were identified across numerous brain regions. Dense clusters of input neurons were observed in the primary and secondary motor cortices (M1 and M2, respectively) and the primary somatosensory cortex (S1). Substantial inputs were observed, including from the ventrolateral (VL), central lateral (CL), and posterior (Po) thalamic nuclei. Additionally, notable presynaptic labeling was detected in subcortical regions such as the zona incerta (ZI) and lateral hypothalamic area (LH), as well as midbrain structures including the substantia nigra pars reticulata (SNR) and the deep mesencephalic nucleus (DpMe). Anterograde synaptophysin-based mapping revealed that TRNGLP1R neurons selectively project to the ventral medial nucleus (VM), paracentral thalamic nucleus (PC), mediodorsal thalamus, lateral part (MDL), and lateral habenula (LHb) nuclei.Conclusions:The results confirm the existence of complex long-range afferent and efferent circuits associated with TRNGLP1R neurons, providing a morphological basis for studying their role in integrating metabolic states with sensory gating.<\/jats:p>","DOI":"10.31083\/jin52117","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:01:26Z","timestamp":1785409286000},"source":"Crossref","is-referenced-by-count":0,"title":["Brain-Wide Connectivity of GLP1R Neurons in the Thalamic Reticular Nucleus"],"prefix":"10.31083","volume":"25","author":[{"given":"Xiao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Bengbu Medical University, 233004 Bengbu, Anhui, China"},{"name":"Department of Endocrinology, Songjiang Research Institute, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 201699\u200c Shanghai, China"},{"name":"Shanghai Key Laboratory of Emotions and Affective Disorders (LEAD), Shanghai Jiao Tong University School of Medicine, 201699\u200c Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanghui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Bengbu Medical University, 233004 Bengbu, Anhui, China"},{"name":"Department of Endocrinology, Songjiang Research Institute, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 201699\u200c Shanghai, China"},{"name":"Shanghai Key Laboratory of Emotions and Affective Disorders (LEAD), Shanghai Jiao Tong University School of Medicine, 201699\u200c Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangzhong","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Bengbu Medical University, 233004 Bengbu, Anhui, China"},{"name":"Department of Endocrinology, Songjiang Research Institute, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 201699\u200c Shanghai, China"},{"name":"Shanghai Key Laboratory of Emotions and Affective Disorders (LEAD), Shanghai Jiao Tong University School of Medicine, 201699\u200c Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumin","family":"Duan","sequence":"additional","affiliation":[{"name":"Liangzhu Laboratory, Zhejiang University, 311121 Hangzhou, Zhejiang, China"},{"name":"MOE Frontier Science Center for Brain Science & Brain-Machine Integration, Zhejiang University, 311121 Hangzhou, Zhejiang, China"},{"name":"State Key Laboratory of Brain-Machine Intelligence, Zhejiang University, 311121 Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0768-046X","authenticated-orcid":true,"given":"Yong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Songjiang Research Institute, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 201699\u200c Shanghai, China"},{"name":"Shanghai Key Laboratory of Emotions and Affective Disorders (LEAD), Shanghai Jiao Tong University School of Medicine, 201699\u200c Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Bengbu Medical University, 233004 Bengbu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Huguenard JR, Prince DA. A novel T-type current underlies prolonged Ca(2+)-dependent burst firing in GABAergic neurons of rat thalamic reticular nucleus. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience. 1992; 12: 3804\u20133817.","DOI":"10.1523\/JNEUROSCI.12-10-03804.1992"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Kim U, Sanchez-Vives MV, McCormick DA. Functional dynamics of GABAergic inhibition in the thalamus. Science. 1997; 278: 130\u2013134.","DOI":"10.1126\/science.278.5335.130"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"de Biasi S, Frassoni C, Spreafico R. GABA immunoreactivity in the thalamic reticular nucleus of the rat. A light and electron microscopical study. Brain Research. 1986; 399: 143\u2013147.","DOI":"10.1016\/0006-8993(86)90608-6"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Yen CT, Conley M, Hendry SH, Jones EG. The morphology of physiologically identified GABAergic neurons in the somatic sensory part of the thalamic reticular nucleus in the cat. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience. 1985; 5: 2254\u20132268.","DOI":"10.1523\/JNEUROSCI.05-08-02254.1985"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Halassa MM, Acs\u00e1dy L. Thalamic Inhibition: Diverse Sources, Diverse Scales. Trends in Neurosciences. 2016; 39: 680\u2013693.","DOI":"10.1016\/j.tins.2016.08.001"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Fan D, Liao F, Wang Q. The pacemaker role of thalamic reticular nucleus in controlling spike-wave discharges and spindles. Chaos. 2017; 27: 073103.","DOI":"10.1063\/1.4991869"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Halassa MM, Chen Z, Wimmer RD, Brunetti PM, Zhao S, Zikopoulos B, et al. State-dependent architecture of thalamic reticular subnetworks. Cell. 2014; 158: 808\u2013821.","DOI":"10.1016\/j.cell.2014.06.025"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Li Y, Lopez-Huerta VG, Adiconis X, Levandowski K, Choi S, Simmons SK, et al. Distinct subnetworks of the thalamic reticular nucleus. Nature. 2020; 583: 819\u2013824.","DOI":"10.1038\/s41586-020-2504-5"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Bu J, Xu G, Zhou Y. Parvalbumin and Somatostatin Neurons in the Thalamic Reticular Nucleus Modulate Visual Information Processing in V1 of Mouse. Neuroscience Bulletin. 2025; 41: 1824\u20131842.","DOI":"10.1007\/s12264-025-01458-5"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Abdelaal MS, Midorikawa M, Suzuki T, Kobayashi K, Takata N, Miyata M, et al. Dysfunction of parvalbumin-expressing cells in the thalamic reticular nucleus induces cortical spike-and-wave discharges and an unconscious state. Brain Communications. 2022; 4: fcac010.","DOI":"10.1093\/braincomms\/fcac010"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Wang XY, Xu X, Chen R, Jia WB, Xu PF, Liu XQ, et al. The thalamic reticular nucleus-lateral habenula circuit regulates depressive-like behaviors in chronic stress and chronic pain. Cell Reports. 2023; 42: 113170.","DOI":"10.1016\/j.celrep.2023.113170"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Steullet P, Cabungcal JH, Bukhari SA, Ardelt MI, Pantazopoulos H, Hamati F, et al. The thalamic reticular nucleus in schizophrenia and bipolar disorder: role of parvalbumin-expressing neuron networks and oxidative stress. Molecular Psychiatry. 2018; 23: 2057\u20132065.","DOI":"10.1038\/mp.2017.230"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Lee SH, Cox CL. Vasoactive intestinal peptide selectively depolarizes thalamic relay neurons and attenuates intrathalamic rhythmic activity. Journal of Neurophysiology. 2003; 90: 1224\u20131234.","DOI":"10.1152\/jn.00280.2003"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Burgunder JM, Heyberger B, Lauterburg T. Thalamic reticular nucleus parcellation delineated by VIP and TRH gene expression in the rat. Journal of Chemical Neuroanatomy. 1999; 17: 147\u2013152.","DOI":"10.1016\/s0891-0618(99)00033-2"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"McAlonan K, Cavanaugh J, Wurtz RH. Attentional modulation of thalamic reticular neurons. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience. 2006; 26: 4444\u20134450.","DOI":"10.1523\/JNEUROSCI.5602-05.2006"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Wimmer RD, Schmitt LI, Davidson TJ, Nakajima M, Deisseroth K, Halassa MM. Thalamic control of sensory selection in divided attention. Nature. 2015; 526: 705\u2013709.","DOI":"10.1038\/nature15398"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Halassa MM, Siegle JH, Ritt JT, Ting JT, Feng G, Moore CI. Selective optical drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles. Nature Neuroscience. 2011; 14: 1118\u20131120.","DOI":"10.1038\/nn.2880"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Thankachan S, Katsuki F, McKenna JT, Yang C, Shukla C, Deisseroth K, et al. Thalamic Reticular Nucleus Parvalbumin Neurons Regulate Sleep Spindles and Electrophysiological Aspects of Schizophrenia in Mice. Scientific Reports. 2019; 9: 3607.","DOI":"10.1038\/s41598-019-40398-9"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Ni KM, Hou XJ, Yang CH, Dong P, Li Y, Zhang Y, et al. Selectively driving cholinergic fibers optically in the thalamic reticular nucleus promotes sleep. elife. 2016; 5: e10382.","DOI":"10.7554\/eLife.10382"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Jagirdar R, Fu CH, Park J, Corbett BF, Seibt FM, Beierlein M, et al. Restoring activity in the thalamic reticular nucleus improves sleep architecture and reduces A\u03b2 accumulation in mice. Science Translational Medicine. 2021; 13: eabh4284.","DOI":"10.1126\/scitranslmed.abh4284"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Cumpana L, Zanoletti O, Kankanamge D, Copits B, Sandi C, Astori S. Corticotropin-releasing hormone modulates NREM sleep consolidation through the thalamic reticular nucleus. Nature Communications. 2025; 16: 7720.","DOI":"10.1038\/s41467-025-63118-6"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Raos VC, Savaki HE. Functional anatomy of the thalamic reticular nucleus as revealed with the [14C]deoxyglucose method following electrical stimulation and electrolytic lesion. Neuroscience. 1995; 68: 287\u2013297.","DOI":"10.1016\/0306-4522(95)00113-w"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Perissinotti PP, Rivero-Echeto MC, Garcia-Rill E, Bisagno V, Urbano FJ. Leptin alters somatosensory thalamic networks by decreasing gaba release from reticular thalamic nucleus and action potential frequency at ventrobasal neurons. Brain Structure & Function. 2018; 223: 2499\u20132514.","DOI":"10.1007\/s00429-018-1645-x"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Scrocchi LA, Brown TJ, MaClusky N, Brubaker PL, Auerbach AB, Joyner AL, et al. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nature Medicine. 1996; 2: 1254\u20131258.","DOI":"10.1038\/nm1196-1254"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CM, Meeran K, et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature. 1996; 379: 69\u201372.","DOI":"10.1038\/379069a0"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Secher A, Jelsing J, Baquero AF, Hecksher-S\u00f8rensen J, Cowley MA, Dalb\u00f8ge LS, et al. The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss. The Journal of Clinical Investigation. 2014; 124: 4473\u20134488.","DOI":"10.1172\/JCI75276"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Kanoski SE, Fortin SM, Arnold M, Grill HJ, Hayes MR. Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4. Endocrinology. 2011; 152: 3103\u20133112.","DOI":"10.1210\/en.2011-0174"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Gong N, Xiao Q, Zhu B, Zhang CY, Wang YC, Fan H, et al. Activation of spinal glucagon-like peptide-1 receptors specifically suppresses pain hypersensitivity. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience. 2014; 34: 5322\u20135334.","DOI":"10.1523\/JNEUROSCI.4703-13.2014"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Montaner M, Denom J, Jiang W, Magnan C, Trapp S, Gurden H. The local GLP-1 system in the olfactory bulb is required for odor-evoked cephalic phase of insulin release in mice. Molecular Metabolism. 2023; 73: 101738.","DOI":"10.1016\/j.molmet.2023.101738"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Shin YK, Martin B, Golden E, Dotson CD, Maudsley S, Kim W, et al. Modulation of taste sensitivity by GLP-1 signaling. Journal of Neurochemistry. 2008; 106: 455\u2013463.","DOI":"10.1111\/j.1471-4159.2008.05397.x"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Williams EK, Chang RB, Strochlic DE, Umans BD, Lowell BB, Liberles SD. Sensory Neurons that Detect Stretch and Nutrients in the Digestive System. Cell. 2016; 166: 209\u2013221.","DOI":"10.1016\/j.cell.2016.05.011"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Takai S, Yasumatsu K, Inoue M, Iwata S, Yoshida R, Shigemura N, et al. Glucagon-like peptide-1 is specifically involved in sweet taste transmission. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology. 2015; 29: 2268\u20132280.","DOI":"10.1096\/fj.14-265355"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"McClean PL, H\u00f6lscher C. Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP\/PS1 mice, a model of Alzheimer's disease. Neuropharmacology. 2014; 76: 57\u201367.","DOI":"10.1016\/j.neuropharm.2013.08.005"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"McClean PL, Parthsarathy V, Faivre E, H\u00f6lscher C. The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience. 2011; 31: 6587\u20136594.","DOI":"10.1523\/JNEUROSCI.0529-11.2011"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"During MJ, Cao L, Zuzga DS, Francis JS, Fitzsimons HL, Jiao X, et al. Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. Nature Medicine. 2003; 9: 1173\u20131179.","DOI":"10.1038\/nm919"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Cork SC, Richards JE, Holt MK, Gribble FM, Reimann F, Trapp S. Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain. Molecular Metabolism. 2015; 4: 718\u2013731.","DOI":"10.1016\/j.molmet.2015.07.008"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"Lein ES, Hawrylycz MJ, Ao N, Ayres M, Bensinger A, Bernard A, et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature. 2007; 445: 168\u2013176.","DOI":"10.1038\/nature05453"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"Zikopoulos B, Barbas H. Prefrontal projections to the thalamic reticular nucleus form a unique circuit for attentional mechanisms. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience. 2006; 26: 7348\u20137361.","DOI":"10.1523\/JNEUROSCI.5511-05.2006"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"Kakei S, Na J, Shinoda Y. Thalamic terminal morphology and distribution of single corticothalamic axons originating from layers 5 and 6 of the cat motor cortex. The Journal of Comparative Neurology. 2001; 437: 170\u2013185.","DOI":"10.1002\/cne.1277"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"Graham DL, Durai HH, Trammell TS, Noble BL, Mortlock DP, Galli A, et al. A novel mouse model of glucagon-like peptide-1 receptor expression: A look at the brain. The Journal of Comparative Neurology. 2020; 528: 2445\u20132470.","DOI":"10.1002\/cne.24905"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"Crabtree JW. Functional Diversity of Thalamic Reticular Subnetworks. Frontiers in Systems Neuroscience. 2018; 12: 41.","DOI":"10.3389\/fnsys.2018.00041"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"Williamson RS, Polley DB. Parallel pathways for sound processing and functional connectivity among layer 5 and 6 auditory corticofugal neurons. elife. 2019; 8: e42974.","DOI":"10.7554\/eLife.42974"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"Bourassa J, Pinault D, Desch\u00eanes M. Corticothalamic projections from the cortical barrel field to the somatosensory thalamus in rats: a single-fibre study using biocytin as an anterograde tracer. The European Journal of Neuroscience. 1995; 7: 19\u201330.","DOI":"10.1111\/j.1460-9568.1995.tb01016.x"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"Bourassa J, Desch\u00eanes M. Corticothalamic projections from the primary visual cortex in rats: a single fiber study using biocytin as an anterograde tracer. Neuroscience. 1995; 66: 253\u2013263.","DOI":"10.1016\/0306-4522(95)00009-8"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"Liu Y, Bech P, Tamura K, D\u00e9lez LT, Crochet S, Petersen CCH. Cell class-specific long-range axonal projections of neurons in mouse whisker-related somatosensory cortices. elife. 2024; 13: RP97602.","DOI":"10.7554\/eLife.97602"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"Einav A, Azouz R. Corticothalamic modulation of somatosensory thalamic tactile processing. The Journal of Physiology. 2025; 603: 2801\u20132819.","DOI":"10.1113\/JP287526"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"Mo C, Sherman SM. A Sensorimotor Pathway via Higher-Order Thalamus. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience. 2019; 39: 692\u2013704.","DOI":"10.1523\/JNEUROSCI.1467-18.2018"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"Wang W, Andolina IM, Lu Y, Jones HE, Sillito AM. Focal Gain Control of Thalamic Visual Receptive Fields by Layer 6 Corticothalamic Feedback. Cerebral Cortex. 2018; 28: 267\u2013280.","DOI":"10.1093\/cercor\/bhw376"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"Crandall SR, Cruikshank SJ, Connors BW. A corticothalamic switch: controlling the thalamus with dynamic synapses. Neuron. 2015; 86: 768\u2013782.","DOI":"10.1016\/j.neuron.2015.03.040"},{"key":"ref50","doi-asserted-by":"publisher","unstructured":"Kim A, Latchoumane C, Lee S, Kim GB, Cheong E, Augustine GJ, et al. Optogenetically induced sleep spindle rhythms alter sleep architectures in mice. Proceedings of the National Academy of Sciences of the United States of America. 2012; 109: 20673\u201320678.","DOI":"10.1073\/pnas.1217897109"},{"key":"ref51","doi-asserted-by":"publisher","unstructured":"Steriade M, Timofeev I. Neuronal plasticity in thalamocortical networks during sleep and waking oscillations. Neuron. 2003; 37: 563\u2013576.","DOI":"10.1016\/s0896-6273(03)00065-5"},{"key":"ref52","doi-asserted-by":"publisher","unstructured":"Hua MH, Chen YL, Chen MH, Huang KL, Hsu JW, Bai YM, et al. Network-Specific Corticothalamic Dysconnection in Attention-Deficit Hyperactivity Disorder. Journal of Developmental and Behavioral Pediatrics. 2021; 42: 122\u2013127.","DOI":"10.1097\/DBP.0000000000000875"},{"key":"ref53","doi-asserted-by":"publisher","unstructured":"Trenado C, Haab L, Strauss DJ. Corticothalamic feedback dynamics for neural correlates of auditory selective attention. IEEE Transactions on Neural Systems and Rehabilitation Engineering: a Publication of the IEEE Engineering in Medicine and Biology Society. 2009; 17: 46\u201352.","DOI":"10.1109\/TNSRE.2008.2010469"},{"key":"ref54","doi-asserted-by":"publisher","unstructured":"Sunahara M, Rios A, Kawabata M, Kato S, Hamada S, Ohtsuka T, et al. Temporally Coordinated Activity among Motor Cortex, Thalamus, and Thalamic Reticular Nucleus Neurons during Rat Forelimb Movements. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience. 2026; 46: e1827252026.","DOI":"10.1523\/JNEUROSCI.1827-25.2026"},{"key":"ref55","doi-asserted-by":"publisher","unstructured":"Jennings JH, Rizzi G, Stamatakis AM, Ung RL, Stuber GD. The inhibitory circuit architecture of the lateral hypothalamus orchestrates feeding. Science (New York, N.Y.). 2013; 341: 1517\u20131521.","DOI":"10.1126\/science.1241812"},{"key":"ref56","doi-asserted-by":"publisher","unstructured":"Burdakov D, Karnani MM, Gonzalez A. Lateral hypothalamus as a sensor-regulator in respiratory and metabolic control. Physiology & Behavior. 2013; 121: 117\u2013124.","DOI":"10.1016\/j.physbeh.2013.03.023"},{"key":"ref57","doi-asserted-by":"publisher","unstructured":"Burt J, Alberto CO, Parsons MP, Hirasawa M. Local network regulation of orexin neurons in the lateral hypothalamus. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2011; 301: R572\u2013R580.","DOI":"10.1152\/ajpregu.00674.2010"},{"key":"ref58","doi-asserted-by":"publisher","unstructured":"Saper CB, Chou TC, Scammell TE. The sleep switch: hypothalamic control of sleep and wakefulness. Trends in Neurosciences. 2001; 24: 726\u2013731.","DOI":"10.1016\/s0166-2236(00)02002-6"},{"key":"ref59","doi-asserted-by":"publisher","unstructured":"Liu K, Kim J, Kim DW, Zhang YS, Bao H, Denaxa M, et al. Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep. Nature. 2017; 548: 582\u2013587.","DOI":"10.1038\/nature23663"},{"key":"ref60","doi-asserted-by":"publisher","unstructured":"Zhang X, van den Pol AN. Rapid binge-like eating and body weight gain driven by zona incerta GABA neuron activation. Science (New York, N.Y.). 2017; 356: 853\u2013859.","DOI":"10.1126\/science.aam7100"},{"key":"ref61","doi-asserted-by":"publisher","unstructured":"Falasconi A, Arber S. Basal ganglia-brainstem interactions. Current Biology. 2025; 35: R1004\u2013R1010.","DOI":"10.1016\/j.cub.2025.07.019"},{"key":"ref62","doi-asserted-by":"publisher","unstructured":"Chen ZK, Dong H, Liu CW, Liu WY, Zhao YN, Xu W, et al. A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy. Cell Discovery. 2022; 8: 115.","DOI":"10.1038\/s41421-022-00456-5"},{"key":"ref63","doi-asserted-by":"publisher","unstructured":"Foster NN, Barry J, Korobkova L, Garcia L, Gao L, Becerra M, et al. The mouse cortico-basal ganglia-thalamic network. Nature. 2021; 598: 188\u2013194.","DOI":"10.1038\/s41586-021-03993-3"},{"key":"ref64","doi-asserted-by":"publisher","unstructured":"Velayos JL, Reinoso-Su\u00e1rez F. Prosencephalic afferents to the mediodorsal thalamic nucleus. The Journal of Comparative Neurology. 1985; 242: 161\u2013181.","DOI":"10.1002\/cne.902420203"},{"key":"ref65","doi-asserted-by":"publisher","unstructured":"de Bourbon-Teles J, Bentley P, Koshino S, Shah K, Dutta A, Malhotra P, et al. Thalamic control of human attention driven by memory and learning. Current Biology. 2014; 24: 993\u2013999.","DOI":"10.1016\/j.cub.2014.03.024"},{"key":"ref66","doi-asserted-by":"publisher","unstructured":"Groos D, Helmchen F. The lateral habenula: A hub for value-guided behavior. Cell Reports. 2024; 43: 113968.","DOI":"10.1016\/j.celrep.2024.113968"},{"key":"ref67","doi-asserted-by":"publisher","unstructured":"Michel L, Molina P, Mameli M. The behavioral relevance of a modular organization in the lateral habenula. Neuron. 2024; 112: 2669\u20132685.","DOI":"10.1016\/j.neuron.2024.04.026"},{"key":"ref68","doi-asserted-by":"publisher","unstructured":"Merchant W, Tinajero A, Khan A, Chu Y, Saleh S, Tasabehji D, et al. RYGB induces vagal sensory neuropathy characterized by altered Glp1r expression and enhanced exendin-4 responsiveness in male mice. American Journal of Physiology. 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