{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:02:21Z","timestamp":1790701341149,"version":"4.1.0"},"reference-count":40,"publisher":"IMR Press","issue":"9","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>Contemporary neuroscience increasingly conceptualizes the self as a dynamic neurocognitive process supported by interacting cortical hubs and large-scale networks. In this Opinion, we introduce self-configuration as a provisional, hypothesis-generating construct: a time-bounded, context-sensitive pattern across self-referential appraisal, interoceptive monitoring, autobiographical framing, and self-other orientation. It is not a validated scale, diagnosis, or neural biomarker and must be distinguished empirically from established constructs such as trait neuroticism, rumination, depressive symptoms, and self-transcendence. We use a heuristic continuum between a rigid, self-focused pole and a flexible, prosocial pole. Evidence supports the component psychological processes and network functions, but no study has directly linked the integrated construct to dementia risk or resilience. Accordingly, regional mappings, disease-specific emphases, and candidate manipulations are presented as falsifiable hypotheses rather than mechanisms or clinical recommendations. The framework is intended to guide multimethod construct validation and longitudinal or experimental testing, not to represent an evidence-based model of dementia risk or prevention.<\/jats:p>","DOI":"10.31083\/jin52204","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:16:31Z","timestamp":1790698591000},"source":"Crossref","is-referenced-by-count":0,"title":["Crossing the Bar of \u2018Self\u2019\u2014A Hypothesis-Generating Value-Based Framework for Dementia Risk and Resilience"],"prefix":"10.31083","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1733-3429","authenticated-orcid":true,"given":"Souvik","family":"Dubey","sequence":"first","affiliation":[{"name":"Department of Neuromedicine, Bangur Institute of Neurosciences, IPGMER & SSKM Hospital, 700020 Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahua Jana","family":"Dubey","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Berhampore Mental Hospital, 742101 West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samya","family":"Sengupta","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine, Bangur Institute of Neurosciences, IPGMER & SSKM Hospital, 700020 Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9075-2000","authenticated-orcid":true,"given":"Shambaditya","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine, Manipal Hospitals Broadway, 700106 Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8192-0807","authenticated-orcid":true,"given":"Ritwik","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Burdwan Medical College & Hospital, 713104 Burdwan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3555-4412","authenticated-orcid":true,"given":"Subhankar","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Metabolism, Medical College & Hospital, 700073 Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1769-4809","authenticated-orcid":true,"given":"Juli\u00e1n","family":"Benito-Le\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Neurology, 12 de Octubre University Hospital, 28041 Madrid, Spain"},{"name":"Group of Neurodegenerative Diseases, Hospital Universitario 12 de Octubre Research Institute (imas12), 28041 Madrid, Spain"},{"name":"Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28029 Madrid, Spain"},{"name":"Department of Medicine, Faculty of Medicine, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Yaden DB, Haidt J, Hood RW Jr, Vago DR, Newberg AB. 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