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Integr. Neurosci."],"abstract":"<jats:p>Background:Though succinate accumulation is a vital contributor to overexcitation and reactive oxygen species (ROS) production, whether it contributes to febrile seizures (FS) is unclear. We sought to mechanistically explore the role of succinate in prolonged FS.Methods:Prolonged FS were induced by hyperthermic treatment in Sprague-Dawley pups. Inhibitors of succinate dehydrogenase (SDH), purine nucleotide cycle (PNC), and malate\/aspartate shuttle (MAS) were administered, respectively. Succinate levels and oxidative stress damage were assessed, and epileptic seizures and learning and memory ability were assessed after hyperthermic treatment.Results:Succinate levels increased significantly, accompanied by oxidative stress injury, seizures, and learning and memory defects, following prolonged FS. Treatment with the SDH inhibitor reduced succinate levels, accompanied by reduced levels of oxidative stress injury, attenuated seizures, and learning and memory deficits. Treatment with inhibitors of MAS and PNC, respectively, played similar protective roles, accompanied by decreased succinate levels.Conclusions:Increased succinate levels promote prolonged FS-induced oxidative stress injury and epileptogenesis. Reducing succinate accumulation may be a potential method for prolonged FS treatment. Moreover, elevated succinate levels may result from the reverse catalysis of SDH-targeting fumarate, which was produced from PNC and MAS.<\/jats:p>","DOI":"10.31083\/jin53240","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:01:26Z","timestamp":1785409286000},"source":"Crossref","is-referenced-by-count":0,"title":["Role of Succinate Accumulation in Prolonged Febrile Seizure-Induced Neuronal Injury and Epileptic Seizures in Sprague-Dawley Rats"],"prefix":"10.31083","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3680-694X","authenticated-orcid":true,"given":"Yi","family":"Yuan","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Shandong Medical and Pharmaceutical University, 264003 Yantai, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2490-2626","authenticated-orcid":true,"given":"Xiaoqian","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Shandong Medical and Pharmaceutical University, 264003 Yantai, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6302-3441","authenticated-orcid":true,"given":"Hua","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Shandong Medical and Pharmaceutical University, 264003 Yantai, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8433-9188","authenticated-orcid":true,"given":"Yunrong","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Shandong Medical and Pharmaceutical University, 264003 Yantai, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3001-6941","authenticated-orcid":true,"given":"Xiangdong","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Shandong Medical and Pharmaceutical University, 264003 Yantai, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8028-5571","authenticated-orcid":true,"given":"Shuping","family":"Yin","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Shandong Medical and Pharmaceutical University, 264003 Yantai, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6839-0025","authenticated-orcid":true,"given":"Beiqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Shandong Medical and Pharmaceutical University, 264003 Yantai, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9590-2270","authenticated-orcid":true,"given":"Qiaoyun","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Shandong Medical and Pharmaceutical University, 264003 Yantai, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9317-4178","authenticated-orcid":true,"given":"Shuang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Yantai Affiliated Hospital of Shandong Medical and Pharmaceutical University, 264100 Yantai, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4753-5219","authenticated-orcid":true,"given":"Hongliu","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Shandong Medical and Pharmaceutical University, 264003 Yantai, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0505-5349","authenticated-orcid":true,"given":"Yan","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yantai Affiliated Hospital of Shandong Medical and Pharmaceutical University, 264100 Yantai, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Gould L, Delavale V, Plovnick C, Wisniewski T, Devinsky O. Are brief febrile seizures benign? A systematic review and narrative synthesis. Epilepsia. 2023; 64: 2539\u20132549.","DOI":"10.1111\/epi.17720"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Harris SA, George AG, Barrett KT, Scantlebury MH, Teskey GC. Febrile seizures lead to prolonged epileptiform activity and hyperoxia that when blocked prevents learning deficits. Epilepsia. 2022; 63: 2650\u20132663.","DOI":"10.1111\/epi.17371"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Suga T, Yoshida T, Yokoyama A, Hanami Y, Ashina K, Nakamura N, et al. Prolonged Febrile Seizure and Long-Term Neurological Sequelae in Otherwise Healthy Children. Annals of Neurology. 2025; 97: 688\u2013693.","DOI":"10.1002\/ana.27192"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Lewis DV, Voyvodic J, Shinnar S, Chan S, Bello JA, Mosh\u00e9 SL, et al. Hippocampal sclerosis and temporal lobe epilepsy following febrile status epilepticus: The FEBSTAT study. Epilepsia. 2024; 65: 1568\u20131580.","DOI":"10.1111\/epi.17979"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Leitner DF, William C, Faustin A, Kanshin E, Snuderl M, McGuone D, et al. Raphe and ventrolateral medulla proteomics in sudden unexplained death in childhood with febrile seizure history. Acta Neuropathologica. 2024; 148: 76.","DOI":"10.1007\/s00401-024-02832-9"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Paul SP, Kirkham EN, Shirt B. Recognition and management of febrile convulsion in children. Nursing Standard. 2015; 29: 36\u201343.","DOI":"10.7748\/ns.29.52.36.e9927"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Moavero R, Santarone ME, Galasso C, Curatolo P. Cognitive and behavioral effects of new antiepileptic drugs in pediatric epilepsy. 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Experimental Neurology. 2021; 341: 113707.","DOI":"10.1016\/j.expneurol.2021.113707"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Oh CJ, Kim MJ, Lee JM, Kim DH, Kim IY, Park S, et al. Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion. Kidney International. 2023; 104: 724\u2013739.","DOI":"10.1016\/j.kint.2023.06.022"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Tabata Fukushima C, Dancil IS, Clary H, Shah N, Nadtochiy SM, Brookes PS. Reactive oxygen species generation by reverse electron transfer at mitochondrial complex I under simulated early reperfusion conditions. Redox Biology. 2024; 70: 103047.","DOI":"10.1016\/j.redox.2024.103047"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Tretter L, Patocs A, Chinopoulos C. Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis. Biochimica et Biophysica Acta. 2016; 1857: 1086\u20131101.","DOI":"10.1016\/j.bbabio.2016.03.012"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Andrienko TN, Pasdois P, Pereira GC, Ovens MJ, Halestrap AP. The role of succinate and ROS in reperfusion injury - A critical appraisal. Journal of Molecular and Cellular Cardiology. 2017; 110: 1\u201314.","DOI":"10.1016\/j.yjmcc.2017.06.016"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Mills EL, Kelly B, Logan A, Costa ASH, Varma M, Bryant CE, et al. Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages. Cell. 2016; 167: 457\u2013470.e13.","DOI":"10.1016\/j.cell.2016.08.064"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Chen B, Feng B, Tang Y, You Y, Wang Y, Hou W, et al. Blocking GluN2B subunits reverses the enhanced seizure susceptibility after prolonged febrile seizures with a wide therapeutic time-window. Experimental Neurology. 2016; 283: 29\u201338.","DOI":"10.1016\/j.expneurol.2016.05.034"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Wu D, Feng B, Dai Y, Wu X, Chen B, Xu C, et al. Intergenerational Transmission of Enhanced Seizure Susceptibility after Febrile Seizures. EBioMedicine. 2017; 17: 206\u2013215.","DOI":"10.1016\/j.ebiom.2017.02.006"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Zhang M, Cheng Y, Zhai Y, Cui Y, Zhang W, Sun H, et al. Attenuated succinate accumulation relieves neuronal injury induced by hypoxia in neonatal mice. Cell Death Discovery. 2022; 8: 138.","DOI":"10.1038\/s41420-022-00940-7"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Zhang M, Cheng Y, Zhai Y, Yuan Y, Hu H, Meng X, et al. Attenuated iron stress and oxidative stress may participate in anti-seizure and neuroprotective roles of xenon in pentylenetetrazole-induced epileptogenesis. Frontiers in Cellular Neuroscience. 2022; 16: 1007458.","DOI":"10.3389\/fncel.2022.1007458"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Zhang H, Jiao W, Cui H, Sun Q, Fan H. Combined exposure of alumina nanoparticles and chronic stress exacerbates hippocampal neuronal ferroptosis via activating IFN-\u03b3\/ASK1\/JNK signaling pathway in rats. Journal of Hazardous Materials. 2021; 411: 125179.","DOI":"10.1016\/j.jhazmat.2021.125179"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Yu LM, Zhang WH, Han XX, Li YY, Lu Y, Pan J, et al. Hypoxia-Induced ROS Contribute to Myoblast Pyroptosis during Obstructive Sleep Apnea via the NF-\u03baB\/HIF-1\u03b1 Signaling Pathway. Oxidative Medicine and Cellular Longevity. 2019; 2019: 4596368.","DOI":"10.1155\/2019\/4596368"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"He G, Nie JJ, Liu X, Ding Z, Luo P, Liu Y, et al. Zinc oxide nanoparticles inhibit osteosarcoma metastasis by downregulating \u03b2-catenin via HIF-1\u03b1\/BNIP3\/LC3B-mediated mitophagy pathway. Bioactive Materials. 2022; 19: 690\u2013702.","DOI":"10.1016\/j.bioactmat.2022.05.006"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Treiman DM. GABAergic mechanisms in epilepsy. Epilepsia. 2001; 42: 8\u201312.","DOI":"10.1046\/j.1528-1157.2001.042suppl.3008.x"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Bal\u00e1zs R, Machiyama Y, Hammond BJ, Julian T, Richter D. The operation of the gamma-aminobutyrate bypath of the tricarboxylic acid cycle in brain tissue in vitro. The Biochemical Journal. 1970; 116: 445\u2013461.","DOI":"10.1042\/bj1160445"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Bouch\u00e9 N, Fait A, Bouchez D, M\u00f8ller SG, Fromm H. Mitochondrial succinic-semialdehyde dehydrogenase of the gamma-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100: 6843\u20136848.","DOI":"10.1073\/pnas.1037532100"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Zeevalk GD, Derr-Yellin E, Nicklas WJ. Relative vulnerability of dopamine and GABA neurons in mesencephalic culture to inhibition of succinate dehydrogenase by malonate and 3-nitropropionic acid and protection by NMDA receptor blockade. The Journal of Pharmacology and Experimental Therapeutics. 1995; 275: 1124\u20131130.","DOI":"10.1016\/S0022-3565(25)12162-9"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Perone I, Ghena N, Wang J, Mackey C, Wan R, Malla S, et al. Mitochondrial SIRT3 Deficiency Results in Neuronal Network Hyperexcitability, Accelerates Age-Related A\u03b2 Pathology, and Renders Neurons Vulnerable to A\u03b2 Toxicity. Neuromolecular Medicine. 2023; 25: 27\u201339.","DOI":"10.1007\/s12017-022-08713-2"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"Del Arroyo AG, Hadjihambi A, Sanchez J, Turovsky E, Kasymov V, Cain D, et al. NMDA receptor modulation of glutamate release in activated neutrophils. EBioMedicine. 2019; 47: 457\u2013469.","DOI":"10.1016\/j.ebiom.2019.08.004"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"Doser RL, Knight KM, Deihl EW, Hoerndli FJ. Activity-dependent mitochondrial ROS signaling regulates recruitment of glutamate receptors to synapses. elife. 2024; 13: e92376.","DOI":"10.7554\/eLife.92376"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"Parsons ALM, Bucknor EMV, Castroflorio E, Soares TR, Oliver PL, Rial D. The Interconnected Mechanisms of Oxidative Stress and Neuroinflammation in Epilepsy. Antioxidants. 2022; 11: 157.","DOI":"10.3390\/antiox11010157"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"Korshunov SS, Skulachev VP, Starkov AA. High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Letters. 1997; 416: 15\u201318.","DOI":"10.1016\/s0014-5793(97)01159-9"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"Moos WH, Faller DV, Glavas IP, Kanara I, Kodukula K, Pernokas J, et al. Epilepsy: Mitochondrial connections to the 'Sacred' disease. Mitochondrion. 2023; 72: 84\u2013101.","DOI":"10.1016\/j.mito.2023.08.002"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"Valdez LB, Zaobornyj T, Bandez MJ, L\u00f3pez-Cepero JM, Boveris A, Navarro A. Complex I syndrome in striatum and frontal cortex in a rat model of Parkinson disease. Free Radical Biology & Medicine. 2019; 135: 274\u2013282.","DOI":"10.1016\/j.freeradbiomed.2019.03.001"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"Chen B, Xu C, Wang Y, Lin W, Wang Y, Chen L, et al. A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy. Nature Communications. 2020; 11: 923.","DOI":"10.1038\/s41467-020-14648-8"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"Hassel B, Sonnewald U. Selective inhibition of the tricarboxylic acid cycle of GABAergic neurons with 3-nitropropionic acid in vivo. Journal of Neurochemistry. 1995; 65: 1184\u20131191.","DOI":"10.1046\/j.1471-4159.1995.65031184.x"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"Urbanska EM, Blaszczak P, Saran T, Kleinrok Z, Turski WA. Mitochondrial toxin 3-nitropropionic acid evokes seizures in mice. European Journal of Pharmacology. 1998; 359: 55\u201358.","DOI":"10.1016\/s0014-2999(98)00648-7"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"Easlon E, Tsang F, Skinner C, Wang C, Lin SJ. The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast. Genes & Development. 2008; 22: 931\u2013944.","DOI":"10.1101\/gad.1648308"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"Sridharan V, Guichard J, Li CY, Muise-Helmericks R, Beeson CC, Wright GL. O(2)-sensing signal cascade: clamping of O(2) respiration, reduced ATP utilization, and inducible fumarate respiration. American Journal of Physiology. Cell Physiology. 2008; 295: C29\u2013C37.","DOI":"10.1152\/ajpcell.00466.2007"},{"key":"ref48","unstructured":"Moreno de Flagge N. Crisis febriles simples y complejas, epilepsia generalizada con crisis febriles plus, FIRES y nuevos s\u00edndromes [Simple febrile seizure, complex seizure, generalized epilepsy with febrile seizure plus, FIRES and new syndromes]. Medicina. 2013; 73: 63\u201370. 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