{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:00:17Z","timestamp":1790701217370,"version":"4.1.0"},"reference-count":116,"publisher":"IMR Press","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Integr. Neurosci."],"abstract":"<jats:p>Early behavioral features associated with autism spectrum disorder (ASD) are frequently examined within separate motor, sensory, and social domains rather than as interacting components of a developing neurobiological system. In this article, we present a hypothesis-driven conceptual framework proposing that variation in developmental timing and coordination across neural, motor, and interpersonal systems may contribute to differences in early social developmental trajectories. Drawing on evidence from fetal, infant, and early childhood development, we consider how hemispheric specialization, interhemispheric coordination, oscillatory synchronization, corticalization of motor control, and dyadic interaction timing may jointly influence the emergence of motor organization and social engagement. From this perspective, persistent primitive reflex expression, atypical motor asymmetry, increased motor variability, and differences in dyadic synchrony are discussed as candidate developmental indicators that may reflect broader variation in neural timing and coordination. Within this framework, we further consider how genetic, neurobiological, and environmental factors associated with ASD risk may converge on developmental timing processes expressed through neural communication, motor regulation, and social interaction. Rather than proposing a deterministic causal sequence, the present account examines how variation in motor-social interaction may influence opportunities for social learning through recurrent cycles of action, perception, prediction, and caregiver feedback. We advance a set of empirically testable developmental hypotheses linking neural timing measures, motor organization indices, reflex integration profiles, and dyadic interaction metrics within prospective longitudinal research designs. Specifically, the framework predicts that variation in early neural timing and coordination will be associated with differences in motor organization and motor-social coupling, which may in turn relate to later social developmental outcomes. By emphasizing developmental timing, coordination, and reciprocal interaction across neural, motor, and interpersonal systems, this conceptual framework is intended not as a causal account of ASD, but a hypothesis-generating developmental model that organizes existing evidence while generating explicit, empirically testable predictions regarding relationships among neural timing, motor organization, and early social interaction.<\/jats:p>","DOI":"10.31083\/jin54429","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:16:31Z","timestamp":1790698591000},"source":"Crossref","is-referenced-by-count":0,"title":["Toward a Developmental Timing Framework for Autism: Linking Hemispheric Asymmetry, Motor Organization, and Motor-Social Coupling"],"prefix":"10.31083","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9975-7331","authenticated-orcid":true,"given":"Gerry","family":"Leisman","sequence":"first","affiliation":[{"name":"Movement and Cognition Laboratory, Department of Physical Therapy, University of Haifa, 3498838 Haifa, Israel"},{"name":"Resonance Therapeutics Laboratory, Department of Neurology, University of the Medical Sciences of Havana, 10600 Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4405-0192","authenticated-orcid":true,"given":"Robert","family":"Melillo","sequence":"additional","affiliation":[{"name":"Movement and Cognition Laboratory, Department of Physical Therapy, University of Haifa, 3498838 Haifa, Israel"},{"name":"Center for Developing Minds, Rockville Centre, NY 11570, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Adolphs R. 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