{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:51:39Z","timestamp":1792759899192,"version":"4.5.0"},"reference-count":27,"publisher":"IMR Press","issue":"7","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Urakami Scholarship Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmazie"],"abstract":"<jats:p>Background:Dry eye disease (DED) is a multifactorial ocular surface condition that causes damage and discomfort, significantly impairing the quality of life of patients. Recently, phytochemicals such as trans-resveratrol (Res) have attracted growing interest due to their potential therapeutic effects against the DED-related pathophysiology. To enable the therapeutic application of water-insoluble Res, this study aimed to evaluate the efficacy of a previously developed water-soluble micelle formulation (stPEG\/Res) containing polyethylene glycol monostearate (stPEG) in treating DED.Methods:The antioxidant activity of stPEG\/Res was assessed using the 2,2-diphenyl-1-picrylhydrazyl radical-scavenging assay, and its cytotoxicity was evaluated in a human corneal epithelial cell line. Furthermore, an in vivo efficacy study was performed using a mouse model of DED induced by lacrimal gland excision. Tear volume, corneal histopathological changes, inflammatory responses, and apoptosis in the cornea were evaluated.Results:The stPEG\/Res formulation exhibited antioxidant activity and a cytotoxicity profile against corneal epithelial cells comparable to that of free Res. Furthermore, in the mouse model of DED, stPEG\/Res alleviated dry eye symptoms not by restoring tear volume, but by suppressing inflammation and apoptosis in the cornea.Conclusions:These findings indicate that stPEG\/Res has potential as a novel therapeutic option for corneal disorders associated with DED.<\/jats:p>","DOI":"10.31083\/pharmazie53494","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:42:49Z","timestamp":1785411769000},"source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic Potential of Water-Soluble Resveratrol-Loaded Polyethylene Glycol Monostearate Micelles in a Mouse Model of Dry Eye Disease"],"prefix":"10.31083","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9892-3465","authenticated-orcid":true,"given":"Aoi","family":"Machida","sequence":"first","affiliation":[{"name":"Graduate School of Pharmacy and Pharmaceutical Sciences, Fukuyama University, 729-0292 Fukuyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0226-6614","authenticated-orcid":true,"given":"Kengo","family":"Banshoya","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, 729-0292 Fukuyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riko","family":"Okada","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, 729-0292 Fukuyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kameda","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, 729-0292 Fukuyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, 729-0292 Fukuyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8496-9641","authenticated-orcid":true,"given":"Sachi","family":"Shibata","sequence":"additional","affiliation":[{"name":"Faculty of Health and Welfare Science, Okayama Prefectural University, 719-1197 Soja, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9381-1440","authenticated-orcid":true,"given":"Yoshiharu","family":"Kaneo","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, 729-0292 Fukuyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8515-6973","authenticated-orcid":true,"given":"Tetsuro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, 729-0292 Fukuyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0940-8523","authenticated-orcid":true,"given":"Masatoshi","family":"Ohnishi","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmacy and Pharmaceutical Sciences, Fukuyama University, 729-0292 Fukuyama, Japan"},{"name":"Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, 729-0292 Fukuyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Ben\u00edtez-Del-Castillo J, Labetoulle M, Baudouin C, Rolando M, Akova YA, Aragona P, et al. 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