{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:33:34Z","timestamp":1761294814241,"version":"3.41.2"},"reference-count":5,"publisher":"IMR Press","issue":"1","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Background: Postpartum cardiomyopathy is defined as an incident of acute heart failure in the postpartum period in the absence of any other cause. Up to 10% of postpartum cardiomyopathy may need to undergo heart transplantation later in life. This study aimed to provide a present-day perspective on all-cause mortality and transplant-related complications after heart transplantation for postpartum cardiomyopathy. Methods: A retrospective analysis of the United Network for Organ Sharing (UNOS) registry was performed for adult patients undergoing heart transplants (01\/2001\u201301\/2023) for postpartum cardiomyopathy. Results: A total of 677 patients were identified, with a mean age of 35 years. The mean body mass index (BMI) was 27.2 kg\/m2; the most common comorbidity was type 2 diabetes (T2D) (n = 589; 87%). Older age was associated with lower overall mortality (hazard ratio (HR): 0.97; 95% CI: 0.95, 0.98; p &lt; 0.01), while diabetes (HR: 1.01; 95% CI: 1.01, 1.01; p &lt; 0.01), dialysis (HR: 1.01; 95% CI: 1.01, 1.01; p &lt; 0.01), days on Status 1 on the UNOS registry (HR: 1.06; 95% CI: 1.03, 10.9; p &lt; 0.01), creatinine (HR: 1.29; 95% CI: 1.02, 1.64; p = 0.034), and length of stay (HR: 1.01; 95% CI: 1.01, 1.02; p = 0.02) were associated with a higher risk of overall mortality. Moreover, 30-day mortality was 2.8%, and 1-year mortality was 11.1%. The era effect was prominent in cases of 1-year mortality (odds ratio (OR): 0.95; 95% CI: 0.91, 0.99, p = 0.006). Conclusions: Our results suggest that younger age, diabetes, pretransplant dialysis, days on Status 1, and creatinine are associated with higher mortality, while an era effect was observed for 1-year mortality after heart transplantation (HTx) in patients with postpartum cardiomyopathy.<\/jats:p>","DOI":"10.31083\/rcm25831","type":"journal-article","created":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T10:40:09Z","timestamp":1737801609000},"source":"Crossref","is-referenced-by-count":1,"title":["Nationwide Outcomes of Heart Transplantation for Postpartum Cardiomyopathy"],"prefix":"10.31083","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4128-7111","authenticated-orcid":true,"given":"Ilias P.","family":"Doulamis","sequence":"first","affiliation":[{"name":"Department of Surgery, Lahey Clinic, Burlington, MA 01805, USA"},{"name":"Divison of Cardiothoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aspasia","family":"Tzani","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Brigham and Women\u2019s Hospital Heart and Vascular Center, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Kilic","sequence":"first","affiliation":[{"name":"Divison of Cardiothoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Kuno","sequence":"first","affiliation":[{"name":"Division of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandros","family":"Briasoulis","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Section of Heart Failure and Transplantation, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Mielniczuk LM, Williams K, Davis DR, Tang ASL, Lemery R, Green MS, et al. Frequency of peripartum cardiomyopathy. The American Journal of Cardiology. 2006; 97: 1765\u20131768.","DOI":"10.1016\/j.amjcard.2006.01.039"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"McNamara DM, Elkayam U, Alharethi R, Damp J, Hsich E, Ewald G, et al. Clinical Outcomes for Peripartum Cardiomyopathy in North America: Results of the IPAC Study (Investigations of Pregnancy-Associated Cardiomyopathy). Journal of the American College of Cardiology. 2015; 66: 905\u2013914.","DOI":"10.1016\/j.jacc.2015.06.1309"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Rasmusson KD, Stehlik J, Brown RN, Renlund DG, Wagoner LE, Torre-Amione G, et al. Long-term outcomes of cardiac transplantation for peri-partum cardiomyopathy: a multiinstitutional analysis. The Journal of Heart and Lung Transplantation: the Official Publication of the International Society for Heart Transplantation. 2007; 26: 1097\u20131104.","DOI":"10.1016\/j.healun.2007.08.002"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Bouabdallaoui N, Demondion P, Mar\u00e9chaux S, Varnous S, Lebreton G, Mouquet F, et al. Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience. Arquivos Brasileiros De Cardiologia. 2018; 110: 181\u2013187.","DOI":"10.5935\/abc.20180014"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Kwon JH, Tedford RJ, Ramu B, Witer LJ, Pope NH, Houston BA, et al. Heart Transplantation for Peripartum Cardiomyopathy: Outcomes Over 3 Decades. The Annals of Thoracic Surgery. 2022; 114: 650\u2013658.","DOI":"10.1016\/j.athoracsur.2021.12.059"}],"container-title":["Reviews in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/26\/1\/10.31083\/RCM25831","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T10:50:34Z","timestamp":1737802234000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/26\/1\/10.31083\/RCM25831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,9]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"alternative-id":["S1530-6550(24)01633-8"],"URL":"https:\/\/doi.org\/10.31083\/rcm25831","relation":{},"ISSN":["1530-6550","2153-8174"],"issn-type":[{"type":"print","value":"1530-6550"},{"type":"electronic","value":"2153-8174"}],"subject":[],"published":{"date-parts":[[2025,1,9]]},"article-number":"25831"}}