{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:00:55Z","timestamp":1778814055284,"version":"3.51.4"},"reference-count":45,"publisher":"IMR Press","issue":"9","license":[{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023475","name":"Fundaci\u00f3n Interhospitalaria para la Investigaci\u00f3n Cardiovascular","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100023475","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Background: There is evidence that pacemaker implantation can trigger Takotsubo syndrome (TTS). However, limited information is available on the prognosis of TTS caused by this trigger, so our study aims to elucidate the clinical features, presentation, and prognostic factors associated with this syndrome in this specific situation. Methods: We analyzed a group of patients with TTS triggered by pacemaker implantation (n = 41), including consecutive cases from the multicenter registry on takotsubo syndrome (RETAKO) and patients identified through a systematic literature search, and compared them to the general RETAKO cohort (n = 1559). We performed a 1:3 propensity score matching (PSM) based on dyslipidemia, diabetes mellitus, smoker\/ex-smoker status, syncope, angina, vagal symptoms, and physical\/mixed trigger, generating two balanced groups. Results: Compared to other triggers, TTS associated with pacemaker implantation was linked to a longer corrected QT interval (551.2 ms vs. 502.5 ms, p = 0.005), lower left ventricular ejection fraction (34.8% vs. 47.3%, p &lt; 0.001), a higher proportion of acute kidney injury (29.3% vs. 11.0%, p = 0.001), and an increased rate of cardiogenic shock (20.6% vs. 8.8%, p = 0.029). However, there were no differences in all-cause mortality (12.2% vs. 13.1%, p = 0.858) or TTS recurrence (0.0% vs. 3.9%, p = 0.639). After PSM, the previously observed differences were no longer present, with no significant differences in death or recurrences. Conclusions: TTS following pacemaker implantation predominantly presents with greater rates of cardiogenic shock and acute kidney injury, without differences in all-cause mortality or TTS recurrence. After PSM, no differences were found regarding cardiovascular outcomes, suggesting that the physical nature of the trigger could account for the initial differences observed.<\/jats:p>","DOI":"10.31083\/rcm39440","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T03:04:17Z","timestamp":1760151857000},"source":"Crossref","is-referenced-by-count":2,"title":["Takotsubo Syndrome in the Setting of Pacemaker Implantation: Results From a Multicenter National Prospective Registry"],"prefix":"10.31083","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5671-4755","authenticated-orcid":true,"given":"Gonzalo","family":"Garc\u00eda-Mart\u00ed","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico San Carlos, IdISSC, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7337-0593","authenticated-orcid":true,"given":"Ravi","family":"Vazirani","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico San Carlos, IdISSC, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5062-3335","authenticated-orcid":true,"given":"\u00d3scar","family":"Vedia","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Universitario de Torrej\u00f3n, 28850 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8662-3791","authenticated-orcid":true,"given":"Agust\u00edn","family":"Mart\u00edn-Garc\u00eda","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario de Salamanca, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6911-7480","authenticated-orcid":true,"given":"Aitor","family":"Uribarri","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Universitario Vall d\u00b4Hebron, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1437-2414","authenticated-orcid":true,"given":"Miguel","family":"Corb\u00ed-Pascual","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital General Universitario de Albacete, 02006 Albacete, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6157-679X","authenticated-orcid":true,"given":"Emilia","family":"Blanco-Ponce","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Universitario Arnau de Vilanova, 25198 L\u00e9rida, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3603-8433","authenticated-orcid":true,"given":"Juan M. Escudier","family":"Villa","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Universitario Puerta de Hierro, 28222 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3462-4183","authenticated-orcid":true,"given":"Rafael","family":"S\u00e1nchez-Del Hoyo","sequence":"first","affiliation":[{"name":"Research Methodological Support Unit and Preventive Department, Hospital Cl\u00ednico San Carlos, IdISSC, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2492-2873","authenticated-orcid":true,"given":"Clara Fern\u00e1ndez","family":"Cord\u00f3n","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario de Valladolid, 47003 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7144-4782","authenticated-orcid":true,"given":"Manuel","family":"Almendro-Delia","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Universitario Virgen de Macarena, 41009 Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6454-7644","authenticated-orcid":true,"given":"Victor M","family":"Becerra","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Regional Universitario de M\u00e1laga, 29010 M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5879-0012","authenticated-orcid":true,"given":"Alberto","family":"P\u00e9rez Castellanos","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Universitario Son Espases, 07120 Palma de Mallorca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3345-2356","authenticated-orcid":true,"given":"Marta","family":"Guillen Marzo","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Universitario Joan XXIII, 43005 Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Alonso","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7480-2511","authenticated-orcid":true,"given":"Fernando","family":"Alfonso","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Universitario La Princesa, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1779-3102","authenticated-orcid":true,"given":"Iv\u00e1n J.","family":"N\u00fa\u00f1ez-Gil","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Universitario de Torrej\u00f3n, 28850 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2025,9,28]]},"reference":[{"key":"ref1","unstructured":"Sato H, Tateishi H, Uchida T. Takotsubo-type cardiomyopathy due to multivessel spasm. In Kodama K, Haze K, Hon M (eds.) Clinical aspect of myocardial injury: From ischemia to heart failure (pp. 56\u201364). Kagakuhyouronsya Co.: Tokyo. 1990. (In Japanese)"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"N\u00fa\u00f1ez-Gil IJ, Almendro-Delia M, Andr\u00e9s M, Sionis A, Martin A, Bastante T, et al. Secondary forms of Takotsubo cardiomyopathy: A whole different prognosis. European Heart Journal. Acute Cardiovascular Care. 2016; 5: 308\u2013316.","DOI":"10.1177\/2048872615589512"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Vazirani R, Blanco-Ponce E, Almendro Delia M, Mart\u00edn-Garcia AC, Fern\u00e1ndez-Cord\u00f3n C, Uribarri A, et al. Peripartum Takotsubo Cardiomyopathy: A Review and Insights from a National Registry. Journal of Cardiovascular Development and Disease. 2024; 11: 37.","DOI":"10.3390\/jcdd11020037"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Jasti JR, Petrasko P, Stys VA, Petrasko MF, Saad Shaukat MH, Stys A. Complete Heart Block Causing Takotsubo Syndrome: A Case Report. Cureus. 2022; 14: e24759.","DOI":"10.7759\/cureus.24759"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Kurisu S, Inoue I, Kawagoe T, Ishihara M, Shimatani Y, Hata T, et al. Persistent left ventricular dysfunction in takotsubo cardiomyopathy after pacemaker implantation. Circulation Journal: Official Journal of the Japanese Circulation Society. 2006; 70: 641\u2013644.","DOI":"10.1253\/circj.70.641"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Niewinski P, Walczak T, Kr\u00f3licki T, Kudla T, Jagielski D, Nowak K, et al. Frailty and cognitive impairment are predictive of takotsubo syndrome following pacemaker implantation. Pacing and Clinical Electrophysiology: PACE. 2020; 43: 730\u2013736.","DOI":"10.1111\/pace.13920"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Strangio A, Leo I, Sabatino J, Romano LR, Critelli C, Canino G, et al. Takotsubo Syndrome after Pacemaker Implantation: A Systematic Review. Reviews in Cardiovascular Medicine. 2022; 23: 401.","DOI":"10.31083\/j.rcm2312401"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"N\u00fa\u00f1ez Gil IJ, Andr\u00e9s M, Almendro Delia M, Sionis A, Mart\u00edn A, Bastante T, et al. Characterization of Tako-tsubo Cardiomyopathy in Spain: Results from the RETAKO National Registry. Revista Espanola De Cardiologia (English Ed.). 2015; 68: 505\u2013512.","DOI":"10.1016\/j.rec.2014.07.026"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Kinbara T, Hayano T, Otani N, Furutani Y, Murakami T, Yano M. An autopsy case of tako-tsubo cardiomyopathy presenting ventricular tachycardia after pacemaker implantation. Journal of Cardiology Cases. 2013; 8: 134\u2013137.","DOI":"10.1016\/j.jccase.2013.06.007"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Boghdadi G, Bassily E. Takotsubo Cardiomyopathy in the Setting of Hypertrophic Cardiomyopathy Following Pacemaker Implantation. Cureus. 2023; 15: e36812.","DOI":"10.7759\/cureus.36812"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Moinudddin I, Anjum I, Zia U, Bila Zia M, Ali S. A rare case of permanent pacemaker-induced takotsubo cardiomyopathy in a male patient. Qatar Medical Journal. 2022; 2022: 4.","DOI":"10.5339\/qmj.2022.4"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Wakatsuki D, Asano T, Mase H, Kurata M, Suzuki H. A case of takotsubo cardiomyopathy developing ventricular fibrillation after a pacemaker implantation. Journal of Cardiology Cases. 2020; 21: 149\u2013152.","DOI":"10.1016\/j.jccase.2019.12.002"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Tiritilli A, Tritar A, Rehal K, Iaria P, Benali T, Olezac AS, et al. Unusual cause of Takotsubo cardiomyopathy after pacemaker implantation. Annales De Cardiologie et D\u2019angeiologie. 2018; 67: 374\u2013380.","DOI":"10.1016\/j.ancard.2018.09.005"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Wei ZH, Dai Q, Wu H, Song J, Wang L, Xu B. Takotsubo cardiomyopathy after pacemaker implantation. Journal of Geriatric Cardiology: JGC. 2018; 15: 246\u2013248.","DOI":"10.11909\/j.issn.1671-5411.2018.03.010"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Dashwood A, Rahman A, Marashi HA, Jennings C, Raniga M, Dhillon P. Pacemaker-induced takotsubo cardiomyopathy. HeartRhythm Case Reports. 2016; 2: 272\u2013276.","DOI":"10.1016\/j.hrcr.2016.02.005"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Postema PG, Wiersma JJ, van der Bilt IAC, Dekkers P, van Bergen PFMM. Takotsubo cardiomyopathy shortly following pacemaker implantation-case report and review of the literature. Netherlands Heart Journal: Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation. 2014; 22: 456\u2013459.","DOI":"10.1007\/s12471-012-0320-8"},{"key":"ref17","unstructured":"Dias A, Franco E, Usatii V. Stress-induced cardiomyopathy shortly after pacemaker placement. The Journal of Invasive Cardiology. 2013; 25: E207\u20139."},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Bonfantino MV, Balzano A, Volpe C, Antonelli G, Santoro G, Corlian\u00f2 L. Tako-tsubo syndrome during an attempt of pacemaker implantation in a patient with persistent left superior vena cava and absent right superior vena cava. Giornale Italiano Di Cardiologia (2006). 2012; 13: 132\u2013135.  (In Italian)","DOI":"10.1714\/1021.11147"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Gardini A, Fracassi F, Boldi E, Albiero R. Apical ballooning syndrome (takotsubo cardiomyopathy) after permanent dual-chamber pacemaker implantation. Case Reports in Cardiology. 2012; 2012: 308580.","DOI":"10.1155\/2012\/308580"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Mazurek JA, Gundewar S, Ji SY, Grushko M, Krumerman A. Left ventricular apical ballooning syndrome after pacemaker implantation in a male. Journal of Cardiology Cases. 2011; 3: e154\u2013e158.","DOI":"10.1016\/j.jccase.2011.03.001"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Brunetti ND, Ieva R, Correale M, De Gennaro L, Pellegrino PL, Dioguardi E, et al. Combined exogenous and endogenous catecholamine release associated with Tako-Tsubo like syndrome in a patient with atrio-ventricular block undergoing pace-maker implantation. Acute Cardiac Care. 2011; 13: 112\u2013114.","DOI":"10.3109\/17482941.2011.553236"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Golzio PG, Anselmino M, Presutti D, Cerrato E, Bollati M, Gaita F. Takotsubo cardiomyopathy as a complication of pacemaker implantation. Journal of Cardiovascular Medicine (Hagerstown, Md.). 2011; 12: 754\u2013760.","DOI":"10.2459\/JCM.0b013e3283403563"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Kohnen RF, Baur LHB. A Dutch case of a takotsubo cardiomyopathy after pacemaker implantation. Netherlands Heart Journal: Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation. 2009; 17: 487\u2013490.","DOI":"10.1007\/BF03086309"},{"key":"ref24","unstructured":"Abu Sham\u2019a RAH, Asher E, Luria D, Berger M, Glikson M. Apical ballooning syndrome: a complication of dual chamber pacemaker implantation. Indian Pacing and Electrophysiology Journal. 2009; 9: 229\u2013232."},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Chun SG, Kwok V, Pang DK, Lau TK. Transient left ventricular apical ballooning syndrome (takotsubo cardiomyopathy) as a complication of permanent pacemaker implantation. International Journal of Cardiology. 2007; 117: e27\u201330.","DOI":"10.1016\/j.ijcard.2006.11.125"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Uribarri A, N\u00fa\u00f1ez-Gil IJ, Conty DA, Vedia O, Almendro-Delia M, Duran Cambra A, et al. Short- and Long-Term Prognosis of Patients With Takotsubo Syndrome Based on Different Triggers: Importance of the Physical Nature. Journal of the American Heart Association. 2019; 8: e013701.","DOI":"10.1161\/JAHA.119.013701"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Vazirani R, Rodr\u00edguez-Gonz\u00e1lez M, Castellano-Martinez A, Andr\u00e9s M, Uribarri A, Corb\u00ed-Pascual M, et al. Pediatric takotsubo cardiomyopathy: A review and insights from a National Multicentric Registry. Heart Failure Reviews. 2024; 29: 739\u2013750.","DOI":"10.1007\/s10741-024-10394-x"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"N\u00fa\u00f1ez-Gil IJ, Vedia O, Almendro-Delia M, Raposeiras-Roub\u00edn S, Sionis A, Martin-Garc\u00eda AC, et al. Takotsubo syndrome and cancer, clinical and prognostic implications, insights of RETAKO. Medicina Clinica. 2020; 155: 521\u2013528.","DOI":"10.1016\/j.medcli.2020.01.033"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Wang X, Pei J, Hu X. The Brain-Heart Connection in Takotsubo Syndrome: The Central Nervous System, Sympathetic Nervous System, and Catecholamine Overload. Cardiology Research and Practice. 2020; 2020: 4150291.","DOI":"10.1155\/2020\/4150291"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Verschure DO, van Eck-Smit BLF, Somsen GA, Verberne HJ. Cardiac sympathetic activity in hypertrophic cardiomyopathy and Tako-tsubo cardiomyopathy. Clinical and Translational Imaging. 2015; 3: 379\u2013385.","DOI":"10.1007\/s40336-015-0133-z"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Paur H, Wright PT, Sikkel MB, Tranter MH, Mansfield C, O\u2019Gara P, et al. High levels of circulating epinephrine trigger apical cardiodepression in a \u03b22-adrenergic receptor\/Gi-dependent manner: a new model of Takotsubo cardiomyopathy. Circulation. 2012; 126: 697\u2013706.","DOI":"10.1161\/CIRCULATIONAHA.112.111591"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Miyahara K, Miyazaki S, Tada H. Silent takotsubo cardiomyopathy after cryoballoon ablation. Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 2019; 21: 1662.","DOI":"10.1093\/europace\/euz185"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Kadosaka T, Kamiya K, Nagai T, Anzai T. Takotsubo Syndrome After Transcatheter Mitral Valve Repair. Circulation Journal: Official Journal of the Japanese Circulation Society. 2021; 85: 1100.","DOI":"10.1253\/circj.CJ-21-0107"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Del-Carpio Munoz F, Gharacholou SM, Scott CG, Nkomo VT, Lopez-Jimenez F, Cha YM, et al. Prolonged Ventricular Conduction and Repolarization During Right Ventricular Stimulation Predicts Ventricular Arrhythmias and Death in Patients With Cardiomyopathy. JACC. Clinical Electrophysiology. 2017; 3: 1580\u20131591.","DOI":"10.1016\/j.jacep.2017.06.003"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"Braschi A, Frasheri A, Lombardo RM, Abrignani MG, Lo Presti R, Vinci D, et al. Association between Tpeak-Tend\/QT and major adverse cardiovascular events in patients with Takotsubo syndrome. Acta Cardiologica. 2021; 76: 732\u2013738.","DOI":"10.1080\/00015385.2020.1776012"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Vazirani R, Mart\u00ednez E, Uribarri A, Blanco-Ponce E, Mart\u00ednez-Sell\u00e9s M, Corb\u00ed-Pascual M, et al. Repolarization parameters and ventricular arrhythmias in Takotsubo syndrome: A substudy from the RETAKO national registry. Heart Rhythm O2. 2023; 4: 517\u2013519.","DOI":"10.1016\/j.hroo.2023.06.008"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"El-Battrawy I, Santoro F, Stiermaier T, M\u00f6ller C, Guastafierro F, Novo G, et al. Prevalence, management, and outcome of adverse rhythm disorders in takotsubo syndrome: insights from the international multicenter GEIST registry. Heart Failure Reviews. 2020; 25: 505\u2013511.","DOI":"10.1007\/s10741-019-09856-4"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"N\u00fa\u00f1ez-Gil IJ, Feltes GI, Mej\u00eda-Renter\u00eda HD, Biagioni C, De Agust\u00edn JA, Vivas D, et al. Transient apical dyskinesia with a pacemaker: Electrocardiographic features. Revista Portuguesa De Cardiologia: Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology: an Official Journal of the Portuguese Society of Cardiology. 2015; 34: 289.e1\u2013289.e4.","DOI":"10.1016\/j.repc.2014.09.008"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"Almendro-Delia M, L\u00f3pez-Flores L, Uribarri A, Vedia O, Blanco-Ponce E, L\u00f3pez-Flores MDC, et al. Recovery of Left Ventricular Function and Long-Term Outcomes in Patients With Takotsubo Syndrome. Journal of the American College of Cardiology. 2024; 84: 1163\u20131174.","DOI":"10.1016\/j.jacc.2024.05.075"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"Camblor-Blasco A, Nu\u00f1ez-Gil IJ, Duran Cambra A, Almendro-Delia M, R\u00f3denas-Alesina E, Fern\u00e1ndez-Cordon C, et al. Prognostic Utility of Society for Cardiovascular Angiography and Interventions Shock Stage Approach for Classifying Cardiogenic Shock Severity in Takotsubo Syndrome. Journal of the American Heart Association. 2024; 13: e032951.","DOI":"10.1161\/JAHA.123.032951"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"Aweimer A, Dietrich JW, Santoro F, F\u00e0bregas MC, M\u00fcgge A, N\u00fa\u00f1ez-Gil IJ, et al. Takotsubo syndrome outcomes predicted by thyroid hormone signature: insights from cluster analysis of a multicentre registry. EBioMedicine. 2024; 102: 105063.","DOI":"10.1016\/j.ebiom.2024.105063"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"Vazirani R, Delia MA, Blanco-Ponce E, Mart\u00edn-Garc\u00eda AC, Fern\u00e1ndez-Cord\u00f3n C, Uribarri A, et al. Renal impairment and outcome in Takotsubo syndrome: Insights from a national multicentric cohort. International Journal of Cardiology. 2024; 405: 131971.","DOI":"10.1016\/j.ijcard.2024.131971"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"Brunetti ND, Tarantino N, Guastafierro F, De Gennaro L, Correale M, Stiermaier T, et al. 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