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Accumulating evidence over recent decades has unequivocally established that epigenetic modifications, most prominently DNA methylation, play a pivotal, non-redundant role in the initiation, development, and progression of CVDs. As a critical molecular bridge linking genetic predisposition, environmental insults, and the pathogenesis of CVDs, DNA methylation dynamically mediates crosstalk among these three components, thereby emerging as a core focus for dissecting the underlying pathological mechanisms of CVDs. Thus, this review summarizes the functional roles of DNA methylation in common CVDs, including coronary heart disease (CHD), hypertension, and heart failure (HF). Special emphasis is placed on the regulatory mechanisms of DNA methylation in driving disease pathogenesis, as well as the associated translational potential for preventing CVDs and for clinical management. Moreover, this review delineates the specific pathways through which DNA methylation modulates CVDs onset and progression\u2014providing a novel perspective for in-depth investigation of disease etiologies\u2014and offers a robust theoretical basis for identifying novel therapeutic targets for CVDs. Ultimately, these insights aim to lay a foundation for the optimization and innovation of clinical diagnostic and therapeutic strategies for CVDs.<\/jats:p>","DOI":"10.31083\/rcm46194","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:31:56Z","timestamp":1777458716000},"source":"Crossref","is-referenced-by-count":1,"title":["DNA Methylation: A Key Epigenetic Regulator of Cardiovascular Diseases"],"prefix":"10.31083","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6622-4558","authenticated-orcid":true,"given":"Weihai","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Suzhou Ninth People's Hospital, Suzhou Ninth Hospital Affiliated to Soochow University, 215200 Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5219-1368","authenticated-orcid":true,"given":"Xiangxiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Suzhou Ninth People's Hospital, Suzhou Ninth Hospital Affiliated to Soochow University, 215200 Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[{"name":"Laboratories of Thrombosis and Vascular Biology, Suzhou Ninth Hospital Affiliated to Soochow University, 215200 Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"ref1","unstructured":"World Heart Federation. 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