{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T01:59:41Z","timestamp":1785117581404,"version":"3.55.0"},"reference-count":73,"publisher":"IMR Press","issue":"5","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Cardiovascular disease (CVD) is the most common cause of morbidity and excess mortality in patients with diabetes. However, CVD risk varies across the different forms of diabetes mellitus owing to underlying pathobiological mechanisms. In the asymptomatic phase of prediabetes and early stages of type 2 diabetes mellitus (T2DM)\u2014the most common form of diabetes\u2014CVD may already be established; meanwhile, the first diagnosis of T2DM in some patients may be established only when the patients are evaluated for risk factors contributing to CVD. In contrast, type 1 diabetes mellitus (T1DM) typically presents with symptoms at the disease onset and is usually associated with a low prevalence and risk for CVD at the time of diagnosis. With good metabolic control, the CVD risk in patients with T1DM can be mitigated to some extent. While the pathophysiology and prognosis of CVD among patients with T2DM have been extensively studied and are well characterized, important uncertainties remain regarding these aspects in patients with T1DM. This clinical update review compiles the current evidence base for the evaluation and management of CVD in patients with T1DM.<\/jats:p>","DOI":"10.31083\/rcm46826","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T01:28:22Z","timestamp":1785115702000},"source":"Crossref","is-referenced-by-count":0,"title":["Type 1 Diabetes and Cardiovascular Risk: The Current Management Strategies"],"prefix":"10.31083","volume":"27","author":[{"given":"Rohit Jacob","family":"Manoj","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Aster DM Healthcare, 8703 Dubai, U.A.E."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarthy","family":"Aravind","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Buckingham Medical School, MK18 1EG Buckingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius J","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Pilgrim Hospital, United Lincolnshire Hospitals NHS Trust, PE21 9QS Boston, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0886-5255","authenticated-orcid":true,"given":"Joseph M","family":"Pappachan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Countess of Chester Hospital NHS Trust, CH2 1UL Chester, UK"},{"name":"Faculty of Science, Manchester Metropolitan University, M15 6BH Manchester, UK"},{"name":"Department of Endocrinology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, 576104 Manipal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Colom C, Rull A, Sanchez-Quesada JL, P\u00e9rez A. 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Diabetologia. 2023; 66: 425\u2013437.","DOI":"10.1007\/s00125-022-05857-5"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Haji M, Erqou S, Fonarow GC, Echouffo-Tcheugui JB. Type 1 diabetes and risk of heart failure: a systematic review and meta-analysis. Diabetes Research and Clinical Practice. 2023; 202: 110805.","DOI":"10.1016\/j.diabres.2023.110805"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Avdic T, Eliasson B, Rawshani A, Boren J, Gerstein HC, Nordanstig J, et al. Non-coronary arterial outcomes in people with type 1 diabetes mellitus: a Swedish retrospective cohort study. The Lancet Regional Health. Europe. 2024; 39: 100852.","DOI":"10.1016\/j.lanepe.2024.100852"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"Guo S, Huang Y, Liu X, Ma J, Zhu W. Association of type 1 diabetes mellitus and risk of atrial fibrillation: systematic review and meta-analysis. Diabetes Research and Clinical Practice. 2023; 199: 110629.","DOI":"10.1016\/j.diabres.2023.110629"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Grigoriou K, Karakasis P, Pamporis K, Theofilis P, Patoulias D, Karagiannidis E, et al. Atrial fibrillation in diabetes: Pathogenesis and targeted rhythm control strategies. Current Issues in Molecular Biology. 2025; 47: 559.","DOI":"10.3390\/cimb47070559"},{"key":"ref37","unstructured":"Inside Precision Medicine. Adult-onset type 1 diabetes increases cardiovascular risk. 2025. Available at: https:\/\/www.insideprecisionmedicine.com\/topics\/patient-care\/adult-onset-type-1-diabetes-increases-cardiovascular-risk\/ (Accessed: 12 December 2025)."},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"Diabetes Control and Complications Trial (DCCT)\/Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Group. Intensive Diabetes Treatment and Cardiovascular Outcomes in Type 1 Diabetes: The DCCT\/EDIC Study 30-Year Follow-up. Diabetes Care. 2016; 39: 686\u2013693.","DOI":"10.2337\/dc15-1990"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"Dastjerdi P, Hosseini Mohammadi NS, Anaraki N, Rahmati S, Nikfar R, Momeni S, et al. Estimated glucose disposal rate and risk of cardiovascular events in type 1 diabetes: a systematic review and meta-analysis. Diabetology & Metabolic Syndrome. 2025; 17: 348.","DOI":"10.1186\/s13098-025-01900-8"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"Purnell JQ, Braffett BH, Zinman B, Gubitosi-Klug RA, Sivitz W, Bantle JP, et al. Impact of excessive weight gain on cardiovascular outcomes in type 1 diabetes: results from the Diabetes Control and Complications Trial\/Epidemiology of Diabetes Interventions and Complications Study. Diabetes Care. 2017; 40: 1756\u20131762.","DOI":"10.2337\/dc16-2523"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"Koufakis T, Patoulias D, Zografou I, Papanas N, Popovic DS. Drawing lines in the sand: The growing threat of obesity in type 1 diabetes. World Journal of Diabetes. 2024; 15: 823\u2013827.","DOI":"10.4239\/wjd.v15.i5.823"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"Yu MG, Shah H, Jangolla S, Gauthier J, Viebranz E, Wu IH, et al. Risk and protective factors for coronary atherosclerosis and myocardial dysfunction in individuals with long-duration type 1 diabetes. Diabetologia. 2025; 68: 2581\u20132594.","DOI":"10.1007\/s00125-025-06521-4"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"Shojaei S, Radkhah H, Azarboo A, Soltani P, Esteki S, Mousavi A. Linking Estimated Glucose Disposal Rate to Major Adverse Cardio-Cerebrovascular Events in Populations With and Without Diabetes: A Systematic Review and Meta-Analysis. Clinical Medicine Insights. Endocrinology and Diabetes. 2025; 18: 11795514251372702.","DOI":"10.1177\/11795514251372702"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"Sullivan AJ, Wragg A, Rathod K. Diabetes and the heart. Clinical Medicine. 2025; 26: 100513.","DOI":"10.1016\/j.clinme.2025.100513"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"Huxley RR, Peters SAE, Mishra GD, Woodward M. Risk of all-cause mortality and vascular events in women versus men with type 1 diabetes: a systematic review and meta-analysis. The Lancet. Diabetes & Endocrinology. 2015; 3: 198\u2013206.","DOI":"10.1016\/S2213-8587(14)70248-7"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"Chiesa ST, Marcovecchio ML. Preventing Cardiovascular Complications in Type 1 Diabetes: The Need for a Lifetime Approach. Frontiers in Pediatrics. 2021; 9: 696499.","DOI":"10.3389\/fped.2021.696499"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"Taageby Nielsen S, Luo J, Tybj\u00e6rg-Hansen A, Iversen K, Bundgaard H, Qvist Thomassen J, et al. Preeclampsia, gestational hypertension, and cardiovascular disease risk: a genetic epidemiological study. European Heart Journal. 2025; 46: 4316\u20134325.","DOI":"10.1093\/eurheartj\/ehaf565"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"Vi\u00f1als C, Conget I, Granados M, Sol\u00e0 C, Ayala D, Mesa A, et al. Factors Involved in the Progression of Preclinical Atherosclerosis in People with Type 1 Diabetes. Journal of Clinical Medicine. 2025; 14: 6004.","DOI":"10.3390\/jcm14176004"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"Riasat MH, Nafees S, Malik S, Rahman S, Lopez K, Abdulhadi O, Wright N, Chikhal R, Benamer S. Eligible but Untreated: Gaps in Statin Therapy for Type 1 Diabetes Under the National Institute for Health and Care Excellence (NICE) Guidelines. Cureus. 2025; 17: e98557.","DOI":"10.7759\/cureus.98557"},{"key":"ref50","doi-asserted-by":"publisher","unstructured":"Lithovius R, Mutter S, Parente EB, Harjutsalo V, Groop PH; FinnDiane Study Group. Adherence to cardio-protective medications and cardiovascular disease in adults with type 1 diabetes. Diabetes Research and Clinical Practice. 2024; 215: 111794.  .","DOI":"10.1016\/j.diabres.2024.111794"},{"key":"ref51","doi-asserted-by":"publisher","unstructured":"J\u00e4rvisalo MJ, Putto-Laurila A, Jartti L, Lehtim\u00e4ki T, Solakivi T, R\u00f6nnemaa T, et al. Carotid artery intima-media thickness in children with type 1 diabetes. Diabetes. 2002; 51: 493\u2013498.","DOI":"10.2337\/diabetes.51.2.493"},{"key":"ref52","doi-asserted-by":"publisher","unstructured":"Mashaba RG, Phoswa W, Maimela E, Lebelo S, Modjadji P, Mokgalaboni K. 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Cardiovascular Imaging. 2022; 23: 1210\u20131221.","DOI":"10.1093\/ehjci\/jeab135"},{"key":"ref55","doi-asserted-by":"publisher","unstructured":"Paliares IC, Dualib PM, Torres LSN, Aroucha PMT, de Almeida-Pititto B, de Sa JR, et al. Evaluation of the Steno Type 1 Risk Engine in predicting cardiovascular events in an ethnic mixed population of type 1 diabetes mellitus and its association with chronic microangiopathy complications. Cardiovascular Diabetology. 2024; 23: 374.","DOI":"10.1186\/s12933-024-02460-3"},{"key":"ref56","doi-asserted-by":"publisher","unstructured":"Konduracka E, Cie\u015blik G, Ma\u0142ecki MT, Gajos G, Siniarski A, Malinowski KP, et al. Obstructive and nonobstructive coronary artery disease in long-lasting type 1 diabetes: a 7-year prospective cohort study. Polish Archives of Internal Medicine. 2019; 129: 97\u2013105.","DOI":"10.20452\/pamw.4440"},{"key":"ref57","doi-asserted-by":"publisher","unstructured":"Zhang J, Fang X, Ye Q, Yin X, Ye D. The shared genetic architecture underlying the autoimmune and cardiovascular disease: a multivariate genome-wide analysis. Cardiovascular Diabetology. 2026; 25: 44.","DOI":"10.1186\/s12933-025-03041-8"},{"key":"ref58","doi-asserted-by":"publisher","unstructured":"Lipes MA, Galderisi A. Cardiac autoimmunity as a novel biomarker, mediator, and therapeutic target of heart disease in type 1 diabetes. Current Diabetes Reports. 2015; 15: 30.","DOI":"10.1007\/s11892-015-0598-1"},{"key":"ref59","doi-asserted-by":"publisher","unstructured":"Erqou S, Shahab A, Fayad FH, Haji M, Yuyun MF, Joseph J, et al. Cardiovascular Risk Prediction Scores in Type 1 Diabetes: A Systematic Review and Meta-Analysis. JACC. Advances. 2024; 4: 101462.","DOI":"10.1016\/j.jacadv.2024.101462"},{"key":"ref60","doi-asserted-by":"publisher","unstructured":"James S, Perry L, Lowe J, Harris M, Colman PG, Craig ME, et al. 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Epicardial and intra-thoracic adipose tissue and cardiovascular calcifications in type 1 diabetes (T1D) in epidemiology of diabetes Interventions and Complications (EDIC): A pilot study. American Journal of Preventive Cardiology. 2024; 18: 100650.","DOI":"10.1016\/j.ajpc.2024.100650"},{"key":"ref64","doi-asserted-by":"publisher","unstructured":"Mavrogeni SI, Bacopoulou F, Markousis-Mavrogenis G, Giannakopoulou A, Kariki O, Vartela V, et al. Cardiovascular Magnetic Resonance as Pathophysiologic Tool in Diabetes Mellitus. Frontiers in Endocrinology (Lausanne). 2021; 12: 672302.","DOI":"10.3389\/fendo.2021.672302"},{"key":"ref65","doi-asserted-by":"publisher","unstructured":"Helmink MAG, Hageman SHJ, Eliasson B, Sattar N, Visseren FLJ, Dorresteijn JAN, et al. Lifetime and 10-year cardiovascular risk prediction in individuals with type 1 diabetes: The LIFE-T1D model. 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Pediatric Diabetes. 2023; 2023: 8662038.","DOI":"10.1155\/2023\/8662038"},{"key":"ref69","doi-asserted-by":"publisher","unstructured":"Apostolopoulou M, Lambadiari V, Roden M, Dimitriadis GD. Insulin resistance in type 1 diabetes: pathophysiological, clinical, and therapeutic relevance. Endocrine Reviews. 2025; 46: 317\u2013348.","DOI":"10.1210\/endrev\/bnae032"},{"key":"ref70","doi-asserted-by":"publisher","unstructured":"Chapman MJ. HDL functionality in type 1 and type 2 diabetes: new insights. Current Opinion in Endocrinology, Diabetes, and Obesity. 2022; 29: 112\u2013123.","DOI":"10.1097\/MED.0000000000000705"},{"key":"ref71","doi-asserted-by":"publisher","unstructured":"Jones TLZ, Kusmartseva I, Litovsky S, Thakar R, Posgai AL, Eckel RH, et al. The Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D): An NIDDK Initiative to Advance Understanding of Mechanisms Underlying Cardiovascular Disease in Type 1 Versus Type 2 Diabetes. Diabetes. 2025; 74: 1078\u20131088.","DOI":"10.2337\/db25-0017"},{"key":"ref72","doi-asserted-by":"publisher","unstructured":"Elian V, Dorita A, Stegaru D, Vinereanu D. Treatment of Dyslipidemia in Patients with Type 1 Diabetes Mellitus: A Review of Current Evidence and Knowledge Gaps. International Journal of Molecular Sciences. 2025; 26: 8558.","DOI":"10.3390\/ijms26178558"},{"key":"ref73","doi-asserted-by":"publisher","unstructured":"Schnell O, Almandoz J, Anderson L, Barnard-Kelly K, Battelino T, Bl\u00fcher M, et al. CVOT summit report 2024: new cardiovascular, kidney, and metabolic outcomes. 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