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Although the adverse effects of these environmental stressors on cardiovascular disease are widely acknowledged, the underlying mechanisms remain incompletely understood. This review examines these mechanisms from a physiological perspective, considering both pathways that act directly on the heart and those mediated through non-cardiac organs. Airborne particulate pollutants from dust storms, wildfires, and haze days can pass through the respiratory system and reach the heart, resulting in cardiac injury. Meanwhile, extreme weather events, including heatwaves, cold spells, hurricanes, and even earthquakes, can increase cardiovascular disease risk by affecting traditional risk factors, autonomic nervous system responses, oxidative stress, inflammation, coagulation disturbances, and behavioral factors. Hence, by providing a comprehensive overview, this review aims to enhance our understanding of the cardiovascular risks associated with climate hazards.<\/jats:p>","DOI":"10.31083\/rcm47388","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:31:56Z","timestamp":1777458716000},"source":"Crossref","is-referenced-by-count":1,"title":["Extreme Weather Events, Air Pollution, and Cardiovascular Health: Mechanisms and Challenges"],"prefix":"10.31083","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0190-2379","authenticated-orcid":true,"given":"Shiying","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Luzhou People's Hospital, 646000 Luzhou, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Luzhou People's Hospital, 646000 Luzhou, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Luzhou People's Hospital, 646000 Luzhou, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4731-1829","authenticated-orcid":true,"given":"Zaiyong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Key Laboratory of Medical Electrophysiology, Ministry of Education; Basic Medicine Research Innovation Center for cardiometabolic diseases, Ministry of Education; The Affiliated Hospital of Southwest Medical University, Southwest Medical University, 646000 Luzhou, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Luzhou People's Hospital, 646000 Luzhou, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6305-2697","authenticated-orcid":true,"given":"Jiali","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Luzhou People's Hospital, 646000 Luzhou, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"ref1","unstructured":"McDaniel E. Weather disasters have become 5 times as common, thanks in part to climate change. NPR. 2021. Available at: https:\/\/www.npr.org\/2021\/09\/07\/1034607602\/weather-disasters-have-become-five-times-as-common-thanks-in-part-to-climate-cha (Accessed: 6 June 2025)."},{"key":"ref2","unstructured":"WMO. 2024. Available at: https:\/\/wmo.int\/topics\/extreme-weather (Accessed: 20 October 2024)."},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Rumel D, Riedel LF, Latorre MD, Duncan BB. Miocardic infarcts and cerebral-vascular accidents associated with high temperature and carbon monoxide in an metropolitan area of Southeastern Brazil. Revista de Sa\u00fade P\u00fablica. 1993; 27: 15\u201322.  (In Portuguese)","DOI":"10.1590\/s0034-89101993000100003"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Peters MN, Moscona JC, Katz MJ, Deandrade KB, Quevedo HC, Tiwari S, et al. Natural disasters and myocardial infarction: the six years after Hurricane Katrina. Mayo Clinic Proceedings. 2014; 89: 472\u2013477.","DOI":"10.1016\/j.mayocp.2013.12.013"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Liu J, Varghese BM, Hansen A, Dear K, Driscoll T, Zhang Y, et al. High temperature and cardiovascular disease in Australia under different climatic, demographic, and adaptive scenarios. European Heart Journal. 2025; 46: 1852\u20131862.","DOI":"10.1093\/eurheartj\/ehaf117"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"L\u00f3pez-Bueno JA, D\u00edaz J, Iriso M, Ruiz-P\u00e1ez R, Navas-Mart\u00edn MA, Linares C. Emergency Hospital Admissions for Cardiovascular Causes Attributable to Air Pollution and Extreme Temperatures in Spain: Influence of Economic and Demographic Factors in a Nationwide Study. Journal of Urban Health: Bulletin of the New York Academy of Medicine. 2025; 102: 813\u2013829.","DOI":"10.1007\/s11524-025-01006-6"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Khatana SAM, Werner RM, Groeneveld PW. Association of Extreme Heat and Cardiovascular Mortality in the United States: A County-Level Longitudinal Analysis From 2008 to 2017. Circulation. 2022; 146: 249\u2013261.","DOI":"10.1161\/CIRCULATIONAHA.122.060746"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Bunker A, Wildenhain J, Vandenbergh A, Henschke N, Rockl\u00f6v J, Hajat S, et al. Effects of Air Temperature on Climate-Sensitive Mortality and Morbidity Outcomes in the Elderly; a Systematic Review and Meta-analysis of Epidemiological Evidence. eBioMedicine. 2016; 6: 258\u2013268.","DOI":"10.1016\/j.ebiom.2016.02.034"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Cesaroni G, Forastiere F, Stafoggia M, Andersen ZJ, Badaloni C, Beelen R, et al. Long term exposure to ambient air pollution and incidence of acute coronary events: prospective cohort study and meta-analysis in 11 European cohorts from the ESCAPE Project. BMJ (Clinical Research Ed.). 2014; 348: f7412.","DOI":"10.1136\/bmj.f7412"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Hameed S, Pan K, Su W, Trupp M, Mi L, Zhao J. Label-free detection and quantification of ultrafine particulate matter in lung and heart of mouse and evaluation of tissue injury. Particle and Fibre Toxicology. 2022; 19: 51.","DOI":"10.1186\/s12989-022-00493-8"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Fournier SB, D\u2019Errico JN, Adler DS, Kollontzi S, Goedken MJ, Fabris L, et al. Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy. Particle and Fibre Toxicology. 2020; 17: 55.","DOI":"10.1186\/s12989-020-00385-9"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Maher BA, Gonz\u00e1lez-Maciel A, Reynoso-Robles R, Torres-Jard\u00f3n R, Calder\u00f3n-Garcidue\u00f1as L. 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Ultrafine particles from diesel vehicle emissions at different driving cycles induce differential vascular pro-inflammatory responses: implication of chemical components and NF-kappaB signaling. Particle and Fibre Toxicology. 2010; 7: 6.","DOI":"10.1186\/1743-8977-7-6"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Husain M, Wu D, Saber AT, Decan N, Jacobsen NR, Williams A, et al. Intratracheally instilled titanium dioxide nanoparticles translocate to heart and liver and activate complement cascade in the heart of C57BL\/6 mice. Nanotoxicology. 2015; 9: 1013\u20131022.","DOI":"10.3109\/17435390.2014.996192"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Gojova A, Guo B, Kota RS, Rutledge JC, Kennedy IM, Barakat AI. Induction of inflammation in vascular endothelial cells by metal oxide nanoparticles: effect of particle composition. Environmental Health Perspectives. 2007; 115: 403\u2013409.","DOI":"10.1289\/ehp.8497"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Kim JB, Kim C, Choi E, Park S, Park H, Pak HN, et al. Particulate air pollution induces arrhythmia via oxidative stress and calcium calmodulin kinase II activation. Toxicology and Applied Pharmacology. 2012; 259: 66\u201373.","DOI":"10.1016\/j.taap.2011.12.007"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Okayama Y, Kuwahara M, Suzuki AK, Tsubone H. Role of reactive oxygen species on diesel exhaust particle-induced cytotoxicity in rat cardiac myocytes. Journal of Toxicology and Environmental Health. Part A. 2006; 69: 1699\u20131710.","DOI":"10.1080\/15287390600631078"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Fetterman JL, Sammy MJ, Ballinger SW. Mitochondrial toxicity of tobacco smoke and air pollution. Toxicology. 2017; 391: 18\u201333.","DOI":"10.1016\/j.tox.2017.08.002"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Chen J, Zhang M, Zou H, Aniagu S, Jiang Y, Chen T. PM2.5 induces mitochondrial dysfunction via AHR-mediated cyp1a1 overexpression during zebrafish heart development. Toxicology. 2023; 487: 153466.","DOI":"10.1016\/j.tox.2023.153466"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Tewodros W, Muhe L, Daniel E, Schal\u00e9n C, Kronvall G. A one-year study of streptococcal infections and their complications among Ethiopian children. Epidemiology and Infection. 1992; 109: 211\u2013225.","DOI":"10.1017\/s0950268800050172"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Maille B, Koutbi L, Resseguier N, Lemoine C, Thuny F, Peyrol M, et al. Seasonal variations in cardiac implantable electronic device infections. Heart and Vessels. 2019; 34: 824\u2013831.","DOI":"10.1007\/s00380-018-1292-4"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Wang C, Tu Y, Yu Z, Lu R. PM2.5 and Cardiovascular Diseases in the Elderly: An Overview. International Journal of Environmental Research and Public Health. 2015; 12: 8187\u20138197.","DOI":"10.3390\/ijerph120708187"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Krittanawong C, Qadeer YK, Hayes RB, Wang Z, Thurston GD, Virani S, et al. PM2.5 and cardiovascular diseases: State-of-the-Art review. International Journal of Cardiology. Cardiovascular Risk and Prevention. 2023; 19: 200217.","DOI":"10.1016\/j.ijcrp.2023.200217"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Zhang S, Lu W, Wei Z, Zhang H. Air Pollution and Cardiac Arrhythmias: From Epidemiological and Clinical Evidences to Cellular Electrophysiological Mechanisms. Frontiers in Cardiovascular Medicine. 2021; 8: 736151.","DOI":"10.3389\/fcvm.2021.736151"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Kumar V, S H, Huligowda LKD, Umesh M, Chakraborty P, Thazeem B, et al. Environmental Pollutants as Emerging Concerns for Cardiac Diseases: A Review on Their Impacts on Cardiac Health. Biomedicines. 2025; 13: 241.","DOI":"10.3390\/biomedicines13010241"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Grifoni D, Bustaffa E, Sabatino L, Calastrini F, Minichilli F, Gaggini M, et al. The Dark Triad of Particulate Matter, Oxidative Stress and Coronary Artery Disease: What About the Antioxidant Therapeutic Potential. Antioxidants. 2025; 14: 572.","DOI":"10.3390\/antiox14050572"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Gao F, Kovalik JP, Zhao X, Chow VJ, Chew H, Teo LL, et al. Exacerbation of cardiovascular ageing by diabetes mellitus and its associations with acyl-carnitines. Aging. 2021; 13: 14785\u201314805.","DOI":"10.18632\/aging.203144"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"El Hayek MS, Ernande L, Benitah JP, Gomez AM, Pereira L. The role of hyperglycaemia in the development of diabetic cardiomyopathy. Archives of Cardiovascular Diseases. 2021; 114: 748\u2013760.","DOI":"10.1016\/j.acvd.2021.08.004"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Mart\u00ednez-Lozano M, Noboa C, Alvarado-Gonz\u00e1lez G, Joshipura KJ. Hurricanes Irma and Maria and Diabetes incidence in Puerto Rico. BMC Public Health. 2023; 23: 1019.","DOI":"10.1186\/s12889-023-15542-w"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"Rao X, Patel P, Puett R, Rajagopalan S. Air pollution as a risk factor for type 2 diabetes. Toxicological Sciences. 2015; 143: 231\u2013241.","DOI":"10.1093\/toxsci\/kfu250"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"Li Z, Xu R, Wang Z, Qian N, Qian Y, Peng J, et al. Ozone exposure induced risk of gestational diabetes mellitus. Chemosphere. 2022; 308: 136241.","DOI":"10.1016\/j.chemosphere.2022.136241"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"Vallianou NG, Geladari EV, Kounatidis D, Geladari CV, Stratigou T, Dourakis SP, et al. Diabetes mellitus in the era of climate change. Diabetes & Metabolism. 2021; 47: 101205.","DOI":"10.1016\/j.diabet.2020.10.003"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"Al-Shihabi F, Moore A, Chowdhury TA. Diabetes and climate change. Diabetic Medicine. 2023; 40: e14971.","DOI":"10.1111\/dme.14971"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"Shih HI, Chao TY, Huang YT, Tu YF, Sung TC, Wang JD, et al. Increased Medical Visits and Mortality among Adults with Cardiovascular Diseases in Severely Affected Areas after Typhoon Morakot. International Journal of Environmental Research and Public Health. 2020; 17: 6531.","DOI":"10.3390\/ijerph17186531"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"Lam HCY, Chan JCN, Luk AOY, Chan EYY, Goggins WB. Short-term association between ambient temperature and acute myocardial infarction hospitalizations for diabetes mellitus patients: A time series study. PLoS Medicine. 2018; 15: e1002612.","DOI":"10.1371\/journal.pmed.1002612"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"Ruberg FL. Myocardial lipid accumulation in the diabetic heart. Circulation. 2007; 116: 1110\u20131112.","DOI":"10.1161\/CIRCULATIONAHA.107.721860"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"Domanski MJ, Wu CO, Tian X, Hasan AA, Ma X, Huang Y, et al. Association of Incident Cardiovascular Disease With Time Course and Cumulative Exposure to Multiple Risk Factors. Journal of the American College of Cardiology. 2023; 81: 1151\u20131161.","DOI":"10.1016\/j.jacc.2023.01.024"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"Yang BY, Guo Y, Markevych I, Qian ZM, Bloom MS, Heinrich J, et al. Association of Long-term Exposure to Ambient Air Pollutants With Risk Factors for Cardiovascular Disease in China. JAMA Network Open. 2019; 2: e190318.","DOI":"10.1001\/jamanetworkopen.2019.0318"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"D\u00edez J. Towards a new paradigm about hypertensive heart disease. The Medical Clinics of North America. 2009; 93: 637\u2013645.","DOI":"10.1016\/j.mcna.2009.02.002"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"Thompson AM, Krousel-Wood MA, Mei H, Webber L, He J, Bazzano L. Abstract P048: Effect of Hurricane Katrina on Medication Adherence and Blood Pressure among Hypertensive Veterans. Circulation. 2012; 125: AP048.","DOI":"10.1161\/circ.125.suppl_10.AP048"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"Prabhakaran D, Mandal S, Krishna B, Magsumbol M, Singh K, Tandon N, et al. Exposure to Particulate Matter Is Associated With Elevated Blood Pressure and Incident Hypertension in Urban India. Hypertension. 2020; 76: 1289\u20131298.","DOI":"10.1161\/HYPERTENSIONAHA.120.15373"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"Lusk SL, Gillespie B, Hagerty BM, Ziemba RA. Acute effects of noise on blood pressure and heart rate. Archives of Environmental Health. 2004; 59: 392\u2013399.","DOI":"10.3200\/AEOH.59.8.392-399"},{"key":"ref50","doi-asserted-by":"publisher","unstructured":"Xu D, Zhang Y, Wang B, Yang H, Ban J, Liu F, et al. Acute effects of temperature exposure on blood pressure: An hourly level panel study. Environment International. 2019; 124: 493\u2013500.","DOI":"10.1016\/j.envint.2019.01.045"},{"key":"ref51","doi-asserted-by":"publisher","unstructured":"Yoshihara K, Tanabe HC, Kawamichi H, Koike T, Yamazaki M, Sudo N, et al. Neural correlates of fear-induced sympathetic response associated with the peripheral temperature change rate. NeuroImage. 2016; 134: 522\u2013531.","DOI":"10.1016\/j.neuroimage.2016.04.040"},{"key":"ref52","doi-asserted-by":"publisher","unstructured":"Tani Y, Nakayama M, Tanaka K, Hayashi Y, Asahi K, Kamata T, et al. Blood pressure elevation in hemodialysis patients after the Great East Japan Earthquake. Hypertension Research. 2014; 37: 139\u2013144.","DOI":"10.1038\/hr.2013.116"},{"key":"ref53","doi-asserted-by":"publisher","unstructured":"Watanabe K, Tani Y, Tanaka K, Hayashi Y, Asahi K, Nakayama M, et al. Acute changes in home blood pressure after the Great East Japan Earthquake among patients with chronic kidney disease in Fukushima City. Clinical and Experimental Nephrology. 2013; 17: 718\u2013724.","DOI":"10.1007\/s10157-012-0750-z"},{"key":"ref54","doi-asserted-by":"publisher","unstructured":"Watanabe H, Kodama M, Okura Y, Aizawa Y, Tanabe N, Chinushi M, et al. Impact of earthquakes on Takotsubo cardiomyopathy. JAMA. 2005; 294: 305\u2013307.","DOI":"10.1001\/jama.294.3.305"},{"key":"ref55","doi-asserted-by":"publisher","unstructured":"Hering D, Lachowska K, Schlaich M. Role of the Sympathetic Nervous System in Stress-Mediated Cardiovascular Disease. Current Hypertension Reports. 2015; 17: 80.","DOI":"10.1007\/s11906-015-0594-5"},{"key":"ref56","doi-asserted-by":"publisher","unstructured":"Nakagami H, Akiyama H, Otsuka H, Takahashi SA, Sawada K, Kobayashi N, et al. Morning surge in sympathetic nervous activity in the indoor environment during the cold winter season. Hypertension Research. 2023; 46: 231\u2013235.","DOI":"10.1038\/s41440-022-01020-0"},{"key":"ref57","doi-asserted-by":"publisher","unstructured":"Nakagami H, Otsuka H, Akiyama H. Monitoring with wearable devices will clarify the association between indoor temperature and blood pressure. Hypertension Research. 2023; 46: 1450\u20131455.","DOI":"10.1038\/s41440-023-01261-7"},{"key":"ref58","doi-asserted-by":"publisher","unstructured":"Zhang X, Zhang S, Wang C, Wang B, Guo P. Effects of moderate strength cold air exposure on blood pressure and biochemical indicators among cardiovascular and cerebrovascular patients. International Journal of Environmental Research and Public Health. 2014; 11: 2472\u20132487.","DOI":"10.3390\/ijerph110302472"},{"key":"ref59","doi-asserted-by":"publisher","unstructured":"Crandall CG, Gonz\u00e1lez-Alonso J. Cardiovascular function in the heat-stressed human. Acta Physiologica. 2010; 199: 407\u2013423.","DOI":"10.1111\/j.1748-1716.2010.02119.x"},{"key":"ref60","doi-asserted-by":"publisher","unstructured":"Gorman AJ, Proppe DW. Mechanisms producing tachycardia in conscious baboons during environmental heat stress. Journal of Applied Physiology. 1984; 56: 441\u2013446.","DOI":"10.1152\/jappl.1984.56.2.441"},{"key":"ref61","doi-asserted-by":"publisher","unstructured":"Kenney MJ, Musch TI. Senescence alters blood flow responses to acute heat stress. American Journal of Physiology. Heart and Circulatory Physiology. 2004; 286: H1480\u2013H1485.","DOI":"10.1152\/ajpheart.00857.2003"},{"key":"ref62","doi-asserted-by":"publisher","unstructured":"Gravel H, Chaseling GK, Barry H, Debray A, Gagnon D. Cardiovascular control during heat stress in older adults: time for an update. American Journal of Physiology. 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Differential effects of inhalation exposure to PM2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats. Neurotoxicology. 2013; 36: 106\u2013111.","DOI":"10.1016\/j.neuro.2012.02.016"},{"key":"ref69","doi-asserted-by":"publisher","unstructured":"Hajat A, Diez Roux AV, Castro-Diehl C, Cosselman K, Golden SH, Hazlehurst MF, et al. The Association between Long-Term Air Pollution and Urinary Catecholamines: Evidence from the Multi-Ethnic Study of Atherosclerosis. Environmental Health Perspectives. 2019; 127: 57007.","DOI":"10.1289\/EHP3286"},{"key":"ref70","unstructured":"Bedi US, Arora R. Cardiovascular manifestations of posttraumatic stress disorder. Journal of the National Medical Association. 2007; 99: 642\u2013649."},{"key":"ref71","doi-asserted-by":"publisher","unstructured":"Fonkoue IT, Marvar PJ, Norrholm S, Li Y, Kankam ML, Jones TN, et al. 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Quality of Care & Clinical Outcomes. 2017; 3: 224\u2013233.","DOI":"10.1093\/ehjqcco\/qcx009"},{"key":"ref77","doi-asserted-by":"publisher","unstructured":"Yehuda R. Psychoneuroendocrinology of post-traumatic stress disorder. The Psychiatric Clinics of North America. 1998; 21: 359\u2013379.","DOI":"10.1016\/s0193-953x(05)70010-1"},{"key":"ref78","doi-asserted-by":"publisher","unstructured":"Tezuka K, Kubota Y, Ohira T, Nakano H, Maeda M, Yabe H, et al. Synergistic Effect of History of Cardiovascular Disease and Mental Distress on Post-Traumatic Stress Disorder after the Great East Japan Earthquake: The Fukushima Health Management Survey. International Journal of Environmental Research and Public Health. 2021; 18: 10283.","DOI":"10.3390\/ijerph181910283"},{"key":"ref79","doi-asserted-by":"publisher","unstructured":"Hsueh B, Chen R, Jo Y, Tang D, Raffiee M, Kim YS, et al. Cardiogenic control of affective behavioural state. 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International Journal of Environmental Research and Public Health. 2022; 19: 1950.","DOI":"10.3390\/ijerph19041950"},{"key":"ref141","doi-asserted-by":"publisher","unstructured":"Yen CC, Hsiao PJ, Chu CM, Chen PL. The impact of COVID-19 pandemic on air particulate matter exposure and heart attacks: a 5-year retrospective cohort study in Taiwan (2017-2021). Frontiers in Public Health. 2024; 12: 1321129.","DOI":"10.3389\/fpubh.2024.1321129"},{"key":"ref142","doi-asserted-by":"publisher","unstructured":"Chen K, Wang M, Huang C, Kinney PL, Anastas PT. Air pollution reduction and mortality benefit during the COVID-19 outbreak in China. The Lancet. Planetary Health. 2020; 4: e210\u2013e212.","DOI":"10.1016\/S2542-5196(20)30107-8"},{"key":"ref143","doi-asserted-by":"publisher","unstructured":"Zheng Z, Li Y, Jiang Q, Zang F, Yu Y, Yue R, et al. Associations between air pollution and hospitalization for cardiovascular disease: a time series study in Nanchong. Frontiers in Public Health. 2025; 13: 1504411.","DOI":"10.3389\/fpubh.2025.1504411"},{"key":"ref144","unstructured":"American Heart Association Council on E. Reduced air pollution in U.S. during pandemic shutdown linked to fewer heart attacks. 2021. Available at: https:\/\/newsroom.heart.org\/news\/reduced-air-pollution-in-u-s-during-pandemic-shutdown-linked-to-fewer-heart-attacks (Accessed: 20 October 2024)."},{"key":"ref145","doi-asserted-by":"publisher","unstructured":"Wang D, Yang D, Jiang S, Yang G, Luo T, Du W, et al. Personal air pollution exposure: Monitoring methods and the emerging role of big data and machine learning. Environmental Technology & Innovation. 2025; 40: 104593.","DOI":"10.1016\/j.eti.2025.104593"},{"key":"ref146","doi-asserted-by":"publisher","unstructured":"Zhang J, Wei S, Chen G, Lip GYH, Lin H. Life-course exposure to PM2.5 components and genetic susceptibility on the risk of atrial fibrillation and subsequent heart failure. European Journal of Preventive Cardiology. 2025; zwaf751.","DOI":"10.1093\/eurjpc\/zwaf751"},{"key":"ref147","doi-asserted-by":"publisher","unstructured":"Xu R, Huang S, Shi C, Wang R, Liu T, Li Y, et al. Extreme Temperature Events, Fine Particulate Matter, and Myocardial Infarction Mortality. Circulation. 2023; 148: 312\u2013323.","DOI":"10.1161\/CIRCULATIONAHA.122.063504"}],"container-title":["Reviews in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/27\/4\/10.31083\/RCM47388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:32:21Z","timestamp":1777458741000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/27\/4\/10.31083\/RCM47388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":147,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"alternative-id":["S1530-6550(26)02689-0"],"URL":"https:\/\/doi.org\/10.31083\/rcm47388","relation":{},"ISSN":["1530-6550","2153-8174"],"issn-type":[{"value":"1530-6550","type":"print"},{"value":"2153-8174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]},"article-number":"47388"}}