{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T01:59:43Z","timestamp":1785117583290,"version":"3.55.0"},"reference-count":111,"publisher":"IMR Press","issue":"5","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Alcohol has been appreciated by civilizations for thousands of years. Nonetheless, alcohol has recently been linked to serious cardiovascular diseases. Therefore, this review summarizes the effects of alcohol on the heart based on the most current literature available. This review covers the effects of alcohol on blood pressure (BP), heart rate (HR), autonomic dysfunction, coronary artery disease (CAD), cardiomyopathy, and cardiac arrhythmias. Evidence supports the harmful effects of both acute (binge) and chronic heavy alcohol consumption on BP, HR, autonomic dysfunction, and the risk of CAD, cardiomyopathy, and various arrhythmias. Some studies suggest that mild to moderate drinking may reduce the risk of CAD and arrhythmias, consistent with a potential J-shaped relationship. However, other evidence contradicts this, thereby indicating that alcohol use may increase the risk of developing hypertension, CAD, and atrial fibrillation. At the time of this review, evidence supports the harmful effects of acute and chronic heavy alcohol consumption on the heart. Findings are mixed for mild to moderate drinking and may be influenced by confounding factors, underscoring the need for further research. Given the inconclusive benefits, the authors recommend that no level of alcohol consumption be promoted as beneficial for cardiac health.<\/jats:p>","DOI":"10.31083\/rcm47953","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T01:28:22Z","timestamp":1785115702000},"source":"Crossref","is-referenced-by-count":0,"title":["Cardiac Responses to Alcohol: A Review of Mechanisms and Clinical Implications"],"prefix":"10.31083","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4744-8012","authenticated-orcid":true,"given":"Kristine E","family":"Johnston","sequence":"first","affiliation":[{"name":"Department of Medicine, St Mary Medical Center, Langhorne, PA 19047, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3541-1697","authenticated-orcid":true,"given":"Aishwarya","family":"Kamble","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Mary Medical Center, Langhorne, PA 19047, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1519-1631","authenticated-orcid":true,"given":"Joanna","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Mary Medical Center, Langhorne, PA 19047, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3870-9360","authenticated-orcid":true,"given":"Kayla","family":"Garley","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Mary Medical Center, Langhorne, PA 19047, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3448-2314","authenticated-orcid":true,"given":"Vincent M","family":"Figueredo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, St Mary Medical Center, Langhorne, PA 19047, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"ref1","unstructured":"Katz B. Traces of 13,000-year-old beer found in Israel. Smithsonian Magazine. 2018. Available at: https:\/\/www.smithsonianmag.com\/smart-news\/traces-13000-year-old-beer-found-israel-180970282\/ (Accessed: 12 October 2025)."},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Chikritzhs T, Livingston M. Alcohol and the Risk of Injury. Nutrients. 2021; 13: 2777.","DOI":"10.3390\/nu13082777"},{"key":"ref3","unstructured":"Centers for Disease Control and Prevention. Alcohol facts and statistics [Internet]. CDC: Atlanta. 2023. Available at: https:\/\/www.cdc.gov\/alcohol\/facts-stats\/index.html (Accessed: 12 October 2025)."},{"key":"ref4","unstructured":"Centers for Disease Control and Prevention. What is a standard drink? [Internet]. CDC: Atlanta. 2023. Available at: https:\/\/www.cdc.gov\/alcohol\/standard-drink-sizes\/index.html (Accessed: 12 October 2025)."},{"key":"ref5","unstructured":"Centers for Disease Control and Prevention. Excessive drinking is draining the U.S. economy [Internet]. CDC: Atlanta. 2023. Available at: https:\/\/www.cdc.gov\/alcohol\/excessive-drinking-data\/index.html (Accessed: 12 October 2025)."},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Varghese J, Dakhode S. Effects of Alcohol Consumption on Various Systems of the Human Body: A Systematic Review. Cureus. 2022; 14: e30057.","DOI":"10.7759\/cureus.30057"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Rachdaoui N, Sarkar DK. Effects of alcohol on the endocrine system. Endocrinology and Metabolism Clinics of North America. 2013; 42: 593\u2013615.","DOI":"10.1016\/j.ecl.2013.05.008"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Ronksley PE, Brien SE, Turner BJ, Mukamal KJ, Ghali WA. Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis. BMJ (Clinical Research Ed.). 2011; 342: d671.","DOI":"10.1136\/bmj.d671"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Xi B, Veeranki SP, Zhao M, Ma C, Yan Y, Mi J. Relationship of Alcohol Consumption to All-Cause, Cardiovascular, and Cancer-Related Mortality in U.S. Adults. Journal of the American College of Cardiology. 2017; 70: 913\u2013922.","DOI":"10.1016\/j.jacc.2017.06.054"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Gusti Y, Liu W, Athar F, Cahill PA, Redmond EM. Endothelial Homeostasis Under the Influence of Alcohol-Relevance to Atherosclerotic Cardiovascular Disease. Nutrients. 2025; 17: 802.","DOI":"10.3390\/nu17050802"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Schmieder RE. End organ damage in hypertension. Deutsches Arzteblatt International. 2010; 107: 866\u2013873.","DOI":"10.3238\/arztebl.2010.0866"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Rundek T, Hundle R, Ratchford E, Ramas R, Sciacca R, Di Tullio MR, et al. Endothelial dysfunction is associated with carotid plaque: a cross-sectional study from the population based Northern Manhattan Study. BMC Cardiovascular Disorders. 2006; 6: 35.","DOI":"10.1186\/1471-2261-6-35"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Mundi S, Massaro M, Scoditti E, Carluccio MA, van Hinsbergh VWM, Iruela-Arispe ML, et al. Endothelial permeability, LDL deposition, and cardiovascular risk factors-a review. Cardiovascular Research. 2018; 114: 35\u201352.","DOI":"10.1093\/cvr\/cvx226"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Bigalke JA, Greenlund IM, Solis-Montenegro TX, Durocher JJ, Joyner MJ, Carter JR. 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International Journal of Clinical and Experimental Medicine. 2015; 8: 14296\u201314302."},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Di Federico S, Filippini T, Whelton PK, Cecchini M, Iamandii I, Boriani G, et al. Alcohol Intake and Blood Pressure Levels: A Dose-Response Meta-Analysis of Nonexperimental Cohort Studies. Hypertension (Dallas, Tex.: 1979). 2023; 80: 1961\u20131969.","DOI":"10.1161\/HYPERTENSIONAHA.123.21224"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Cecchini M, Filippini T, Whelton PK, Iamandii I, Di Federico S, Boriani G, et al. Alcohol Intake and Risk of Hypertension: A Systematic Review and Dose-Response Meta-Analysis of Nonexperimental Cohort Studies. Hypertension (Dallas, Tex.: 1979). 2024; 81: 1701\u20131715.","DOI":"10.1161\/HYPERTENSIONAHA.124.22703"},{"key":"ref28","unstructured":"NutritionHeart. Alcohol drinks: grams of alcohol explained [Internet]. 2024. Available at: https:\/\/www.nutritionheart.com\/alcohol-drinks-grams-of-alcohol\/ (Accessed: 12 October 2025)."},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Semlitsch T, Krenn C, Jeitler K, Berghold A, Horvath K, Siebenhofer A. Long-term effects of weight-reducing diets in people with hypertension. The Cochrane Database of Systematic Reviews. 2021; 2: CD008274.","DOI":"10.1002\/14651858.CD008274.pub4"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Puddey IB, Beilin LJ, Vandongen R, Rouse IL, Rogers P. Evidence for a direct effect of alcohol consumption on blood pressure in normotensive men. A randomized controlled trial. Hypertension (Dallas, Tex.: 1979). 1985; 7: 707\u2013713.","DOI":"10.1161\/01.hyp.7.5.707"},{"key":"ref31","unstructured":"World Health Organization (WHO). Cardiovascular diseases (CVDs). World Health Organization: Geneva. 2024. Available at: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cardiovascular-diseases-(cvds) (Accessed: 13 January 2026)."},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Mensah GA, Fuster V, Murray CJL, Roth GA; Global Burden of Cardiovascular Diseases and Risks Collaborators. Global Burden of Cardiovascular Diseases and Risks, 1990-2022. Journal of the American College of Cardiology. 2023; 82: 2350\u20132473.","DOI":"10.1016\/j.jacc.2023.11.007"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Corrao G, Rubbiati L, Bagnardi V, Zambon A, Poikolainen K. Alcohol and coronary heart disease: a meta-analysis. Addiction (Abingdon, England). 2000; 95: 1505\u20131523.","DOI":"10.1046\/j.1360-0443.2000.951015056.x"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Zheng YL, Lian F, Shi Q, Zhang C, Chen YW, Zhou YH, et al. Alcohol intake and associated risk of major cardiovascular outcomes in women compared with men: a systematic review and meta-analysis of prospective observational studies. BMC Public Health. 2015; 15: 773.","DOI":"10.1186\/s12889-015-2081-y"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"Biddinger KJ, Emdin CA, Haas ME, Wang M, Hindy G, Ellinor PT, et al. Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease. JAMA Network Open. 2022; 5: e223849.","DOI":"10.1001\/jamanetworkopen.2022.3849"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Zhao J, Stockwell T, Roemer A, Naimi T, Chikritzhs T. Alcohol Consumption and Mortality From Coronary Heart Disease: An Updated Meta-Analysis of Cohort Studies. Journal of Studies on Alcohol and Drugs. 2017; 78: 375\u2013386.","DOI":"10.15288\/jsad.2017.78.375"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"Zhao J, Stockwell T, Naimi T, Churchill S, Clay J, Sherk A. Association Between Daily Alcohol Intake and Risk of All-Cause Mortality: A Systematic Review and Meta-analyses. JAMA Network Open. 2023; 6: e236185.","DOI":"10.1001\/jamanetworkopen.2023.6185"},{"key":"ref38","unstructured":"National Institutes of Health (NIH). NIH ends funding for moderate alcohol and cardiovascular health trial. U.S. Department of Health and Human Services. 2018. Available at: https:\/\/www.nih.gov\/news-events\/news-releases\/nih-end-funding-moderate-alcohol-cardiovascular-health-trial (Accessed: 13 January 2026)."},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"Leong DP, Smyth A, Teo KK, McKee M, Rangarajan S, Pais P, et al. Patterns of alcohol consumption and myocardial infarction risk: observations from 52 countries in the INTERHEART case-control study. Circulation. 2014; 130: 390\u2013398.","DOI":"10.1161\/CIRCULATIONAHA.113.007627"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"George S, John SD, George S, Thottiyil JJ. Lipid profile and alcoholism. International Journal of Advances in Medicine. 2019; 6: 1408\u20131415.","DOI":"10.18203\/2349-3933.ijam20193595"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"Gaziano JM, Buring JE, Breslow JL, Goldhaber SZ, Rosner B, VanDenburgh M, et al. Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction. The New England Journal of Medicine. 1993; 329: 1829\u20131834.","DOI":"10.1056\/NEJM199312163292501"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"Dom\u00ednguez F, Adler E, Garc\u00eda-Pav\u00eda P. Alcoholic cardiomyopathy: an update. European Heart Journal. 2024; 45: 2294\u20132305.","DOI":"10.1093\/eurheartj\/ehae362"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"Walsh CR, Larson MG, Evans JC, Djousse L, Ellison RC, Vasan RS, et al. Alcohol consumption and risk for congestive heart failure in the Framingham Heart Study. Annals of Internal Medicine. 2002; 136: 181\u2013191.","DOI":"10.7326\/0003-4819-136-3-200202050-00005"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"Wang S, Ren J. Role of autophagy and regulatory mechanisms in alcoholic cardiomyopathy. Biochimica et Biophysica Acta. Molecular Basis of Disease. 2018; 1864: 2003\u20132009.","DOI":"10.1016\/j.bbadis.2018.03.016"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"Bozkurt B, Colvin M, Cook J, Cooper LT, Deswal A, Fonarow GC, et al. Current Diagnostic and Treatment Strategies for Specific Dilated Cardiomyopathies: A Scientific Statement From the American Heart Association. Circulation. 2016; 134: e579\u2013e646.","DOI":"10.1161\/CIR.0000000000000455"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"Zuin M, Jering K, McGonagle B, Sato A, Bilato C, Piazza G. Alcoholic Cardiomyopathy-Attributed Mortality in the United States, 2010 to 2020. JACC. Heart Failure. 2025; 13: 102486.","DOI":"10.1016\/j.jchf.2025.04.006"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"Kasper EK, Agema WR, Hutchins GM, Deckers JW, Hare JM, Baughman KL. The causes of dilated cardiomyopathy: a clinicopathologic review of 673 consecutive patients. Journal of the American College of Cardiology. 1994; 23: 586\u2013590.","DOI":"10.1016\/0735-1097(94)90740-4"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"Gavazzi A, De Maria R, Parolini M, Porcu M. Alcohol abuse and dilated cardiomyopathy in men. The American Journal of Cardiology. 2000; 85: 1114\u20131118.","DOI":"10.1016\/s0002-9149(00)00706-2"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"Zuin M, Dom\u00ednguez F, Dalla Valle C, Maloberti A, De Rosa C, Mojoli M, et al. Alcoholic cardiomyopathy-attributed mortality in Europe, 2012-20. European Heart Journal. Quality of Care & Clinical Outcomes. 2025; 11: 1082\u20131090.","DOI":"10.1093\/ehjqcco\/qcaf036"},{"key":"ref50","doi-asserted-by":"publisher","unstructured":"White AM. Gender Differences in the Epidemiology of Alcohol Use and Related Harms in the United States. Alcohol Research: Current Reviews. 2020; 40: 01.","DOI":"10.35946\/arcr.v40.2.01"},{"key":"ref51","doi-asserted-by":"publisher","unstructured":"Mogos MF, Salemi JL, Phillips SA, Piano MR. Contemporary Appraisal of Sex Differences in Prevalence, Correlates, and Outcomes of Alcoholic Cardiomyopathy. Alcohol and Alcoholism (Oxford, Oxfordshire). 2019; 54: 386\u2013395.","DOI":"10.1093\/alcalc\/agz050"},{"key":"ref52","doi-asserted-by":"publisher","unstructured":"Park SK, Moon K, Ryoo JH, Oh CM, Choi JM, Kang JG, et al. The association between alcohol consumption and left ventricular diastolic function and geometry change in general Korean population. European Heart Journal. Cardiovascular Imaging. 2018; 19: 271\u2013278.","DOI":"10.1093\/ehjci\/jex091"},{"key":"ref53","doi-asserted-by":"publisher","unstructured":"G\u00e9mes K, Janszky I, Strand LB, L\u00e1szl\u00f3 KD, Ahnve S, Vatten LJ, et al. Light-moderate alcohol consumption and left ventricular function among healthy, middle-aged adults: the HUNT study. BMJ Open. 2018; 8: e020777.","DOI":"10.1136\/bmjopen-2017-020777"},{"key":"ref54","doi-asserted-by":"publisher","unstructured":"Rodrigues P, Santos-Ribeiro S, Teodoro T, Gomes FV, Leal I, Reis JP, et al. Association Between Alcohol Intake and Cardiac Remodeling. Journal of the American College of Cardiology. 2018; 72: 1452\u20131462.","DOI":"10.1016\/j.jacc.2018.07.050"},{"key":"ref55","doi-asserted-by":"publisher","unstructured":"Matyas C, Varga ZV, Mukhopadhyay P, Paloczi J, Lajtos T, Erdelyi K, et al. Chronic plus binge ethanol feeding induces myocardial oxidative stress, mitochondrial and cardiovascular dysfunction, and steatosis. 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Acetaldehyde depresses shortening and intracellular Ca2+ transients in adult rat ventricular myocytes. Cellular and Molecular Biology (Noisy-le-Grand, France). 1997; 43: 825\u2013834."},{"key":"ref60","unstructured":"Brown RA, Jefferson L, Sudan N, Lloyd TC, Ren J. Acetaldehyde depresses myocardial contraction and cardiac myocyte shortening in spontaneously hypertensive rats: role of intracellular Ca2+. Cellular and Molecular Biology (Noisy-le-Grand, France). 1999; 45: 453\u2013465."},{"key":"ref61","doi-asserted-by":"publisher","unstructured":"Zhang Y, Ren J. ALDH2 in alcoholic heart diseases: molecular mechanism and clinical implications. Pharmacology & Therapeutics. 2011; 132: 86\u201395.","DOI":"10.1016\/j.pharmthera.2011.05.008"},{"key":"ref62","doi-asserted-by":"publisher","unstructured":"Harakalova M, Kummeling G, Sammani A, Linschoten M, Baas AF, van der Smagt J, et al. A systematic analysis of genetic dilated cardiomyopathy reveals numerous ubiquitously expressed and muscle-specific genes. European Journal of Heart Failure. 2015; 17: 484\u2013493.","DOI":"10.1002\/ejhf.255"},{"key":"ref63","doi-asserted-by":"publisher","unstructured":"Ware JS, Amor-Salamanca A, Tayal U, Govind R, Serrano I, Salazar-Mendiguch\u00eda J, et al. Genetic Etiology for Alcohol-Induced Cardiac Toxicity. Journal of the American College of Cardiology. 2018; 71: 2293\u20132302.","DOI":"10.1016\/j.jacc.2018.03.462"},{"key":"ref64","doi-asserted-by":"publisher","unstructured":"Eldemire R, Mestroni L, Taylor MRG. Genetics of Dilated Cardiomyopathy. Annual Review of Medicine. 2024; 75: 417\u2013426.","DOI":"10.1146\/annurev-med-052422-020535"},{"key":"ref65","doi-asserted-by":"publisher","unstructured":"Johnson R, Fletcher RA, Peters S, Ohanian M, Soka M, Smolnikov A, et al. Titin-related familial dilated cardiomyopathy: factors associated with disease onset. 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The effect of controlled drinking in alcoholic cardiomyopathy. Annals of Internal Medicine. 2002; 136: 192\u2013200.","DOI":"10.7326\/0003-4819-136-3-200202050-00007"},{"key":"ref72","doi-asserted-by":"publisher","unstructured":"Guzzo-Merello G, Segovia J, Dominguez F, Cobo-Marcos M, Gomez-Bueno M, Avellana P, et al. Natural history and prognostic factors in alcoholic cardiomyopathy. JACC. Heart Failure. 2015; 3: 78\u201386.","DOI":"10.1016\/j.jchf.2014.07.014"},{"key":"ref73","doi-asserted-by":"publisher","unstructured":"Aggarwal M, Bozkurt B, Panjrath G, Aggarwal B, Ostfeld RJ, Barnard ND, et al. Lifestyle Modifications for Preventing and Treating Heart Failure. 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Available at: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459340\/ (Accessed: 13 January 2026)."},{"key":"ref77","doi-asserted-by":"publisher","unstructured":"Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, et al. Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association. Circulation. 2017; 135: e146\u2013e603.","DOI":"10.1161\/CIR.0000000000000485"},{"key":"ref78","doi-asserted-by":"publisher","unstructured":"Kodama S, Saito K, Tanaka S, Horikawa C, Saito A, Heianza Y, et al. Alcohol consumption and risk of atrial fibrillation: a meta-analysis. Journal of the American College of Cardiology. 2011; 57: 427\u2013436.","DOI":"10.1016\/j.jacc.2010.08.641"},{"key":"ref79","doi-asserted-by":"publisher","unstructured":"Groh CA, Faulkner M, Getabecha S, Taffe V, Nah G, Sigona K, et al. Patient-reported triggers of paroxysmal atrial fibrillation. 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Circulation. 2005; 112: 1736\u20131742.","DOI":"10.1161\/CIRCULATIONAHA.105.547844"},{"key":"ref83","doi-asserted-by":"publisher","unstructured":"Gallagher C, Hendriks JML, Elliott AD, Wong CX, Rangnekar G, Middeldorp ME, et al. Alcohol and incident atrial fibrillation - A systematic review and meta-analysis. International Journal of Cardiology. 2017; 246: 46\u201352.","DOI":"10.1016\/j.ijcard.2017.05.133"},{"key":"ref84","doi-asserted-by":"publisher","unstructured":"Larsson SC, Drca N, Wolk A. Alcohol consumption and risk of atrial fibrillation: a prospective study and dose-response meta-analysis. Journal of the American College of Cardiology. 2014; 64: 281\u2013289.","DOI":"10.1016\/j.jacc.2014.03.048"},{"key":"ref85","unstructured":"Jain A, Yelamanchili VS, Brown KN, Goel A. Holiday Heart Syndrome. In: StatPearls [Internet]. StatPearls Publishing: Treasure Island (FL). 2024. Available at: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK537185\/ (Accessed: 13 January 2026)."},{"key":"ref86","doi-asserted-by":"publisher","unstructured":"Ettinger PO, Wu CF, De La Cruz C, Jr, Weisse AB, Ahmed SS, Regan TJ. Arrhythmias and the \u201cHoliday Heart\u201d: alcohol-associated cardiac rhythm disorders. American Heart Journal. 1978; 95: 555\u2013562.","DOI":"10.1016\/0002-8703(78)90296-x"},{"key":"ref87","doi-asserted-by":"publisher","unstructured":"Marcus GM, Dukes JW, Vittinghoff E, Nah G, Badhwar N, Moss JD, et al. A Randomized, Double-Blind, Placebo-Controlled Trial of Intravenous Alcohol to Assess Changes in Atrial Electrophysiology. JACC. Clinical Electrophysiology. 2021; 7: 662\u2013670.","DOI":"10.1016\/j.jacep.2020.11.026"},{"key":"ref88","doi-asserted-by":"publisher","unstructured":"Tu SJ, Gallagher C, Elliott AD, Linz D, Pitman BM, Hendriks JML, et al. Risk Thresholds for Total and Beverage-Specific Alcohol Consumption and Incident Atrial Fibrillation. JACC. 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Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 2019; 21: 864\u2013870.","DOI":"10.1093\/europace\/euz008"},{"key":"ref99","doi-asserted-by":"publisher","unstructured":"Brunner S, Herbel R, Drobesch C, Peters A, Massberg S, K\u00e4\u00e4b S, et al. Alcohol consumption, sinus tachycardia, and cardiac arrhythmias at the Munich Octoberfest: results from the Munich Beer Related Electrocardiogram Workup Study (MunichBREW). European Heart Journal. 2017; 38: 2100\u20132106.","DOI":"10.1093\/eurheartj\/ehx156"},{"key":"ref100","doi-asserted-by":"publisher","unstructured":"Ahmed S, Hisamatsu T, Kadota A, Fujiyoshi A, Segawa H, Torii S, et al. Premature Atrial Contractions and Their Determinants in a General Population of Japanese Men. Circulation Journal: Official Journal of the Japanese Circulation Society. 2022; 86: 1298\u20131306.","DOI":"10.1253\/circj.CJ-21-0872"},{"key":"ref101","doi-asserted-by":"publisher","unstructured":"Khurshid S, Choi SH, Weng LC, Wang EY, Trinquart L, Benjamin EJ, et al. Frequency of Cardiac Rhythm Abnormalities in a Half Million Adults. Circulation. Arrhythmia and Electrophysiology. 2018; 11: e006273.","DOI":"10.1161\/CIRCEP.118.006273"},{"key":"ref102","doi-asserted-by":"publisher","unstructured":"Mandyam MC, Vedantham V, Scheinman MM, Tseng ZH, Badhwar N, Lee BK, et al. Alcohol and vagal tone as triggers for paroxysmal atrial fibrillation. The American Journal of Cardiology. 2012; 110: 364\u2013368.","DOI":"10.1016\/j.amjcard.2012.03.033"},{"key":"ref103","doi-asserted-by":"publisher","unstructured":"Brunner S, Krewitz C, Winter R, von Falkenhausen AS, Kern A, Brunner D, et al. Acute alcohol consumption and arrhythmias in young adults: the MunichBREW II study. European Heart Journal. 2024; 45: 4938\u20134949.","DOI":"10.1093\/eurheartj\/ehae695"},{"key":"ref104","doi-asserted-by":"publisher","unstructured":"Tu SJ, Gallagher C, Elliott AD, Linz D, Pitman BM, Hendriks JML, et al. Alcohol consumption and risk of ventricular arrhythmias and sudden cardiac death: An observational study of 408,712 individuals. Heart Rhythm. 2022; 19: 177\u2013184.","DOI":"10.1016\/j.hrthm.2021.09.040"},{"key":"ref105","doi-asserted-by":"publisher","unstructured":"Park CS, Choi J, Choi J, Lee KY, Ahn HJ, Kwon S, et al. Alcohol is neither a risk factor nor a protective factor for sudden cardiac death and\/or fatal ventricular arrhythmia: A population-based study with genetic traits and alcohol consumption in the UK Biobank. Heart Rhythm. 2024; 21: 1820\u20131826.","DOI":"10.1016\/j.hrthm.2024.04.097"},{"key":"ref106","doi-asserted-by":"publisher","unstructured":"Jabbari R, Engstr\u00f8m T, Glinge C, Risgaard B, Jabbari J, Winkel BG, et al. Incidence and risk factors of ventricular fibrillation before primary angioplasty in patients with first ST-elevation myocardial infarction: a nationwide study in Denmark. Journal of the American Heart Association. 2015; 4: e001399.","DOI":"10.1161\/JAHA.114.001399"},{"key":"ref107","doi-asserted-by":"publisher","unstructured":"Fauchier L. Alcoholic cardiomyopathy and ventricular arrhythmias. Chest. 2003; 123: 1320.","DOI":"10.1378\/chest.123.4.1320"},{"key":"ref108","doi-asserted-by":"publisher","unstructured":"Cooper HA, Exner DV, Domanski MJ. Light-to-moderate alcohol consumption and prognosis in patients with left ventricular systolic dysfunction. Journal of the American College of Cardiology. 2000; 35: 1753\u20131759.","DOI":"10.1016\/s0735-1097(00)00625-2"},{"key":"ref109","doi-asserted-by":"publisher","unstructured":"Albert CM, Manson JE, Cook NR, Ajani UA, Gaziano JM, Hennekens CH. Moderate alcohol consumption and the risk of sudden cardiac death among US male physicians. Circulation. 1999; 100: 944\u2013950.","DOI":"10.1161\/01.cir.100.9.944"},{"key":"ref110","doi-asserted-by":"publisher","unstructured":"Bertoia ML, Triche EW, Michaud DS, Baylin A, Hogan JW, Neuhouser ML, et al. Long-term alcohol and caffeine intake and risk of sudden cardiac death in women. The American Journal of Clinical Nutrition. 2013; 97: 1356\u20131363.","DOI":"10.3945\/ajcn.112.044248"},{"key":"ref111","doi-asserted-by":"publisher","unstructured":"Chiuve SE, Rimm EB, Mukamal KJ, Rexrode KM, Stampfer MJ, Manson JE, et al. Light-to-moderate alcohol consumption and risk of sudden cardiac death in women. 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