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This technique involves denervation of specific vagal nerve structures within the atria to modulate autonomic balance and prevent symptomatic bradycardia. The efficacy of this approach stems from the recognition that an imbalance between sympathetic and parasympathetic tones, often characterized by excessive vagal activity, underpins these arrhythmogenic conditions. Indeed, CNA may be more effective than a permanent PM implantation in some patients, as this method addresses the underlying etiology rather than merely treating symptoms. Specifically, modulating autonomic nervous system (ANS) signaling through procedures such as CNA holds considerable promise for preventing and treating a range of cardiac arrhythmias. This review aims to synthesize current knowledge regarding various CNA techniques, exploring the associated mechanisms, clinical applications, and outcomes across diverse patient populations.<\/jats:p>","DOI":"10.31083\/rcm48106","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T01:28:22Z","timestamp":1785115702000},"source":"Crossref","is-referenced-by-count":0,"title":["Cardioneuroablation: A Comprehensive Review"],"prefix":"10.31083","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6683-6781","authenticated-orcid":true,"given":"Sergio","family":"Conti","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Section of Cardiac Electrophysiology, The Carver College of Medicine, University of Iowa Health Care Center, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6454-6665","authenticated-orcid":true,"given":"Andrea Giuseppe","family":"Porto","sequence":"additional","affiliation":[{"name":"U.O.C. di Cardiologia con UTIC ed Emodinamica, Ospedale Cannizzaro, 95126 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5014-5353","authenticated-orcid":true,"given":"Paolo","family":"Zappulla","sequence":"additional","affiliation":[{"name":"Divisione di Cardiologia, Azienda Ospedaliero Universitaria Policlinico \u201cG.Rodolico - San Marco\u201d, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6003-6054","authenticated-orcid":true,"given":"Giuseppe","family":"Sgarito","sequence":"additional","affiliation":[{"name":"IRCCS ISMETT-UPMC Heart Center, Institute for Transplantation and Advanced Specialized Therapies, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Serletis A, Rose S, Sheldon AG, Sheldon RS. 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