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Med."],"abstract":"<jats:p>Myocardial ischemia-reperfusion injury is a significant complication of reperfusion therapy and a primary cause of mortality in patients with acute myocardial infarction. The pathogenic mechanism involved in myocardial ischemia-reperfusion injury is intricate, and effective preventive and therapeutic strategies remain limited in clinical practice. Recently, pyroptosis has emerged as a novel regulatory form of cell death and has attracted widespread attention as a key focus in the study of disease mechanisms and therapeutic targets. Studies indicate a close association between pyroptosis and the pathophysiological processes underlying myocardial ischemia-reperfusion injury. This article provides a comprehensive review of recent advances in research on pyroptosis in the context of myocardial ischemia-reperfusion injury. Therefore, this review aims to offer new insights into the prevention and treatment of myocardial ischemia-reperfusion injury while minimizing redundancy in the existing literature.<\/jats:p>","DOI":"10.31083\/rcm48469","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T01:28:22Z","timestamp":1785115702000},"source":"Crossref","is-referenced-by-count":0,"title":["Pyroptosis: Novel Targets in Molecular Mechanisms and Drug Therapy Research for Myocardial Ischemia Reperfusion Injury"],"prefix":"10.31083","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5187-3598","authenticated-orcid":true,"given":"Dong","family":"Zhang","sequence":"first","affiliation":[{"name":"Interventional Diagnosis and Treatment Center, Yichang Central People's Hospital, 443000 Yichang, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5948-5987","authenticated-orcid":true,"given":"Hui","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Disease, China Three Gorges University, 443005 Yichang, Hubei, China"},{"name":"Department of Cardiology, Yichang Central People's Hospital, 443000 Yichang, Hubei, China"},{"name":"Central Laboratory, The First College of Clinical Medical Science, China Three Gorges University, 443005 Yichang, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8482-0116","authenticated-orcid":true,"given":"ShengYu","family":"Gong","sequence":"additional","affiliation":[{"name":"Pharmaceutical Department, Yichang Central People's Hospital, 443000 Yichang, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Disease, China Three Gorges University, 443005 Yichang, Hubei, China"},{"name":"Department of Cardiology, Yichang Central People's Hospital, 443000 Yichang, Hubei, China"},{"name":"Central Laboratory, The First College of Clinical Medical Science, China Three Gorges University, 443005 Yichang, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Disease, China Three Gorges University, 443005 Yichang, Hubei, China"},{"name":"Department of Cardiology, Yichang Central People's Hospital, 443000 Yichang, Hubei, China"},{"name":"Central Laboratory, The First College of Clinical Medical Science, China Three Gorges University, 443005 Yichang, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Disease, China Three Gorges University, 443005 Yichang, Hubei, China"},{"name":"Department of Cardiology, Yichang Central People's Hospital, 443000 Yichang, Hubei, China"},{"name":"Central Laboratory, The First College of Clinical Medical Science, China Three Gorges University, 443005 Yichang, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Disease, China Three Gorges University, 443005 Yichang, Hubei, China"},{"name":"Department of Cardiology, Yichang Central People's Hospital, 443000 Yichang, Hubei, China"},{"name":"Central Laboratory, The First College of Clinical Medical Science, China Three Gorges University, 443005 Yichang, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Barr\u00e8re-Lemaire S, Vincent A, Jorgensen C, Piot C, Nargeot J, Djouad F. Mesenchymal stromal cells for improvement of cardiac function following acute myocardial infarction: a matter of timing. Physiological Reviews. 2024; 104: 659\u2013725.","DOI":"10.1152\/physrev.00009.2023"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Lindahl B, Mills NL. A new clinical classification of acute myocardial infarction. Nature Medicine. 2023; 29: 2200\u20132205.","DOI":"10.1038\/s41591-023-02513-2"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Zhang J, Jia L, Yang Y, Xiao A, Lin X. Lipoprotein (a) and myocardial infarction: impact on long-term mortality. Lipids in Health and Disease. 2023; 22: 70.","DOI":"10.1186\/s12944-023-01841-z"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Liu Y, Li L, Wang Z, Zhang J, Zhou Z. Myocardial ischemia-reperfusion injury; Molecular mechanisms and prevention. 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Journal of Molecular and Cellular Cardiology. 2022; 171: 81\u201389.","DOI":"10.1016\/j.yjmcc.2022.07.005"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"Liu X, Luo P, Zhang W, Zhang S, Yang S, Hong F. Roles of pyroptosis in atherosclerosis pathogenesis. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 2023; 166: 115369.","DOI":"10.1016\/j.biopha.2023.115369"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"Amarante-Mendes GP, Adjemian S, Branco LM, Zanetti LC, Weinlich R, Bortoluci KR. Pattern Recognition Receptors and the Host Cell Death Molecular Machinery. Frontiers in Immunology. 2018; 9: 2379.","DOI":"10.3389\/fimmu.2018.02379"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"Broz P. Unconventional protein secretion by gasdermin pores. Seminars in Immunology. 2023; 69: 101811.","DOI":"10.1016\/j.smim.2023.101811"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"Gao L, Zhang A. Copper-instigated modulatory cell mortality mechanisms and progress in oncological treatment investigations. Frontiers in Immunology. 2023; 14: 1236063.","DOI":"10.3389\/fimmu.2023.1236063"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"Xie Y, Kang R, Klionsky DJ, Tang D. GPX4 in cell death, autophagy, and disease. Autophagy. 2023; 19: 2621\u20132638.","DOI":"10.1080\/15548627.2023.2218764"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"Mou Y, Liao W, Liang Y, Li Y, Zhao M, Guo Y, et al. Environmental pollutants induce NLRP3 inflammasome activation and pyroptosis: Roles and mechanisms in various diseases. The Science of the Total Environment. 2023; 900: 165851.","DOI":"10.1016\/j.scitotenv.2023.165851"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"Li K, You G, Jiang K, Wang R, Li W, Meng Y, et al. Root extract of Hemsleya amabilis Diels suppresses renal cell carcinoma cell growth through inducing apoptosis and G2\/M phase arrest via PI3K\/AKT signaling pathway. Journal of Ethnopharmacology. 2024; 318: 117014.","DOI":"10.1016\/j.jep.2023.117014"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"Gorgij E, Fanaei H, Yaghmaei P, Shahraki MR, Mirahmadi H. Maternal treadmill exercise ameliorates impairment of neurological outcome, caspase-1 and NLRP3 gene expression alteration in neonatal hypoxia-ischemia rats. Iranian Journal of Basic Medical Sciences. 2023; 26: 228\u2013234.","DOI":"10.22038\/IJBMS.2022.66183.14544"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"Hu Y, He S, Xu X, Cui X, Wei Y, Zhao C, et al. Shenhuangdan decoction alleviates sepsis-induced lung injury through inhibition of GSDMD-mediated pyroptosis. Journal of Ethnopharmacology. 2024; 318: 117047.","DOI":"10.1016\/j.jep.2023.117047"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"Li SJ, Liu AB, Yu YY, Ma JH. The role and mechanism of pyroptosis and potential therapeutic targets in non-alcoholic fatty liver disease (NAFLD). Frontiers in Cell and Developmental Biology. 2024; 12: 1407738.","DOI":"10.3389\/fcell.2024.1407738"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"Wertman RS, Yost W, Herrmann BI, Bourne CM, Sorobetea D, Go CK, et al. Distinct sequential death complexes regulate pyroptosis and IL-1\u03b2 release in response to Yersinia blockade of immune signaling. Science Advances. 2024; 10: eadl3629.","DOI":"10.1126\/sciadv.adl3629"},{"key":"ref50","doi-asserted-by":"publisher","unstructured":"Liu Z, Wang C, Yang J, Chen Y, Zhou B, Abbott DW, et al. Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. Immunity. 2020; 53: 106\u2013114.e5.","DOI":"10.1016\/j.immuni.2020.06.007"},{"key":"ref51","doi-asserted-by":"publisher","unstructured":"Ye Z, Li L, Li Y, Hu Y, Wu M, Yu H, et al. Tou Nong powder obstructs ulcerative colitis through the regulation of NF-\u03baB\/NLRP3\/Caspase-1\/GSDMD inflammasome pyroptotic pathway. Journal of Ethnopharmacology. 2023; 317: 116846.","DOI":"10.1016\/j.jep.2023.116846"},{"key":"ref52","doi-asserted-by":"publisher","unstructured":"Yao J, Wang Z, Song W, Zhang Y. Targeting NLRP3 inflammasome for neurodegenerative disorders. Molecular Psychiatry. 2023; 28: 4512\u20134527.","DOI":"10.1038\/s41380-023-02239-0"},{"key":"ref53","doi-asserted-by":"publisher","unstructured":"Marrocco A, Ortiz LA. Role of metabolic reprogramming in pro-inflammatory cytokine secretion from LPS or silica-activated macrophages. Frontiers in Immunology. 2022; 13: 936167.","DOI":"10.3389\/fimmu.2022.936167"},{"key":"ref54","doi-asserted-by":"publisher","unstructured":"Xu YJ, Zheng L, Hu YW, Wang Q. Pyroptosis and its relationship to atherosclerosis. Clinica Chimica Acta; International Journal of Clinical Chemistry. 2018; 476: 28\u201337.","DOI":"10.1016\/j.cca.2017.11.005"},{"key":"ref55","doi-asserted-by":"publisher","unstructured":"Zhaolin Z, Guohua L, Shiyuan W, Zuo W. Role of pyroptosis in cardiovascular disease. Cell Proliferation. 2019; 52: e12563.","DOI":"10.1111\/cpr.12563"},{"key":"ref56","doi-asserted-by":"publisher","unstructured":"Devant P, Kagan JC. Molecular mechanisms of gasdermin D pore-forming activity. Nature Immunology. 2023; 24: 1064\u20131075.","DOI":"10.1038\/s41590-023-01526-w"},{"key":"ref57","doi-asserted-by":"publisher","unstructured":"R\u00fchl S, Broz P. Regulation of Lytic and Non-Lytic Functions of Gasdermin Pores. Journal of Molecular Biology. 2022; 434: 167246.","DOI":"10.1016\/j.jmb.2021.167246"},{"key":"ref58","doi-asserted-by":"publisher","unstructured":"Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015; 526: 660\u2013665.","DOI":"10.1038\/nature15514"},{"key":"ref59","doi-asserted-by":"publisher","unstructured":"Zhang R, Gou W, Yi P, Qin Z, Zhu D, Jia J, et al. Tetracaine hydrochloride induces macrophage pyroptosis through caspase 1\/11 GSDMD signaling pathways. Experimental and Therapeutic Medicine. 2023; 26: 428.","DOI":"10.3892\/etm.2023.12127"},{"key":"ref60","doi-asserted-by":"publisher","unstructured":"Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. 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Interplay between Exosomes and Autophagy in Cardiovascular Diseases: Novel Promising Target for Diagnostic and Therapeutic Application. Aging and Disease. 2019; 10: 1302\u20131310.","DOI":"10.14336\/AD.2018.1020"},{"key":"ref78","doi-asserted-by":"publisher","unstructured":"Martinez B, Peplow PV. MicroRNAs as potential biomarkers for diagnosis of attention deficit hyperactivity disorder. Neural Regeneration Research. 2024; 19: 557\u2013562.","DOI":"10.4103\/1673-5374.380880"},{"key":"ref79","doi-asserted-by":"publisher","unstructured":"Basu P, Maier C, Averitt DL, Basu A. NLR family pyrin domain containing 3 (NLRP3) inflammasomes and peripheral neuropathic pain - Emphasis on microRNAs (miRNAs) as important regulators. European Journal of Pharmacology. 2023; 955: 175901.","DOI":"10.1016\/j.ejphar.2023.175901"},{"key":"ref80","doi-asserted-by":"publisher","unstructured":"Li X, Du N, Zhang Q, Li J, Chen X, Liu X, et al. MicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathy. Cell Death & Disease. 2014; 5: e1479.","DOI":"10.1038\/cddis.2014.430"},{"key":"ref81","doi-asserted-by":"publisher","unstructured":"Jia Y, Li D, Yu J, Jiang W, Liao X, Zhao Q. Potential diabetic cardiomyopathy therapies targeting pyroptosis: A mini review. Frontiers in Cardiovascular Medicine. 2022; 9: 985020.","DOI":"10.3389\/fcvm.2022.985020"},{"key":"ref82","doi-asserted-by":"publisher","unstructured":"Yang F, Li A, Qin Y, Che H, Wang Y, Lv J, et al. A Novel Circular RNA Mediates Pyroptosis of Diabetic Cardiomyopathy by Functioning as a Competing Endogenous RNA. Molecular Therapy. Nucleic Acids. 2019; 17: 636\u2013643.","DOI":"10.1016\/j.omtn.2019.06.026"},{"key":"ref83","doi-asserted-by":"publisher","unstructured":"Peng L, Lei Z, Rao Z, Yang R, Zheng L, Fan Y, et al. Cardioprotective activity of ethyl acetate extract of Cinnamomi Ramulus against myocardial ischemia\/reperfusion injury in rats via inhibiting NLRP3 inflammasome activation and pyroptosis. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology. 2021; 93: 153798.","DOI":"10.1016\/j.phymed.2021.153798"},{"key":"ref84","doi-asserted-by":"publisher","unstructured":"Luan F, Lei Z, Peng X, Chen L, Peng L, Liu Y, et al. Cardioprotective effect of cinnamaldehyde pretreatment on ischemia\/ reperfusion injury via inhibiting NLRP3 inflammasome activation and gasdermin D mediated cardiomyocyte pyroptosis. Chemico-biological Interactions. 2022; 368: 110245.","DOI":"10.1016\/j.cbi.2022.110245"},{"key":"ref85","doi-asserted-by":"publisher","unstructured":"Xu XN, Jiang Y, Yan LY, Yin SY, Wang YH, Wang SB, et al. Aesculin suppresses the NLRP3 inflammasome-mediated pyroptosis via the Akt\/GSK3\u03b2\/NF-\u03baB pathway to mitigate myocardial ischemia\/reperfusion injury. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology. 2021; 92: 153687.","DOI":"10.1016\/j.phymed.2021.153687"},{"key":"ref86","doi-asserted-by":"publisher","unstructured":"Wu J, Chen S, Wu P, Wang Y, Qi X, Zhang R, et al. Cathepsin B\/HSP70 complex induced by Ilexsaponin I suppresses NLRP3 inflammasome activation in myocardial ischemia\/reperfusion injury. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology. 2022; 105: 154358.","DOI":"10.1016\/j.phymed.2022.154358"},{"key":"ref87","doi-asserted-by":"publisher","unstructured":"An L, Zhong Y, Tan J, Liu Y, Li A, Yang T, et al. Sevoflurane exerts protection against myocardial ischemia-reperfusion injury and pyroptosis through the circular RNA PAN3\/microRNA-29b-3p\/stromal cell-derived factor 4 axis. International Immunopharmacology. 2023; 120: 110219.","DOI":"10.1016\/j.intimp.2023.110219"},{"key":"ref88","doi-asserted-by":"publisher","unstructured":"Lei Z, Luan F, Zhang X, Peng L, Li B, Peng X, et al. Piperazine ferulate protects against cardiac ischemia\/reperfusion injury in rat via the suppression of NLRP3 inflammasome activation and pyroptosis. European Journal of Pharmacology. 2022; 920: 174856.","DOI":"10.1016\/j.ejphar.2022.174856"},{"key":"ref89","doi-asserted-by":"publisher","unstructured":"Mao C, Li D, Zhou E, Gao E, Zhang T, Sun S, et al. Extracellular vesicles from anoxia preconditioned mesenchymal stem cells alleviate myocardial ischemia\/reperfusion injury. Aging. 2021; 13: 6156\u20136170.","DOI":"10.18632\/aging.202611"},{"key":"ref90","doi-asserted-by":"publisher","unstructured":"Pan SS, Wang F, Hui YP, Chen KY, Zhou L, Gao WL, et al. 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