{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:19:53Z","timestamp":1783423193692,"version":"3.54.6"},"reference-count":24,"publisher":"IMR Press","issue":"6","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Postgraduate Research & Practice Innovation Program of Jiangsu Province","award":["SJCX25_2401"],"award-info":[{"award-number":["SJCX25_2401"]}]},{"name":"Postgraduate Research & Practice Innovation Program of Jiangsu Province","award":["SJCX24_2350"],"award-info":[{"award-number":["SJCX24_2350"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Background:This study aimed to investigate clinical factors associated with hyperuricemia (HUA) in patients with newly diagnosed coronary heart disease (CHD) and to evaluate the correlation of novel derived biomarkers with HUA, thereby providing a reference for clinical risk identification, prevention, and treatment.Methods:This retrospective study analyzed 2265 patients with newly diagnosed CHD (2019\u20132024) who were randomly assigned to a modeling group (n = 1812) and a validation group (n = 453); HUA was defined as serum uric acid (UA) \u2265420 \u03bcmol\/L. Least absolute shrinkage and selection operator (LASSO) regression and multivariate logistic regression were used to identify associated factors. A prediction model was constructed and evaluated using receiver operating characteristic (ROC) curves, decision curve analysis (DCA), and calibration plots.Results:Independent factors associated with HUA included triglycerides (odds ratio (OR) = 1.097, 95% CI: 1.036\u20131.160), creatinine (OR = 1.030, 95% CI: 1.025\u20131.035), monocyte-to-high-density lipoprotein cholesterol ratio (MHR; OR = 1.447, 95% CI: 1.057\u20131.981), remnant cholesterol (RC; OR = 1.812, 95% CI: 1.406\u20132.337), and alcohol use (OR = 1.596, 95% CI: 1.202\u20132.119) (all p &lt; 0.05). The model demonstrated good discrimination with areas under the ROC curve (AUROCs) of 0.781 (0.729\u20130.832) in the modeling group and 0.780 (0.751\u20130.808) in the validation group, as well as good calibration and clinical utility at threshold probabilities of 0.22\u20131.00 and 0.20\u20130.66, respectively. MHR and RC exhibited a positive nonlinear relationship with HUA risk, with a stronger association for MHR in the hypertensive subgroup (p &lt; 0.05).Conclusion:MHR and RC are novel biomarkers associated with HUA risk in patients with new-onset CHD. When combined with traditional factors such as triglycerides and creatinine, these novel biomarkers support a multifactorial, integrated evaluation of HUA-related risk and serve as a reference for clinical risk stratification and management.<\/jats:p>","DOI":"10.31083\/rcm49042","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:06:15Z","timestamp":1783422375000},"source":"Crossref","is-referenced-by-count":0,"title":["Factors Associated With Hyperuricemia in Patients With Coronary Heart Disease"],"prefix":"10.31083","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4896-7168","authenticated-orcid":true,"given":"Qinyu","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Cardiology, Northern Jiangsu People\u2019s Hospital Affiliated to Yangzhou University, 225001 Yangzhou, Jiangsu, China"},{"name":"Department of Cardiology, Northern Jiangsu People\u2019s Hospital, 225001 Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Northern Jiangsu People\u2019s Hospital Affiliated to Yangzhou University, 225001 Yangzhou, Jiangsu, China"},{"name":"Department of Cardiology, Northern Jiangsu People\u2019s Hospital, 225001 Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Urology, Northern Jiangsu People\u2019s Hospital Affiliated to Yangzhou University, 225001 Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Northern Jiangsu People\u2019s Hospital Affiliated to Yangzhou University, 225001 Yangzhou, Jiangsu, China"},{"name":"Department of Cardiology, Northern Jiangsu People\u2019s Hospital, 225001 Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3660-8088","authenticated-orcid":true,"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Affiliated Hospital of Yangzhou University, 225000 Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3079-3788","authenticated-orcid":true,"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Northern Jiangsu People\u2019s Hospital Affiliated to Yangzhou University, 225001 Yangzhou, Jiangsu, China"},{"name":"Department of Cardiology, Northern Jiangsu People\u2019s Hospital, 225001 Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Sun Q, Deng Y, Zhang Y, Fang Z, Ji J, He S, et al. The Relationship Between the C-reactive Protein-Triglyceride Glucose Index and the Risk of Coronary Heart Disease Alongside the Severity of Coronary Artery Stenosis in Older Adults With Different Levels of Glucose Metabolism: A Real-World Retrospective Clinical Study. Reviews in Cardiovascular Medicine. 2025; 26: 45886.","DOI":"10.31083\/RCM45886"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Yanai H, Adachi H, Hakoshima M, Katsuyama H. Molecular Biological and Clinical Understanding of the Pathophysiology and Treatments of Hyperuricemia and Its Association with Metabolic Syndrome, Cardiovascular Diseases and Chronic Kidney Disease. International Journal of Molecular Sciences. 2021; 22: 9221.","DOI":"10.3390\/ijms22179221"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Gu W, Zhao J, Xu Y. Hyperuricemia-induced complications: dysfunctional macrophages serve as a potential bridge. Frontiers in Immunology. 2025; 16: 1512093.","DOI":"10.3389\/fimmu.2025.1512093"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Shubietah A, Awashra A, Milhem F, Ghannam M, Hattab M, Rajab I, et al. Hyperuricemia and Cardiovascular Risk: Insights and Implications. Critical Pathways in Cardiology. 2025; 24: e0388.","DOI":"10.1097\/HPC.0000000000000388"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Yu W, Cheng JD. Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective. Frontiers in Pharmacology. 2020; 11: 582680.","DOI":"10.3389\/fphar.2020.582680"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Kuwabara M, Hisatome I, Ae R, Kosami K, Aoki Y, Andres-Hernando A, et al. Hyperuricemia, A new cardiovascular risk. Nutrition, Metabolism, and Cardiovascular Diseases: NMCD. 2025; 35: 103796.","DOI":"10.1016\/j.numecd.2024.103796"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Cri\u0219an TO, Cleophas MCP, Oosting M, Lemmers H, Toenhake-Dijkstra H, Netea MG, et al. Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1Ra. Annals of the Rheumatic Diseases. 2016; 75: 755\u2013762.","DOI":"10.1136\/annrheumdis-2014-206564"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Zheng Y, Chen Z, Yang J, Zheng J, Shui X, Yan Y, et al. The Role of Hyperuricemia in Cardiac Diseases: Evidence, Controversies, and Therapeutic Strategies. Biomolecules. 2024; 14: 753.","DOI":"10.3390\/biom14070753"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Cockerill GW, Rye KA, Gamble JR, Vadas MA, Barter PJ. High-density lipoproteins inhibit cytokine-induced expression of endothelial cell adhesion molecules. Arteriosclerosis, Thrombosis, and Vascular Biology. 1995; 15: 1987\u20131994.","DOI":"10.1161\/01.atv.15.11.1987"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Meng H, Zhou X, Li L, Liu Y, Liu Y, Zhang Y. Monocyte to high-density lipoprotein cholesterol ratio predicts restenosis of drug-eluting stents in patients with unstable angina pectoris. Scientific Reports. 2024; 14: 30175.","DOI":"10.1038\/s41598-024-81818-9"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Fu S, Xie L, Li D, Ye P, Luo L. The predictive capacity and additional prognostic power of N-terminal pro-B-type natriuretic peptide in Chinese elderly with chronic heart failure. Clinical Interventions in Aging. 2015; 10: 359\u2013365.","DOI":"10.2147\/CIA.S77417"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Li Q, Lin X, Bo X, Li F, Chen S, Miao X, et al. Monocyte to high-density lipoprotein cholesterol ratio predicts poor outcomes in ischaemic heart failure patients combined with diabetes: a retrospective study. European Journal of Medical Research. 2023; 28: 493.","DOI":"10.1186\/s40001-023-01451-6"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Zhang J, Hao Z, Ma Y, Zheng P, Huang L, Xu J, et al. Residual cholesterol is an independent risk factor for new-onset hyperuricemia: a nationwide cohort study based on a middle-aged and elderly population. Nutrition, Metabolism, and Cardiovascular Diseases: NMCD. 2025; 35: 104118.","DOI":"10.1016\/j.numecd.2025.104118"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Xiao Z, Lin Z, Xu L, Xu W, Huang H, Wang Y, et al. Cumulative remnant cholesterol predicts cardiovascular outcomes in elderly patients with atherosclerotic cardiovascular disease. European Journal of Preventive Cardiology. 2023; 30: 1924\u20131934.","DOI":"10.1093\/eurjpc\/zwad297"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Liu W, Liu W, Wang S, Tong H, Yuan J, Zou Z, et al. Prevalence and Risk Factors Associated with Hyperuricemia in the Pearl River Delta, Guangdong Province, China. Risk Management and Healthcare Policy. 2021; 14: 655\u2013663.","DOI":"10.2147\/RMHP.S293913"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Yip K, Cohen RE, Pillinger MH. Asymptomatic hyperuricemia: is it really asymptomatic? Current Opinion in Rheumatology. 2020; 32: 71\u201379.","DOI":"10.1097\/BOR.0000000000000679"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Helget LN, Mikuls TR. Environmental Triggers of Hyperuricemia and Gout. Rheumatic diseases clinics of North America. 2022; 48: 891\u2013906. https:\/\/doi:","DOI":"10.1016\/j.rdc.2022.06.009"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Cui WX, Wang SW, Gao L, Mu DH, Li N, Pan FH, et al. Triglycerides and HDL Cholesterol Mediate the Association Between Waist Circumference and Hyperuricemia in Normal-Weight Men. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2024; 17: 4599\u20134610.","DOI":"10.2147\/DMSO.S493327"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Kim Y, Kang J, Kim GT. Prevalence of hyperuricemia and its associated factors in the general Korean population: an analysis of a population-based nationally representative sample. Clinical Rheumatology. 2018; 37: 2529\u20132538.","DOI":"10.1007\/s10067-018-4130-2"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Takata T, Mae Y, Hoi S, Iyama T, Isomoto H. Hyperuricemia in Chronic Kidney Disease: Emerging Pathophysiology and a Novel Therapeutic Strategy. International Journal of Molecular Sciences. 2025; 26: 9000.","DOI":"10.3390\/ijms26189000"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Kuwabara M, Kodama T, Ae R, Kanbay M, Andres-Hernando A, Borghi C, et al. Update in uric acid, hypertension, and cardiovascular diseases. Hypertension Research: Official Journal of the Japanese Society of Hypertension. 2023; 46: 1714\u20131726.","DOI":"10.1038\/s41440-023-01273-3"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Kim BS, Shin JH, Kim W, Kook H, Lee Y, Park JK, et al. Association of office blood pressure with ischemic and bleeding events in patients undergoing percutaneous coronary intervention. Scientific Reports. 2024; 14: 20310.","DOI":"10.1038\/s41598-024-71060-8"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Zheng R, Yang T, Chen Q, Chen C, Mao Y. Serum Uric Acid Concentrations Can Predict Hypertension: A Longitudinal Population-Based Epidemiological Study. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones et Metabolisme. 2017; 49: 873\u2013879.","DOI":"10.1055\/s-0043-119129"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Centola M, Maloberti A, Castini D, Persampieri S, Sabatelli L, Ferrante G, et al. Impact of admission serum acid uric levels on in-hospital outcomes in patients with acute coronary syndrome. European Journal of Internal Medicine. 2020; 82: 62\u201367.","DOI":"10.1016\/j.ejim.2020.07.013"}],"container-title":["Reviews in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/27\/6\/10.31083\/RCM49042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:10:19Z","timestamp":1783422619000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/27\/6\/10.31083\/RCM49042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,9]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026]]}},"alternative-id":["S1530-6550(26)02979-0"],"URL":"https:\/\/doi.org\/10.31083\/rcm49042","relation":{},"ISSN":["1530-6550","2153-8174"],"issn-type":[{"value":"1530-6550","type":"print"},{"value":"2153-8174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,9]]},"article-number":"49042"}}