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With an aging population and increased exposure to risk factors, the incidence of AA is rising, and rupture is associated with a mortality rate of 80\u201390%. Recent advances in molecular biology, imaging, and interventional techniques have expanded the understanding of AA pathogenesis beyond the traditional \u201cdegenerative disease\u201d model to encompass genetic variation, extracellular matrix (ECM) remodeling, inflammatory responses, and dysregulated signaling pathway. Meanwhile, diagnostic approaches have become increasingly precise, enabling earlier detection through routine screening and three-dimensional vascular reconstruction. Clinical management has evolved into a comprehensive strategy centered on surgical intervention, supported by pharmacological therapy and long-term monitoring. This review systematically examines the pathophysiological mechanisms, advancements in diagnostic technologies, and evidence-based clinical management of AA, discusses current controversies, and explores future applications of precision medicine.<\/jats:p>","DOI":"10.31083\/rcm49246","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:06:15Z","timestamp":1783422375000},"source":"Crossref","is-referenced-by-count":0,"title":["Pathogenesis, Diagnosis, and Clinical Management of Aortic Aneurysms: Current Status and Future Perspectives"],"prefix":"10.31083","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4270-9582","authenticated-orcid":true,"given":"Biyue","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Radiology, West China School of Public Health and West China Fourth Hospital, Sichuan University, 610041 Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0516-3255","authenticated-orcid":true,"given":"Weilin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, 610041 Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Berger T, Dumfarth J, Kreibich M, Minatoya K, Ziganshin BA, Czerny M. 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