{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:00:09Z","timestamp":1790697609364,"version":"4.1.0"},"reference-count":27,"publisher":"IMR Press","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The University Reform and Development Fund of the Hunan Provincial Department of Finance for the Hypertensive Nephropathy Pathogenesis Research Project","award":["0531120"],"award-info":[{"award-number":["0531120"]}]},{"name":"The Hunan Provincial Natural Science Foundation Project","award":["2026JJ81645"],"award-info":[{"award-number":["2026JJ81645"]}]},{"name":"The Hunan Provincial \u201cFurong Program\u201d Health Young Talents Project and the Natural Science Foundation of Hunan Province","award":["2026JJ81725"],"award-info":[{"award-number":["2026JJ81725"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Background: Left ventricular global longitudinal strain (LVGLS) is a sensitive index of left ventricular systolic function. However, the prognostic value of this metric in patients with acute non-ST-segment elevation myocardial infarction (NSTEMI) has not been fully established. Methods: We retrospectively enrolled patients with newly diagnosed NSTEMI at Hunan Provincial People\u2019s Hospital between April 2020 and October 2023. All participants underwent transthoracic echocardiography (TTE) within 48 hours before coronary revascularization. Major adverse cardiovascular events (MACEs) were defined as readmission for unstable angina, non-fatal myocardial infarction, readmission for heart failure, or cardiac death. Results: We followed 181 patients with NSTEMI for a median of 599 days (interquartile range (IQR): 297\u2013800). MACEs occurred in 40 patients. Patients who experienced MACEs had significantly worse LVGLS than those without events (\u201311.00 [\u201313.70, \u20137.77] vs. \u201316.10 [\u201318.90, \u201313.50]; p &lt; 0.001). In multivariable Cox regression analysis, LVGLS independently predicted MACEs (hazard ratio (HR) = 1.310, 95% confidence interval (CI): 1.172\u20131.465; p &lt; 0.001). For 12-month risk prediction, adding LVGLS to the baseline clinical model improved discrimination, increasing the area under the curve (AUC) from 0.668 to 0.835. Kaplan\u2013Meier analysis showed a markedly higher risk of MACEs in patients with LVGLS &gt;\u201313.75% than in those with LVGLS \u2264\u201313.75% (HR = 7.463; 95% CI, 3.831\u201314.540; p &lt; 0.001). Conclusions: LVGLS is a strong, independent predictor of adverse cardiovascular events and may improve early risk stratification in patients with NSTEMI.<\/jats:p>","DOI":"10.31083\/rcm49528","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:57:11Z","timestamp":1790693831000},"source":"Crossref","is-referenced-by-count":0,"title":["Outcome Stratification in Non-ST-Segment Elevation Myocardial Infarction: Standardized Assessment of Left Ventricular Global Longitudinal Strain"],"prefix":"10.31083","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4104-2286","authenticated-orcid":true,"given":"Yaoyuan","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hunan Provincial People\u2019s Hospital, The First Affiliated Hospital of Hunan Normal University, Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Normal University, 410005 Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0221-6596","authenticated-orcid":true,"given":"Xi","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Research Department, Shenzhen Qianhai Shekou Free Trade Zone Hospital, 518067 Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1703-2394","authenticated-orcid":true,"given":"Qinghua","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hunan Provincial People\u2019s Hospital, The First Affiliated Hospital of Hunan Normal University, Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Normal University, 410005 Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3785-1947","authenticated-orcid":true,"given":"Yi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hunan Provincial People\u2019s Hospital, The First Affiliated Hospital of Hunan Normal University, Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Normal University, 410005 Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6695-7072","authenticated-orcid":true,"given":"Mingxiang","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hunan Provincial People\u2019s Hospital, The First Affiliated Hospital of Hunan Normal University, Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Normal University, 410005 Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Puymirat E, Simon T, Cayla G, Cottin Y, Elbaz M, Coste P, et al. 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