{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T13:13:01Z","timestamp":1788441181180,"version":"build-2803163510"},"reference-count":57,"publisher":"IMR Press","issue":"8","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Left ventricular thrombus (LVT) remains a critical complication of acute myocardial infarction (MI), particularly in patients with anterior ST-segment elevation myocardial infarction (STEMI) and apical dysfunction. While primary percutaneous coronary intervention (PCI) has reduced its overall incidence compared with the pre-thrombolytic era, LVT continues to pose a significant risk of systemic embolization and stroke, driven by the interplay of endothelial injury, hypercoagulability, and stasis within the aneurysmal apex. This review synthesizes current evidence on the pathophysiology, diagnosis, and management of LVT. We critically evaluate diagnostic modalities, highlighting the substantial sensitivity gap between the clinical standard, transthoracic echocardiography (TTE), and the gold standard, cardiac magnetic resonance (CMR). This discrepancy has important implications for clinical decision-making, as TTE often overestimates thrombus resolution, potentially leading to the premature cessation of therapy. Therapeutically, the landscape has shifted from the empiric use of vitamin K antagonists (VKAs) toward the adoption of direct oral anticoagulants (DOACs). Thus, we analyze recent randomized data, including the Comparative Study of Oral Anticoagulation in Left Ventricular Thrombi (No-LVT) and the Rivaroxaban vs Warfarin in Acute Left Ventricular Thrombus Following Myocardial Infarction (RIVAWAR) trials, which demonstrate that DOACs are non-inferior to VKAs for embolic prevention and may offer superior resolution velocity, a crucial metric for stabilizing friable thrombi. We conclude that DOACs represent a reasonable, patient-centered alternative to warfarin. Nonetheless, future management strategies must integrate precise, serial imaging with rapid-onset anticoagulation to ensure complete histologic resolution while minimizing the hemorrhagic burden of prolonged triple antithrombotic therapy.<\/jats:p>","DOI":"10.31083\/rcm50947","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:17:46Z","timestamp":1788437866000},"source":"Crossref","is-referenced-by-count":0,"title":["Direct Oral Anticoagulants Versus Vitamin K Antagonists for Treatment of Left Ventricular Thrombus: A Review of Efficacy and Safety"],"prefix":"10.31083","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7461-4779","authenticated-orcid":true,"given":"Malik","family":"Alqawasmi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osaid","family":"Alrahamneh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Altamash","family":"Jawadi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Blankenship","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Camaj A, Fuster V, Giustino G, Bienstock SW, Sternheim D, Mehran R, et al. 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The New England Journal of Medicine. 1981; 305: 297\u2013302.","DOI":"10.1056\/NEJM198108063050601"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Cambronero-Cortinas E, Bonanad C, Monmeneu JV, Lopez-Lereu MP, Gavara J, de Dios E, et al. Incidence, Outcomes, and Predictors of Ventricular Thrombus after Reperfused ST-Segment-Elevation Myocardial Infarction by Using Sequential Cardiac MR Imaging. Radiology. 2017; 284: 372\u2013380.","DOI":"10.1148\/radiol.2017161898"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Khaled S, Hachicha Z, Elkhateeb O. Left Ventricular Thrombus in Myocardial Infarction After Successful Primary Percutaneous Coronary Intervention: Prevalence and Predictors-A Middle Eastern Single-Centre Experience. CJC Open. 2020; 2: 104\u2013110.","DOI":"10.1016\/j.cjco.2020.02.001"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Vaitkus PT, Barnathan ES. Embolic potential, prevention and management of mural thrombus complicating anterior myocardial infarction: a meta-analysis. Journal of the American College of Cardiology. 1993; 22: 1004\u20131009.","DOI":"10.1016\/0735-1097(93)90409-t"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Kernan WN, Ovbiagele B, Black HR, Bravata DM, Chimowitz MI, Ezekowitz MD, et al. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke. 2014; 45: 2160\u20132236.","DOI":"10.1161\/STR.0000000000000024"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Witt BJ, Brown RD Jr, Jacobsen SJ, Weston SA, Yawn BP, Roger VL. A community-based study of stroke incidence after myocardial infarction. Annals of Internal Medicine. 2005; 143: 785\u2013792.","DOI":"10.7326\/0003-4819-143-11-200512060-00006"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Chen PF, Tang L, Yi JL, Pei JY, Hu XQ. The prognostic effect of left ventricular thrombus formation after acute myocardial infarction in the contemporary era of primary percutaneous coronary intervention: A meta-analysis. European Journal of Internal Medicine. 2020; 73: 43\u201350.","DOI":"10.1016\/j.ejim.2019.10.029"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Fuster V, Halperin JL. Left ventricular thrombi and cerebral embolism. The New England Journal of Medicine. 1989; 320: 392\u2013394.","DOI":"10.1056\/NEJM198902093200610"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). European Heart Journal. 2018; 39: 119\u2013177.","DOI":"10.1093\/eurheartj\/ehx393"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"O'Gara PT, Kushner FG, Ascheim DD, Casey DE Jr, Chung MK, de Lemos JA, et al. 2013 ACCF\/AHA guideline for the management of ST-elevation myocardial infarction: executive summary: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the American College of Emergency Physicians and Society for Cardiovascular Angiography and Interventions. Catheterization and Cardiovascular Interventions. 2013; 82: E1\u201327.","DOI":"10.1002\/ccd.24776"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Levine GN, McEvoy JW, Fang JC, Ibeh C, McCarthy CP, Misra A, et al. Management of Patients at Risk for and With Left Ventricular Thrombus: A Scientific Statement From the American Heart Association. 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International Journal of Cardiology. 2016; 221: 554\u2013559.","DOI":"10.1016\/j.ijcard.2016.07.069"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Lamas GA, Vaughan DE, Pfeffer MA. Left ventricular thrombus formation after first anterior wall acute myocardial infarction. The American Journal of Cardiology. 1988; 62: 31\u201335.","DOI":"10.1016\/0002-9149(88)91360-4"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Johannessen KA, Nordrehaug JE, von der Lippe G. Left ventricular thrombosis and cerebrovascular accident in acute myocardial infarction. British Heart Journal. 1984; 51: 553\u2013556.","DOI":"10.1136\/hrt.51.5.553"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"K\u00fcpper AJ, Verheugt FW, Peels CH, Galema TW, Roos JP. Left ventricular thrombus incidence and behavior studied by serial two-dimensional echocardiography in acute anterior myocardial infarction: left ventricular wall motion, systemic embolism and oral anticoagulation. Journal of the American College of Cardiology. 1989; 13: 1514\u20131520.","DOI":"10.1016\/0735-1097(89)90341-0"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Lema\u00eetre AI, Picard F, Maurin V, Faure M, Dos Santos P, Girerd N. Clinical profile and midterm prognosis of left ventricular thrombus in heart failure. ESC Heart Failure. 2021; 8: 1333\u20131341.","DOI":"10.1002\/ehf2.13211"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Youssef AA, Alrefae MA, Khalil HH, Abdullah HI, Khalifa ZS, Al Shaban AA, et al. Apixaban in Patients With Post-Myocardial Infarction Left Ventricular Thrombus: A Randomized Clinical Trial. CJC Open. 2023; 5: 191\u2013199.","DOI":"10.1016\/j.cjco.2022.12.003"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"You J, Wang X, Wu J, Gao L, Wang X, Du P, et al. 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Assessment of left ventricular thrombi using cardiac CT: A comparative evaluation of non-contrast, CT-angiography, delayed-enhanced images, and extracellular volume maps. Journal of Cardiovascular Computed Tomography. 2026; 20: 25\u201332.","DOI":"10.1016\/j.jcct.2025.10.015"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Catalani F, Sarzilla S, Will M, Pedrazzini G, Demarchi A. Left Ventricular Thrombosis in Ischemic and Non-Ischemic Cardiomyopathies: Focus on Evidence-Based Treatment. Journal of Clinical Medicine. 2025; 14: 1615.","DOI":"10.3390\/jcm14051615"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Rao SV, O'Donoghue ML, Ruel M, Rab T, Tamis-Holland JE, Alexander JH, et al. 2025 ACC\/AHA\/ACEP\/NAEMSP\/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. Journal of the American College of Cardiology. 2025; 85: 2135\u20132237.","DOI":"10.1016\/j.jacc.2024.11.009"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Phuah Y, Tan YX, Zaghloul S, Sim S, Wong J, Usmani S, et al. A systematic review and meta-analysis of transthoracic echocardiogram vs. cardiac magnetic resonance imaging for the detection of left ventricular thrombus. European Heart Journal. Imaging Methods and Practice. 2023; 1: qyad041.","DOI":"10.1093\/ehjimp\/qyad041"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Albulushi A, Xie F, Porter TR. Ultrasound enhancing agents in cardiovascular imaging: expanding horizons beyond coronary arteries. Cardiovascular Ultrasound. 2024; 22: 10.","DOI":"10.1186\/s12947-024-00330-2"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"Weinsaft JW, Kim RJ, Ross M, Krauser D, Manoushagian S, LaBounty TM, et al. Contrast-enhanced anatomic imaging as compared to contrast-enhanced tissue characterization for detection of left ventricular thrombus. JACC. Cardiovascular Imaging. 2009; 2: 969\u2013979.","DOI":"10.1016\/j.jcmg.2009.03.017"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Haider MZ, Tahir MF, Nasir Z, Ain QU. 6-011 Evaluating transthoracic echocardiography versus cardiac MRI for left ventricular thrombus detection in resource-limited settings. Heart. 2025; 111: A184.","DOI":"10.1136\/heartjnl-2025-BCS.183"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"Weinsaft JW, Kim HW, Crowley AL, Klem I, Shenoy C, Van Assche L, et al. LV thrombus detection by routine echocardiography: insights into performance characteristics using delayed enhancement CMR. JACC. Cardiovascular Imaging. 2011; 4: 702\u2013712.","DOI":"10.1016\/j.jcmg.2011.03.017"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"Weinsaft JW, Kim HW, Shah DJ, Klem I, Crowley AL, Brosnan R, et al. Detection of left ventricular thrombus by delayed-enhancement cardiovascular magnetic resonance prevalence and markers in patients with systolic dysfunction. Journal of the American College of Cardiology. 2008; 52: 148\u2013157.","DOI":"10.1016\/j.jacc.2008.03.041"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"Velangi PS, Choo C, Chen KHA, Kazmirczak F, Nijjar PS, Farzaneh-Far A, et al. Long-Term Embolic Outcomes After Detection of Left Ventricular Thrombus by Late Gadolinium Enhancement Cardiovascular Magnetic Resonance Imaging: A Matched Cohort Study. Circulation. Cardiovascular Imaging. 2019; 12: e009723.","DOI":"10.1161\/CIRCIMAGING.119.009723"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"Johannessen KA, Nordrehaug JE, von der Lippe G. Left ventricular thrombi after short-term high-dose anticoagulants in acute myocardial infarction. European Heart Journal. 1987; 8: 975\u2013980.","DOI":"10.1093\/oxfordjournals.eurheartj.a062374"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo A, et al. 2023 ESC Guidelines for the management of acute coronary syndromes. European Heart Journal. 2023; 44: 3720\u20133826.","DOI":"10.1093\/eurheartj\/ehad191"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"Mar PL, Gopinathannair R, Gengler BE, Chung MK, Perez A, Dukes J, et al. Drug Interactions Affecting Oral Anticoagulant Use. Circulation. Arrhythmia and Electrophysiology. 2022; 15: e007956.","DOI":"10.1161\/CIRCEP.121.007956"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"Hansen ML, S\u00f8rensen R, Clausen MT, Fog-Petersen ML, Rauns\u00f8 J, Gadsb\u00f8ll N, et al. Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation. Archives of Internal Medicine. 2010; 170: 1433\u20131441.","DOI":"10.1001\/archinternmed.2010.271"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"Mansouri P, Jazi ZA, Mansouri MH, Dehghan H, Zavar R, Hashemi SM, et al. Evaluation of the efficacy and safety of rivaroxaban compared to warfarin in patients with left ventricular apical thrombus: a randomized clinical trial. Thrombosis Journal. 2024; 22: 66.","DOI":"10.1186\/s12959-024-00632-5"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"Jenab Y, Sadeghipour P, Mohseni-Badalabadi R, Kaviani R, Hosseini K, Pasebani Y, et al. Direct oral anticoagulants or warfarin in patients with left ventricular thrombus after ST-elevation myocardial infarction: a pilot trial and a prespecified meta-analysis of randomised trials. EuroIntervention. 2025; 21: 82\u201392.","DOI":"10.4244\/EIJ-D-24-00527"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"Isa WY, Hwong N, Yusof AK, Yusof Z, Loong NS, Wan-Arfah N, et al. Apixaban versus Warfarin in Patients with Left Ventricular Thrombus: A Pilot Prospective Randomized Outcome Blinded Study Investigating Size Reduction or Resolution of Left Ventricular Thrombus. Journal of Clinical and Preventive Cardiology. 2020; 9: 150\u2013154.","DOI":"10.4103\/JCPC.JCPC_41_20"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"Kassab J, Hajj J, Puri R, Harb SC, Kapadia SR. Direct oral anticoagulants vs. warfarin for left ventricular thrombus. European Heart Journal Open. 2026; 6: oeaf166.","DOI":"10.1093\/ehjopen\/oeaf166"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"Koeckerling D, Reddy RK, Barker J, Braun V, Howard JP, Ahmad Y, et al. 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Systematic review of efficacy of direct oral anticoagulants and vitamin K antagonists in left ventricular thrombus. ESC Heart Failure. 2022; 9: 3519\u20133532.","DOI":"10.1002\/ehf2.14084"},{"key":"ref54","doi-asserted-by":"publisher","unstructured":"Shah S, Shah K, Turagam MK, Sharma A, Natale A, Lakkireddy D, et al. Direct oral anticoagulants to treat left ventricular thrombus-A systematic review and meta-analysis: ELECTRAM investigators. Journal of Cardiovascular Electrophysiology. 2021; 32: 1764\u20131771.","DOI":"10.1111\/jce.15016"},{"key":"ref55","doi-asserted-by":"publisher","unstructured":"Pham TTT, Le TM, Tran CC, Nguyen KD, Nguyen ADQ, Nguyen CD, et al. Left ventricular thrombus in patient with nonischemic cardiomyopathy: A case report. Radiology Case Reports. 2024; 19: 5241\u20135247.","DOI":"10.1016\/j.radcr.2024.07.179"},{"key":"ref56","doi-asserted-by":"publisher","unstructured":"Jones J, Morgan H, Rathod K, O'Dowling R, Pieri C, Coldea B, et al. The role of aetiology in determining anticoagulation effectiveness for the treatment of left ventricular thrombus. European Heart Journal. Cardiovascular Pharmacotherapy. 2026; 12: 88\u201396.","DOI":"10.1093\/ehjcvp\/pvaf091"},{"key":"ref57","doi-asserted-by":"publisher","unstructured":"He J, Ge H, Dong JX, Zhang W, Kong LC, Qiao ZQ, et al. Rationale and design of a prospective multi-center randomized trial of EARLY treatment by rivaroxaban versus warfarin in ST-segment elevation MYOcardial infarction with Left Ventricular Thrombus (EARLY-MYO-LVT trial). 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