{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:59:17Z","timestamp":1790697557374,"version":"4.1.0"},"reference-count":26,"publisher":"IMR Press","issue":"9","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hubei Provincial Natural Science Foundation","award":["2025AFD873"],"award-info":[{"award-number":["2025AFD873"]}]},{"name":"Medical Science and Technology Innovation Platform Support Project of Zhongnan Hospital of Wuhan University","award":["PTXM2025026"],"award-info":[{"award-number":["PTXM2025026"]}],"id":[{"id":"https:\/\/ror.org\/01v5mqw79","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Science and Technology Innovation Cultivation Fund of Zhongnan Hospital of Wuhan University","award":["CXPY2024076"],"award-info":[{"award-number":["CXPY2024076"]}],"id":[{"id":"https:\/\/ror.org\/01v5mqw79","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Hubei Province Key research and development projects","award":["2025BCB019"],"award-info":[{"award-number":["2025BCB019"]}]},{"name":"Wuhan University Zhongnan Hospital Science and Technology Achievement Transformation Fund Clinical Research and Development Fund","award":["LCYFMS2023008"],"award-info":[{"award-number":["LCYFMS2023008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Cardiovasc. Med."],"abstract":"<jats:p>Background: This study aimed to investigate the diagnostic efficacy of transthoracic echocardiography (TTE) in classifying patent ductus arteriosus (PDA). Methods: A total of 616 patients diagnosed with PDA underwent TTE. TTE measurements were obtained using the parasternal short-axis view of the great arteries and the suprasternal fossa aortic long-axis view. Using digital subtraction angiography (DSA) as the gold standard, the diagnostic efficacy of TTE for PDA classification was evaluated. Results: Among true-positive cases correctly diagnosed by both TTE and DSA, the sensitivity for tubular PDA was 100.00%, and the specificity was 50.74%. For funnel-type PDA, the sensitivity was 50.57%, and the specificity was 100.00%. For a window-type PDA, the sensitivity was 60.00%, and the specificity was 100.00%. The internal diameters of the tubular PDA and the pulmonary artery side of the funnel-type PDA measured by TTE showed good agreement with those measured by DSA. In addition, in the suprasternal long-axis view of the ascending aorta (SSLAX-AA) of TTE among true-positive cases, the sensitivity for diagnosing tubular PDA was 100.00%, and the specificity was 75.25%; the sensitivity for funnel-type PDA was 75.51%, and the specificity was 100.00%; the sensitivity for window-type PDA was 66.67%, and the specificity was 100.00%. The diagnostic efficacy of this view was improved compared with the overall TTE, which may be due to the similarity between this view and the DSA view. Conclusions: Among true-positive cases, TTE has high sensitivity for diagnosing tubular PDA and high specificity for diagnosing funnel-type PDA. Meanwhile, TTE shows good agreement with DSA in measuring key parameters. Furthermore, TTE demonstrates stability in the diagnostic classification of PDA, with no significant influence from operator variability. TTE could serve as a reliable basis for clinical decision-making to aid in the diagnostic classification of PDA.<\/jats:p>","DOI":"10.31083\/rcm51081","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:57:11Z","timestamp":1790693831000},"source":"Crossref","is-referenced-by-count":0,"title":["A Single-Center Retrospective Analysis of the Diagnostic Efficacy of Transthoracic Echocardiography in the Classification of Patent Ductus Arteriosus"],"prefix":"10.31083","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4425-1405","authenticated-orcid":true,"given":"Minxin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, 430071 Wuhan, Hubei, China"},{"name":"Hubei Provincial Engineering Research Center of Minimally Invasive Cardiovascular Surgery, 430071 Wuhan, Hubei, China"},{"name":"Wuhan Clinical Research Center for Minimally Invasive Treatment of Structural Heart Disease, 430071 Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3481-2717","authenticated-orcid":true,"given":"Chen","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, 430071 Wuhan, Hubei, China"},{"name":"Hubei Provincial Engineering Research Center of Minimally Invasive Cardiovascular Surgery, 430071 Wuhan, Hubei, China"},{"name":"Wuhan Clinical Research Center for Minimally Invasive Treatment of Structural Heart Disease, 430071 Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8148-7152","authenticated-orcid":true,"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Ultrasound, Zhongnan Hospital of Wuhan University, Wuhan University, 430071 Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6291-8271","authenticated-orcid":true,"given":"Tianxing","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, 430071 Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0201-9154","authenticated-orcid":true,"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Ultrasound, Zhongnan Hospital of Wuhan University, Wuhan University, 430071 Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9384-4880","authenticated-orcid":true,"given":"Jinping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, 430071 Wuhan, Hubei, China"},{"name":"Hubei Provincial Engineering Research Center of Minimally Invasive Cardiovascular Surgery, 430071 Wuhan, Hubei, China"},{"name":"Wuhan Clinical Research Center for Minimally Invasive Treatment of Structural Heart Disease, 430071 Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Chugh R, Salem MM. Echocardiography for patent ductus arteriosus including closure in adults. Echocardiography (Mount Kisco, N.Y.). 2015; 32: S125\u2013S139.","DOI":"10.1111\/echo.12457"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Hamrick SEG, Sallmon H, Rose AT, Porras D, Shelton EL, Reese J, et al. Patent Ductus Arteriosus of the Preterm Infant. Pediatrics. 2020; 146: e20201209.","DOI":"10.1542\/peds.2020-1209"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"de Carvalho Nunes G, Wutthigate P, Simoneau J, Beltempo M, Sant'Anna GM, Altit G. Natural evolution of the patent ductus arteriosus in the extremely premature newborn and respiratory outcomes. Journal of Perinatology : Official Journal of the California Perinatal Association. 2022; 42: 642\u2013648.","DOI":"10.1038\/s41372-021-01277-2"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Coceani F. Therapeutic manipulation of the ductus arteriosus: current options and future prospects. Polskie Archiwum Medycyny Wewnetrznej. 2014; 124: 58\u201364.","DOI":"10.20452\/pamw.2081"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Gillam-Krakauer M, Reese J. Diagnosis and Management of Patent Ductus Arteriosus. NeoReviews. 2018; 19: e394\u2013e402.","DOI":"10.1542\/neo.19-7-e394"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Jain A, Shah PS. Diagnosis, Evaluation, and Management of Patent Ductus Arteriosus in Preterm Neonates. JAMA Pediatrics. 2015; 169: 863\u2013872.","DOI":"10.1001\/jamapediatrics.2015.0987"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Qian A, Jiang S, Gu X, Li S, Lei X, Shi W, et al. Treatment of patent ductus arteriosus and short-term outcomes among extremely preterm infants: a multicentre cohort study. EClinicalMedicine. 2023; 67: 102356.","DOI":"10.1016\/j.eclinm.2023.102356"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Ambalavanan N, Aucott SW, Salavitabar A, Levy VY, Committee on Fetus and Newborn, Section on Cardiology and Cardiac Surgery. Patent Ductus Arteriosus in Preterm Infants. Pediatrics. 2025; 155: e2025071425.","DOI":"10.1542\/peds.2025-071425"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Terrin G, Di Chiara M, Boscarino G, Versacci P, Di Donato V, Giancotti A, et al. Echocardiography-Guided Management of Preterms With Patent Ductus Arteriosus Influences the Outcome: A Cohort Study. Frontiers in Pediatrics. 2020; 8: 582735.","DOI":"10.3389\/fped.2020.582735"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Prescott S, Keim-Malpass J. Patent Ductus Arteriosus in the Preterm Infant: Diagnostic and Treatment Options. Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses. 2017; 17: 10\u201318.","DOI":"10.1097\/ANC.0000000000000340"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Krichenko A, Benson LN, Burrows P, M\u00f6es CA, McLaughlin P, Freedom RM. Angiographic classification of the isolated, persistently patent ductus arteriosus and implications for percutaneous catheter occlusion. The American Journal of Cardiology. 1989; 63: 877\u2013880.","DOI":"10.1016\/0002-9149(89)90064-7"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Mitra S, Weisz D, Jain A, Jong G'. Management of the patent ductus arteriosus in preterm infants. Paediatrics & Child Health. 2022; 27: 63\u201364.","DOI":"10.1093\/pch\/pxab085"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Schmidt B, Davis P, Moddemann D, Ohlsson A, Roberts RS, Saigal S, et al. Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants. The New England Journal of Medicine. 2001; 344: 1966\u20131972.","DOI":"10.1056\/NEJM200106283442602"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Moore JW. PDA Stenting for Ductal-Dependent Cyanotic Congenital Heart Disease: History and View From 10,000 Feet. Pediatric Cardiology. 2024.","DOI":"10.1007\/s00246-024-03714-3"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Mitra S, de Boode WP, Weisz DE, Shah PS. Interventions for patent ductus arteriosus (PDA) in preterm infants: an overview of Cochrane Systematic Reviews. The Cochrane Database of Systematic Reviews. 2023; 4: CD013588.","DOI":"10.1002\/14651858.CD013588.pub2"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Shah SMA, Khan SA, Sadiq F, Gul R, Sadiq F, Khan MU, et al. Comparison of the Effectiveness of Paracetamol and Ibuprofen in the Management of Patent Ductus Arteriosus in Preterm Neonates: A Randomized Controlled Trial. Molecular and Cellular Pediatrics. 2025; 12: 2.","DOI":"10.1186\/s40348-025-00189-x"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Philip R, Waller BR 3rd, Agrawal V, Wright D, Arevalo A, Zurakowski D, et al. Morphologic characterization of the patent ductus arteriosus in the premature infant and the choice of transcatheter occlusion device. Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions. 2016; 87: 310\u2013317.","DOI":"10.1002\/ccd.26287"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Ye Z, Li Z, Yi H, Zhu Y, Sun Y, Li P, et al. Percutaneous device closure of pediatirc patent ductus arteriosus through femoral artery guidance by transthoracic echocardiography without radiation and contrast agents. Journal of Cardiothoracic Surgery. 2020; 15: 107.","DOI":"10.1186\/s13019-020-01119-w"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Yucel SM, Sahin IO. Ligation of left pulmonary artery instead of patent ductus arteriosus. Cardiology in the Young. 2020; 30: 1943\u20131945.","DOI":"10.1017\/S1047951120002784"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Buckland CC, Potts JE, Mawson JB, Culham JAG. Ductus arteriosus: more than just the patent ductus arteriosus. Pediatric Radiology. 2022; 52: 1426\u20131436.","DOI":"10.1007\/s00247-022-05387-7"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Kutty S, Biko DM, Goldberg AB, Quartermain MD, Feinstein SB. Contrast-enhanced ultrasound in pediatric echocardiography. Pediatric Radiology. 2021; 51: 2408\u20132417.","DOI":"10.1007\/s00247-021-05119-3"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Harling S, Hansen-Pupp I, Baigi A, Pesonen E. Echocardiographic prediction of patent ductus arteriosus in need of therapeutic intervention. Acta Paediatrica (Oslo, Norway : 1992). 2011; 100: 231\u2013235.","DOI":"10.1111\/j.1651-2227.2010.02027.x"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Chen H, Kumaralingam L, Zhang S, Song S, Zhang F, Zhang H, et al. Neural implicit surface reconstruction of freehand 3D ultrasound volume with geometric constraints. Medical Image Analysis. 2024; 98: 103305.","DOI":"10.1016\/j.media.2024.103305"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"May LA, Masand PM, Qureshi AM, Jadhav SP. The ductus arteriosus: a review of embryology to intervention. Pediatric Radiology. 2023; 53: 509\u2013522.","DOI":"10.1007\/s00247-022-05518-0"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Stevenson JG, Kawabori I, Guntheroth WG. Pulsed Doppler echocardiographic diagnosis of patent ductus arteriosus: sensitivity, specificity, limitations, and technical features. Catheterization and Cardiovascular Diagnosis. 1980; 6: 255\u2013263.","DOI":"10.1002\/ccd.1810060306"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Zhang XY, Cao TS, Yuan LJ, Liu J, Duan YY. Value of the echocardiographic suprasternal view for diagnosis of patent ductus arteriosus subtypes. Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine. 2012; 31: 1421\u20131427.","DOI":"10.7863\/jum.2012.31.9.1421"}],"container-title":["Reviews in Cardiovascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/27\/9\/10.31083\/RCM51081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:58:43Z","timestamp":1790693923000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/RCM\/27\/9\/10.31083\/RCM51081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,4]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026]]}},"alternative-id":["S2153-8174(26)03819-0"],"URL":"https:\/\/doi.org\/10.31083\/rcm51081","relation":{},"ISSN":["1530-6550","2153-8174"],"issn-type":[{"value":"1530-6550","type":"print"},{"value":"2153-8174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,4]]},"article-number":"51081"}}