{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:39:31Z","timestamp":1753889971260,"version":"3.41.2"},"reference-count":25,"publisher":"IMR Press","issue":"1","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Neurol."],"abstract":"<jats:p>Introduction: Autoimmune encephalitis (AE) represents a severe neuropsychiatric disorder that requires early diagnosis. This study describes the frequency, clinical characteristics, and paraclinical findings in patients with possible autoimmune encephalitis treated in a neurological emergency department, as well as factors associated with poor functional prognosis at discharge. Material and Methods: This was an observational ambispective cohort study including patients diagnosed with AE who were treated in a neurological emergency department in 2022. Demographic, clinical, and paraclinical characteristics were evaluated, along with functional outcomes using the modified Rankin scale (mRS)\u037e \u22642 points, was considered as good prognosis. In the statistical analysis we used the chi-squared test, Fisher\u2019s exact test, Student\u2019s T-test, and Mann-Whitney U test. Results: Out of 9046 patients, 31 (0.3%) met the criteria for probable autoimmune encephalitis (PAE). The average age was 28.4 \u00b1 12.1 years and 51.6% were female. Cognitive alterations (90.3%), psychosis (74.2%), abnormal movements (71%), catatonia (67.7%), seizures\/status epilepticus (64.5%, 19.4%), and dysautonomia (58.1%) were observed\u037e 58.1% had a good functional prognosis. Factors associated with poor prognosis included older age (24.8 \u00b1 5.0 vs. 33.4 \u00b1 16.8, p = 0.049), status epilepticus (0% vs. 46.2%, p = 0.002), and lower frequency of headache (61.1% vs. 15.4%, p = 0.025). Conclusions: AE represents a rare diagnosis even in a neurological emergency center\u037e older age, status epilepticus and absence of headache were associated with poor functional prognosis at discharge.<\/jats:p>","DOI":"10.31083\/rn36202","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T08:50:27Z","timestamp":1741337427000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical Features and Functional Prognosis in Patients with Possible Autoimmune Encephalitis in a Neurological Emergency Department"],"prefix":"10.31083","volume":"80","author":[{"given":"Paula Catalina","family":"Robles-Monroy","sequence":"first","affiliation":[{"name":"Departamento de Neuropsiquiatr\u00eda, Subdirecci\u00f3n de Psiquiatr\u00eda, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Suarez, 14269 Ciudad de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Mart\u00ednez-Angeles","sequence":"first","affiliation":[{"name":"Departamento de Neuropsiquiatr\u00eda, Subdirecci\u00f3n de Psiquiatr\u00eda, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Suarez, 14269 Ciudad de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Ram\u00edrez-Berm\u00fadez","sequence":"first","affiliation":[{"name":"Departamento de Neuropsiquiatr\u00eda, Subdirecci\u00f3n de Psiquiatr\u00eda, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Suarez, 14269 Ciudad de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Violante-Villanueva","sequence":"first","affiliation":[{"name":"Departamento de Urgencias Neurolog\u00eda, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Suarez, 14269 Ciudad de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilia","family":"Salas-Alvarado","sequence":"first","affiliation":[{"name":"Departamento de Urgencias Neurolog\u00eda, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Suarez, 14269 Ciudad de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiomara","family":"Garc\u00eda","sequence":"first","affiliation":[{"name":"Departamento de Urgencias Neurolog\u00eda, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Suarez, 14269 Ciudad de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3419-5160","authenticated-orcid":true,"given":"Juan Carlos","family":"L\u00f3pez-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Departamento de Urgencias Neurolog\u00eda, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Suarez, 14269 Ciudad de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Graus F, Titulaer MJ, Balu R, Benseler S, Bien CG, Cellucci T, et al. A clinical approach to diagnosis of autoimmune encephalitis. The Lancet. Neurology. 2016; 15: 391\u2013404.","DOI":"10.1016\/S1474-4422(15)00401-9."},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Steiner J, Pr\u00fcss H, K\u00f6hler S, Frodl T, Hasan A, Falkai P. Autoimmune encephalitis with psychosis: Warning signs, step-by-step diagnostics and treatment. The World Journal of Biological Psychiatry: the Official Journal of the World Federation of Societies of Biological Psychiatry. 2020; 21: 241\u2013254.","DOI":"10.1080\/15622975.2018.1555376."},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Dalmau J, Armangu\u00e9 T, Planagum\u00e0 J, Radosevic M, Mannara F, Leypoldt F, et al. An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models. The Lancet. Neurology. 2019; 18: 1045\u20131057.","DOI":"10.1016\/S1474-4422(19)30244-3."},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Dinoto A, Zara P, Mariotto S, Ferrari S, Flanagan EP, Budhram A, et al. Autoimmune encephalitis misdiagnosis and mimics. Journal of Neuroimmunology. 2023; 378: 578071.","DOI":"10.1016\/j.jneuroim.2023.578071."},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Dalmau J, Graus F. Antibody-mediated encephalitis. The New England Journal of Medicine. 2018; 378: 840\u2013851.","DOI":"10.1056\/NEJMra1708712."},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Venkatesan A, Tunkel AR, Bloch KC, Lauring AS, Sejvar J, Bitnun A, et al. Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium. Clinical Infectious Diseases: an Official Publication of the Infectious Diseases Society of America. 2013; 57: 1114\u20131128.","DOI":"10.1093\/cid\/cit458."},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Sonneville R, Klein I, de Broucker T, Wolff M. Post-infectious encephalitis in adults: diagnosis and management. The Journal of Infection. 2009; 58: 321\u2013328.","DOI":"10.1016\/j.jinf.2009.02.011."},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Bush G, Fink M, Petrides G, Dowling F, Francis A. Catatonia. I. Rating scale and standardized examination. Acta Psychiatrica Scandinavica. 1996; 93: 129\u2013136.","DOI":"10.1111\/j.1600-0447.1996.tb09814.x."},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Siavoshi F, Safavi-Naini SAA, Shirzadeh Barough S, Azizmohammad Looha M, Hatamabadi H, Ommi D, et al. On-admission and dynamic trend of laboratory profiles as prognostic biomarkers in COVID-19 inpatients. Scientific Reports. 2023; 13: 6993.","DOI":"10.1038\/s41598-023-34166-z."},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Abdelnaby R, Elgenidy A, Heckelmann J, Bedewy MM, Shabib AS, Ebrahim MA, et al. The role of creatine kinase in distinguishing generalized tonic-clonic seizures from psychogenic non-epileptic seizures (PNES) and syncope: a retrospective study and meta-analysis of 1300 patients. Neurological Research and Practice. 2023; 5: 56.","DOI":"10.1186\/s42466-023-00286-0."},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"\u00d6r\u00fcm M, Y\u0131lmaz Kafal\u0131 H, Bildik T, Kara M, Gonul A, Erermis S, et al. Differential diagnosis of psychotic disorder with high creatine kinase and subfebrile fever: a case report. Azerbaijan Medical Association Journal. 2017; 2: 23\u201326.","DOI":"10.5455\/amaj.2017.02.034."},{"key":"ref12","unstructured":"Emmady PD, Anilkumar AC. EEG abnormal waveforms. StatPearls Publishing: Treasure Island (FL). 2024. Disponible en: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557655\/ (Accedido: 15 de mayo del 2024)."},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Macher S, Bsteh G, H\u00f6ftberger R, Berger T, Rommer P, Zrzavy T. Clinical scales in autoimmune encephalitis-A retrospective monocentric cohort study. Annals of Clinical and Translational Neurology. 2023; 10: 1768\u20131775.","DOI":"10.1002\/acn3.51865."},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Flanagan EP, Geschwind MD, Lopez-Chiriboga AS, Blackburn KM, Turaga S, Binks S, et al. Autoimmune encephalitis misdiagnosis in adults. JAMA Neurology. 2023; 80: 30\u201339.","DOI":"10.1001\/jamaneurol.2022.4251."},{"key":"ref15","unstructured":"Gole S, Anand A. Autoimmune encephalitis. StatPearls Publishing: Treasure Island (FL). 2024. Disponible en: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK578203\/ (Accedido: 15 de mayo del 2024)."},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Restrepo-Mart\u00ednez M, Espinola-Nadurille M, L\u00f3pez-Hern\u00e1ndez JC, Mart\u00ednez V, T\u00e9llez-Mart\u00ednez JA, Bustamante-G\u00f3mez PA, et al. Neuropsychiatric aspects of anti-NMDA receptor encephalitis. Revista Alergia Mexico (Tecamachalco, Puebla, Mexico: 1993). 2021; 68: 251\u2013263.","DOI":"10.29262\/ram.v68i4.953."},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Kvam KA, Stahl JP, Chow FC, Soldatos A, Tattevin P, Sejvar J, et al. Outcome and sequelae of autoimmune encephalitis. Journal of Clinical Neurology (Seoul, Korea). 2024; 20: 3\u201322.","DOI":"10.3988\/jcn.2023.0242."},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Lewerenz J. Cerebrospinal fluid findings in patients with autoimmune encephalitis-a systematic analysis. Frontiers in Neurology. 2019; 10: 804.","DOI":"10.3389\/fneur.2019.00804."},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Zrzavy T, H\u00f6ftberger R, Wimmer I, Berger T, Rommer P, Macher S. Longitudinal CSF findings in autoimmune encephalitis-a monocentric cohort study. Frontiers in Immunology. 2021; 12: 646940.","DOI":"10.3389\/fimmu.2021.646940."},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Herken J, Pr\u00fcss H. Red Flags: Clinical signs for identifying autoimmune encephalitis in psychiatric patients. Frontiers in Psychiatry. 2017; 8: 25.","DOI":"10.3389\/fpsyt.2017.00025."},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Sun Y, Ren G, Ren J, Shan W, Han X, Lian Y, et al. The association between age and prognosis in patients under 45 years of age with anti-NMDR receptor encephalitis. Frontiers in Neurology. 2020; 11: 612632.","DOI":"10.3389\/fneur.2020.612632."},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Pollak TA, Lennox BR, M\u00fcller S, Benros ME, Pr\u00fcss H, Tebartz van Elst L, et al. Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin. The Lancet. Psychiatry. 2020; 7: 93\u2013108.","DOI":"10.1016\/S2215-0366(19)30290-1."},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Man YL, Sanna G. Neuropsychiatric Manifestations of Antiphospholipid Syndrome-A Narrative Review. Brain Sciences. 2022; 12: 91.","DOI":"10.3390\/brainsci12010091."},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Sarwar S, Mohamed AS, Rogers S, Sarmast ST, Kataria S, Mohamed KH, et al. Neuropsychiatric systemic lupus erythematosus: a 2021 update on diagnosis, management, and current challenges. Cureus. 2021; 13: e17969.","DOI":"10.7759\/cureus.17969."},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Liu X, Yan B, Wang R, Li C, Chen C, Zhou D, et al. Seizure outcomes in patients with anti-NMDAR encephalitis: A follow-up study. Epilepsia. 2017; 58: 2104\u20132111.","DOI":"10.1111\/epi.13929."}],"container-title":["Revista de Neurolog\u00eda"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/RN\/80\/1\/10.31083\/RN36202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T08:50:27Z","timestamp":1741337427000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/RN\/80\/1\/10.31083\/RN36202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,5]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"alternative-id":["S0210-0010(25)00026-X"],"URL":"https:\/\/doi.org\/10.31083\/rn36202","relation":{},"ISSN":["0210-0010","1576-6578"],"issn-type":[{"type":"print","value":"0210-0010"},{"type":"electronic","value":"1576-6578"}],"subject":[],"published":{"date-parts":[[2025,3,5]]},"article-number":"36202"}}