{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:53:35Z","timestamp":1774954415669,"version":"3.50.1"},"reference-count":10,"publisher":"IMR Press","issue":"3","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3n Hospitalaria San Vicente de Paul"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Neurol."],"abstract":"<jats:p>Introduction: In countries with a low incidence of human rabies, this lethal virus is rarely considered in the differential diagnosis of acute flaccid paralysis. Clinical Case: A young woman presented with fever and progressive weakness that evolved into flaccid quadriparesis, associated with neuropsychiatric symptoms, multiple cranial neuropathy, and dysautonomia. The complementary tests and the unusual reflexes that accompanied the diagnosis of brain death are described. The diagnosis was confirmed postmortem by compatible histopathological findings. Conclusions: Human rabies should be considered in cases of flaccid paralysis with encephalitis due to its implications for preventing further deaths through public health measures.<\/jats:p>","DOI":"10.31083\/rn49292","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T09:56:37Z","timestamp":1774950997000},"source":"Crossref","is-referenced-by-count":0,"title":["Acute Flacid Paralysis and Encephalitis: A Deadly Combination. Report of the Latest Case of Human Rabies in Colombia: A Reminder of a Preventable Enemy"],"prefix":"10.31083","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5623-5123","authenticated-orcid":true,"given":"Francisco Aureliano","family":"Garc\u00eda Jimenez","sequence":"first","affiliation":[{"name":"Departament of Antioquia, Fundaci\u00f3n Hospitalaria San Vicente de Paul, 050010 Medellin, Colombia"},{"name":"Departament of Antioquia, Universidad de Antioquia, 050010 Medellin, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1321-8074","authenticated-orcid":true,"given":"Paula Andrea","family":"Valencia-Rey","sequence":"additional","affiliation":[{"name":"Departament of Antioquia, Fundaci\u00f3n Hospitalaria San Vicente de Paul, 050010 Medellin, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2673-925X","authenticated-orcid":true,"given":"Kevin","family":"Tutalch\u00e1 Oviedo","sequence":"additional","affiliation":[{"name":"Departament of Antioquia, Universidad de Antioquia, 050010 Medellin, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6404-5628","authenticated-orcid":true,"given":"Santiago","family":"Mej\u00eda L\u00f3pez","sequence":"additional","affiliation":[{"name":"Departament of Antioquia, Fundaci\u00f3n Hospitalaria San Vicente de Paul, 050010 Medellin, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0017-402X","authenticated-orcid":true,"given":"Juan Carlos","family":"Arango Viana","sequence":"additional","affiliation":[{"name":"Departament of Antioquia, Fundaci\u00f3n Hospitalaria San Vicente de Paul, 050010 Medellin, Colombia"},{"name":"Departament of Antioquia, Universidad de Antioquia, 050010 Medellin, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0970-0172","authenticated-orcid":true,"given":"Juan David","family":"Cuartas Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Departament of Antioquia, Universidad de Antioquia, 050010 Medellin, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Hampson K, Coudeville L, Lembo T, Sambo M, Kieffer A, Attlan M, et al. Correction: Estimating the global burden of endemic canine rabies. PLOS Neglected Tropical Diseases. 2015; 9: e0003786.","DOI":"10.1371\/journal.pntd.0003786"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Tierradentro-Garc\u00eda LO, Cort\u00e9s-Albornoz MC, Talero-Guti\u00e9rrez C. Of love and other demons: depicting human rabies in Colombia. Heliyon. 2022; 8: e09703.","DOI":"10.1016\/j.heliyon.2022.e09703"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Jin J. Rabies. JAMA. 2023; 329: 350.","DOI":"10.1001\/jama.2022.22254"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Hemachudha T, Ugolini G, Wacharapluesadee S, Sungkarat W, Shuangshoti S, Laothamatas J. Human rabies: neuropathogenesis, diagnosis, and management. Lancet Neurology. 2013; 12: 498\u2013513.","DOI":"10.1016\/s1474-4422(13)70038-3"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Venkatesan A, Michael BD, Probasco JC, Geocadin RG, Solomon T. Acute encephalitis in immunocompetent adults. Lancet. 2019; 393: 702\u2013716.","DOI":"10.1016\/s0140-6736(18)32526-1"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Concei\u00e7\u00e3o P, Abreu C. Raiva Humana: Optimiza\u00e7\u00e3o da Preven\u00e7\u00e3o e Caminhos Para a Cura. Acta M\u00e9dica Portuguesa. 2021; 34: 767\u2013773.  (En Portugu\u00e9s)","DOI":"10.20344\/amp.10657"},{"key":"ref7","unstructured":"Barrat J, Picard-Meyer E, Cliquet F. Rabies diagnosis. Developments in Biologicals. 2006; 125: 71\u201377."},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Lacy M, Phasuk N, Scholand SJ. Human rabies treatment\u2014from palliation to promise. Viruses. 2024; 16: 160.","DOI":"10.3390\/v16010160"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Whitehouse ER, Mandra A, Bonwitt J, Beasley EA, Taliano J, Rao AK. Human rabies despite post-exposure prophylaxis: a systematic review of fatal breakthrough infections after zoonotic exposures. 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