{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:55:59Z","timestamp":1792788959696,"version":"4.5.0"},"reference-count":79,"publisher":"IMR Press","issue":"9","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Shandong Province","award":["ZR2024QH188"],"award-info":[{"award-number":["ZR2024QH188"]}]},{"name":"Shandong Cancer Hospital Youth Talent Cultivation Program \u2014 Sailing Plan","award":["qh-202510"],"award-info":[{"award-number":["qh-202510"]}],"id":[{"id":"https:\/\/ror.org\/01413r497","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Collaborative Academic Innovation Project of Shandong Cancer Hospital","award":["FC002"],"award-info":[{"award-number":["FC002"]}],"id":[{"id":"https:\/\/ror.org\/01413r497","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Project of Guangdong Medical Science and Technology Research Foundation","award":["A2023443"],"award-info":[{"award-number":["A2023443"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Neurol."],"abstract":"<jats:p>As the global population ages, the incidence of meningiomas rises, and the demand for clinical management of elderly patients also rises. Meningiomas are common intracranial tumors, and their incidence increases with age. Elderly patients with meningiomas are prone to comorbidities, reduced reserve function, atypical manifestations, increased perioperative risks, and impaired functional recovery, making management more difficult. The application of neuroimaging leads to more elderly patients with asymptomatic or incidentally discovered meningiomas. Choosing the best strategy among monitoring, surgery, radiotherapy, and other strategies is therefore key to clinical decision-making. For asymptomatic, small, and radiologically low-risk meningiomas in elderly patients, active surveillance is generally the preferred initial strategy. Surgery is more appropriate for symptomatic tumors, lesions with mass effect, documented growth, progressive peritumoral edema, neurological deterioration, or other high-risk clinical and radiological features. However, the treatment goal for elderly patients should emphasize symptom relief, preservation of neurological function, and quality of life more than pursuing gross total resection as routine. Stereotactic radiosurgery and fractionated radiotherapy provide important supplementary treatments for very elderly patients, high surgical risk patients, and postoperative residual lesions. This article reviews recent advances in understanding meningiomas in elderly and very elderly patients, focuses on epidemiology, clinical characteristics, prognostic factors, and treatment strategies, and also discusses the core principles of individualized management for this population to guide clinical practice.<\/jats:p>","DOI":"10.31083\/rn53896","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:33:19Z","timestamp":1790699599000},"source":"Crossref","is-referenced-by-count":0,"title":["Meningiomas in Elderly Patients: Epidemiology, Clinical Characteristics, Prognostic Factors, and Personalized Treatment Strategies"],"prefix":"10.31083","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6996-3900","authenticated-orcid":true,"given":"Shuaishuai","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Intensive Care Medicine, Shandong Provincial Third Hospital, Shandong University, 250100 Jinan, Shandong, China"},{"name":"Department of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, 250117 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4498-0855","authenticated-orcid":true,"given":"Jingjing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, 250117 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4797-4641","authenticated-orcid":true,"given":"Liu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Jinan University, 510632 Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1903-3910","authenticated-orcid":true,"given":"Xiangji","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, 250117 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0313-1000","authenticated-orcid":true,"given":"Yanfen","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Shandong Provincial Third Hospital, Shandong University, 250100 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6774-9955","authenticated-orcid":true,"given":"Haiyan","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Shandong Provincial Third Hospital, Shandong University, 250100 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3069-3758","authenticated-orcid":true,"given":"Zongxu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Shandong Provincial Third Hospital, Shandong University, 250100 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0770-9779","authenticated-orcid":true,"given":"Yahu","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Shandong Provincial Third Hospital, Shandong University, 250100 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1728-2655","authenticated-orcid":true,"given":"Haixia","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Shandong Provincial Third Hospital, Shandong University, 250100 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2435-2717","authenticated-orcid":true,"given":"Lingzhi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Shandong Provincial Third Hospital, Shandong University, 250100 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1754-187X","authenticated-orcid":true,"given":"Changli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, 250117 Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"ref1","unstructured":"World Health Organization. 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Neuro-oncology. 2019; 21: 380\u2013391.","DOI":"10.1093\/neuonc\/noy162"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Porter KR, McCarthy BJ, Freels S, Kim Y, Davis FG. Prevalence estimates for primary brain tumors in the United States by age, gender, behavior, and histology. Neuro-oncology. 2010; 12: 520\u2013527.","DOI":"10.1093\/neuonc\/nop066"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Davis FG, Kupelian V, Freels S, McCarthy B, Surawicz T. Prevalence estimates for primary brain tumors in the United States by behavior and major histology groups. Neuro-oncology. 2001; 3: 152\u2013158.","DOI":"10.1093\/neuonc\/3.3.152"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Chen ZY, Zheng CH, Li T, Su XY, Lu GH, Zhang CY, et al. Intracranial meningioma surgery in the elderly (over 65 years): prognostic factors and outcome. 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Journal of Neuro-oncology. 2016; 128: 195\u2013205.","DOI":"10.1007\/s11060-016-2115-z"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Hendrix P, Hans E, Griessenauer CJ, Simgen A, Oertel J, Karbach J. Neurocognitive Function Surrounding the Resection of Frontal WHO Grade I Meningiomas: A Prospective Matched-Control Study. World Neurosurgery. 2017; 98: 203\u2013210.","DOI":"10.1016\/j.wneu.2016.10.095"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Petersen RC, Lopez O, Armstrong MJ, Getchius TSD, Ganguli M, Gloss D, et al. Practice guideline update summary: Mild cognitive impairment [RETIRED]: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology. 2018; 90: 126\u2013135.","DOI":"10.1212\/WNL.0000000000004826"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Butts AM, Weigand S, Brown PD, Petersen RC, Jack CR Jr, Machulda MM, et al. Neurocognition in individuals with incidentally-identified meningioma. Journal of Neuro-oncology. 2017; 134: 125\u2013132.","DOI":"10.1007\/s11060-017-2495-8"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Englot DJ, Magill ST, Han SJ, Chang EF, Berger MS, McDermott MW. Seizures in supratentorial meningioma: a systematic review and meta-analysis. Journal of Neurosurgery. 2016; 124: 1552\u20131561.","DOI":"10.3171\/2015.4.JNS142742"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Whittle IR, Smith C, Navoo P, Collie D. Meningiomas. Lancet (London, England). 2004; 363: 1535\u20131543.","DOI":"10.1016\/S0140-6736(04)16153-9"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Brokinkel B, Holling M, Spille DC, He\u00df K, Sauerland C, Bleim\u00fcller C, et al. Surgery for meningioma in the elderly and long-term survival: comparison with an age- and sex-matched general population and with younger patients. Journal of Neurosurgery. 2017; 126: 1201\u20131211.","DOI":"10.3171\/2016.2.JNS152611"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"Cohen-Inbar O, Soustiel JF, Zaaroor M. Meningiomas in the elderly, the surgical benefit and a new scoring system. Acta Neurochirurgica. 2010; 152: 87\u201397; discussion 97.","DOI":"10.1007\/s00701-009-0552-6"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Caroli M, Locatelli M, Prada F, Beretta F, Martinelli-Boneschi F, Campanella R, et al. Surgery for intracranial meningiomas in the elderly: a clinical-radiological grading system as a predictor of outcome. Journal of Neurosurgery. 2005; 102: 290\u2013294.","DOI":"10.3171\/jns.2005.102.2.0290"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"Poon MTC, Fung LHK, Pu JKS, Leung GKK. Outcome of elderly patients undergoing intracranial meningioma resection--a systematic review and meta-analysis. 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Journal of Neurosurgery. 2006; 105: 538\u2013543.","DOI":"10.3171\/jns.2006.105.4.538"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"Islim AI, Millward CP, Mills SJ, Fountain DM, Zakaria R, Pathmanaban ON, et al. The management of incidental meningioma: An unresolved clinical conundrum. Neuro-oncology Advances. 2023; 5: i26\u2013i34.","DOI":"10.1093\/noajnl\/vdac109"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"Schwartz C, Ueberschaer MF, Rautalin I, Grauvogel J, Bissolo M, Masalha W, et al. Frailty indices predict mortality, complications and functional improvements in supratentorial meningioma patients over 80 years of age. Journal of Neuro-oncology. 2024; 170: 89\u2013100.","DOI":"10.1007\/s11060-024-04780-6"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"Boviatsis EJ, Bouras TI, Kouyialis AT, Themistocleous MS, Sakas DE. Impact of age on complications and outcome in meningioma surgery. Surgical Neurology. 2007; 68: 407\u2013411.","DOI":"10.1016\/j.surneu.2006.11.071"},{"key":"ref50","doi-asserted-by":"publisher","unstructured":"Karhade AV, Fandino L, Gupta S, Cote DJ, Iorgulescu JB, Broekman ML, et al. Impact of operative length on post-operative complications in meningioma surgery: a NSQIP analysis. Journal of Neuro-oncology. 2017; 131: 59\u201367.","DOI":"10.1007\/s11060-016-2262-2"},{"key":"ref51","doi-asserted-by":"publisher","unstructured":"Combs SE, Farzin M, Boehmer J, Oehlke O, Molls M, Debus J, et al. Clinical outcome after high-precision radiotherapy for skull base meningiomas: Pooled data from three large German centers for radiation oncology. Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology. 2018; 127: 274\u2013279.","DOI":"10.1016\/j.radonc.2018.03.006"},{"key":"ref52","doi-asserted-by":"publisher","unstructured":"Castilla MT, Gonzalez YC, Rivas FJ. Complications and outcomes in the elderly with intracranial meningioma. Revista Espa\u00f1ola de Geriatr\u00eda y Gerontolog\u00eda. 2016; 51: 82\u201387.  (In Spanish)","DOI":"10.1016\/j.regg.2015.06.004"},{"key":"ref53","doi-asserted-by":"publisher","unstructured":"Poon MTC, Fung LHK, Pu JKS, Leung GKK. Outcome comparison between younger and older patients undergoing intracranial meningioma resections. Journal of Neuro-oncology. 2013; 114: 219\u2013227.","DOI":"10.1007\/s11060-013-1173-8"},{"key":"ref54","doi-asserted-by":"publisher","unstructured":"Patil CG, Veeravagu A, Lad SP, Boakye M. Craniotomy for resection of meningioma in the elderly: a multicentre, prospective analysis from the National Surgical Quality Improvement Program. Journal of Neurology, Neurosurgery, and Psychiatry. 2010; 81: 502\u2013505.","DOI":"10.1136\/jnnp.2009.185074"},{"key":"ref55","doi-asserted-by":"publisher","unstructured":"Nishizaki T, Kamiryo T, Fujisawa H, Ohshita N, Ishihara H, Ito H, et al. 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An international multicenter matched cohort analysis of incidental meningioma progression during active surveillance or after stereotactic radiosurgery: the IMPASSE study. Neuro-oncology. 2022; 24: 116\u2013124.","DOI":"10.1093\/neuonc\/noab132"},{"key":"ref61","doi-asserted-by":"publisher","unstructured":"Marchetti M, Sahgal A, De Salles AAF, Levivier M, Ma L, Paddick I, et al. Stereotactic Radiosurgery for Intracranial Noncavernous Sinus Benign Meningioma: International Stereotactic Radiosurgery Society Systematic Review, Meta-Analysis and Practice Guideline. Neurosurgery. 2020; 87: 879\u2013890.","DOI":"10.1093\/neuros\/nyaa169"},{"key":"ref62","doi-asserted-by":"publisher","unstructured":"Jenkinson MD, Weber DC, Haylock BJ, Mallucci CL, Zakaria R, Javadpour M. Atypical meningoma: current management dilemmas and prospective clinical trials. Journal of Neuro-oncology. 2015; 121: 1\u20137.","DOI":"10.1007\/s11060-014-1620-1"},{"key":"ref63","doi-asserted-by":"publisher","unstructured":"Lee G, Lamba N, Niemierko A, Kim DW, Chapman PH, Loeffler JS, et al. Adjuvant Radiation Therapy Versus Surveillance After Surgical Resection of Atypical Meningiomas. International Journal of Radiation Oncology, Biology, Physics. 2021; 109: 252\u2013266.","DOI":"10.1016\/j.ijrobp.2020.08.015"},{"key":"ref64","doi-asserted-by":"publisher","unstructured":"Jenkinson MD, Waqar M, Farah JO, Farrell M, Barbagallo GMV, McManus R, et al. Early adjuvant radiotherapy in the treatment of atypical meningioma. Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia. 2016; 28: 87\u201392.","DOI":"10.1016\/j.jocn.2015.09.021"},{"key":"ref65","doi-asserted-by":"publisher","unstructured":"Orton A, Frandsen J, Jensen R, Shrieve DC, Suneja G. Anaplastic meningioma: an analysis of the National Cancer Database from 2004 to 2012. Journal of Neurosurgery. 2018; 128: 1684\u20131689.","DOI":"10.3171\/2017.2.JNS162282"},{"key":"ref66","doi-asserted-by":"publisher","unstructured":"Rogers CL, Won M, Vogelbaum MA, Perry A, Ashby LS, Modi JM, et al. High-risk Meningioma: Initial Outcomes From NRG Oncology\/RTOG 0539. International Journal of Radiation Oncology, Biology, Physics. 2020; 106: 790\u2013799.","DOI":"10.1016\/j.ijrobp.2019.11.028"},{"key":"ref67","doi-asserted-by":"publisher","unstructured":"Sughrue ME, Sanai N, Shangari G, Parsa AT, Berger MS, McDermott MW. Outcome and survival following primary and repeat surgery for World Health Organization Grade III meningiomas. Journal of Neurosurgery. 2010; 113: 202\u2013209.","DOI":"10.3171\/2010.1.JNS091114"},{"key":"ref68","doi-asserted-by":"publisher","unstructured":"Makale MT, McDonald CR, Hattangadi-Gluth JA, Kesari S. Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours. Nature Reviews. Neurology. 2017; 13: 52\u201364.","DOI":"10.1038\/nrneurol.2016.185"},{"key":"ref69","doi-asserted-by":"publisher","unstructured":"van Nieuwenhuizen D, Klein M, Stalpers LJA, Leenstra S, Heimans JJ, Reijneveld JC. Differential effect of surgery and radiotherapy on neurocognitive functioning and health-related quality of life in WHO grade I meningioma patients. Journal of Neuro-oncology. 2007; 84: 271\u2013278.","DOI":"10.1007\/s11060-007-9366-7"},{"key":"ref70","doi-asserted-by":"publisher","unstructured":"Rue\u00df D, Weyer V, Tutunji J, Grau S, Kocher M, Hoevels M, et al. Stereotactic radiosurgery of benign brain tumors in elderly patients: evaluation of outcome and toxicity. Radiation Oncology (London, England). 2020; 15: 274.","DOI":"10.1186\/s13014-020-01714-0"},{"key":"ref71","doi-asserted-by":"publisher","unstructured":"Ek\u015fi M\u015e, Canbolat \u00c7, Akba\u015f A, \u00d6zmen BB, Akp\u0131nar E, Usseli M\u0130, et al. Elderly Patients with Intracranial Meningioma: Surgical Considerations in 228 Patients with a Comprehensive Analysis of the Literature. World Neurosurgery. 2019; 132: e350\u2013e365.","DOI":"10.1016\/j.wneu.2019.08.150"},{"key":"ref72","doi-asserted-by":"publisher","unstructured":"Price M, Ballard C, Benedetti J, Neff C, Cioffi G, Waite KA, et al. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2017-2021. Neuro-oncology. 2024; 26: vi1\u2013vi85.","DOI":"10.1093\/neuonc\/noae145"},{"key":"ref73","doi-asserted-by":"publisher","unstructured":"Danho S, Saary J. Incidental Findings on MRI Brain Imaging in Pilots from the Canadian White Matter Hyperintensity Study. Aerospace Medicine and Human Performance. 2025; 96: 255\u2013259.","DOI":"10.3357\/AMHP.6388.2025"},{"key":"ref74","doi-asserted-by":"publisher","unstructured":"Zhang C, Zhang H. Stereotactic Radiosurgery Versus Observation for Treating Incidental Meningiomas: A Systematic Review and Meta-Analysis. Turkish Neurosurgery. 2021; 31: 151\u2013160.","DOI":"10.5137\/1019-5149.JTN.31405-20.2"},{"key":"ref75","doi-asserted-by":"publisher","unstructured":"Zoia C, Bongetta D, Guerrini F, Alicino C, Cattalani A, Bianchini S, et al. Outcome of elderly patients undergoing intracranial meningioma resection: a single-center experience. Journal of Neurosurgical Sciences. 2021; 65: 513\u2013517.","DOI":"10.23736\/S0390-5616.18.04333-3"},{"key":"ref76","doi-asserted-by":"publisher","unstructured":"Armocida D, Arcidiacono UA, Palmieri M, Pesce A, Cofano F, Picotti V, et al. Intracranial Meningioma in Elderly Patients. Retrospective Multicentric Risk and Surgical Factors Study of Morbidity and Mortality. Diagnostics (Basel, Switzerland). 2022; 12: 351.","DOI":"10.3390\/diagnostics12020351"},{"key":"ref77","doi-asserted-by":"publisher","unstructured":"Ekaireb RI, Edwards CS, Ali MS, Nguyen MP, Daggubati V, Aghi MK, et al. Meningioma surgical outcomes and complications in patients aged 75 years and older. Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia. 2021; 88: 88\u201394.","DOI":"10.1016\/j.jocn.2021.03.032"},{"key":"ref78","doi-asserted-by":"publisher","unstructured":"Steinberger J, Bronheim RS, Vempati P, Oermann EK, Ladner TR, Lee NJ, et al. Morbidity and Mortality of Meningioma Resection Increases in Octogenarians. World Neurosurgery. 2018; 109: e16\u2013e23.","DOI":"10.1016\/j.wneu.2017.09.021"},{"key":"ref79","doi-asserted-by":"publisher","unstructured":"Pikis S, Mantziaris G, Samanci Y, Peker S, Nabeel AM, Reda WA, et al. 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