{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:41:42Z","timestamp":1753890102609,"version":"3.41.2"},"reference-count":349,"publisher":"IMR Press","issue":"2","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cContrato-Programa\u201d","award":["UIDB\/04050\/2020"],"award-info":[{"award-number":["UIDB\/04050\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Biosci. (Elite Ed)"],"abstract":"<jats:p>Microbes are traditionally regarded as planktonic organisms, individual cells that live independently from each other. Although this is true, microbes in nature mostly live within large multi-species communities forming complex ecosystems. In these communities, microbial cells are held together and organised spatially by an extracellular matrix (ECM). Unlike the ECM from the tissues of higher eukaryotes, microbial ECM, mostly that of yeasts, is still poorly studied. However, microbial biofilms are a serious cause for concern, for being responsible for the development of nosocomial infections by pharmacological drugs-resistant strains of pathogens, or for critically threatening plant health and food security under climate change. Understanding the organization and behaviour of cells in biofilms or other communities is therefore of extreme importance. Within colonies or biofilms, extremely large numbers of individual microbial cells adhere to inert surfaces or living tissues, differentiate, die or multiply and invade adjacent space, often following a 3D architectural programme genetically determined. For all this, cells depend on the production and secretion of ECM, which might, as in higher eukaryotes, actively participate in the regulation of the group behaviour. This work presents an overview of the state-of-the-art on the composition and structure of the ECM produced by yeasts, and the inherent physicochemical properties so often undermined, as well as the available information on its production and delivery pathways.<\/jats:p>","DOI":"10.31083\/j.fbe1502013","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T01:34:01Z","timestamp":1685410441000},"source":"Crossref","is-referenced-by-count":1,"title":["The Extracellular Matrix of Yeasts: A Key Player in the Microbial Biology Change of Paradigm"],"prefix":"10.31083","volume":"15","author":[{"given":"C\u00e2ndida","family":"Lucas","sequence":"first","affiliation":[{"name":"Molecular and Environmental Biology Centre (CBMA), University of Minho, 4710-057 Braga, Portugal"},{"name":"Institute for Science and Innovation on Bio-Sustainability (IB-S), University of Minho, 4710-057 Braga, Portugal"},{"name":"Aquatic Research Network (ARNET), CBMA, University of Minho, 4710-057 Braga, Portugal"}]},{"given":"Coralie","family":"Silva","sequence":"first","affiliation":[{"name":"Molecular and Environmental Biology Centre (CBMA), University of Minho, 4710-057 Braga, Portugal"},{"name":"Institute for Science and Innovation on Bio-Sustainability (IB-S), University of Minho, 4710-057 Braga, Portugal"}]}],"member":"16242","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Flemming HC, Wingender J. The biofilm matrix. Nature Reviews Microbiology. 2010; 8: 623\u2013633.","DOI":"10.1038\/nrmicro2415"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Yang L, Liu Y, Wu H, H\u00f3iby N, Molin S, Song ZJ. Current understanding of multi-species biofilms. International Journal of Oral Science. 2011; 3: 74\u201381.","DOI":"10.4248\/IJOS11027"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Otto M. Staphylococcal Biofilms. In Romeo T. (ed.) Bacterial Biofilms. Current Topics in Microbiology and Immunology (pp. 207\u2013228). Springer: Berlin, Heidelberg. 2008.","DOI":"10.1007\/978-3-540-75418-3_10"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Harding MW, Marques LLR, Howard RJ, Olson ME. Can filamentous fungi form biofilms? Trends in Microbiology. 2009; 17: 475\u2013480.","DOI":"10.1016\/j.tim.2009.08.007"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Ramage G, Mowat E, Jones B, Williams C, Lopez-Ribot J. Our current understanding of fungal biofilms. Critical Reviews in Microbiology. 2009; 35: 340\u2013355.","DOI":"10.3109\/10408410903241436"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"van der Wende E, Characklis WG. Biofilms in potable water distribution systems. In McFeters GA (ed.) Drinking Water Microbiology (pp. 249\u2013268). Brock\/Springer Series in Contemporary Bioscience. Springer: New York, NY. 1990.","DOI":"10.1007\/978-1-4612-4464-6_12"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Mattila\u2010Sandholm T, Wirtanen G. Biofilm formation in the industry: a review. Food Reviews International. 1992; 8: 573\u2013603.","DOI":"10.1080\/87559129209540953"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Andersson S, Kuttuva Rajarao G, Land CJ, Dalhammar G. Biofilm formation and interactions of bacterial strains found in wastewater treatment systems. FEMS Microbiology Letters. 2008; 283: 83\u201390.","DOI":"10.1111\/j.1574-6968.2008.01149.x"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Marchand S, de Block J, de Jonghe V, Coorevits A, Heyndrickx M, Herman L. Biofilm formation in milk production and processing environments; influence on milk quality and safety. Comprehensive Reviews in Food Science and Food Safety. 2012; 11: 133\u2013147.","DOI":"10.1111\/j.1541-4337.2011.00183.x"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Maifreni M, Frigo F, Bartolomeoli I, Buiatti S, Picon S, Marino M. Bacterial biofilm as a possible source of contamination in the microbrewery environment. Food Control. 2015; 50: 809\u2013814.","DOI":"10.1016\/j.foodcont.2014.10.032"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Cao S, Wang JD, Chen HS, Chen D. Progress of marine biofouling and antifouling technologies. Chinese Science Bulletin. 2011; 56: 598\u2013612.","DOI":"10.1007\/s11434-010-4158-4"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Lacoste E, Gaertner-Mazouni N. Biofouling impact on production and ecosystem functioning: a review for bivalve aquaculture. Reviews in Aquaculture. 2015; 7: 187\u2013196.","DOI":"10.1111\/raq.12063"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Kojic EM, Darouiche RO. Candida infections of medical devices. Clinical Microbiology Reviews. 2004; 17: 255\u2013267.","DOI":"10.1128\/CMR.17.2.255-267.2004"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Haque M, Sartelli M, McKimm J, Abu Bakar M. Health care-associated infections \u2013 An overview. Infection and Drug Resistance. 2018; 11: 2321\u20132333.","DOI":"10.2147\/IDR.S177247"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"V\u00e1zquez-Gonz\u00e1lez D, Perusqu\u00eda-Ortiz AM, Hundeiker M, Bonifaz A. Opportunistic yeast infections: Candidiasis, cryptococcosis, trichosporonosis and geotrichosis. JDDG - Journal of the German Society of Dermatology. 2013; 11: 381\u201393; quiz 394.","DOI":"10.1111\/ddg.12097"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Donlan RM, Costerton JW. Biofilms: Biofilms: survival mechanisms of clinically relevant microorganisms. Clinical Microbiology. 2002; 15: 167\u2013193.","DOI":"10.1128\/CMR.15.2.167-193.2002"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Martinez LR, Casadevall A. Cryptococcus neoformans biofilm formation depends on surface support and carbon source and reduces fungal cell susceptibility to heat, cold, and UV light. Applied and Environmental Microbiology. 2007; 73: 4592\u20134601.","DOI":"10.1128\/AEM.02506-06"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Tart AH, Wozniak DJ. Shifting paradigms in Pseudomonas aeruginosa biofilm research. Current Topics in Microbiology and Immunology. 2008; 322: 193\u2013206.","DOI":"10.1007\/978-3-540-75418-3_9"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Uppuluri P, Lopez Ribot JL. Candida albicans biofilms. In Prasad R (ed.) Candida albicans: Cellular and Molecular Biology (pp. 63\u201375). Springer: Cham. 2017.","DOI":"10.1007\/978-3-319-50409-4_5"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Yadav M, Malvi Y. Animal infections: the role of fungal biofilms. In Gupta A, Singh N (eds.) Recent Developments in Fungal Diseases of Laboratory Animals (pp. 149\u2013162). Springer: Cham. 2019.","DOI":"10.1007\/978-3-030-18586-2_10"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Perez-Nadales E, Nogueira MFA, Baldin C, Castanheira S, El Ghalid M, Grund E, et al. Fungal model systems and the elucidation of pathogenicity determinants. Fungal Genetics and Biology. 2014; 70: 42\u201367.","DOI":"10.1016\/j.fgb.2014.06.011"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Galiana E, Fourr\u00e9 S, Engler G. Phytophthora parasitica biofilm formation: installation and organization of microcolonies on the surface of a host plant. Environmental Microbiology. 2008; 10: 2164\u20132171.","DOI":"10.1111\/j.1462-2920.2008.01619.x"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Gardner AJ, Percival SL, Cochrane CA. Biofilms and role to infection and disease in veterinary medicine. In Percival S, Knottenbelt D, Cochrane C (eds.) Biofilms and Veterinary Medicine (pp. 111\u2013128). Springer Series on Biofilms (Vol 6). Springer: Berlin, Heidelberg. 2011.","DOI":"10.1007\/978-3-642-21289-5_4"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Theodorakopoulos N, Govetto B, Industri B, Massi L, Gaysinski M, Deleury E, et al. Biology and ecology of biofilms formed by a plant pathogen Phytophthora parasitica: from biochemical ecology to ecological engineering. Procedia Environmental Sciences. 2011; 9: 178\u2013182.","DOI":"10.1016\/j.proenv.2011.11.027"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Abdullahi UF, Igwenagu E, Mu\u2019azu A, Aliyu S, Umar MI. Intrigues of biofilm: A perspective. Veterinary World. 2016; 9: 12\u201318.","DOI":"10.14202\/vetworld.2016.12-18"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Villa F, Cappitelli F, Cortesi P, Kunova A. Fungal biofilms: targets for the development of novel strategies in plant disease management. Frontiers in Microbiology. 2017; 8: 1\u201310.","DOI":"10.3389\/fmicb.2017.00654"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Chen XP, Ali L, Wu LY, Liu C, Gang CX, Huang QF, et al. Biofilm formation plays a role in the formation of multidrug-resistant Escherichia coli toward nutrients in microcosm experiments. Frontiers in Microbiology. 2018; 9: 367.","DOI":"10.3389\/fmicb.2018.00367"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Roilides E, Simitsopoulou M, Katragkou A, Walsh TJ. How biofilms evade host defenses. Microbiology Spectrum. 2015; 3:","DOI":"10.1128\/microbiolspec.MB-0012-2014."},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Singh S, Singh SK, Chowdhury I, Singh R. Understanding the mechanism of bacterial biofilms resistance to antimicrobial agents. The Open Microbiology Journal. 2017; 11: 53\u201362.","DOI":"10.2174\/1874285801711010053"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Kowalski CH, Morelli KA, Schultz D, Nadell CD, Cramer RA. ungal biofilm architecture produces hypoxic microenvironments that drive antifungal resistance. Proceedings of the National Academy of Sciences USA. 2020; 117: 22473\u201322483.","DOI":"10.1073\/pnas.2003700117"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Li XZ, Webb JS, Kjelleberg S, Rosche B. Enhanced benzaldehyde tolerance in Zymomonas mobilis biofilms and the potential of biofilm applications in fine-chemical production. Applied and Environmental Microbiology. 2006; 72: 1639\u20131644.","DOI":"10.1128\/AEM.72.2.1639-1644.2006"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Hall CW, Mah TF. Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria. FEMS Microbiology Reviews. 2017; 41: 276\u2013301.","DOI":"10.1093\/femsre\/fux010"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Smolentseva O, Gusarov I, Gautier L, Shamovsky I, DeFrancesco AS, Losick R, et al. Mechanism of biofilm-mediated stress resistance and lifespan extension in C. elegans. Scientific Reports. 2017; 7: 7137.","DOI":"10.1038\/s41598-017-07222-8"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Khot PD, Suci PA, Miller RL, Nelson RD, Tyler BJ. A small subpopulation of blastospores in Candida albicans biofilms exhibit resistance to amphotericin B associated with differential regulation of ergosterol and \u03b2-1,6-glucan pathway genes. Antimicrobial Agents and Chemotherapy. 2006; 50: 3708\u20133716.","DOI":"10.1128\/AAC.00997-06"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Piddock LJV. Multidrug-resistance efflux pumps - not just for resistance. Nature Reviews Microbiology. 2006; 4: 629\u2013636.","DOI":"10.1038\/nrmicro1464"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Bueid A, Howard SJ, Moore CB, Richardson MD, Harrison E, Bowyer P, et al. Azole antifungal resistance in Aspergillus fumigatus: 2008 and 2009. Journal of Antimicrobial Chemotherapy. 2010; 65: 2116\u20132118.","DOI":"10.1093\/jac\/dkq279"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Chandra J, Kuhn DM, Mukherjee PK, Hoyer LL, McCormick T, Ghannoum MA. Biofilm formation by the fungal pathogen Candida albicans: development, architecture, and drug resistance. Journal of Bacteriology. 2001; 183: 5385\u20135394.","DOI":"10.1128\/JB.183.18.5385-5394.2001"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Loussert C, Schmitt C, Prevost MC, Balloy V, Fadel E, Philippe B, et al. In vivo biofilm composition of Aspergillus fumigatus. Cellular Microbiology. 2010; 12: 405\u2013410.","DOI":"10.1111\/j.1462-5822.2009.01409.x"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Sheppard DC, Howell PL. Biofilm exopolysaccharides of pathogenic fungi: lessons from bacteria. Journal of Biological Chemistry. 2016; 291: 12529\u201312537.","DOI":"10.1074\/jbc.R116.720995"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Karygianni L, Ren Z, Koo H, Thurnheer T. Biofilm matrixome: extracellular components in structured microbial communities. Trends in Microbiology. 2020; 28: 668\u2013681.","DOI":"10.1016\/j.tim.2020.03.016"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Osi\u0144ska-Jaroszuk M, Jarosz-Wilko\u0142azka A, Jaroszuk-\u015acise\u0142 J, Sza\u0142apata K, Nowak A, Jaszek M, et al. Extracellular polysaccharides from Ascomycota and Basidiomycota: production conditions, biochemical characteristics, and biological properties. World Journal of Microbiology and Biotechnology. 2015; 31: 1823\u20131844.","DOI":"10.1007\/s11274-015-1937-8"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Beauvais A, Loussert C, Prevost MC, Verstrepen K, Latg\u00e9 JP. Characterization of a biofilm-like extracellular matrix in FLO1-expressing Saccharomyces cerevisiae cells. FEMS Yeast Research. 2009; 9: 411\u2013419.","DOI":"10.1111\/j.1567-1364.2009.00482.x"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Singh RS, Saini GK. Pullulan-hyperproducing color variant strain of Aureobasidium pullulans FB-1 newly isolated from phylloplane of Ficus sp. Bioresource Technology. 2008; 99: 3896\u20133899.","DOI":"10.1016\/j.biortech.2007.08.003"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Kumirska J, Czerwicka M, Kaczy\u0144ski Z, Bychowska A, Brzozowski K, Th\u00f6ming J, et al. Application of spectroscopic methods for structural analysis of chitin and chitosan. Marine Drugs. 2010; 8: 1567\u20131636.","DOI":"10.3390\/md8051567"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Fang W, Chen K, Ji L, Zhu J, Wu B, Wu Y. Solubility and thermodynamic properties of N-acetylglucosamine in mono-solvents and binary solvents at different temperatures. Physics and Chemistry of Liquids. 2018; 57: 1\u201313.","DOI":"10.1080\/00319104.2018.1506921"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Benedict K, Richardson M, Vallabhaneni S, Jackson BR, Chiller T. Emerging issues, challenges, and changing epidemiology of fungal disease outbreaks. The Lancet. Infectious Diseases. 2017; 17: e403\u2013e411.","DOI":"10.1016\/S1473-3099(17)30443-7"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Casadevall A. Fungal diseases in the 21st century: The near and far horizons. Pathogens and Immunity. 2018; 3: 183\u2013196.","DOI":"10.20411\/pai.v3i2.249"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Trivedi P, Batista BD, Bazany KE, Singh BK. Plant-microbiome interactions under a changing world: Responses, consequences and perspectives. New Physiologist. 2022; 234: 1951\u20131959.","DOI":"10.1111\/nph.18016"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Elinov NP, Anan\u2019eva EP, Vitovskaya GA, Trushina OA. Extracellular polysaccharides of Bullera alba VKM Y-2141. Chemistry of Natural Compounds. 1990; 26: 139\u2013142.","DOI":"10.1007\/BF00607528"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Elinov NP, Vitovskaya GA, Anan\u2019eva EP, Maryukhta YB. The mannan formed by the yeast Bullera tsugae. Chemistry of Natural Compounds. 1985; 21: 704\u2013708.","DOI":"10.1007\/BF00576200"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Oluwa SW. Structure and foaming properties of viscous exopolysaccharides from a wild grape-associated basidiomycetous yeast Papiliotrema flavescens formerly known as Cryptococcus flavescens. Journal of Microbiology and Biotechnololy. 2020; 30: 1739\u20131749.","DOI":"10.4014\/jmb.2002.02065"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Pavlova K, Panchev I, Krachanova M, Gocheva M. Production of an exopolysaccharide by antarctic yeast. Folia Microbiologica. 2009; 54: 343\u2013348.","DOI":"10.1007\/s12223-009-0049-y"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Pavlova K, Rusinova-Videva S, Kuncheva M, Kratchanova M, Gocheva M, Dimitrova S. S Synthesis and characterization of an exopolysaccharide by antarctic yeast strain Cryptococcus laurentii AL100. Applied Biochemistry and Biotechnology. 2011; 163: 1038\u20131052.","DOI":"10.1007\/s12010-010-9107-9"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Smirnou D, Hrubo\u0161ov\u00e1 D, Kulh\u00e1nek J, \u0160v\u00edk K, Bobkov\u00e1 L, Moravcov\u00e1 V, et al. Cryptococcus laurentii extracellular biopolymer production for application in wound management. Applied Biochemistry and Biotechnology. 2014; 174: 1344\u20131353.","DOI":"10.1007\/s12010-014-1105-x"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Rusinova-Videva S, Pavlova K, Georgieva K. Effect of different carbon sources on biosynthesis of exopolysaccharide from Antarctic strain Cryptococcus laurentii \u0410L62. Biotechnology and Biotechnology. 2011; 25: 80\u201384.","DOI":"10.5504\/BBEQ.2011.0121"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Matulov\u00e1 M, Kolarova N, Capek P. An extracellular galactoglucoxylomannan protein from the yeast Cryptococcus laurentii var. laurentii. Journal of Carbohydrate Chemistry. 2002; 21: 521\u2013537.","DOI":"10.1081\/CAR-120016851"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Perry MB, Webb AC. Structure of the acidic capsular polysaccharide of Cryptococcus laurentii (NRRL Y-1401) Canadian Journal of Biochemistry. 1982; 60: 124\u2013130.","DOI":"10.1139\/o82-017"},{"key":"ref58","doi-asserted-by":"crossref","unstructured":"Abercrombie MJ, Jones JKN, Lock MV, Perry MB, Stoodley RJ. The polysaccharides of Cryptococcus laurentii (Nrrl Y-1401): Part I. Canadian Journal of Chemistry. 1960; 38: 1617\u20131624.","DOI":"10.1139\/v60-222"},{"key":"ref59","doi-asserted-by":"crossref","unstructured":"Ankel H, Ankel E, Schutzbach JS, Garancis JC. Mannosyl transfer in Cryptococcus laurentii. Journal of Biological Chemistry. 1970; 245: 3945\u20133955.","DOI":"10.1016\/S0021-9258(18)62940-0"},{"key":"ref60","doi-asserted-by":"crossref","unstructured":"Kolarova N, Matulov\u00e1 M, Capek P. Structure of glucomannan-protein from the yeast Cryptococcus laurentii. Journal of Carbohydrate Chemistry. 1997; 16: 609\u2013623.","DOI":"10.1080\/07328309708007339"},{"key":"ref61","doi-asserted-by":"crossref","unstructured":"Foda MSA, Badr-Eldin SM, Phaff HJ. Biochemical investigation on the capsule-amylose relationship in Cryptococcus laurentii. Mycologia. 1973; 65: 365\u2013372.","DOI":"10.1080\/00275514.1973.12019445"},{"key":"ref62","doi-asserted-by":"crossref","unstructured":"Breierov\u00e1 E, Hrom\u00e1dkov\u00e1 Z, Stratilov\u00e1 E, Sasinkov\u00e1 V, Ebringerov\u00e1 A. Effect of salt stress on the production and properties of extracellular polysaccharides produced by Cryptococcus laurentii. Zeitschrift f\u00fcr Naturforschung. 2005; 60: 444\u2013450.","DOI":"10.1515\/znc-2005-5-613"},{"key":"ref63","doi-asserted-by":"crossref","unstructured":"Frases S, Nimrichter L, Viana NB, Nakouzi A, Casadevall A. Cryptococcus neoformans capsular polysaccharide and exopolysaccharide fractions manifest physical, chemical, and antigenic differences. Eukaryotic Cell. 2008; 7: 319\u2013327.","DOI":"10.1128\/EC.00378-07"},{"key":"ref64","doi-asserted-by":"crossref","unstructured":"Bhattacharjee AK, Bennett JE, Glaudemans CPJ. Capsular polysaccharides of Cryptococcus neoformans. Clinical Infectious Diseases. 1984; 6: 619\u2013624.","DOI":"10.1093\/clinids\/6.5.619"},{"key":"ref65","doi-asserted-by":"crossref","unstructured":"Turner S, Cherniak R, Reiss E, Kwon-Chung K. Structural variability in the glucuronoxylomannan of Cryptococcus neoformans serotype A isolates determined by 13C NMR spectroscopy. Carbohydrate Research. 1992; 233: 205\u2013218.","DOI":"10.1016\/S0008-6215(00)90932-7"},{"key":"ref66","doi-asserted-by":"crossref","unstructured":"Cherniak R, Morris LC, Belay T, Spitzer ED, Casadevall A. Variation in the structure of glucuronoxylomannan in isolates from patients with recurrent cryptococcal meningitis. Infection and Immunity. 1995; 63: 1899\u20131905.","DOI":"10.1128\/iai.63.5.1899-1905.1995"},{"key":"ref67","doi-asserted-by":"crossref","unstructured":"Heiss C, Stacey Klutts J, Wang Z, Doering T, Azadi P. T The structure of Cryptococcus neoformans galactoxylomannan contains \u03b2-D-glucuronic acid. Carbohydrate Research. 2009; 344: 915\u2013920.","DOI":"10.1016\/j.carres.2009.03.003"},{"key":"ref68","doi-asserted-by":"crossref","unstructured":"Chen Z, Shi J, Yang X, Liu Y, Nan B, Wang Z. Isolation of exopolysaccharide-producing bacteria and yeasts from Tibetan kefir and characterisation of the exopolysaccharides. International Journal of Dairy Technology. 2016; 69: 410\u2013417.","DOI":"10.1111\/1471-0307.12276"},{"key":"ref69","doi-asserted-by":"crossref","unstructured":"Ustyuzhanina NE, Kulakovskaya EV, Kulakovskaya TV, Menshov VM, Dmitrenok AS, Shashkov AS, et al. Mannan and phosphomannan from Kuraishia capsulata yeast. 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Influence of metals and metalloids on the composition and fluorescence quenching of the extracellular polymeric substances produced by the polymorphic fungus Aureobasidium pullulans. Applied Microbiology and Biotechnology. 2020; 104: 7155\u20137164.","DOI":"10.1007\/s00253-020-10732-7"},{"key":"ref104","doi-asserted-by":"crossref","unstructured":"Wu S, Chen J, Pan S. Optimization of fermentation conditions for the production of pullulan by a new strain of Aureobasidium pullulans isolated from sea mud and its characterization. Carbohydrate Polymers. 2012; 87: 1696\u20131700.","DOI":"10.1016\/j.carbpol.2011.09.078"},{"key":"ref105","doi-asserted-by":"crossref","unstructured":"Yurlova NA, de Hoog GS. A new variety of Aureobasidium pullulans characterized by exopolysaccharide structure, nutritional physiology and molecular features. 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The extracellular polysaccharide of Pichia (Hansenula) holstii NRRL Y-2448: the structure of the phosphomannan backbone. Carbohydrate Research. 1996; 293: 101\u2013117.","DOI":"10.1016\/0008-6215(96)00190-5"},{"key":"ref119","doi-asserted-by":"crossref","unstructured":"San Blas GS, Cunningham WL. Structure of cell wall and exocellular mannans from the yeast Hansenula holstii. I. Mannans produced in phosphate-containing medium. Biochimica et Biophysica Acta. 1974; 354: 233\u2013246.","DOI":"10.1016\/0304-4165(74)90009-9"},{"key":"ref120","doi-asserted-by":"crossref","unstructured":"Faria-Oliveira F, Carvalho J, Belmiro C, Ramalho G, Pav\u00e3o M, Lucas C, et al. Elemental biochemical analysis of the polysaccharides in the extracellular matrix of the yeast Saccharomyces cerevisiae. Journal of Basic Microbiology. 2015; 55: 685\u2013694.","DOI":"10.1002\/jobm.201400781"},{"key":"ref121","doi-asserted-by":"crossref","unstructured":"Domizio P, Liu Y, Bisson LF, Barile D. 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An overview of the functionality of exopolysaccharides produced by lactic acid bacteria. International Dairy Journal. 2002; 12: 163\u2013171.","DOI":"10.1016\/S0958-6946(01)00160-1"},{"key":"ref135","doi-asserted-by":"crossref","unstructured":"Fringant C, Desbri\u00e8res J, Milas M, Rinaudo M, Joly C, Escoubes M. Characterisation of sorbed water molecules on neutral and ionic polysaccharides. International Journal of Biological Macromolecules. 1996; 18: 281\u2013286.","DOI":"10.1016\/0141-8130(95)01087-4"},{"key":"ref136","doi-asserted-by":"crossref","unstructured":"Davies E, M\u00fcller K, Wong W, Pickard C, Reid D, Skepper J, et al. Citrate bridges between mineral platelets in bone. Proceedings of the National Academy of Sciences of the United States of America. 2014; 111: E1354\u2013E1363.","DOI":"10.1073\/pnas.1315080111"},{"key":"ref137","doi-asserted-by":"crossref","unstructured":"B\u00f6rek\u00e7i BS, Kaban G, Kaya M. Citric acid production of yeasts: an overview. 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The MEC-4 DEG\/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals. Nature Neuroscience. 2005; 8: 43\u201350.","DOI":"10.1038\/nn1362"},{"key":"ref148","doi-asserted-by":"crossref","unstructured":"Ismailov II, Berdiev BK, Shlyonsky VG, Benos DJ. Mechanosensitivity of an epithelial Na+ channel in planar lipid bilayers: release from Ca2+ block. Biophysical Journal. 1997; 72: 1182\u20131192.","DOI":"10.1016\/S0006-3495(97)78766-6"},{"key":"ref149","doi-asserted-by":"crossref","unstructured":"Kizer N, Guo XL, Hruska K. Reconstitution of stretch-activated cation channels by expression of the alpha-subunit of the epithelial sodium channel cloned from osteoblasts. Proceedings of the National Academy of Sciences of the United States of America. 1997; 94: 1013\u20131018.","DOI":"10.1073\/pnas.94.3.1013"},{"key":"ref150","doi-asserted-by":"crossref","unstructured":"Hohmann S. Control of high osmolarity signalling in the yeast Saccharomyces cerevisiae. FEBS Letters. 2009; 583: 4025\u20134029.","DOI":"10.1016\/j.febslet.2009.10.069"},{"key":"ref151","doi-asserted-by":"crossref","unstructured":"de Nadal E, Posas F. The HOG pathway and the regulation of osmoadaptive responses in yeast. FEMS Yeast Research. 2022; 22: foac013.","DOI":"10.1093\/femsyr\/foac013"},{"key":"ref152","doi-asserted-by":"crossref","unstructured":"Roelants FM, Leskoske KL, Martinez Marshall MN, Locke MN, Thorner J. The TORC2-dependent signaling network in the yeast Saccharomyces cerevisiae. Biomolecules. 2017; 7: 66.","DOI":"10.3390\/biom7030066"},{"key":"ref153","doi-asserted-by":"crossref","unstructured":"Thorner J. TOR Complex 2 is a master regulator of plasma membrane homeostasis. The Biochemical Journal. 2022; 479: 1917\u20131940.","DOI":"10.1042\/BCJ20220388"},{"key":"ref154","doi-asserted-by":"crossref","unstructured":"Zarnowski R, Sanchez H, Covelli AS, Dominguez E, Jaromin A, Bernhardt J, et al. Candida albicans biofilm-induced vesicles confer drug resistance through matrix biogenesis. PLoS Biology. 2018; 16: e2006872.","DOI":"10.1371\/journal.pbio.2006872"},{"key":"ref155","doi-asserted-by":"crossref","unstructured":"Schmidt O, Weyer Y, Sprenger S, Widerin MA, Eising S, Baumann V, et al. TOR Complex 2 (TORC2) signaling and the ESCRT machinery cooperate in the protection of plasma membrane integrity in yeast. The Journal of Biological Chemistry. 2020; 295: 12028\u201312044.","DOI":"10.1074\/jbc.RA120.013222"},{"key":"ref156","doi-asserted-by":"crossref","unstructured":"Lucas C, Ferreira C, Cazzanelli G, Franco-Duarte R, Tulha J. Yeast Gup1(2) proteins are homologues of the Hedgehog morphogens acyltransferases HHAT(L): facts and implications. Journal of Developmental Biology. 2016; 4: 33.","DOI":"10.3390\/jdb4040033"},{"key":"ref157","doi-asserted-by":"crossref","unstructured":"Faria-Oliveira F, Carvalho J, Ferreira C, Hern\u00e1ez ML, Gil C, Lucas C. Quantitative differential proteomics of yeast extracellular matrix: there is more to it than meets the eye. BMC Microbiology. 2015; 15: 1\u201318.","DOI":"10.1186\/s12866-015-0550-1"},{"key":"ref158","doi-asserted-by":"crossref","unstructured":"Tulha J, Amorim-Rodrigues M, Esquembre LA, Rauch S, Tam\u00e1s MJ, Lucas C. Physical, genetic and functional interactions between the eisosome protein Pil1 and the MBOAT O-acyltransferase Gup1. FEMS Yeast Research. 2021; 21: foaa070.","DOI":"10.1093\/femsyr\/foaa070"},{"key":"ref159","doi-asserted-by":"crossref","unstructured":"Bleve G, Di Sansebastiano GP, Grieco F. Over-expression of functional Saccharomyces cerevisiae GUP1, induces proliferation of intracellular membranes containing ER and Golgi resident proteins. Biochimica et Biophysica Acta. 2011; 1808: 733\u2013744.","DOI":"10.1016\/j.bbamem.2010.12.005"},{"key":"ref160","doi-asserted-by":"crossref","unstructured":"Klein T, Bischoff R. Physiology and pathophysiology of matrix metalloproteases. Amino Acids. 2011; 41: 271\u2013290.","DOI":"10.1007\/s00726-010-0689-x"},{"key":"ref161","doi-asserted-by":"crossref","unstructured":"Sbardella D, Fasciglione GF, Gioia M, Ciaccio C, Tundo GR, Marini S, et al. Human matrix metalloproteinases: an ubiquitarian class of enzymes involved in several pathological processes. Molecular Aspects of Medicine. 2012; 33: 119\u2013208.","DOI":"10.1016\/j.mam.2011.10.015"},{"key":"ref162","doi-asserted-by":"crossref","unstructured":"Miller AE, Hu P, Barker TH. Feeling things out: bidirectional signaling of the cell-ECM interface, implications in the mechanobiology of cell spreading, migration, proliferation, and differentiation. Advanced Healthcare Materials. 2020; 9: e1901445.","DOI":"10.1002\/adhm.201901445"},{"key":"ref163","doi-asserted-by":"crossref","unstructured":"Levine M. The Zincins: collagen fiber processing and degradation. Topics in Dental Biochemistry. 2010; 113\u2013128.","DOI":"10.1007\/978-3-540-88116-2_8"},{"key":"ref164","doi-asserted-by":"crossref","unstructured":"Van Bogaert INA, De Maeseneire SL, Vandamme EJ. Extracellular polysaccharides produced by yeasts and yeast-Like fungi. In Satyanarayana T, Kunze G (eds.) Yeast Biotechnology: Diversity and Applications (Chapter 29) (pp. 651\u2013671). Springer: Dordrecht. 2009.","DOI":"10.1007\/978-1-4020-8292-4_29"},{"key":"ref165","doi-asserted-by":"crossref","unstructured":"Gientka I, B\u0142a\u017cejak S, Stasiak-R\u00f3\u017ca\u0144ska L, Chlebowska-\u015amigiel A. Exopolysaccharides from yeast: insight into optimal conditions for biosynthesis, chemical composition and functional properties - review. Acta Scientiarum Polonorum, Technologia Alimentaria. 2015; 14: 283\u2013292.","DOI":"10.17306\/J.AFS.2015.4.29"},{"key":"ref166","unstructured":"Gancedo C, Serrano R. Energy yielding metabolism. In Rose AH, Harrison JS (eds.) The Yeasts (Volume 3). 2nd edn. Academic Press: London. 1989."},{"key":"ref167","doi-asserted-by":"crossref","unstructured":"Pavlova K, Grigorova D. Production and properties of exopolysaccharide by Rhodotorula acheniorum MC. Food Research International. 1999; 32: 473\u2013477.","DOI":"10.1016\/S0963-9969(99)00110-6"},{"key":"ref168","doi-asserted-by":"crossref","unstructured":"Vlaev S, Rusinova-Videva S, Pavlova K, Kuncheva M, Panchev I, Dobreva S. Submerged culture process for biomass and exopolysaccharide production by Antarctic yeast: some engineering considerations. Applied Microbiology and Biotechnology. 2013; 97: 5303\u20135313.","DOI":"10.1007\/s00253-013-4864-3"},{"key":"ref169","doi-asserted-by":"crossref","unstructured":"Donot F, Fontana A, Baccou JC, Schorr-Galindo S. Microbial exopolysaccharides: Main examples of synthesis, excretion, genetics and extraction. Carbohydrate Polymers. 2012; 87: 951\u2013962.","DOI":"10.1016\/j.carbpol.2011.08.083"},{"key":"ref170","doi-asserted-by":"crossref","unstructured":"Seo C, Lee HW, Suresh A, Yang JW, Jung JK, Kim YC. Improvement of fermentative production of exopolysaccharides from Aureobasidium pullulans under various conditions. Korean Journal of Chemical Engineering. 2014; 31: 1433\u20131437.","DOI":"10.1007\/s11814-014-0064-9"},{"key":"ref171","doi-asserted-by":"crossref","unstructured":"Moscovici M, Ionescu C, Oniscu C. Exopolysaccharide biosynthesis by a fast-producing strain of Aureobasidium pullulans. Biotechnology Letters. 1993; 15: 1167\u20131172.","DOI":"10.1007\/BF00131210"},{"key":"ref172","doi-asserted-by":"crossref","unstructured":"Marini AM, Soussi-Boudekou S, Vissers S, Andre B. A family of ammonium transporters in Saccharomyces cerevisiae. Molecular and Cellular Biology. 1997; 17: 4282\u20134293.","DOI":"10.1128\/MCB.17.8.4282"},{"key":"ref173","doi-asserted-by":"crossref","unstructured":"Andrade SLA, Einsle O. The Amt\/Mep\/Rh family of ammonium transport proteins. Molecular Membrane Biology. 2007; 24: 357\u2013365.","DOI":"10.1080\/09687680701388423"},{"key":"ref174","doi-asserted-by":"crossref","unstructured":"Ariz I, Boeckstaens M, Gouveia C, Martins AP, Sanz-Luque E, Fern\u00e1ndez E, et al. Nitrogen isotope signature evidences ammonium deprotonation as a common transport mechanism for the AMT-Mep-Rh protein superfamily. Science Advances. 2018; 4: eaar3599.","DOI":"10.1126\/sciadv.aar3599"},{"key":"ref175","doi-asserted-by":"crossref","unstructured":"Khademi S, O\u2019Connell J 3rd, Remis J, Robles-Colmenares Y, Miercke LJ, Stroud RM. Mechanism of ammonia transport by Amt\/MEP\/Rh: structure of AmtB at 1.35 A. Science. 2004; 305: 1587\u20131594.","DOI":"10.1126\/science.1101952"},{"key":"ref176","doi-asserted-by":"crossref","unstructured":"Zheng L, Kostrewa D, Bern\u00e8che S, Winkler FK, Li XD. The mechanism of ammonia transport based on the crystal structure of AmtB of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 2004; 101: 17090\u201317095.","DOI":"10.1073\/pnas.0406475101"},{"key":"ref177","doi-asserted-by":"crossref","unstructured":"Boeckstaens M, Andr\u00e9 B, Marini AM. Distinct transport mechanisms in yeast ammonium transport\/sensor proteins of the Mep\/Amt\/Rh family and impact on filamentation. The Journal of Biological Chemistry. 2008; 283: 21362\u201321370.","DOI":"10.1074\/jbc.M801467200"},{"key":"ref178","doi-asserted-by":"crossref","unstructured":"Palkov\u00e1 Z, Janderov\u00e1 B, Gabriel J, Zik\u00e1nov\u00e1 B, Posp\u00edsek M, Forstov\u00e1 J. Ammonia mediates communication between yeast colonies. Nature. 1997; 390: 532\u2013536.","DOI":"10.1038\/37398"},{"key":"ref179","doi-asserted-by":"crossref","unstructured":"Tan CH, Oh HS, Sheraton VM, Mancini E, Joachim Loo SC, Kjelleberg S, et al. Convection and the extracellular matrix dictate inter- and intra-biofilm Quorum Sensing communication in environmental systems. Environmental Science Technology. 2020; 54: 6730\u20136740.","DOI":"10.1021\/acs.est.0c00716"},{"key":"ref180","doi-asserted-by":"crossref","unstructured":"Goffeau A, Slayman CW. The proton-translocating ATPase of the fungal plasma membrane. Biochimica et Biophysica Acta-Reviews on Bioenergetics. 1981; 639: 197\u2013223.","DOI":"10.1016\/0304-4173(81)90010-0"},{"key":"ref181","doi-asserted-by":"crossref","unstructured":"Sigler K, Knotkov\u00e1 A, Kotyk A. Factors governing substrate-induced generation and extrusion of protons in the yeast Saccharomyces cerevisiae. Biochimica et Biophysica Acta-Biomembranes. 1981; 643: 572\u2013582.","DOI":"10.1016\/0005-2736(81)90353-9"},{"key":"ref182","doi-asserted-by":"crossref","unstructured":"Serrano R. In vivo glucose activation of the yeast plasma membrane ATPase. FEBS Letters. 1983; 156: 11\u201314.","DOI":"10.1016\/0014-5793(83)80237-3"},{"key":"ref183","doi-asserted-by":"crossref","unstructured":"Orr D, Zheng W, Campbell BS, McDougall BM, Seviour RJ. Culture conditions affect the chemical composition of the exopolysaccharide synthesized by the fungus Aureobasidium pullulans. Journal of Applied Microbiology. 2009; 107: 691\u2013698.","DOI":"10.1111\/j.1365-2672.2009.04247.x"},{"key":"ref184","doi-asserted-by":"crossref","unstructured":"Cheng KC, Demirci A, Catchmark JM. Pullulan: biosynthesis, production, and applications. 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International Journal of Biological Macromolecules. 2020; 150: 1037\u20131045.","DOI":"10.1016\/j.ijbiomac.2019.10.108"},{"key":"ref188","doi-asserted-by":"crossref","unstructured":"Wei X, Liu GL, Jia SL, Chi Z, Hu Z, Chi ZM. Pullulan biosynthesis and its regulation in Aureobasidium spp. Carbohydrate Polymers. 2021; 251: 117076.","DOI":"10.1016\/j.carbpol.2020.117076"},{"key":"ref189","doi-asserted-by":"crossref","unstructured":"Klis FM, Boorsma A, De Groot PWJ. Cell wall construction in Saccharomyces cerevisiae. Yeast. 2006; 23: 185\u2013202.","DOI":"10.1002\/yea.1349"},{"key":"ref190","doi-asserted-by":"crossref","unstructured":"de Groot PW, Ruiz C, V\u00e1zquez de Aldana CR, Duenas E, Cid VJ, Del Rey F, et al. A genomic approach for the identification and classification of genes involved in cell wall formation and its regulation in Saccharomyces cerevisiae. Comparative and Functional Genomics. 2001; 2: 124\u2013142.","DOI":"10.1002\/cfg.85"},{"key":"ref191","doi-asserted-by":"crossref","unstructured":"Klis FM, Mol P, Hellingwerf K, Brul S. Dynamics of cell wall structure in Saccharomyces cerevisiae. FEMS Microbiology Reviews. 2002; 26: 239\u2013256.","DOI":"10.1111\/j.1574-6976.2002.tb00613.x"},{"key":"ref192","doi-asserted-by":"crossref","unstructured":"Majumdar S, Ghatak J, Mukherji S, Bhattacharjee H, Bhaduri A. UDPgalactose 4-epimerase from Saccharomyces cerevisiae. A bifunctional enzyme with aldose 1-epimerase activity. European Journal of Biochemistry. 2004; 271: 753\u2013759.","DOI":"10.1111\/j.1432-1033.2003.03974.x"},{"key":"ref193","doi-asserted-by":"crossref","unstructured":"Salas M, Vinuela E, Sols A. Spontaneous and enzymatically catalyzed anomerization of glucose-6-P and anomeric specificity of related enzymes. The Journal of Biological Chemistry. 1965; 240: 561\u2013568.","DOI":"10.1016\/S0021-9258(17)45210-0"},{"key":"ref194","unstructured":"Beegle FM. A Study of the Mutarotation of Glucose and Fructose. Columbia University: New York. 1918."},{"key":"ref195","doi-asserted-by":"crossref","unstructured":"Oliva L, Fernandez-Lopez JA, Remesar X, Alemany M. The anomeric nature of glucose and its implications on its analyses and the influence of diet: are routine glycaemia measurements reliable enough? Journal of Endocrinology and Metabolism. 2019; 9: 63\u201370.","DOI":"10.14740\/jem555"},{"key":"ref196","doi-asserted-by":"crossref","unstructured":"Caraballo R, Deng L, Amorim L, Brinck T, Ramstrom O. pH-Dependent mutarotation of 1-thioaldoses in water. Unexpected behaviour of (2S)-D-aldopyranoses. Journal of Organic Chemistry. 2010; 75: 6115\u20136121.","DOI":"10.1021\/jo100826e"},{"key":"ref197","unstructured":"Lehninger AL. Biochemistry (pp. 253). 2nd edn. Worth Publishers, Inc: New York, NY. 1978."},{"key":"ref198","doi-asserted-by":"crossref","unstructured":"Nobile CJ, Nett JE, Hernday AD, Homann OR, Deneault JS, Nantel A, et al. Biofilm matrix regulation by Candida albicans Zap1. PLoS Biology. 2009; 7: e1000133.","DOI":"10.1371\/journal.pbio.1000133"},{"key":"ref199","doi-asserted-by":"crossref","unstructured":"Ganguly S, Mitchell AP. Mucosal biofilms of Candida albicans. Current Opinion in Microbiology. 2011; 14: 380\u2013385.","DOI":"10.1016\/j.mib.2011.06.001"},{"key":"ref200","doi-asserted-by":"crossref","unstructured":"Popolo L, Degani G, Camilloni C, Fonzi WA. The Phr family: the role of extracellular transglycosylases in shaping Candida albicans cells. Journal of Fungi (Basel, Switzerland). 2017; 3: 59.","DOI":"10.3390\/jof3040059"},{"key":"ref201","doi-asserted-by":"crossref","unstructured":"Mitchell KF, Zarnowski R, Sanchez H, Edward JA, Reinicke EL, Nett JE, et al. Community participation in biofilm matrix assembly and function. Proceedings of the National Academy of Sciences of the United States of America. 2015; 112: 4092\u20134097.","DOI":"10.1073\/pnas.1421437112"},{"key":"ref202","doi-asserted-by":"publisher","unstructured":"Desai JV, Mitchell AP. Candida albicans biofilm development and its genetic control. Microbiology Spectrum. 2015; 3:","DOI":"10.1128\/microbiolspec.MB-0005-2014."},{"key":"ref203","doi-asserted-by":"crossref","unstructured":"Finkel JS, Mitchell AP. Genetic control of Candida albicans biofilm development. Nature Reviews Microbiology. 2011; 9: 109\u2013118.","DOI":"10.1038\/nrmicro2475"},{"key":"ref204","doi-asserted-by":"crossref","unstructured":"Nett JE, Andes DR. Contributions of the biofilm matrix to Candida pathogenesis. Journal of Fungi. 2020; 6: 21.","DOI":"10.3390\/jof6010021"},{"key":"ref205","doi-asserted-by":"crossref","unstructured":"Xue SJ, Chen L, Jiang H, Liu GL, Chi ZM, Hu Z, et al. High pullulan biosynthesis from high concentration of glucose by a hyperosmotic resistant, yeast-like fungal strain isolated from a natural comb-honey. Food Chemistry. 2019; 286: 123\u2013128.","DOI":"10.1016\/j.foodchem.2019.01.206"},{"key":"ref206","doi-asserted-by":"crossref","unstructured":"Conrad M, Schothorst J, Kankipati HN, Van Zeebroeck G, Rubio-Texeira M, Thevelein JM. Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae. FEMS Microbiology Reviews. 2014; 38: 254\u2013299.","DOI":"10.1111\/1574-6976.12065"},{"key":"ref207","doi-asserted-by":"crossref","unstructured":"R\u00f8dkaer SV, Faergeman NJ. Glucose- and nitrogen sensing and regulatory mechanisms in Saccharomyces cerevisiae. FEMS Yeast Research. 2014; 14: 683\u2013696.","DOI":"10.1111\/1567-1364.12157"},{"key":"ref208","doi-asserted-by":"crossref","unstructured":"Gil-Bona A, Llama-Palacios A, Parra CM, Vivanco F, Nombela C, Monteoliva L, et al. Proteomics unravels extracellular vesicles as carriers of classical cytoplasmic proteins in Candida albicans. Journal of Proteome Research. 2015; 14: 142\u2013153.","DOI":"10.1021\/pr5007944"},{"key":"ref209","doi-asserted-by":"crossref","unstructured":"Vargas G, Rocha JDB, Oliveira DL, Albuquerque PC, Frases S, Santos SS, et al. Compositional and immunobiological analyses of extracellular vesicles released by Candida albicans. Cellular Microbiology. 2015; 17: 389\u2013407.","DOI":"10.1111\/cmi.12374"},{"key":"ref210","doi-asserted-by":"crossref","unstructured":"Oliveira DL, Nakayasu ES, Joffe LS, Guimar\u00e3es AJ, Sobreira TJP, Nosanchuk JD, et al. Characterization of yeast extracellular vesicles: evidence for the participation of different pathways of cellular traffic in vesicle biogenesis. PLoS ONE. 2010; 5: e11113.","DOI":"10.1371\/journal.pone.0011113"},{"key":"ref211","doi-asserted-by":"crossref","unstructured":"Stein K, Chiang HL. Exocytosis and endocytosis of small vesicles across the plasma membrane in Saccharomyces cerevisiae. Membranes. 2014; 4: 608\u2013629.","DOI":"10.3390\/membranes4030608"},{"key":"ref212","doi-asserted-by":"crossref","unstructured":"Rodrigues ML, Nimrichter L, Oliveira DL, Frases S, Miranda K, Zaragoza O, et al. Vesicular polysaccharide export in Cryptococcus neoformans is a eukaryotic solution to the problem of fungal trans-cell wall transport. Eukaryotic Cell. 2007; 6: 48\u201359.","DOI":"10.1128\/EC.00318-06"},{"key":"ref213","doi-asserted-by":"crossref","unstructured":"Rekstina VV, Bykova AA, Ziganshin RH, Kalebina TS. GPI\u2000modified proteins non covalently attached to Saccharomyces cerevisiae yeast cell wall. Biochemistry (Moscow). 2019; 84: 1513\u20131520.","DOI":"10.1134\/S0006297919120101"},{"key":"ref214","doi-asserted-by":"crossref","unstructured":"De Nobel JG, Barnett JA. Passage of molecules through yeast cell walls: a brief essay-review. Yeast (Chichester, England). 1991; 7: 313\u2013323.","DOI":"10.1002\/yea.320070402"},{"key":"ref215","doi-asserted-by":"crossref","unstructured":"de Souza Pereira R, Geibel J. Direct observation of oxidative stress on the cell wall of Saccharomyces cerevisiae strains with atomic force microscopy. Molecular and Cellular Biochemistry. 1999; 201: 17\u201324.","DOI":"10.1023\/A:1007007704657"},{"key":"ref216","doi-asserted-by":"crossref","unstructured":"Santi L, Beys-da-Silva WO, Berger M, Calzolari D, Guimar\u00e3es JA, Moresco JJ, et al. Proteomic profile of Cryptococcus neoformans biofilm reveals changes in metabolic processes. Journal of Proteome Research. 2014; 13: 1545\u20131559.","DOI":"10.1021\/pr401075f"},{"key":"ref217","doi-asserted-by":"crossref","unstructured":"Mar\u0161\u00edkov\u00e1 J, Wilkinson D, Hlav\u00e1\u010dek O, Gilfillan GD, Mizeranschi A, Hughes T, et al. Metabolic differentiation of surface and invasive cells of yeast colony biofilms revealed by gene expression profiling. BMC Genomics. 2017; 18: 814.","DOI":"10.1186\/s12864-017-4214-4"},{"key":"ref218","doi-asserted-by":"crossref","unstructured":"Zhao K, Bleackley M, Chisanga D, Gangoda L, Fonseka P, Liem M, et al. Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling. Communications Biology. 2019; 2: 305.","DOI":"10.1038\/s42003-019-0538-8"},{"key":"ref219","doi-asserted-by":"crossref","unstructured":"Thomas DP, Bachmann SP, Lopez-Ribot JL. Proteomics for the analysis of the Candida albicans biofilm lifestyle. Proteomics. 2006; 6: 5795\u20135804.","DOI":"10.1002\/pmic.200600332"},{"key":"ref220","doi-asserted-by":"crossref","unstructured":"Marriott MS. Isolation and chemical characterization of plasma membranes from the yeast and mycelial forms of Candida albicans. Journal of General Microbiology. 1975; 86: 115\u2013132.","DOI":"10.1099\/00221287-86-1-115"},{"key":"ref221","doi-asserted-by":"crossref","unstructured":"Lattif AA, Mukherjee PK, Chandra J, Roth MR, Welti R, Rouabhia M, et al. Lipidomics of Candida albicans biofilms reveals phase-dependent production of phospholipid molecular classes and role for lipid rafts in biofilm formation. Microbiology. 2011; 157: 3232\u20133242.","DOI":"10.1099\/mic.0.051086-0"},{"key":"ref222","doi-asserted-by":"crossref","unstructured":"Gil-Navarro I, Gil ML, Casanova M, O\u2019Connor JE, Mart\u00ednez JP, Gozalbo D. The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase of Candida albicans is a surface antigen. Journal of Bacteriology. 1997; 179: 4992\u20134999.","DOI":"10.1128\/jb.179.16.4992-4999.1997"},{"key":"ref223","doi-asserted-by":"crossref","unstructured":"Gozalbo D, Gil-Navarro I, Azor\u00edn I, Renau-Piqueras J, Mart\u00ednez JP, Gil ML. The cell wall-associated glyceraldehyde-3-phosphate dehydrogenase of Candida albicans is also a fibronectin and laminin binding protein. Infection and Immunity. 1998; 66: 2052\u20132059.","DOI":"10.1128\/IAI.66.5.2052-2059.1998"},{"key":"ref224","doi-asserted-by":"crossref","unstructured":"Flores CL, Gancedo C. Unraveling moonlighting functions with yeasts. IUBMB Life. 2011; 63: 457\u2013462.","DOI":"10.1002\/iub.454"},{"key":"ref225","doi-asserted-by":"crossref","unstructured":"Gancedo C, Flores CL, Gancedo JM. The expanding landscape of moonlighting proteins in yeasts. Microbiology and Molecular Biology Reviews. 2016; 80: 765\u2013777.","DOI":"10.1128\/MMBR.00012-16"},{"key":"ref226","doi-asserted-by":"crossref","unstructured":"Zhu Z, Wang H, Shang Q, Jiang Y, Cao Y, Chai Y. Time course analysis of Candida albicans metabolites during biofilm development. Journal of Proteome Research. 2013; 12: 2375\u20132385.","DOI":"10.1021\/pr300447k"},{"key":"ref227","doi-asserted-by":"crossref","unstructured":"Brandt P, Garbe E, Vylkova S. Catch the wave: Metabolomic analyses in human pathogenic fungi. PLoS Pathogens. 2020; 16: e1008757.","DOI":"10.1371\/journal.ppat.1008757"},{"key":"ref228","doi-asserted-by":"crossref","unstructured":"Silva S, Negri M, Henriques M, Oliveira R, Williams DW, Azeredo J. Adherence and biofilm formation of non-Candida albicans Candida species. Trends in Microbiology. 2011; 19: 241\u2013247.","DOI":"10.1016\/j.tim.2011.02.003"},{"key":"ref229","doi-asserted-by":"crossref","unstructured":"Douglas LJ. Candida biofilms and their role in infection. Trends in Microbiology. 2003; 11: 30\u201336.","DOI":"10.1016\/S0966-842X(02)00002-1"},{"key":"ref230","unstructured":"Fox E, Nobile C. The role of Candida albicans biofilms in human disease. In Dietrich LA, Friedmann TS (eds.) Candida albicans: Symptoms, Causes and Treatment Options (Chapter 1). Nova Science Publishers Inc: New York. 2013."},{"key":"ref231","doi-asserted-by":"crossref","unstructured":"Ganguly S, Bishop AC, Xu W, Ghosh S, Nickerson KW, Lanni F, et al. Zap1 control of cell-cell signaling in Candida albicans biofilms. Eukaryotic Cell. 2011; 10: 1448\u20131454.","DOI":"10.1128\/EC.05196-11"},{"key":"ref232","doi-asserted-by":"crossref","unstructured":"Jacobsen ID, Wilson D, W\u00e4chtler B, Brunke S, Naglik JR, Hube B. Candida albicans dimorphism as a therapeutic target. Expert Review of Anti-Infective Therapy. 2012; 10: 85\u201393.","DOI":"10.1586\/eri.11.152"},{"key":"ref233","doi-asserted-by":"crossref","unstructured":"Braun BR, Johnson AD. Control of filament formation in Candida albicans by the transcriptional repressor TUP1. Science. 1997; 277: 105\u2013109.","DOI":"10.1126\/science.277.5322.105"},{"key":"ref234","doi-asserted-by":"crossref","unstructured":"Lo HJ, K\u00f6hler JR, DiDomenico B, Loebenberg D, Cacciapuoti A, Fink GR. Nonfilamentous C. albicans mutants are avirulent. Cell. 1997; 90: 939\u2013949.","DOI":"10.1016\/S0092-8674(00)80358-X"},{"key":"ref235","doi-asserted-by":"crossref","unstructured":"Murad AM, Leng P, Straffon M, Wishart J, Macaskill S, MacCallum D, et al. NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans. The EMBO Journal. 2001; 20: 4742\u20134752.","DOI":"10.1093\/emboj\/20.17.4742"},{"key":"ref236","doi-asserted-by":"crossref","unstructured":"Saville SP, Lazzell AL, Monteagudo C, Lopez-Ribot JL. Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection. Eukaryotic Cell. 2003; 2: 1053\u20131060.","DOI":"10.1128\/EC.2.5.1053-1060.2003"},{"key":"ref237","doi-asserted-by":"crossref","unstructured":"Baillie GS, Douglas LJ. Matrix polymers of Candida biofilms and their possible role in biofilm resistance to antifungal agents. The Journal of Antimicrobial Chemotherapy. 2000; 46: 397\u2013403.","DOI":"10.1093\/jac\/46.3.397"},{"key":"ref238","doi-asserted-by":"crossref","unstructured":"Oh KB, Miyazawa H, Naito T, Matsuoka H. Purification and characterization of an autoregulatory substance capable of regulating the morphological transition in Candida albicans. Proceedings of the National Academy of Sciences of the United States of America. 2001; 98: 4664\u20134668.","DOI":"10.1073\/pnas.071404698"},{"key":"ref239","doi-asserted-by":"crossref","unstructured":"Ramage G, Bachmann S, Patterson TF, Wickes BL, L\u00f3pez-Ribot JL. Investigation of multidrug efflux pumps in relation to fluconazole resistance in Candida albicans biofilms. The Journal of Antimicrobial Chemotherapy. 2002; 49: 973\u2013980.","DOI":"10.1093\/jac\/dkf049"},{"key":"ref240","doi-asserted-by":"crossref","unstructured":"Nobile CJ, Mitchell AP. Genetics and genomics of Candida albicans biofilm formation. Cellular Microbiology. 2006; 8: 1382\u20131391.","DOI":"10.1111\/j.1462-5822.2006.00761.x"},{"key":"ref241","doi-asserted-by":"crossref","unstructured":"Ene IV, Bennett RJ. Hwp1 and related adhesins contribute to both mating and biofilm formation in Candida albicans. Eukaryotic Cell. 2009; 8: 1909\u20131913.","DOI":"10.1128\/EC.00245-09"},{"key":"ref242","doi-asserted-by":"crossref","unstructured":"Molin S, Tolker-Nielsen T. Gene transfer occurs with enhanced efficiency in biofilms and induces enhanced stabilisation of the biofilm structure. Current Opinion in Biotechnology. 2003; 14: 255\u2013261.","DOI":"10.1016\/S0958-1669(03)00036-3"},{"key":"ref243","doi-asserted-by":"crossref","unstructured":"Kouzel N, Oldewurtel ER, Maier B. Gene transfer efficiency in gonococcal biofilms: role of biofilm age, architecture, and pilin antigenic variation. Journal of Bacteriology. 2015; 197: 2422\u20132431.","DOI":"10.1128\/JB.00171-15"},{"key":"ref244","doi-asserted-by":"crossref","unstructured":"Stalder T, Top E. Plasmid transfer in biofilms: a perspective on limitations and opportunities. NPJ Biofilms and Microbiomes. 2016; 2: 16022.","DOI":"10.1038\/npjbiofilms.2016.22"},{"key":"ref245","doi-asserted-by":"crossref","unstructured":"Anderson JB. Evolution of antifungal-drug resistance: mechanisms and pathogen fitness. Nature Reviews Microbiology. 2005; 3: 547\u2013556.","DOI":"10.1038\/nrmicro1179"},{"key":"ref246","doi-asserted-by":"crossref","unstructured":"Cowen LE. The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype. Nature Reviews Microbiology. 2008; 6: 187\u2013198.","DOI":"10.1038\/nrmicro1835"},{"key":"ref247","doi-asserted-by":"crossref","unstructured":"Mateus C, Crow SA, Jr, Ahearn DG. Adherence of Candida albicans to silicone induces immediate enhanced tolerance to fluconazole. Antimicrobial Agents and Chemotherapy. 2004; 48: 3358\u20133366.","DOI":"10.1128\/AAC.48.9.3358-3366.2004"},{"key":"ref248","doi-asserted-by":"crossref","unstructured":"Mukherjee PK, Chandra J, Kuhn DM, Ghannoum MA. Mechanism of fluconazole resistance in Candida albicans biofilms: phase-specific role of efflux pumps and membrane sterols. Infection and Immunity. 2003; 71: 4333\u20134340.","DOI":"10.1128\/IAI.71.8.4333-4340.2003"},{"key":"ref249","doi-asserted-by":"crossref","unstructured":"Nett JE, Lepak AJ, Marchillo K, Andes DR. Time course global gene expression analysis of an in vivo Candida biofilm. The Journal of Infectious Diseases. 2009; 200: 307\u2013313.","DOI":"10.1086\/599838"},{"key":"ref250","doi-asserted-by":"crossref","unstructured":"Nobile CJ, Fox EP, Nett JE, Sorrells TR, Mitrovich QM, Hernday AD, et al. A recently evolved transcriptional network controls biofilm development in Candida albicans. Cell. 2012; 148: 126\u2013138.","DOI":"10.1016\/j.cell.2011.10.048"},{"key":"ref251","doi-asserted-by":"crossref","unstructured":"Yeater KM, Chandra J, Cheng G, Mukherjee PK, Zhao X, Rodriguez-Zas SL, et al. Temporal analysis of Candida albicans gene expression during biofilm development. Microbiology. 2007; 153: 2373\u20132385.","DOI":"10.1099\/mic.0.2007\/006163-0"},{"key":"ref252","doi-asserted-by":"crossref","unstructured":"LaFleur MD, Kumamoto CA, Lewis K. Candida albicans biofilms produce antifungal-tolerant persister cells. Antimicrobial Agents and Chemotherapy. 2006; 50: 3839\u20133846.","DOI":"10.1128\/AAC.00684-06"},{"key":"ref253","doi-asserted-by":"crossref","unstructured":"Lafleur MD, Qi Q, Lewis K. Patients with long-term oral carriage harbor high-persister mutants of Candida albicans. Antimicrobial Agents and Chemotherapy. 2010; 54: 39\u201344.","DOI":"10.1128\/AAC.00860-09"},{"key":"ref254","doi-asserted-by":"crossref","unstructured":"Lewis K. Persister cells, dormancy and infectious disease. Nature Reviews Microbiology. 2007; 5: 48\u201356.","DOI":"10.1038\/nrmicro1557"},{"key":"ref255","doi-asserted-by":"crossref","unstructured":"Nett J, Lincoln L, Marchillo K, Massey R, Holoyda K, Hoff B, et al. Putative role of beta-1,3 glucans in Candida albicans biofilm resistance. Antimicrobial Agents and Chemotherapy. 2007; 51: 510\u2013520.","DOI":"10.1128\/AAC.01056-06"},{"key":"ref256","doi-asserted-by":"crossref","unstructured":"Nett JE, Crawford K, Marchillo K, Andes DR. Role of Fks1p and matrix glucan in Candida albicans biofilm resistance to an echinocandin, pyrimidine, and polyene. Antimicrobial Agents and Chemotherapy. 2010; 54: 3505\u20133508.","DOI":"10.1128\/AAC.00227-10"},{"key":"ref257","doi-asserted-by":"crossref","unstructured":"Nett JE, Sanchez H, Cain MT, Andes DR. Genetic basis of Candida biofilm resistance due to drug-sequestering matrix glucan. The Journal of Infectious Diseases. 2010; 202: 171\u2013175.","DOI":"10.1086\/651200"},{"key":"ref258","doi-asserted-by":"crossref","unstructured":"Martins M, Henriques M, Lopez-Ribot JL, Oliveira R. Addition of DNase improves the in vitro activity of antifungal drugs against Candida albicans biofilms. Mycoses. 2012; 55: 80\u201385.","DOI":"10.1111\/j.1439-0507.2011.02047.x"},{"key":"ref259","doi-asserted-by":"crossref","unstructured":"Brown SM, Campbell LT, Lodge JK. Cryptococcus neoformans, a fungus under stress. Current Opinion in Microbiology. 2007; 10: 320\u2013325.","DOI":"10.1016\/j.mib.2007.05.014"},{"key":"ref260","doi-asserted-by":"crossref","unstructured":"Mitchell TG, Perfect JR. Cryptococcosis in the era of AIDS\u2013100 years after the discovery of Cryptococcus neoformans. Clinical Microbiology Reviews. 1995; 8: 515\u2013548.","DOI":"10.1128\/CMR.8.4.515-548.1995"},{"key":"ref261","doi-asserted-by":"crossref","unstructured":"Shapiro RS, Robbins N, Cowen LE. Regulatory circuitry governing fungal development, drug resistance, and disease. Microbiology and Molecular Biology Reviews. 2011; 75: 213\u2013267.","DOI":"10.1128\/MMBR.00045-10"},{"key":"ref262","doi-asserted-by":"crossref","unstructured":"Casadevall A, Coelho C, Cordero RJB, Dragotakes Q, Jung E, Vij R, et al. The capsule of Cryptococcus neoformans. Virulence. 2019; 10: 822\u2013831.","DOI":"10.1080\/21505594.2018.1431087"},{"key":"ref263","doi-asserted-by":"crossref","unstructured":"Zaragoza O, Rodrigues ML, De Jesus M, Frases S, Dadachova E, Casadevall A. The capsule of the fungal pathogen Cryptococcus neoformans. Advances in Applied Microbiology. 2009; 68: 133\u2013216.","DOI":"10.1016\/S0065-2164(09)01204-0"},{"key":"ref264","doi-asserted-by":"crossref","unstructured":"Chang YC, Kwon-Chung KJ. Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence. Molecular and Cellular Biology. 1994; 14: 4912\u20134919.","DOI":"10.1128\/mcb.14.7.4912-4919.1994"},{"key":"ref265","doi-asserted-by":"crossref","unstructured":"Vij R, Cordero RJB, Casadevall A. The buoyancy of Cryptococcus neoformans is affected by capsule size. MSphere. 2018; 3: e00534-18.","DOI":"10.1128\/mSphere.00534-18"},{"key":"ref266","doi-asserted-by":"crossref","unstructured":"Doering TL. How sweet it is! Cell wall biogenesis and polysaccharide capsule formation in Cryptococcus neoformans. Annual Review of Microbiology. 2009; 63: 223\u2013247.","DOI":"10.1146\/annurev.micro.62.081307.162753"},{"key":"ref267","doi-asserted-by":"crossref","unstructured":"Kumar P, Yang M, Haynes BC, Skowyra ML, Doering TL. Emerging themes in cryptococcal capsule synthesis. Current Opinion in Structural Biology. 2011; 21: 597\u2013602.","DOI":"10.1016\/j.sbi.2011.08.006"},{"key":"ref268","doi-asserted-by":"crossref","unstructured":"Kozel TR, Gotschlich EC. The capsule of Cryptococcus neoformans passively inhibits phagocytosis of the yeast by macrophages. Journal of Immunology. 1982; 129: 1675\u20131680.","DOI":"10.4049\/jimmunol.129.4.1675"},{"key":"ref269","doi-asserted-by":"crossref","unstructured":"Kozel TR, Mastroianni RP. Inhibition of phagocytosis by cryptococcal polysaccharide: dissociation of the attachment and ingestion phases of phagocytosis. Infection and Immunity. 1976; 14: 62\u201367.","DOI":"10.1128\/iai.14.1.62-67.1976"},{"key":"ref270","doi-asserted-by":"crossref","unstructured":"Chiapello LS, Baronetti JL, Garro AP, Spesso MF, Masih DT. Cryptococcus neoformans glucuronoxylomannan induces macrophage apoptosis mediated by nitric oxide in a caspase-independent pathway. International Immunology. 2008; 20: 1527\u20131541.","DOI":"10.1093\/intimm\/dxn112"},{"key":"ref271","doi-asserted-by":"crossref","unstructured":"De Jesus M, Nicola AM, Frases S, Lee IR, Mieses S, Casadevall A. Galactoxylomannan-mediated immunological paralysis results from specific B cell depletion in the context of widespread immune system damage. Journal of Immunology. 2009; 183: 3885\u20133894.","DOI":"10.4049\/jimmunol.0900449"},{"key":"ref272","doi-asserted-by":"crossref","unstructured":"Monari C, Pericolini E, Bistoni G, Casadevall A, Kozel TR, Vecchiarelli A. Cryptococcus neoformans capsular glucuronoxylomannan induces expression of fas ligand in macrophages. Journal of Immunology. 2005; 174: 3461\u20133468.","DOI":"10.4049\/jimmunol.174.6.3461"},{"key":"ref273","doi-asserted-by":"crossref","unstructured":"Blackstock R, Hall NK. Non-specific immunosuppression by Cryptococcus neoformans infection. Mycopathologia. 1984; 86: 35\u201343.","DOI":"10.1007\/BF00437227"},{"key":"ref274","doi-asserted-by":"crossref","unstructured":"Murphy JW, Cozad GC. Immunological unresponsiveness induced by cryptococcal capsular polysaccharide assayed by the hemolytic plaque technique. Infection and Immunity. 1972; 5: 896\u2013901.","DOI":"10.1128\/iai.5.6.896-901.1972"},{"key":"ref275","doi-asserted-by":"crossref","unstructured":"Murphy JW, Mosley RL, Cherniak R, Reyes GH, Kozel TR, Reiss E. Serological, electrophoretic, and biological properties of Cryptococcus neoformans antigens. Infection and Immunity. 1988; 56: 424\u2013431.","DOI":"10.1128\/iai.56.2.424-431.1988"},{"key":"ref276","doi-asserted-by":"crossref","unstructured":"Reiss E, Huppert M, Cherniak R. Characterization of protein and mannan polysaccharide antigens of yeasts, moulds, and actinomycetes. Current Topics in Medical Mycology. 1985; 1: 172\u2013207.","DOI":"10.1007\/978-1-4613-9547-8_7"},{"key":"ref277","doi-asserted-by":"crossref","unstructured":"Jong A, Wu CH, Chen HM, Luo F, Kwon-Chung KJ, Chang YC, et al. Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of Cryptococcus neoformans infection. Eukaryotic Cell. 2007; 6: 1486\u20131496.","DOI":"10.1128\/EC.00120-07"},{"key":"ref278","doi-asserted-by":"crossref","unstructured":"Jong A, Wu CH, Gonzales-Gomez I, Kwon-Chung KJ, Chang YC, Tseng HK, et al. Hyaluronic acid receptor CD44 deficiency is associated with decreased Cryptococcus neoformans brain infection. The Journal of Biological Chemistry. 2012; 287: 15298\u201315306.","DOI":"10.1074\/jbc.M112.353375"},{"key":"ref279","doi-asserted-by":"crossref","unstructured":"Jong A, Wu CH, Shackleford GM, Kwon-Chung KJ, Chang YC, Chen HM, et al. Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cells. Cellular Microbiology. 2008; 10: 1313\u20131326.","DOI":"10.1111\/j.1462-5822.2008.01128.x"},{"key":"ref280","doi-asserted-by":"publisher","unstructured":"Martinez LR, Casadevall A. Biofilm formation by Cryptococcus neoformans. Microbiology Spectrum. 2015; 3:","DOI":"10.1128\/microbiolspec.MB-0006-2014."},{"key":"ref281","doi-asserted-by":"crossref","unstructured":"Ahrens T, Assmann V, Fieber C, Termeer C, Herrlich P, Hofmann M, et al. CD44 is the principal mediator of hyaluronic-acid-induced melanoma cell proliferation. The Journal of Investigative Dermatology. 2001; 116: 93\u2013101.","DOI":"10.1046\/j.1523-1747.2001.00236.x"},{"key":"ref282","doi-asserted-by":"crossref","unstructured":"Chi A, Shirodkar SP, Escudero DO, Ekwenna OO, Yates TJ, Ayyathurai R, et al. Molecular characterization of kidney cancer: association of hyaluronic acid family with histological subtypes and metastasis. Cancer. 2012; 118: 2394\u20132402.","DOI":"10.1002\/cncr.26520"},{"key":"ref283","doi-asserted-by":"crossref","unstructured":"Wu RL, Huang L, Zhao HC, Geng XP. Hyaluronic acid in digestive cancers. Journal of Cancer Research and Clinical Oncology. 2017; 143: 1\u201316.","DOI":"10.1007\/s00432-016-2213-5"},{"key":"ref284","doi-asserted-by":"crossref","unstructured":"Martinez LR, Casadevall A. Cryptococcus neoformans cells in biofilms are less susceptible than planktonic cells to antimicrobial molecules produced by the innate immune system. Infection and Immunity. 2006; 74: 6118\u20136123.","DOI":"10.1128\/IAI.00995-06"},{"key":"ref285","doi-asserted-by":"crossref","unstructured":"Martinez LR, Casadevall A. Susceptibility of Cryptococcus neoformans biofilms to antifungal agents in vitro. Antimicrobial Agents and Chemotherapy. 2006; 50: 1021\u20131033.","DOI":"10.1128\/AAC.50.3.1021-1033.2006"},{"key":"ref286","doi-asserted-by":"crossref","unstructured":"Martinez LR, Casadevall A. Specific antibody can prevent fungal biofilm formation and this effect correlates with protective efficacy. Infection and Immunity. 2005; 73: 6350\u20136362.","DOI":"10.1128\/IAI.73.10.6350-6362.2005"},{"key":"ref287","doi-asserted-by":"crossref","unstructured":"Aslanyan L, Sanchez DA, Valdebenito S, Eugenin EA, Ramos RL, Martinez LR. The crucial role of biofilms in Cryptococcus neoformans survival within macrophages and colonization of the central nervous system. Journal of Fungi. 2017; 3: 10.","DOI":"10.3390\/jof3010010"},{"key":"ref288","doi-asserted-by":"crossref","unstructured":"Denham ST, Verma S, Reynolds RC, Worne CL, Daugherty JM, Lane TE, et al. Regulated release of cryptococcal polysaccharide drives virulence and suppresses immune cell infiltration into the central nervous system. Infection and Immunity. 2018; 86: e00662-17.","DOI":"10.1128\/IAI.00662-17"},{"key":"ref289","doi-asserted-by":"crossref","unstructured":"Graybill JR, Sobel J, Saag M, van Der Horst C, Powderly W, Cloud G, et al. Diagnosis and management of increased intracranial pressure in patients with AIDS and cryptococcal meningitis. The NIAID Mycoses Study Group and AIDS Cooperative Treatment Groups. Clinical Infectious Diseases. 2000; 30: 47\u201354.","DOI":"10.1086\/313603"},{"key":"ref290","doi-asserted-by":"crossref","unstructured":"Jarvis JN, Percival A, Bauman S, Pelfrey J, Meintjes G, Williams GN, et al. Evaluation of a novel point-of-care cryptococcal antigen test on serum, plasma, and urine from patients with HIV-associated cryptococcal meningitis. Clinical Infectious Diseases. 2011; 53: 1019\u20131023.","DOI":"10.1093\/cid\/cir613"},{"key":"ref291","doi-asserted-by":"crossref","unstructured":"Robertson EJ, Najjuka G, Rolfes MA, Akampurira A, Jain N, Anantharanjit J, et al. Cryptococcus neoformans ex vivo capsule size is associated with intracranial pressure and host immune response in HIV-associated cryptococcal meningitis. The Journal of Infectious Diseases. 2014; 209: 74\u201382.","DOI":"10.1093\/infdis\/jit435"},{"key":"ref292","doi-asserted-by":"crossref","unstructured":"Decote-Ricardo D, LaRocque-de-Freitas IF, Rocha JDB, Nascimento DO, Nunes MP, Morrot A, et al. Immunomodulatory role of capsular polysaccharides constituents of Cryptococcus neoformans. Frontiers in Medicine. 2019; 6: 129.","DOI":"10.3389\/fmed.2019.00129"},{"key":"ref293","doi-asserted-by":"crossref","unstructured":"Nosanchuk JD, Casadevall A. Cellular charge of Cryptococcus neoformans: contributions from the capsular polysaccharide, melanin, and monoclonal antibody binding. Infection and Immunity. 1997; 65: 1836\u20131841.","DOI":"10.1128\/iai.65.5.1836-1841.1997"},{"key":"ref294","doi-asserted-by":"crossref","unstructured":"Palkov\u00e1 Z, V\u00e1chov\u00e1 L. Life within a community: benefit to yeast long-term survival. FEMS Microbiology Reviews. 2006; 30: 806\u2013824.","DOI":"10.1111\/j.1574-6976.2006.00034.x"},{"key":"ref295","doi-asserted-by":"crossref","unstructured":"Reynolds TB, Fink GR. Bakers\u2019 yeast, a model for fungal biofilm formation. Science. 2001; 291: 878\u2013881.","DOI":"10.1126\/science.291.5505.878"},{"key":"ref296","doi-asserted-by":"crossref","unstructured":"Reynolds TB, Jansen A, Peng X, Fink GR. Mat formation in Saccharomyces cerevisiae requires nutrient and pH gradients. Eukaryotic Cell. 2008; 7: 122\u2013130.","DOI":"10.1128\/EC.00310-06"},{"key":"ref297","doi-asserted-by":"crossref","unstructured":"Andersen KS, Bojsen R, S\u00f8rensen LGR, Nielsen MW, Lisby M, Folkesson A, et al. Genetic basis for Saccharomyces cerevisiae biofilm in liquid medium. G3: Genes, Genomes, Genetics. 2014; 4: 1671\u20131680.","DOI":"10.1534\/g3.114.010892"},{"key":"ref298","doi-asserted-by":"crossref","unstructured":"Lindquist W. Cell surface constituents and yeast flocculation. Nature. 1952; 170: 544\u2013545.","DOI":"10.1038\/170544a0"},{"key":"ref299","doi-asserted-by":"crossref","unstructured":"Craig Maclean R, Brandon C. Stable public goods cooperation and dynamic social interactions in yeast. Journal of Evolutionary Biology. 2008; 21: 1836\u20131843.","DOI":"10.1111\/j.1420-9101.2008.01579.x"},{"key":"ref300","doi-asserted-by":"crossref","unstructured":"Gore J, Youk H, van Oudenaarden A. Snowdrift game dynamics and facultative cheating in yeast. Nature. 2009; 459: 253\u2013256.","DOI":"10.1038\/nature07921"},{"key":"ref301","doi-asserted-by":"crossref","unstructured":"Palkov\u00e1 Z. Multicellular microorganisms: laboratory versus nature. EMBO Reports. 2004; 5: 470\u2013476.","DOI":"10.1038\/sj.embor.7400145"},{"key":"ref302","doi-asserted-by":"crossref","unstructured":"Hall-Stoodley L, Costerton JW, Stoodley P. Bacterial biofilms: from the natural environment to infectious diseases. Nature Reviews Microbiology. 2004; 2: 95\u2013108.","DOI":"10.1038\/nrmicro821"},{"key":"ref303","doi-asserted-by":"crossref","unstructured":"Kuthan M, Devaux F, Janderov\u00e1 B, Slaninov\u00e1 I, Jacq C, Palkov\u00e1 Z. Domestication of wild Saccharomyces cerevisiae is accompanied by changes in gene expression and colony morphology. Molecular Microbiology. 2003; 47: 745\u2013754.","DOI":"10.1046\/j.1365-2958.2003.03332.x"},{"key":"ref304","doi-asserted-by":"crossref","unstructured":"V\u00e1chov\u00e1 L, Stov\u00edcek V, Hlav\u00e1cek O, Chernyavskiy O, St\u0115p\u00e1nek L, Kub\u00ednov\u00e1 L, et al. Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies. The Journal of Cell Biology. 2011; 194: 679\u2013687.","DOI":"10.1083\/jcb.201103129"},{"key":"ref305","doi-asserted-by":"crossref","unstructured":"Zara G, Zara S, Pinna C, Marceddu S, Budroni M. FLO11 gene length and transcriptional level affect biofilm-forming ability of wild flor strains of Saccharomyces cerevisiae. Microbiology. 2009; 155: 3838\u20133846.","DOI":"10.1099\/mic.0.028738-0"},{"key":"ref306","doi-asserted-by":"crossref","unstructured":"St\u2019ov\u00ed\u010dek V, V\u00e1chov\u00e1 L, Kuthan M, Palkov\u00e1 Z. General factors important for the formation of structured biofilm-like yeast colonies. Fungal Genetics and Biology. 2010; 47: 1012\u20131022.","DOI":"10.1016\/j.fgb.2010.08.005"},{"key":"ref307","doi-asserted-by":"crossref","unstructured":"V\u00e1chov\u00e1 L, Chernyavskiy O, Strachotov\u00e1 D, Bianchini P, Burd\u00edkov\u00e1 Z, Ferc\u00edkov\u00e1 I, et al. Architecture of developing multicellular yeast colony: spatio-temporal expression of Ato1p ammonium exporter. Environmental Microbiology. 2009; 11: 1866\u20131877.","DOI":"10.1111\/j.1462-2920.2009.01911.x"},{"key":"ref308","doi-asserted-by":"crossref","unstructured":"V\u00e1chov\u00e1 L, C\u00e1p M, Palkov\u00e1 Z. Yeast colonies: a model for studies of aging, environmental adaptation, and longevity. Oxidative Medicine and Cellular Longevity. 2012; 2012: 601836.","DOI":"10.1155\/2012\/601836"},{"key":"ref309","unstructured":"Tokunaga M, Kusamichi M, Koike H. Ultrastructure of outermost layer of cell wall in Candida albicans observed by rapid-freezing technique. Journal of Electron Microscopy. 1986; 35: 237\u2013246."},{"key":"ref310","doi-asserted-by":"crossref","unstructured":"Faria-Oliveira F, Carvalho J, Belmiro CLR, Martinez-Gomariz M, Hernaez ML, Pav\u00e3o M, et al. Methodologies to generate, extract, purify and fractionate yeast ECM for analytical use in proteomics and glycomics. BMC Microbiology. 2014; 14: 244.","DOI":"10.1186\/s12866-014-0244-0"},{"key":"ref311","doi-asserted-by":"crossref","unstructured":"Varon M, Choder M. Organization and cell-cell interaction in starved Saccharomyces cerevisiae colonies. Journal of Bacteriology. 2000; 182: 3877\u20133880.","DOI":"10.1128\/JB.182.13.3877-3880.2000"},{"key":"ref312","doi-asserted-by":"crossref","unstructured":"V\u00e1chov\u00e1 L, Palkov\u00e1 Z. Physiological regulation of yeast cell death in multicellular colonies is triggered by ammonia. The Journal of Cell Biology. 2005; 169: 711\u2013717.","DOI":"10.1083\/jcb.200410064"},{"key":"ref313","doi-asserted-by":"crossref","unstructured":"C\u00e1p M, V\u00e1chov\u00e1 L, Palkov\u00e1 Z. How to survive within a yeast colony?: Change metabolism or cope with stress? Communicative and Integrative Biology. 2010; 3: 198\u2013200.","DOI":"10.4161\/cib.3.2.11026"},{"key":"ref314","doi-asserted-by":"crossref","unstructured":"Karunanithi S, Vadaie N, Chavel CA, Birkaya B, Joshi J, Grell L, et al. Shedding of the mucin-like flocculin Flo11p reveals a new aspect of fungal adhesion regulation. Current Biology. 2010; 20: 1389\u20131395.","DOI":"10.1016\/j.cub.2010.06.033"},{"key":"ref315","doi-asserted-by":"crossref","unstructured":"Bojsen RK, Andersen KS, Regenberg B. Saccharomyces cerevisiae - a model to uncover molecular mechanisms for yeast biofilm biology. FEMS Immunology and Medical Microbiology. 2012; 65: 169\u2013182.","DOI":"10.1111\/j.1574-695X.2012.00943.x"},{"key":"ref316","doi-asserted-by":"crossref","unstructured":"Br\u00fcckner S, M\u00f6sch HU. Choosing the right lifestyle: adhesion and development in Saccharomyces cerevisiae. FEMS Microbiology Reviews. 2012; 36: 25\u201358.","DOI":"10.1111\/j.1574-6976.2011.00275.x"},{"key":"ref317","doi-asserted-by":"crossref","unstructured":"Lo WS, Dranginis AM. FLO11, a yeast gene related to the STA genes, encodes a novel cell surface flocculin. Journal of Bacteriology. 1996; 178: 7144\u20137151.","DOI":"10.1128\/jb.178.24.7144-7151.1996"},{"key":"ref318","doi-asserted-by":"crossref","unstructured":"Guo B, Styles CA, Feng Q, Fink GR. A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating. Proceedings of the National Academy of Sciences of the United States of America. 2000; 97: 12158\u201312163.","DOI":"10.1073\/pnas.220420397"},{"key":"ref319","doi-asserted-by":"crossref","unstructured":"Halme A, Bumgarner S, Styles C, Fink GR. Genetic and epigenetic regulation of the FLO gene family generates cell-surface variation in yeast. Cell. 2004; 116: 405\u2013415.","DOI":"10.1016\/S0092-8674(04)00118-7"},{"key":"ref320","doi-asserted-by":"crossref","unstructured":"Ryan O, Shapiro RS, Kurat CF, Mayhew D, Baryshnikova A, Chin B, et al. Global gene deletion analysis exploring yeast filamentous growth. Science. 2012; 337: 1353\u20131356.","DOI":"10.1126\/science.1224339"},{"key":"ref321","doi-asserted-by":"crossref","unstructured":"Smukalla S, Caldara M, Pochet N, Beauvais A, Guadagnini S, Yan C, et al. FLO1 is a variable green beard gene that drives biofilm-like cooperation in budding yeast. Cell. 2008; 135: 726\u2013737.","DOI":"10.1016\/j.cell.2008.09.037"},{"key":"ref322","doi-asserted-by":"crossref","unstructured":"Hoyer LL, Cota E. Candida albicans agglutinin-like sequence (Als) family vignettes: A review of als protein structure and function. Frontiers in Microbiology. 2016; 7: 280.","DOI":"10.3389\/fmicb.2016.00280"},{"key":"ref323","doi-asserted-by":"crossref","unstructured":"Kaur R, Domergue R, Zupancic ML, Cormack BP. A yeast by any other name: Candida glabrata and its interaction with the host. Current Opinion in Microbiology. 2005; 8: 378\u2013384.","DOI":"10.1016\/j.mib.2005.06.012"},{"key":"ref324","doi-asserted-by":"crossref","unstructured":"Verstrepen KJ, Klis FM. Flocculation, adhesion and biofilm formation in yeasts. Molecular Microbiology. 2006; 60: 5\u201315.","DOI":"10.1111\/j.1365-2958.2006.05072.x"},{"key":"ref325","doi-asserted-by":"crossref","unstructured":"Veelders M, Br\u00fcckner S, Ott D, Unverzagt C, M\u00f6sch HU, Essen LO. Structural basis of flocculin-mediated social behavior in yeast. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107: 22511\u201322516.","DOI":"10.1073\/pnas.1013210108"},{"key":"ref326","doi-asserted-by":"crossref","unstructured":"Van Mulders SE, Christianen E, Saerens SMG, Daenen L, Verbelen PJ, Willaert R, et al. Phenotypic diversity of Flo protein family-mediated adhesion in Saccharomyces cerevisiae. FEMS Yeast Research. 2009; 9: 178\u2013190.","DOI":"10.1111\/j.1567-1364.2008.00462.x"},{"key":"ref327","doi-asserted-by":"crossref","unstructured":"Lo WS, Dranginis AM. The cell surface flocculin Flo11 is required for pseudohyphae formation and invasion by Saccharomyces cerevisiae. Molecular Biology of the Cell. 1998; 9: 161\u2013171.","DOI":"10.1091\/mbc.9.1.161"},{"key":"ref328","doi-asserted-by":"crossref","unstructured":"Cullen PJ, Sprague GF Jr. The regulation of filamentous growth in yeast. Genetics. 2012; 190: 23\u201349.","DOI":"10.1534\/genetics.111.127456"},{"key":"ref329","doi-asserted-by":"crossref","unstructured":"Vop\u00e1lensk\u00e1 I, St\u2019ov\u00edcek V, Janderov\u00e1 B, V\u00e1chov\u00e1 L, Palkov\u00e1 Z. Role of distinct dimorphic transitions in territory colonizing and formation of yeast colony architecture. Environmental Microbiology. 2010; 12: 264\u2013277.","DOI":"10.1111\/j.1462-2920.2009.02067.x"},{"key":"ref330","doi-asserted-by":"crossref","unstructured":"Legras JL, Erny C, Charpentier C. Population structure and comparative genome hybridization of European flor yeast reveal a unique group of Saccharomyces cerevisiae strains with few gene duplications in their genome. PLoS ONE. 2014; 9: e108089.","DOI":"10.1371\/journal.pone.0108089"},{"key":"ref331","doi-asserted-by":"crossref","unstructured":"Ishigami M, Nakagawa Y, Hayakawa M, Iimura Y. FLO11 is essential for flor formation caused by the C-terminal deletion of NRG1 in Saccharomyces cerevisiae. FEMS Microbiology Letters. 2004; 237: 425\u2013430.","DOI":"10.1111\/j.1574-6968.2004.tb09726.x"},{"key":"ref332","doi-asserted-by":"crossref","unstructured":"Sarode N, Miracle B, Peng X, Ryan O, Reynolds TB. Vacuolar protein sorting genes regulate mat formation in Saccharomyces cerevisiae by Flo11p-dependent and -independent mechanisms. Eukaryotic Cell. 2011; 10: 1516\u20131526.","DOI":"10.1128\/EC.05078-11"},{"key":"ref333","doi-asserted-by":"crossref","unstructured":"Nguyen PV, Hlav\u00e1\u010dek O, Mar\u0161\u00edkov\u00e1 J, V\u00e1chov\u00e1 L, Palkov\u00e1 Z. Cyc8p and Tup1p transcription regulators antagonistically regulate Flo11p expression and complexity of yeast colony biofilms. PLoS Genetics. 2018; 14: e1007495.","DOI":"10.1371\/journal.pgen.1007495"},{"key":"ref334","doi-asserted-by":"crossref","unstructured":"Van Nguyen P, Plocek V, V\u00e1chov\u00e1 L, Palkov\u00e1 Z. Glucose, Cyc8p and Tup1p regulate biofilm formation and dispersal in wild Saccharomyces cerevisiae. NPJ Biofilms and Microbiomes. 2020; 6: 7.","DOI":"10.1038\/s41522-020-0118-1"},{"key":"ref335","doi-asserted-by":"crossref","unstructured":"Granek JA, Magwene PM. Environmental and genetic determinants of colony morphology in yeast. PLoS Genetics. 2010; 6: e1000823.","DOI":"10.1371\/journal.pgen.1000823"},{"key":"ref336","doi-asserted-by":"crossref","unstructured":"V\u00e1chov\u00e1 L, Palkov\u00e1 Z. Diverse roles of Tup1p and Cyc8p transcription regulators in the development of distinct types of yeast populations. Current Genetics. 2019; 65: 147\u2013151.","DOI":"10.1007\/s00294-018-0883-z"},{"key":"ref337","doi-asserted-by":"crossref","unstructured":"Barrales RR, Korber P, Jimenez J, Ibeas JI. Chromatin modulation at the FLO11 promoter of Saccharomyces cerevisiae by HDAC and Swi\/Snf complexes. Genetics. 2012; 191: 791\u2013803.","DOI":"10.1534\/genetics.112.140301"},{"key":"ref338","doi-asserted-by":"crossref","unstructured":"Bumgarner SL, Dowell RD, Grisafi P, Gifford DK, Fink GR. Toggle involving cis-interfering noncoding RNAs controls variegated gene expression in yeast. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106: 18321\u201318326.","DOI":"10.1073\/pnas.0909641106"},{"key":"ref339","doi-asserted-by":"crossref","unstructured":"Octavio LM, Gedeon K, Maheshri N. Epigenetic and conventional regulation is distributed among activators of FLO11 allowing tuning of population-level heterogeneity in its expression. PLoS Genetics. 2009; 5: e1000673.","DOI":"10.1371\/journal.pgen.1000673"},{"key":"ref340","doi-asserted-by":"crossref","unstructured":"Ringel AE, Ryznar R, Picariello H, Huang KL, Lazarus AG, Holmes SG. Yeast Tdh3 (glyceraldehyde 3-phosphate dehydrogenase) is a Sir2-interacting factor that regulates transcriptional silencing and rDNA recombination. PLoS Genetics. 2013; 9: e1003871.","DOI":"10.1371\/journal.pgen.1003871"},{"key":"ref341","doi-asserted-by":"crossref","unstructured":"Kama R, Robinson M, Gerst JE. Btn2, a Hook1 ortholog and potential Batten disease-related protein, mediates late endosome-Golgi protein sorting in yeast. Molecular and Cellular Biology. 2007; 27: 605\u2013621.","DOI":"10.1128\/MCB.00699-06"},{"key":"ref342","doi-asserted-by":"crossref","unstructured":"Espinazo-Romeu M, Cantoral JM, Matallana E, Aranda A. Btn2p is involved in ethanol tolerance and biofilm formation in flor yeast. FEMS Yeast Research. 2008; 8: 1127\u20131136.","DOI":"10.1111\/j.1567-1364.2008.00397.x"},{"key":"ref343","doi-asserted-by":"crossref","unstructured":"Zara S, Antonio Farris G, Budroni M, Bakalinsky AT. HSP12 is essential for biofilm formation by a Sardinian wine strain of S. cerevisiae. Yeast. 2002; 19: 269\u2013276.","DOI":"10.1002\/yea.831"},{"key":"ref344","doi-asserted-by":"crossref","unstructured":"Martineau CN, Beckerich JM, Kabani M. Flo11p-independent control of \u201cmat\u201d formation by hsp70 molecular chaperones and nucleotide exchange factors in yeast. Genetics. 2007; 177: 1679\u20131689.","DOI":"10.1534\/genetics.107.081141"},{"key":"ref345","doi-asserted-by":"crossref","unstructured":"Moreno-Garc\u00eda J, Coi AL, Zara G, Garc\u00eda-Mart\u00ednez T, Mauricio JC, Budroni M. Study of the role of the covalently linked cell wall protein (Ccw14p) and yeast glycoprotein (Ygp1p) within biofilm formation in a flor yeast strain. FEMS Yeast Research. 2018; 18: foy005.","DOI":"10.1093\/femsyr\/foy005"},{"key":"ref346","doi-asserted-by":"crossref","unstructured":"Zarnowski R, Sanchez H, Andes DR. Large-scale production and isolation of Candida biofilm extracellular matrix. Nature Protocols. 2016; 11: 2320\u20132327.","DOI":"10.1038\/nprot.2016.132"},{"key":"ref347","doi-asserted-by":"crossref","unstructured":"Fisher RM, Regenberg B. Multicellular group formation in Saccharomyces cerevisiae. Proceedings of the Royal Society B. 2019; 286: 20191098.","DOI":"10.1098\/rspb.2019.1098"},{"key":"ref348","doi-asserted-by":"crossref","unstructured":"Ratcliff WC, Denison RF, Borrello M, Travisano M. Experimental evolution of multicellularity. Proceedings of the National Academy of Sciences of the United States of America. 2012; 109: 1595\u20131600.","DOI":"10.1073\/pnas.1115323109"},{"key":"ref349","doi-asserted-by":"crossref","unstructured":"Ratcliff WC, Fankhauser JD, Rogers DW, Greig D, Travisano M. Origins of multicellular evolvability in snowflake yeast. 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