{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:36:50Z","timestamp":1768282610029,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":395,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> Ovarian hyperstimulation syndrome (OHSS) is a severe side effect of in vitro fertilization (IVF). The aim of this study was to identify independent predictors which could be used to identify IVF patients at risk for OHSS. <jats:italic>Design.<\/jats:italic> A prospective observational study. <jats:italic>Setting<\/jats:italic>: University hospital. <jats:italic>Population.<\/jats:italic> Six hundred and twenty\u2010four consecutive patients treated with conventional IVF or intracytoplasmic sperm injection. <jats:italic>Methods.<\/jats:italic> Observational clinical data were compared. <jats:italic>Main outcome measures.<\/jats:italic> Patients who developed OHSS were compared with patients who did not develop OHSS using univariate and multivariate analyses. <jats:italic>Results.<\/jats:italic> Twenty\u2010eight patients developed OHSS considered as severe and requiring hospitalization. Independent predictors of OHSS were number of follicles at oocyte aspiration, number of aspirated oocytes and total number of medium\/large\u2010sized follicles before hCG. When these variables were combined in a receiver operating characteristic (ROC) curve they showed a sensitivity of 82.1% and a specificity of 90% for OHSS. The only independent predictor of OHSS before the ovulatory dose of hCG was total number of medium\/large\u2010sized follicles before hCG. A corresponding ROC found a sensitivity of 82.1% and specificity of 79.4%. <jats:italic>Conclusion.<\/jats:italic> Prediction of OHSS that is of severity requiring hospitalization can be done with reasonable high sensitivity and specificity both before and after the ovulatory dose of hCG.<\/jats:p>","DOI":"10.3109\/00016340903287482","type":"journal-article","created":{"date-parts":[[2009,12,7]],"date-time":"2009-12-07T06:23:11Z","timestamp":1260166991000},"page":"1373-1381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Prediction of ovarian hyperstimulation syndrome in women undergoing in vitro fertilization"],"prefix":"10.1111","volume":"88","author":[{"given":"ANNIKA","family":"KAHNBERG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDERS","family":"ENSKOG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MATS","family":"BR\u00c4NNSTR\u00d6M","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KERSTI","family":"LUNDIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRISTINA","family":"BERGH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-198906000-00004"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)43508-9"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a137488"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00090-4"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/00313029500169273"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-199807000-00024"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00414-006-0104-z"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/8.6.559"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-5-9"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)55188-7"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.07.1292"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0188-4409(01)00327-7"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/6.4.307"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90523-6"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/oxfordjournals.humrep.a138261","article-title":"The ovarian hyperstimulation syndrome in in\u2010vitro fertilization: a Belgian multicentric study. II. Multiple discriminant analysis for risk prediction","volume":"8","author":"Delvigne A","year":"1993","journal-title":"Hum Reprod"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a019059"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh638"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmg018"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","unstructured":"D'AngeloA AmsoN.\u201cCoasting\u201d (withholding gonadotrophins) for preventing ovarian hyperstimulation syndrome.Cochrane database Syst Rev (Online).2002:CD002811.","DOI":"10.1002\/14651858.CD002811"},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","unstructured":"D'AngeloA AmsoN.Embryo freezing for preventing Ovarian Hyperstimulation Syndrome.Cochrane database Syst Rev (Online).2002:CD002806.","DOI":"10.1002\/14651858.CD002806"},{"key":"e_1_2_6_22_2","first-page":"CD001750","article-title":"Gonadotrophin\u2010releasing hormone antagonists for assisted conception","volume":"3","author":"Al\u2010Inany HG","year":"2006","journal-title":"Cochrane database Syst Rev (Online)"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml038"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.05.032"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.2.8197"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei150"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh765"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi045"},{"key":"e_1_2_6_29_2","doi-asserted-by":"crossref","unstructured":"HumaidanP BredkjaerHE WestergaardLG Yding AndersenC.1 500 IU human chorionic gonadotropin administered at oocyte retrieval rescues the luteal phase when gonadotropin\u2010releasing hormone agonist is used for ovulation induction: a prospective randomized controlled study.Fertil Steril.2009. (Epub Feb 5 2009) (in press).","DOI":"10.1016\/j.fertnstert.2008.12.042"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60360-2"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem120"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3109%2F00016340903287482","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.3109\/00016340903287482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T22:53:11Z","timestamp":1697064791000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.3109\/00016340903287482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.3109\/00016340903287482"],"URL":"https:\/\/doi.org\/10.3109\/00016340903287482","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"2010-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}