{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T17:13:43Z","timestamp":1771866823773,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":333,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic>To assess the efficacy of the cervical phosphorylated insulin\u2010like growth factor binding protein\u20101 (pIGFBP\u20101) in combination with cervical length measurement for the prediction of preterm delivery.<jats:italic>Design.<\/jats:italic>Observational prospective study.<jats:italic>Setting.<\/jats:italic>University Hospital, Spain.<jats:italic>Sample.<\/jats:italic>A total of 276 women between 24 and 34 weeks gestational age complaining of uterine contractions and intact membranes.<jats:italic>Methods.<\/jats:italic>Transvaginal scan to assess cervical length and cervical swabs for pIGFBP\u20101 detection.<jats:italic>Main outcome measures.<\/jats:italic>Prevalence of preterm delivery within 48 hours and 7 days, delivery at &lt; 32, &lt; 34 weeks, admission\u2010to\u2010delivery interval by cervical length and the presence of pIGFBP\u20101.<jats:italic>Results.<\/jats:italic>The prevalence of preterm delivery at &lt; 34 weeks was 14.1% (39\/276) and 7.6% (21\/276) at &lt; 32 weeks. Cervical pIGFBP\u20101 was positive in 38.7% (107\/276), whereas cervical length &lt; 15 mm was present in 7.2% (20\/276) and was &gt; 30 mm for 64.8% (179\/276) of the women. The presence of a positive pIGFBP\u20101 appeared useful for prediction of delivery before 32 (likelihood ratio (LR) = 2.21, confidence interval (CI): 1.63\u20133.00) and 34 weeks (LR = 1.76, CI: 1.25\u20132.41), respectively. Receiver operating characteristic curves were significant for cervical length and pIGFBP\u20101 for prediction of delivery at &lt; 34 weeks, &lt; 32 weeks, &lt; 48 hours and &lt; 7 days. Combining pIGFBP\u20101 and cervical length had a median interval that was shorter when both were positive as compared to only one positive or both negative, but the CIs overlapped.<jats:italic>Conclusions.<\/jats:italic>Both cervical length measurement and pIGFBP\u20101 are useful for prediction of spontaneous preterm delivery. 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