{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:21:08Z","timestamp":1793506868565,"version":"4.5.0"},"reference-count":98,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":274,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>. While active maternal tobacco smoking has well established adverse perinatal outcomes, the effects of passive maternal smoking, also called environmental tobacco exposure (ETS), are less well studied and less consistent. <jats:italic>Objective<\/jats:italic>: To determine to the effect of ETS on perinatal outcomes. <jats:italic>Search strategy<\/jats:italic>. Medline, EMBASE and reference lists were searched. <jats:italic>Selection criteria<\/jats:italic>. Studies comparing ETS\u2010exposed pregnant women with those unexposed which adequately addressed active maternal smoking. <jats:italic>Data collection and analysis<\/jats:italic>. Two reviewers independently assessed titles, abstracts, full studies, extracted data and assessed quality. Dichotomous data were pooled using odds ratios (OR) and continuous data with weighted mean differences (WMD) using a random effects model. <jats:italic>Main results<\/jats:italic>. Seventy\u2010six articles were included with a total of 48,439 ETS\u2010exposed women and 90,918 unexposed women. ETS\u2010exposed infants weighed less [WMD \u201360 g, 95% confidence interval (CI) \u201380 to \u201339 g], with a trend towards increased low birthweight (LBW, &lt; 2,500 g; RR 1.16; 95% CI 0.99\u20131.36), although the duration of gestation and preterm delivery were similar (WMD 0.02 weeks, 95% CI \u20130.09 to 0.12 weeks and RR 1.07; 95% CI 0.93\u20131.22). ETS\u2010exposed infants had longer infant lengths (1.75 cm; 95% CI 1.37\u20132.12 cm), increased risks of congenital anomalies (OR 1.17; 95% CI 1.03\u20131.34) and a trend towards smaller head circumferences (\u20130.11 cm; 95% CI \u20130.22 to 0.01 cm). <jats:italic>Conclusions<\/jats:italic>. ETS\u2010exposed women have increased risks of infants with lower birthweight, congenital anomalies, longer lengths, and trends towards smaller head circumferences and LBW.<\/jats:p>","DOI":"10.3109\/00016340903505748","type":"journal-article","created":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T11:18:56Z","timestamp":1263986336000},"page":"423-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":215,"title":["Environmental tobacco smoke exposure and perinatal outcomes: a systematic review and meta\u2010analyses"],"prefix":"10.1111","volume":"89","author":[{"given":"GISELLE","family":"SALMASI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROSHEEN","family":"GRADY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JENNIFER","family":"JONES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SARAH D.","family":"MCDONALD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On behalf of the Knowledge Synthesis Group*","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199706)55:6<382::AID-TERA5>3.0.CO;2-#"},{"key":"e_1_2_6_3_2","first-page":"1059","article-title":"Effects of maternal smoking on adverse pregnancy outcomes: examination of the criteria of causation","volume":"66","author":"Walsh RA","year":"1994","journal-title":"Hum Biol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf190"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-0005(96)80083-8"},{"key":"e_1_2_6_6_2","first-page":"385","article-title":"Effect of maternal cigarette smoking on pregnancy complications and Sudden Infant Death Syndrome","volume":"40","author":"DiFranza JR","year":"1995","journal-title":"J Fam Prac"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/26.5.978"},{"key":"e_1_2_6_8_2","first-page":"333","article-title":"Does maternal cigarette smoking during pregnancy cause cleft lip and palate in offspring?","volume":"143","author":"Khoury MJ","year":"1989","journal-title":"Am J Dis Child"},{"key":"e_1_2_6_9_2","first-page":"84","article-title":"Effects of exposure to environmental tobacco smoke on reproductive health","volume":"28","author":"Lindbohm ML","year":"2002","journal-title":"Scand J Work Environ. 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