{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:43:59Z","timestamp":1789940639574,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":244,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To compare 24\u2010hour controlled\u2010release vaginal dinoprostone pessary vs. gel for induction of labor at term in women with an unfavorable cervix. <jats:italic>Design.<\/jats:italic> Randomized controlled trial. <jats:italic>Setting.<\/jats:italic> University hospital. <jats:italic>Population.<\/jats:italic> A total of 133 women with singleton pregnancies, fetal cephalic presentation, Bishop score \u2264 4, gestational age of 37\u201342 weeks, no previous cesarean section and intact membranes admitted for induction of labor. <jats:italic>Methods.<\/jats:italic> Random allocation to either 24\u2010hour 10\u2010mg controlled\u2010release vaginal dinoprostone pessary or repeat doses of 2 mg vaginal dinoprostone gel. <jats:italic>Main outcome measures.<\/jats:italic> Rate of spontaneous vaginal, operative vaginal and cesarean delivery. <jats:italic>Results.<\/jats:italic> The rate of spontaneous vaginal delivery was significantly higher in the pessary group (72%) than in the gel group (54%), paralleled by a lower rate of operative vaginal deliveries (3 vs. 15%). The difference in cesarean section rate (25 vs. 31%) did not reach statistical significance. Both methods of induction of labor appeared to be safe, with no cases of 5\u2010minute Apgar scores &lt; 7 or episodes of uterine hyperstimulation in either group. The medication cost was lower in the pessary group, with a median saving of 50.20\u20ac compared to the gel group. <jats:italic>Conclusions.<\/jats:italic> Both the 24\u2010hour dinoprostone vaginal pessary and the vaginal gel appear to be safe for labor induction. In women induced at term with a Bishop score \u2264 4 the pessary achieved a significantly higher rate of spontaneous vaginal delivery.<\/jats:p>","DOI":"10.3109\/00016340903575998","type":"journal-article","created":{"date-parts":[[2010,3,4]],"date-time":"2010-03-04T12:58:00Z","timestamp":1267707480000},"page":"651-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["A randomized controlled trial of 24\u2010hour vaginal dinoprostone pessary compared to gel for induction of labor in term pregnancies with a Bishop score \u2264 4"],"prefix":"10.1111","volume":"89","author":[{"given":"MARIA TERESA","family":"TRIGLIA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FABRIZIO","family":"PALAMARA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANDREA","family":"LOJACONO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FEDERICO","family":"PREFUMO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TIZIANA","family":"FRUSCA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70153-4"},{"key":"e_1_2_6_3_2","first-page":"89","article-title":"Prostaglandins in preinduction cervical ripening. 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