{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:59:21Z","timestamp":1787025561496,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":244,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . To determine the risk of preeclampsia in a population with respect to maternal and sister histories of chronic hypertension, preeclampsia and eclampsia.\n                    <jats:italic>Design.<\/jats:italic>\n                    A case\u2010control study of severe preeclampsia.\n                    <jats:italic>Setting<\/jats:italic>\n                    . Maternity hospital in Natal, Brazil.\n                    <jats:italic>Participants.<\/jats:italic>\n                    A total of 412 subjects were enrolled, 148 cases and 264 controls.\n                    <jats:italic>Main outcome measures<\/jats:italic>\n                    . Personal and familial histories of hypertensive disorders. Odds ratio estimates of preeclampsia with respect to family history of hypertensive diseases.\n                    <jats:italic>Results<\/jats:italic>\n                    . Women with a history of hypertensive disorders were more frequent in the case group (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.001). Women whose mothers had a history of hypertension (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.003), preeclampsia (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.007) or eclampsia (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.038) were at increased risk of severe preeclampsia. The risk of preeclampsia was greater when the woman had a sister with a history of hypertension (OR 2.60, 95% CI 1.60\u20134.21,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), preeclampsia (OR 2.33, 95% CI 1.58\u20133.45,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), or eclampsia (OR 2.57, 95% CI 1.28\u20135.16,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.008). The risk of preeclampsia was also higher for women who had both a mother and sister with a history of hypertension (OR 3.65, 95% CI 1.65\u20138.09,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.001).\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . A family history of hypertensive disorders increased the risk of eclampsia and hemolysis elevated liver enzymes and low platelet (HELLP) syndrome in a Brazilian population.\n                  <\/jats:p>","DOI":"10.3109\/00016341003623720","type":"journal-article","created":{"date-parts":[[2010,4,28]],"date-time":"2010-04-28T02:42:34Z","timestamp":1272422554000},"page":"612-617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Family history of hypertension as an important risk factor for the development of severe preeclampsia"],"prefix":"10.1111","volume":"89","author":[{"given":"PATRICIA C.F.M.","family":"BEZERRA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARCOS D.","family":"LE\u00c3O","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOS\u00c9 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